UniProtKB - P58462 (FOXP1_MOUSE)
(max 400 entries)x
Your basket is currently empty. i
Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)
Protein
Forkhead box protein P1
Gene
Foxp1
Organism
Mus musculus (Mouse)
Status
Functioni
Transcriptional repressor. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (PubMed:11358962, PubMed:14701752). Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2 (PubMed:11358962, PubMed:22675208). Essential transcriptional regulator of B-cell development (PubMed:16819554). Involved in regulation of cardiac muscle cell proliferation (PubMed:20713518). Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal chord motor columns requires cooperation with other Hox proteins (PubMed:18667151, PubMed:18662545). Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3 (PubMed:20175877). Negatively regulates the differentiation of T follicular helper cells T(FH)s (PubMed:24859450). Involved in maintenance of hair follicle stem cell quiescence; the function probably involves regulation of FGF18 (PubMed:23946441). Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis. Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions; repression of CSF1R in monocytes seems to involve NCOR2 as corepressor. Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis; the role in neovascularization seems to implicate suppression of SEMA5B. Can negatively regulate androgen receptor signaling (By similarity).By similarity3 Publications9 Publications
Isoform 5: Involved in transcriptional regulation in embryonic stem cells (ESCs). Stimulates expression of transcription factors that are required for pluripotency and decreases expression of differentiation-associated genes. Has distinct DNA-binding specifities as compared to the canonical form and preferentially binds DNA with the sequence 5'-CGATACAA-3' (or closely related sequences) (By similarity). Promotes ESC self-renewal and pluripotency (PubMed:21924763).By similarity1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 334 – 359 | C2H2-typeAdd BLAST | 26 | |
DNA bindingi | 493 – 583 | Fork-headPROSITE-ProRule annotationAdd BLAST | 91 |
GO - Molecular functioni
- chromatin binding Source: MGI
- DNA binding Source: MGI
- DNA binding transcription factor activity Source: MGI
- metal ion binding Source: UniProtKB-KW
- protein heterodimerization activity Source: MGI
- protein homodimerization activity Source: MGI
- protein self-association Source: UniProtKB
- RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB
- transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB
- transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Source: MGI
- transcription factor binding Source: Ensembl
GO - Biological processi
- cardiac muscle cell differentiation Source: MGI
- cardiovascular system development Source: MGI
- cellular response to ionomycin Source: Ensembl
- cellular response to tumor necrosis factor Source: Ensembl
- chemokine (C-C motif) ligand 2 secretion Source: UniProtKB
- endothelial cell activation Source: UniProtKB
- heart development Source: MGI
- immunoglobulin V(D)J recombination Source: MGI
- interleukin-21 secretion Source: UniProtKB
- in utero embryonic development Source: MGI
- lung development Source: MGI
- lung secretory cell differentiation Source: MGI
- macrophage activation Source: UniProtKB
- monocyte activation Source: UniProtKB
- motor neuron axon guidance Source: UniProtKB
- negative regulation of androgen receptor signaling pathway Source: UniProtKB
- negative regulation of B cell apoptotic process Source: UniProtKB
- negative regulation of cell growth involved in cardiac muscle cell development Source: Ensembl
- negative regulation of lung goblet cell differentiation Source: MGI
- negative regulation of transcription, DNA-templated Source: MGI
- negative regulation of transcription by RNA polymerase II Source: NTNU_SB
- osteoclast development Source: UniProtKB
- osteoclast differentiation Source: UniProtKB
- positive regulation of cardiac muscle cell differentiation Source: MGI
- positive regulation of endothelial cell migration Source: UniProtKB
- positive regulation of epithelial cell proliferation Source: MGI
- positive regulation of hydrogen peroxide-induced cell death Source: Ensembl
- positive regulation of immunoglobulin production Source: MGI
- positive regulation of mesenchymal cell proliferation Source: MGI
- positive regulation of smooth muscle cell proliferation Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: MGI
