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P58462

- FOXP1_MOUSE

UniProt

P58462 - FOXP1_MOUSE

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Protein
Forkhead box protein P1
Gene
Foxp1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Transcriptional repressor that plays an important role in the specification and differentiation of lung epithelium. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Essential transcriptional regulator of B-cell development.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri334 – 35926C2H2-type
Add
BLAST
DNA bindingi493 – 58391Fork-head
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. DNA binding, bending Source: RefGenome
  3. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: MGI
  4. chromatin binding Source: MGI
  5. metal ion binding Source: UniProtKB-KW
  6. protein binding Source: UniProtKB
  7. protein heterodimerization activity Source: MGI
  8. protein homodimerization activity Source: MGI
  9. sequence-specific DNA binding Source: InterPro
  10. sequence-specific DNA binding transcription factor activity Source: MGI
Complete GO annotation...

GO - Biological processi

  1. cardiac muscle cell differentiation Source: MGI
  2. cardiovascular system development Source: MGI
  3. heart development Source: MGI
  4. immunoglobulin V(D)J recombination Source: MGI
  5. in utero embryonic development Source: MGI
  6. lung development Source: MGI
  7. lung secretory cell differentiation Source: MGI
  8. motor neuron axon guidance Source: UniProtKB
  9. negative regulation of lung goblet cell differentiation Source: MGI
  10. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  11. negative regulation of transcription, DNA-templated Source: MGI
  12. pattern specification process Source: RefGenome
  13. positive regulation of cardiac muscle cell differentiation Source: MGI
  14. positive regulation of epithelial cell proliferation Source: MGI
  15. positive regulation of immunoglobulin production Source: MGI
  16. positive regulation of mesenchymal cell proliferation Source: MGI
  17. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  18. positive regulation of transcription, DNA-templated Source: UniProtKB
  19. pre-B cell differentiation Source: MGI
  20. regulation of cardiac muscle cell proliferation Source: MGI
  21. regulation of lung goblet cell differentiation Source: MGI
  22. sarcomere organization Source: MGI
  23. skeletal muscle tissue development Source: MGI
  24. smooth muscle tissue development Source: MGI
  25. transcription from RNA polymerase II promoter Source: GOC
  26. ventral spinal cord development Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein P1
Alternative name(s):
Forkhead-related transcription factor 1
Gene namesi
Name:Foxp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:1914004. Foxp1.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. cytoplasm Source: RefGenome
  2. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi388 – 3881Missing: Loss of dimerization. Almost complete loss of DNA-binding. Reduced transcriptional repression activity. 1 Publication
Mutagenesisi410 – 4145PLNLV → AANAA: No significant effect on transcriptional repression activity. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 705705Forkhead box protein P1
PRO_0000009336Add
BLAST

Proteomic databases

MaxQBiP58462.
PaxDbiP58462.
PRIDEiP58462.

PTM databases

PhosphoSiteiP58462.

Expressioni

Tissue specificityi

Highest expression in the lung, brain, and spleen. Lower expression in heart, skeletal muscle, kidney, small intestine (isoform 3 not present) and liver.

Developmental stagei

Expressed in developing lung, neural, intestinal and cardiovascular tissues. Expressed in both the airway epithelium of the forming lung as well as in the surrounding mesenchyme. By 16.5 dpc, expressed throughout the conducting airway epithelium, with highest expression in the distal alveolar regions. Also expressed in the endotheial cells of the pulmonary vasculature. During intestinal development, expressed in the mucosal layer but absent from the epithelium at 12.5 dpc. By 16.5 dpc, expressed in both the inner circular and outer longitudinal muscular layers of the intestine as well as in the epithelium of the intestine and developing stomach.1 Publication

Gene expression databases

ArrayExpressiP58462.
BgeeiP58462.
CleanExiMM_FOXP1.
GenevestigatoriP58462.

Interactioni

Subunit structurei

Forms homodimers and heterodimers with FOXP2 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1.1 Publication

Protein-protein interaction databases

BioGridi224357. 9 interactions.

Structurei

3D structure databases

ProteinModelPortaliP58462.
SMRiP58462. Positions 339-397, 490-576.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni376 – 39722Leucine-zipper
Add
BLAST
Regioni410 – 4145CTBP1-binding

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi55 – 258204Gln-rich
Add
BLAST

Domaini

The leucine-zipper is required for dimerization and transcriptional repression.1 Publication

Sequence similaritiesi

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiCOG5025.
GeneTreeiENSGT00750000117475.
HOGENOMiHOG000092089.
HOVERGENiHBG051657.
KOiK09409.
OrthoDBiEOG7M6D7G.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
SM00355. ZnF_C2H2. 1 hit.
[Graphical view]
PROSITEiPS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing and alternative initiation. Align

Isoform 1 (identifier: P58462-1) [UniParc]FASTAAdd to Basket

Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MMQESGSETK SNGSAIQNGS SGGNHLLECG ALRDTRSNGE APAVDLGAAD    50
LAHVQQQQQQ ALQVARQLLL QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ 100
QQQQQQQVSG LKSPKRNDKQ PALQVPVSVA MMTPQVITPQ QMQQILQQQV 150
LSPQQLQVLL QQQQALMLQQ QLQEFYKKQQ EQLQLQLLQQ QHAGKQPKEQ 200
QVATQQLAFQ QQLLQMQQLQ QQHLLSLQRQ GLLTIQPGQP ALPLQPLAQG 250
MIPTELQQLW KEVTSAHTAE ETTSSNHSSL DLTSTCVSSS APSKSSLIMN 300
PHASTNGQLS VHTPKRESLS HEEHPHSHPL YGHGVCKWPG CEAVCDDFPA 350
FLKHLNSEHA LDDRSTAQCR VQMQVVQQLE LQLAKDKERL QAMMTHLHVK 400
STEPKAAPQP LNLVSSVTLS KSASEASPQS LPHTPTTPTA PLTPVTQGPS 450
VITTTSMHTV GPIRRRYSDK YNVPISSADI AQNQEFYKNA EVRPPFTYAS 500
LIRQAILESP EKQLTLNEIY NWFTRMFAYF RRNAATWKNA VRHNLSLHKC 550
FVRVENVKGA VWTVDEVEFQ KRRPQKISGN PSLIKNMQSS HAYCTPLNAA 600
LQASMAENSI PLYTTASMGN PTLGSLASAI REELNGAMEH TNSNESDSSP 650
GRSPMQAVHP IHVKEEPLDP EEAEGPLSLV TTANHSPDFD HDRDYEDEPV 700
NEDME 705
Length:705
Mass (Da):78,833
Last modified:December 5, 2001 - v1
Checksum:i92962B82917CC79D
GO
Isoform 2 (identifier: P58462-2) [UniParc]FASTAAdd to Basket

Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     539-602: Missing.

Show »
Length:641
Mass (Da):71,591
Checksum:i8B898F9AC3BB917C
GO
Isoform 3 (identifier: P58462-3) [UniParc]FASTAAdd to Basket

Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     1-250: Missing.

Note: Produced by alternative initiation at Met-251 of isoform 1.

Show »
Length:455
Mass (Da):50,493
Checksum:iEA5EC089D4DB8168
GO
Isoform 4 (identifier: P58462-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-130: Missing.

Note: Produced by alternative splicing. No experimental confirmation available.

Show »
Length:575
Mass (Da):64,422
Checksum:i381CAA8E3720A7F0
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 250250Missing in isoform 3.
VSP_018732Add
BLAST
Alternative sequencei1 – 130130Missing in isoform 4.
VSP_026670Add
BLAST
Alternative sequencei539 – 60264Missing in isoform 2.
VSP_001557Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti61 – 9232Missing in AAH64764. 1 Publication
Add
BLAST
Sequence conflicti199 – 1991E → EQ in BAC28249. 1 Publication
Sequence conflicti199 – 1991E → EQ in BAC36586. 1 Publication
Sequence conflicti281 – 2811D → H in BAC28249. 1 Publication
Sequence conflicti353 – 3531K → T in BAC28249. 1 Publication
Sequence conflicti597 – 5971L → F in BAC28249. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF339103 mRNA. Translation: AAK69648.1.
AF339104 mRNA. Translation: AAK69649.1.
AF339105 mRNA. Translation: AAK69650.1.
AK033368 mRNA. Translation: BAC28249.1.
AK077062 mRNA. Translation: BAC36586.1.
BC064764 mRNA. Translation: AAH64764.1.
CCDSiCCDS39578.1. [P58462-1]
RefSeqiNP_001184250.1. NM_001197321.1.
NP_001184251.1. NM_001197322.1.
NP_444432.1. NM_053202.2. [P58462-1]
XP_006505385.1. XM_006505322.1.
XP_006505386.1. XM_006505323.1.
UniGeneiMm.234965.
Mm.392884.
Mm.485266.

