Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P58462

- FOXP1_MOUSE

UniProt

P58462 - FOXP1_MOUSE

Protein

Forkhead box protein P1

Gene

Foxp1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 1 (05 Dec 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Transcriptional repressor that plays an important role in the specification and differentiation of lung epithelium. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Essential transcriptional regulator of B-cell development.2 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri334 – 35926C2H2-typeAdd
    BLAST
    DNA bindingi493 – 58391Fork-headPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. chromatin binding Source: MGI
    2. DNA binding Source: MGI
    3. metal ion binding Source: UniProtKB-KW
    4. protein binding Source: UniProtKB
    5. protein heterodimerization activity Source: MGI
    6. protein homodimerization activity Source: MGI
    7. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
    8. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: NTNU_SB
    9. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: MGI
    10. sequence-specific DNA binding transcription factor activity Source: MGI

    GO - Biological processi

    1. cardiac muscle cell differentiation Source: MGI
    2. cardiovascular system development Source: MGI
    3. heart development Source: MGI
    4. immunoglobulin V(D)J recombination Source: MGI
    5. in utero embryonic development Source: MGI
    6. lung development Source: MGI
    7. lung secretory cell differentiation Source: MGI
    8. motor neuron axon guidance Source: UniProtKB
    9. negative regulation of lung goblet cell differentiation Source: MGI
    10. negative regulation of transcription, DNA-templated Source: MGI
    11. negative regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
    12. positive regulation of cardiac muscle cell differentiation Source: MGI
    13. positive regulation of epithelial cell proliferation Source: MGI
    14. positive regulation of immunoglobulin production Source: MGI
    15. positive regulation of mesenchymal cell proliferation Source: MGI
    16. positive regulation of transcription, DNA-templated Source: UniProtKB
    17. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    18. pre-B cell differentiation Source: MGI
    19. regulation of cardiac muscle cell proliferation Source: MGI
    20. regulation of lung goblet cell differentiation Source: MGI
    21. sarcomere organization Source: MGI
    22. skeletal muscle tissue development Source: MGI
    23. smooth muscle tissue development Source: MGI
    24. transcription from RNA polymerase II promoter Source: GOC
    25. ventral spinal cord development Source: UniProtKB

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Forkhead box protein P1
    Alternative name(s):
    Forkhead-related transcription factor 1
    Gene namesi
    Name:Foxp1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:1914004. Foxp1.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi388 – 3881Missing: Loss of dimerization. Almost complete loss of DNA-binding. Reduced transcriptional repression activity. 1 Publication
    Mutagenesisi410 – 4145PLNLV → AANAA: No significant effect on transcriptional repression activity.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 705705Forkhead box protein P1PRO_0000009336Add
    BLAST

    Proteomic databases

    MaxQBiP58462.
    PaxDbiP58462.
    PRIDEiP58462.

    PTM databases

    PhosphoSiteiP58462.

    Expressioni

    Tissue specificityi

    Highest expression in the lung, brain, and spleen. Lower expression in heart, skeletal muscle, kidney, small intestine (isoform 3 not present) and liver.

    Developmental stagei

    Expressed in developing lung, neural, intestinal and cardiovascular tissues. Expressed in both the airway epithelium of the forming lung as well as in the surrounding mesenchyme. By 16.5 dpc, expressed throughout the conducting airway epithelium, with highest expression in the distal alveolar regions. Also expressed in the endotheial cells of the pulmonary vasculature. During intestinal development, expressed in the mucosal layer but absent from the epithelium at 12.5 dpc. By 16.5 dpc, expressed in both the inner circular and outer longitudinal muscular layers of the intestine as well as in the epithelium of the intestine and developing stomach.1 Publication

    Gene expression databases

    ArrayExpressiP58462.
    BgeeiP58462.
    CleanExiMM_FOXP1.
    GenevestigatoriP58462.

    Interactioni

    Subunit structurei

    Forms homodimers and heterodimers with FOXP2 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1.1 Publication

    Protein-protein interaction databases

    BioGridi224357. 9 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliP58462.
    SMRiP58462. Positions 339-397, 490-576.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni376 – 39722Leucine-zipperAdd
    BLAST
    Regioni410 – 4145CTBP1-binding

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi55 – 258204Gln-richAdd
    BLAST

    Domaini

    The leucine-zipper is required for dimerization and transcriptional repression.1 Publication

    Sequence similaritiesi

    Contains 1 C2H2-type zinc finger.Curated
    Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri334 – 35926C2H2-typeAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5025.
    GeneTreeiENSGT00750000117475.
    HOGENOMiHOG000092089.
    HOVERGENiHBG051657.
    KOiK09409.
    OrthoDBiEOG7M6D7G.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    IPR015880. Znf_C2H2-like.
    [Graphical view]
    PfamiPF00250. Fork_head. 1 hit.
    [Graphical view]
    PRINTSiPR00053. FORKHEAD.
    SMARTiSM00339. FH. 1 hit.
    SM00355. ZnF_C2H2. 1 hit.
    [Graphical view]
    PROSITEiPS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing and alternative initiation. Align