- pre-B cell differentiation Source: MGI
- regulation of cardiac muscle cell proliferation Source: MGI
- regulation of defense response to bacterium Source: UniProtKB
- regulation of lung goblet cell differentiation Source: MGI
- regulation of macrophage colony-stimulating factor production Source: UniProtKB
- regulation of monocyte differentiation Source: UniProtKB
- regulation of tumor necrosis factor production Source: UniProtKB
- response to lipopolysaccharide Source: UniProtKB
- response to testosterone Source: Ensembl
- sarcomere organization Source: MGI
- skeletal muscle tissue development Source: MGI
- smooth muscle tissue development Source: MGI
- striatum development Source: Ensembl
- T follicular helper cell differentiation Source: UniProtKB
- transcription, DNA-templated Source: UniProtKB-KW
- ventral spinal cord development Source: UniProtKB
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Forkhead box protein P1Alternative name(s): Forkhead-related transcription factor 1 |
Gene namesi | Name:Foxp1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1914004. Foxp1. |
Pathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 388 | Missing : Loss of dimerization. Almost complete loss of DNA-binding. Reduced transcriptional repression activity. 1 Publication | 1 | |
Mutagenesisi | 410 – 414 | PLNLV → AANAA: No significant effect on transcriptional repression activity. 1 Publication | 5 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000009336 | 1 – 705 | Forkhead box protein P1Add BLAST | 705 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 113 | PhosphoserineBy similarity | 1 | |
Cross-linki | 315 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 400 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 405 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 470 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 681 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 686 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P58462. |
MaxQBi | P58462. |
PaxDbi | P58462. |
PeptideAtlasi | P58462. |
PRIDEi | P58462. |
PTM databases
iPTMneti | P58462. |
PhosphoSitePlusi | P58462. |
Expressioni
Tissue specificityi
Isoform 5 is specifically expressed in embryonic stem cells (PubMed:21924763). Highest expression in the lung, brain, and spleen. Lower expression in heart, skeletal muscle, kidney, small intestine (isoform 3 not present) and liver.1 Publication
Developmental stagei
Expressed in developing lung, neural, intestinal and cardiovascular tissues. Expressed in both the airway epithelium of the forming lung as well as in the surrounding mesenchyme. By 16.5 dpc, expressed throughout the conducting airway epithelium, with highest expression in the distal alveolar regions. Also expressed in the endotheial cells of the pulmonary vasculature. During intestinal development, expressed in the mucosal layer but absent from the epithelium at 12.5 dpc. By 16.5 dpc, expressed in both the inner circular and outer longitudinal muscular layers of the intestine as well as in the epithelium of the intestine and developing stomach (PubMed:14516685). Expressed in E12.5 midbrain dopaminergic neurons (PubMed:20175877).2 Publications
Gene expression databases
Bgeei | ENSMUSG00000030067. |
CleanExi | MM_FOXP1. |
ExpressionAtlasi | P58462. baseline and differential. |
Genevisiblei | P58462. MM. |
Interactioni
Subunit structurei
Forms homodimers and heterodimers with FOXP2 and FOXP4. Dimerization is required for DNA-binding. Self-associates (By similarity). Interacts with CTBP1 (PubMed:14701752). Interacts with NCOR2 and AR. Interacts with FOXP2 (By similarity).By similarity1 Publication
GO - Molecular functioni
- protein heterodimerization activity Source: MGI
- protein homodimerization activity Source: MGI
- protein self-association Source: UniProtKB
- transcription factor binding Source: Ensembl
Protein-protein interaction databases
BioGridi | 224357. 10 interactors. |
STRINGi | 10090.ENSMUSP00000073953. |
Structurei
3D structure databases
ProteinModelPortali | P58462. |
SMRi | P58462. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 376 – 397 | Leucine-zipperAdd BLAST | 22 | |
Regioni | 410 – 414 | CTBP1-binding | 5 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 55 – 258 | Gln-richAdd BLAST | 204 |
Domaini
The leucine-zipper is required for dimerization and transcriptional repression.1 Publication
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 334 – 359 | C2H2-typeAdd BLAST | 26 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG4385. Eukaryota. COG5025. LUCA. |
