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Protein

Cycloviolacin-O11

Gene

Voc2

Organism
Viola odorata (Sweet violet)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probably participates in a plant defense mechanism.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Plant defense

Names & Taxonomyi

Protein namesi
Recommended name:
Cycloviolacin-O11
Alternative name(s):
Cyclotide c2
Gene namesi
Name:Voc2
OrganismiViola odorata (Sweet violet)
Taxonomic identifieri97441 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsMalpighialesViolaceaeViola

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
PropeptideiPRO_000029493823 – 84Add BLAST62
PeptideiPRO_000004470485 – 115Cycloviolacin-O11Add BLAST31
PropeptideiPRO_0000294939116 – 1183

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki85 ↔ 115Cyclopeptide (Gly-Asn)
Disulfide bondi89 ↔ 105
Disulfide bondi93 ↔ 107
Disulfide bondi98 ↔ 112

Post-translational modificationi

Cycloviolacin-O11 is a cyclic peptide.

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliP58443.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.

Sequence similaritiesi

Belongs to the cyclotide family. Bracelet subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Knottin, Signal

Family and domain databases

InterProiIPR005535. Cyclotide.
IPR012323. Cyclotide_bracelet_CS.
[Graphical view]
PfamiPF03784. Cyclotide. 1 hit.
[Graphical view]
SUPFAMiSSF57038. SSF57038. 1 hit.
PROSITEiPS51052. CYCLOTIDE. 1 hit.
PS60008. CYCLOTIDE_BRACELET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P58443-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEMKNMVVGL FLIAAFALPA LATSFEKDFI THETVQAILK KVGPSSNGML
60 70 80 90 100
DEQAISALTG KTIISNPVLE EALLTHSNSI NALGGTLPCG ESCVWIPCIS
110
AVVGCSCKSK VCYKNSLA
Length:118
Mass (Da):12,404
Last modified:July 10, 2007 - v2
Checksum:iCADD4E1C663A46BD
GO

Mass spectrometryi

Molecular mass is 3209.5 Da from positions 85 - 115. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY630563 mRNA. Translation: AAU04392.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY630563 mRNA. Translation: AAU04392.1.

3D structure databases

ProteinModelPortaliP58443.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR005535. Cyclotide.
IPR012323. Cyclotide_bracelet_CS.
[Graphical view]
PfamiPF03784. Cyclotide. 1 hit.
[Graphical view]
SUPFAMiSSF57038. SSF57038. 1 hit.
PROSITEiPS51052. CYCLOTIDE. 1 hit.
PS60008. CYCLOTIDE_BRACELET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCYO11_VIOOD
AccessioniPrimary (citable) accession number: P58443
Secondary accession number(s): Q5USP0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: July 10, 2007
Last modified: October 5, 2016
This is version 45 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.