    Isoform 1 (identifier: P58462-1) [UniParc]FASTAAdd to Basket

    Also known as: A

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MMQESGSETK SNGSAIQNGS SGGNHLLECG ALRDTRSNGE APAVDLGAAD    50
    LAHVQQQQQQ ALQVARQLLL QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ 100
    QQQQQQQVSG LKSPKRNDKQ PALQVPVSVA MMTPQVITPQ QMQQILQQQV 150
    LSPQQLQVLL QQQQALMLQQ QLQEFYKKQQ EQLQLQLLQQ QHAGKQPKEQ 200
    QVATQQLAFQ QQLLQMQQLQ QQHLLSLQRQ GLLTIQPGQP ALPLQPLAQG 250
    MIPTELQQLW KEVTSAHTAE ETTSSNHSSL DLTSTCVSSS APSKSSLIMN 300
    PHASTNGQLS VHTPKRESLS HEEHPHSHPL YGHGVCKWPG CEAVCDDFPA 350
    FLKHLNSEHA LDDRSTAQCR VQMQVVQQLE LQLAKDKERL QAMMTHLHVK 400
    STEPKAAPQP LNLVSSVTLS KSASEASPQS LPHTPTTPTA PLTPVTQGPS 450
    VITTTSMHTV GPIRRRYSDK YNVPISSADI AQNQEFYKNA EVRPPFTYAS 500
    LIRQAILESP EKQLTLNEIY NWFTRMFAYF RRNAATWKNA VRHNLSLHKC 550
    FVRVENVKGA VWTVDEVEFQ KRRPQKISGN PSLIKNMQSS HAYCTPLNAA 600
    LQASMAENSI PLYTTASMGN PTLGSLASAI REELNGAMEH TNSNESDSSP 650
    GRSPMQAVHP IHVKEEPLDP EEAEGPLSLV TTANHSPDFD HDRDYEDEPV 700
    NEDME 705
    Length:705
    Mass (Da):78,833
    Last modified:December 5, 2001 - v1
    Checksum:i92962B82917CC79D
    GO
    Isoform 2 (identifier: P58462-2) [UniParc]FASTAAdd to Basket

    Also known as: B

    The sequence of this isoform differs from the canonical sequence as follows:
         539-602: Missing.

    Show »
    Length:641
    Mass (Da):71,591
    Checksum:i8B898F9AC3BB917C
    GO
    Isoform 3 (identifier: P58462-3) [UniParc]FASTAAdd to Basket

    Also known as: C

    The sequence of this isoform differs from the canonical sequence as follows:
         1-250: Missing.

    Note: Produced by alternative initiation at Met-251 of isoform 1.

    Show »
    Length:455
    Mass (Da):50,493
    Checksum:iEA5EC089D4DB8168
    GO
    Isoform 4 (identifier: P58462-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-130: Missing.

    Note: Produced by alternative splicing. No experimental confirmation available.

    Show »
    Length:575
    Mass (Da):64,422
    Checksum:i381CAA8E3720A7F0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti61 – 9232Missing in AAH64764. (PubMed:15489334)CuratedAdd
    BLAST
    Sequence conflicti199 – 1991E → EQ in BAC28249. (PubMed:16141072)Curated
    Sequence conflicti199 – 1991E → EQ in BAC36586. (PubMed:16141072)Curated
    Sequence conflicti281 – 2811D → H in BAC28249. (PubMed:16141072)Curated
    Sequence conflicti353 – 3531K → T in BAC28249. (PubMed:16141072)Curated
    Sequence conflicti597 – 5971L → F in BAC28249. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 250250Missing in isoform 3. 1 PublicationVSP_018732Add
    BLAST
    Alternative sequencei1 – 130130Missing in isoform 4. 1 PublicationVSP_026670Add
    BLAST
    Alternative sequencei539 – 60264Missing in isoform 2. 1 PublicationVSP_001557Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF339103 mRNA. Translation: AAK69648.1.
    AF339104 mRNA. Translation: AAK69649.1.
    AF339105 mRNA. Translation: AAK69650.1.
    AK033368 mRNA. Translation: BAC28249.1.
    AK077062 mRNA. Translation: BAC36586.1.
    BC064764 mRNA. Translation: AAH64764.1.
    CCDSiCCDS39578.1. [P58462-1]
    RefSeqiNP_001184250.1. NM_001197321.1.
    NP_001184251.1. NM_001197322.1.
    NP_444432.1. NM_053202.2. [P58462-1]
    XP_006505385.1. XM_006505322.1.
    XP_006505386.1. XM_006505323.1.
    UniGeneiMm.234965.
    Mm.392884.
    Mm.485266.