GeneTreei | ENSGT00910000144016. |
HOGENOMi | HOG000092089. |
HOVERGENi | HBG051657. |
InParanoidi | P58462. |
KOi | K09409. |
Family and domain databases
CDDi | cd00059. FH. 1 hit. |
Gene3Di | 1.10.10.10. 1 hit. |
InterProi | View protein in InterPro IPR001766. Fork_head_dom. IPR032354. FOXP-CC. IPR030456. TF_fork_head_CS_2. IPR036388. WH-like_DNA-bd_sf. IPR036390. WH_DNA-bd_sf. |
Pfami | View protein in Pfam PF00250. Forkhead. 1 hit. PF16159. FOXP-CC. 1 hit. |
PRINTSi | PR00053. FORKHEAD. |
SMARTi | View protein in SMART SM00339. FH. 1 hit. |
SUPFAMi | SSF46785. SSF46785. 1 hit. |
PROSITEi | View protein in PROSITE PS00658. FORK_HEAD_2. 1 hit. PS50039. FORK_HEAD_3. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 1 hit. |
s (5)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing and alternative initiation. AlignAdd to basket
Isoform 1 (identifier: P58462-1) [UniParc]FASTAAdd to basket
Also known as: A
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MMQESGSETK SNGSAIQNGS SGGNHLLECG ALRDTRSNGE APAVDLGAAD
60 70 80 90 100
LAHVQQQQQQ ALQVARQLLL QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ
110 120 130 140 150
QQQQQQQVSG LKSPKRNDKQ PALQVPVSVA MMTPQVITPQ QMQQILQQQV
160 170 180 190 200
LSPQQLQVLL QQQQALMLQQ QLQEFYKKQQ EQLQLQLLQQ QHAGKQPKEQ
210 220 230 240 250
QVATQQLAFQ QQLLQMQQLQ QQHLLSLQRQ GLLTIQPGQP ALPLQPLAQG
260 270 280 290 300
MIPTELQQLW KEVTSAHTAE ETTSSNHSSL DLTSTCVSSS APSKSSLIMN
310 320 330 340 350
PHASTNGQLS VHTPKRESLS HEEHPHSHPL YGHGVCKWPG CEAVCDDFPA
360 370 380 390 400
FLKHLNSEHA LDDRSTAQCR VQMQVVQQLE LQLAKDKERL QAMMTHLHVK
410 420 430 440 450
STEPKAAPQP LNLVSSVTLS KSASEASPQS LPHTPTTPTA PLTPVTQGPS
460 470 480 490 500
VITTTSMHTV GPIRRRYSDK YNVPISSADI AQNQEFYKNA EVRPPFTYAS
510 520 530 540 550
LIRQAILESP EKQLTLNEIY NWFTRMFAYF RRNAATWKNA VRHNLSLHKC
560 570 580 590 600
FVRVENVKGA VWTVDEVEFQ KRRPQKISGN PSLIKNMQSS HAYCTPLNAA
610 620 630 640 650
LQASMAENSI PLYTTASMGN PTLGSLASAI REELNGAMEH TNSNESDSSP
660 670 680 690 700
GRSPMQAVHP IHVKEEPLDP EEAEGPLSLV TTANHSPDFD HDRDYEDEPV
NEDME
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 61 – 92 | Missing in AAH64764 (PubMed:15489334).CuratedAdd BLAST | 32 | |
Sequence conflicti | 199 | E → EQ in BAC28249 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 199 | E → EQ in BAC36586 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 281 | D → H in BAC28249 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 353 | K → T in BAC28249 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 597 | L → F in BAC28249 (PubMed:16141072).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_018732 | 1 – 250 | Missing in isoform 3. 1 PublicationAdd BLAST | 250 | |
Alternative sequenceiVSP_026670 | 1 – 130 | Missing in isoform 4. 1 PublicationAdd BLAST | 130 | |
Alternative sequenceiVSP_001557 | 539 – 602 | Missing in isoform 2. 1 PublicationAdd BLAST | 64 | |
Alternative sequenceiVSP_057342 | 540 – 579 | AVRHN…QKISG → GAIRTLSLHKCFIRVEDEFG SFWTVDDEEFLRGRHIQRGR PRKYCPDENSDELGAH in isoform 5. 1 PublicationAdd BLAST | 40 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF339103 mRNA. Translation: AAK69648.1. AF339104 mRNA. Translation: AAK69649.1. AF339105 mRNA. Translation: AAK69650.1. AK033368 mRNA. Translation: BAC28249.1. AK077062 mRNA. Translation: BAC36586.1. BC064764 mRNA. Translation: AAH64764.1. |
CCDSi | CCDS39578.1. [P58462-1] |
RefSeqi | NP_001184250.1. NM_001197321.1. NP_001184251.1. NM_001197322.1. NP_444432.1. NM_053202.2. [P58462-1] XP_006505385.1. XM_006505322.1. XP_006505386.1. XM_006505323.3. |
UniGenei | Mm.234965. Mm.392884. Mm.485266. Mm.487716. |
Genome annotation databases
Ensembli | ENSMUST00000074346; ENSMUSP00000073953; ENSMUSG00000030067. [P58462-1] ENSMUST00000113322; ENSMUSP00000108948; ENSMUSG00000030067. [P58462-1] ENSMUST00000113329; ENSMUSP00000108955; ENSMUSG00000030067. [P58462-2] |
GeneIDi | 108655. |
KEGGi | mmu:108655. |
UCSCi | uc009dbi.2. mouse. [P58462-1] uc009dbl.2. mouse. [P58462-2] |
Keywords - Coding sequence diversityi
Alternative initiation, Alternative splicingSimilar proteinsi
Entry informationi
Entry namei | FOXP1_MOUSE | |
Accessioni | P58462Primary (citable) accession number: P58462 Secondary accession number(s): Q6P221, Q8C5V2, Q8CCD9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 5, 2001 |
Last sequence update: | December 5, 2001 | |
Last modified: | March 28, 2018 | |
This is version 152 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |