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Protein

Kalata-B3/B6

Gene

OAK2

Organism
Oldenlandia affinis
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probably participates in a plant defense mechanism. Has hemolytic activity.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cytolysis, Hemolysis, Plant defense

Names & Taxonomyi

Protein namesi
Recommended name:
Kalata-B3/B6
Cleaved into the following 2 chains:
Gene namesi
Name:OAK2
OrganismiOldenlandia affinis
Taxonomic identifieri60225 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsGentianalesRubiaceaeRubioideaeSpermacoceaeHedyotis-Oldenlandia complexOldenlandia

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
PropeptideiPRO_000000662723 – 661 PublicationAdd BLAST44
PeptideiPRO_000000662867 – 96Kalata-B6Add BLAST30
PropeptideiPRO_000000662997 – 1211 PublicationAdd BLAST25
PeptideiPRO_0000006630122 – 151Kalata-B3Add BLAST30
PropeptideiPRO_0000006631152 – 1587

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki67 ↔ 96Cyclopeptide (Gly-Asn)
Disulfide bondi71 ↔ 85PROSITE-ProRule annotation
Disulfide bondi75 ↔ 87PROSITE-ProRule annotation
Disulfide bondi80 ↔ 93PROSITE-ProRule annotation
Cross-linki122 ↔ 151Cyclopeptide (Gly-Asp)
Disulfide bondi126 ↔ 140PROSITE-ProRule annotation
Disulfide bondi130 ↔ 142PROSITE-ProRule annotation
Disulfide bondi135 ↔ 148PROSITE-ProRule annotation

Post-translational modificationi

Kalata-B3 and kalata-B6 are cyclic peptides.

Keywords - PTMi

Disulfide bond

Structurei

Secondary structure

1158
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni106 – 108Combined sources3
Helixi109 – 120Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WN8NMR-A103-124[»]
ProteinModelPortaliP58455.
SMRiP58455.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP58455.

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.By similarity

Sequence similaritiesi

Belongs to the cyclotide family. Moebius subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Knottin, Repeat, Signal

Family and domain databases

InterProiIPR005535. Cyclotide.
IPR012324. Cyclotide_moebius_CS.
[Graphical view]
PfamiPF03784. Cyclotide. 2 hits.
[Graphical view]
SUPFAMiSSF57038. SSF57038. 2 hits.
PROSITEiPS51052. CYCLOTIDE. 2 hits.
PS60009. CYCLOTIDE_MOEBIUS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P58455-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKFTKSLVL CLLLAAFVGA FGAELSEADK ANVVNEIAAN IQREILKGVK
60 70 80 90 100
SSETTLTMFL KEMQLKGLPT CGETCFGGTC NTPGCSCSSW PICTRNGLPK
110 120 130 140 150
RAGVKSSETT LTMFLKEMQL KGLPTCGETC FGGTCNTPGC TCDPWPICTR

DGLPSAAA
Length:158
Mass (Da):16,643
Last modified:December 5, 2001 - v1
Checksum:iA5C3B4DAB8503F3B
GO

Mass spectrometryi

Molecular mass is 3029.5 Da from positions 67 - 96. Determined by ESI. 1 Publication
Molecular mass is 3082.5 Da from positions 122 - 151. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF393826 mRNA. Translation: AAL05478.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF393826 mRNA. Translation: AAL05478.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WN8NMR-A103-124[»]
ProteinModelPortaliP58455.
SMRiP58455.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP58455.

Family and domain databases

InterProiIPR005535. Cyclotide.
IPR012324. Cyclotide_moebius_CS.
[Graphical view]
PfamiPF03784. Cyclotide. 2 hits.
[Graphical view]
SUPFAMiSSF57038. SSF57038. 2 hits.
PROSITEiPS51052. CYCLOTIDE. 2 hits.
PS60009. CYCLOTIDE_MOEBIUS. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKAB3_OLDAF
AccessioniPrimary (citable) accession number: P58455
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: December 5, 2001
Last modified: November 2, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.