    Genome annotation databases

    EnsembliENSMUST00000074346; ENSMUSP00000073953; ENSMUSG00000030067. [P58462-1]
    ENSMUST00000113322; ENSMUSP00000108948; ENSMUSG00000030067. [P58462-1]
    ENSMUST00000113326; ENSMUSP00000108952; ENSMUSG00000030067.
    ENSMUST00000113329; ENSMUSP00000108955; ENSMUSG00000030067. [P58462-2]
    ENSMUST00000177437; ENSMUSP00000135809; ENSMUSG00000030067.
    GeneIDi108655.
    KEGGimmu:108655.
    UCSCiuc009dbi.2. mouse. [P58462-1]
    uc009dbl.2. mouse. [P58462-2]

    Keywords - Coding sequence diversityi

    Alternative initiation, Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF339103 mRNA. Translation: AAK69648.1 .
    AF339104 mRNA. Translation: AAK69649.1 .
    AF339105 mRNA. Translation: AAK69650.1 .
    AK033368 mRNA. Translation: BAC28249.1 .
    AK077062 mRNA. Translation: BAC36586.1 .
    BC064764 mRNA. Translation: AAH64764.1 .
    CCDSi CCDS39578.1. [P58462-1 ]
    RefSeqi NP_001184250.1. NM_001197321.1.
    NP_001184251.1. NM_001197322.1.
    NP_444432.1. NM_053202.2. [P58462-1 ]
    XP_006505385.1. XM_006505322.1.
    XP_006505386.1. XM_006505323.1.
    UniGenei Mm.234965.
    Mm.392884.
    Mm.485266.

    3D structure databases

    ProteinModelPortali P58462.
    SMRi P58462. Positions 339-397, 490-576.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 224357. 9 interactions.

    PTM databases

    PhosphoSitei P58462.

    Proteomic databases

    MaxQBi P58462.
    PaxDbi P58462.
    PRIDEi P58462.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000074346 ; ENSMUSP00000073953 ; ENSMUSG00000030067 . [P58462-1 ]
    ENSMUST00000113322 ; ENSMUSP00000108948 ; ENSMUSG00000030067 . [P58462-1 ]
    ENSMUST00000113326 ; ENSMUSP00000108952 ; ENSMUSG00000030067 .
    ENSMUST00000113329 ; ENSMUSP00000108955 ; ENSMUSG00000030067 . [P58462-2 ]
    ENSMUST00000177437 ; ENSMUSP00000135809 ; ENSMUSG00000030067 .
    GeneIDi 108655.
    KEGGi mmu:108655.
    UCSCi uc009dbi.2. mouse. [P58462-1 ]
    uc009dbl.2. mouse. [P58462-2 ]

    Organism-specific databases

    CTDi 27086.
    MGIi MGI:1914004. Foxp1.

    Phylogenomic databases

    eggNOGi COG5025.
    GeneTreei ENSGT00750000117475.
    HOGENOMi HOG000092089.
    HOVERGENi HBG051657.
    KOi K09409.
    OrthoDBi EOG7M6D7G.

    Miscellaneous databases

    ChiTaRSi FOXP1. mouse.
    NextBioi 361173.
    PROi P58462.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P58462.
    Bgeei P58462.
    CleanExi MM_FOXP1.
    Genevestigatori P58462.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    IPR015880. Znf_C2H2-like.
    [Graphical view ]
    Pfami PF00250. Fork_head. 1 hit.
    [Graphical view ]
    PRINTSi PR00053. FORKHEAD.
    SMARTi SM00339. FH. 1 hit.
    SM00355. ZnF_C2H2. 1 hit.
    [Graphical view ]
    PROSITEi PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of a new subfamily of winged-helix/forkhead (Fox) genes that are expressed in the lung and act as transcriptional repressors."
      Shu W., Yang H., Zhang L., Lu M.M., Morrisey E.E.
      J. Biol. Chem. 276:27488-27497(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).
      Strain: C57BL/6.
      Tissue: Lung.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Strain: C57BL/6J.
      Tissue: Lung and Testis.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Embryo.
    4. "Foxp4: a novel member of the Foxp subfamily of winged-helix genes co-expressed with Foxp1 and Foxp2 in pulmonary and gut tissues."
      Lu M.M., Li S., Yang H., Morrisey E.E.
      Mech. Dev. 119:S197-S202(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: DEVELOPMENTAL STAGE.
    5. "Transcriptional and DNA binding activity of the Foxp1/2/4 family is modulated by heterotypic and homotypic protein interactions."
      Li S., Weidenfeld J., Morrisey E.E.
      Mol. Cell. Biol. 24:809-822(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DIMERIZATION, INTERACTION WITH CTBP1, DOMAIN, MUTAGENESIS OF GLU-388 AND 410-PRO--VAL-414.
    6. "Foxp1 is an essential transcriptional regulator of B cell development."
      Hu H., Wang B., Borde M., Nardone J., Maika S., Allred L., Tucker P.W., Rao A.
      Nat. Immunol. 7:819-826(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiFOXP1_MOUSE
    AccessioniPrimary (citable) accession number: P58462
    Secondary accession number(s): Q6P221, Q8C5V2, Q8CCD9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 5, 2001
    Last sequence update: December 5, 2001
    Last modified: October 1, 2014
    This is version 121 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3