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Protein

Kappa-sparatoxin-Hv1b

Gene
N/A
Organism
Heteropoda venatoria (Brown huntsman spider) (Aranea venatoria)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Inhibitor of voltage-gated potassium channels of the Kv4/KCND family. Inhibition of Kv4.3/KCND3 and Kv4.2/KCND2 is strongly voltage-dependent, while inhibition of Kv4.1/KCND1 shows less voltage-dependence. Its binding site may be near the potassium channel voltage sensor. Also blocks calcium channels.3 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalcium channel impairing toxin, Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Protein family/group databases

TCDBi8.B.5.2.2. the na(+)/k(+)/ca(2+) channel targeting tarantula huwentoxin (tht) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Kappa-sparatoxin-Hv1b
Short name:
Kappa-SPRTX-Hv1b
Alternative name(s):
Heteropodatoxin-2
Short name:
HpTX2
Toxin KJ6
OrganismiHeteropoda venatoria (Brown huntsman spider) (Aranea venatoria)
Taxonomic identifieri152925 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeAraneomorphaeEntelegynaeDionychaSparassidaeHeteropoda

Organism-specific databases

ArachnoServeriAS000345. kappa-sparatoxin-Hv1b.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000445521 – 30Kappa-sparatoxin-Hv1bAdd BLAST30

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi3 ↔ 171 Publication
Disulfide bondi10 ↔ 221 Publication
Disulfide bondi16 ↔ 261 Publication
Modified residuei30Tryptophan amide1 Publication1

Keywords - PTMi

Amidation, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

Secondary structure

130
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi23 – 25Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EMXNMR-A1-30[»]
ProteinModelPortaliP58426.
SMRiP58426.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP58426.

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.

Sequence similaritiesi

Belongs to the huwentoxin-1 family. HpTX2 subfamily.Curated

Keywords - Domaini

Knottin

Family and domain databases

InterProiView protein in InterPro
IPR011696. Huwentoxin-1.
PfamiView protein in Pfam
PF07740. Toxin_12. 1 hit.

Sequencei

Sequence statusi: Complete.

P58426-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30
DDCGKLFSGC DTNADCCEGY VCRLWCKLDW
Length:30
Mass (Da):3,420
Last modified:December 5, 2001 - v1
Checksum:iF2A1DC16B695CFCF
GO

Mass spectrometryi

Molecular mass is 3412.70 Da from positions 1 - 30. Determined by ESI. 1 Publication
Molecular mass is 3412.72 Da from positions 1 - 30. Determined by ESI. 1 Publication

Cross-referencesi

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EMXNMR-A1-30[»]
ProteinModelPortaliP58426.
SMRiP58426.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi8.B.5.2.2. the na(+)/k(+)/ca(2+) channel targeting tarantula huwentoxin (tht) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ArachnoServeriAS000345. kappa-sparatoxin-Hv1b.

Miscellaneous databases

EvolutionaryTraceiP58426.

Family and domain databases

InterProiView protein in InterPro
IPR011696. Huwentoxin-1.
PfamiView protein in Pfam
PF07740. Toxin_12. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTXHP2_HETVE
AccessioniPrimary (citable) accession number: P58426
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: December 5, 2001
Last modified: November 2, 2016
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Miscellaneous

Has no affinity for Kv1.4/KCNA4, Kv2.1/KCNB1, and Kv3.4/KCNC4.1 Publication

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.