Genome annotation databases

EnsembliENSMUST00000074346; ENSMUSP00000073953; ENSMUSG00000030067. [P58462-1]
ENSMUST00000113322; ENSMUSP00000108948; ENSMUSG00000030067. [P58462-1]
ENSMUST00000113326; ENSMUSP00000108952; ENSMUSG00000030067.
ENSMUST00000113329; ENSMUSP00000108955; ENSMUSG00000030067. [P58462-2]
ENSMUST00000177437; ENSMUSP00000135809; ENSMUSG00000030067.
GeneIDi108655.
KEGGimmu:108655.
UCSCiuc009dbi.2. mouse. [P58462-1]
uc009dbl.2. mouse. [P58462-2]

Keywords - Coding sequence diversityi

Alternative initiation, Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF339103 mRNA. Translation: AAK69648.1 .
AF339104 mRNA. Translation: AAK69649.1 .
AF339105 mRNA. Translation: AAK69650.1 .
AK033368 mRNA. Translation: BAC28249.1 .
AK077062 mRNA. Translation: BAC36586.1 .
BC064764 mRNA. Translation: AAH64764.1 .
CCDSi CCDS39578.1. [P58462-1 ]
RefSeqi NP_001184250.1. NM_001197321.1.
NP_001184251.1. NM_001197322.1.
NP_444432.1. NM_053202.2. [P58462-1 ]
XP_006505385.1. XM_006505322.1.
XP_006505386.1. XM_006505323.1.
UniGenei Mm.234965.
Mm.392884.
Mm.485266.

3D structure databases

ProteinModelPortali P58462.
SMRi P58462. Positions 339-397, 490-576.
ModBasei Search...

Protein-protein interaction databases

BioGridi 224357. 9 interactions.

PTM databases

PhosphoSitei P58462.

Proteomic databases

MaxQBi P58462.
PaxDbi P58462.
PRIDEi P58462.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000074346 ; ENSMUSP00000073953 ; ENSMUSG00000030067 . [P58462-1 ]
ENSMUST00000113322 ; ENSMUSP00000108948 ; ENSMUSG00000030067 . [P58462-1 ]
ENSMUST00000113326 ; ENSMUSP00000108952 ; ENSMUSG00000030067 .
ENSMUST00000113329 ; ENSMUSP00000108955 ; ENSMUSG00000030067 . [P58462-2 ]
ENSMUST00000177437 ; ENSMUSP00000135809 ; ENSMUSG00000030067 .
GeneIDi 108655.
KEGGi mmu:108655.
UCSCi uc009dbi.2. mouse. [P58462-1 ]
uc009dbl.2. mouse. [P58462-2 ]

Organism-specific databases

CTDi 27086.
MGIi MGI:1914004. Foxp1.

Phylogenomic databases

eggNOGi COG5025.
GeneTreei ENSGT00750000117475.
HOGENOMi HOG000092089.
HOVERGENi HBG051657.
KOi K09409.
OrthoDBi EOG7M6D7G.

Miscellaneous databases

ChiTaRSi FOXP1. mouse.
NextBioi 361173.
PROi P58462.
SOURCEi Search...

Gene expression databases

ArrayExpressi P58462.
Bgeei P58462.
CleanExi MM_FOXP1.
Genevestigatori P58462.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
IPR015880. Znf_C2H2-like.
[Graphical view ]
Pfami PF00250. Fork_head. 1 hit.
[Graphical view ]
PRINTSi PR00053. FORKHEAD.
SMARTi SM00339. FH. 1 hit.
SM00355. ZnF_C2H2. 1 hit.
[Graphical view ]
PROSITEi PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a new subfamily of winged-helix/forkhead (Fox) genes that are expressed in the lung and act as transcriptional repressors."
    Shu W., Yang H., Zhang L., Lu M.M., Morrisey E.E.
    J. Biol. Chem. 276:27488-27497(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).
    Strain: C57BL/6.
    Tissue: Lung.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Strain: C57BL/6J.
    Tissue: Lung and Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Embryo.
  4. "Foxp4: a novel member of the Foxp subfamily of winged-helix genes co-expressed with Foxp1 and Foxp2 in pulmonary and gut tissues."
    Lu M.M., Li S., Yang H., Morrisey E.E.
    Mech. Dev. 119:S197-S202(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.
  5. "Transcriptional and DNA binding activity of the Foxp1/2/4 family is modulated by heterotypic and homotypic protein interactions."
    Li S., Weidenfeld J., Morrisey E.E.
    Mol. Cell. Biol. 24:809-822(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DIMERIZATION, INTERACTION WITH CTBP1, DOMAIN, MUTAGENESIS OF GLU-388 AND 410-PRO--VAL-414.
  6. "Foxp1 is an essential transcriptional regulator of B cell development."
    Hu H., Wang B., Borde M., Nardone J., Maika S., Allred L., Tucker P.W., Rao A.
    Nat. Immunol. 7:819-826(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiFOXP1_MOUSE
AccessioniPrimary (citable) accession number: P58462
Secondary accession number(s): Q6P221, Q8C5V2, Q8CCD9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: December 5, 2001
Last modified: July 9, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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