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P58421

- FZD5_XENLA

UniProt

P58421 - FZD5_XENLA

Protein

Frizzled-5

Gene

fzd5

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (05 Dec 2001)
      Previous versions | rss
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    Functioni

    Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW

    GO - Biological processi

    1. camera-type eye development Source: AgBase
    2. neuron development Source: AgBase
    3. regulation of cell differentiation Source: AgBase
    4. regulation of cell proliferation Source: AgBase
    5. Wnt signaling pathway Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein, G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Wnt signaling pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Frizzled-5
    Short name:
    Fz-5
    Short name:
    Xfz5
    Gene namesi
    Name:fzd5
    Synonyms:fz5
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-865299. fzd5.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 559533Frizzled-5PRO_0000012992Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi33 ↔ 94PROSITE-ProRule annotation
    Disulfide bondi41 ↔ 87PROSITE-ProRule annotation
    Glycosylationi47 – 471N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi78 ↔ 116PROSITE-ProRule annotation
    Disulfide bondi105 ↔ 146PROSITE-ProRule annotation
    Disulfide bondi109 ↔ 133PROSITE-ProRule annotation
    Glycosylationi150 – 1501N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi468 – 4681N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Expressioni

    Tissue specificityi

    Expressed in retina.

    Developmental stagei

    First detected at the late neurula stage in retinal primordia. Throughout the tailbud stage, expressed exclusively in the neural retina within the optic vesicles. During tadpole stage, expression becomes restricted to the ciliary marginal zone.

    Structurei

    3D structure databases

    ProteinModelPortaliP58421.
    SMRiP58421. Positions 31-149.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini27 – 220194ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini242 – 25716CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini279 – 30123ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini323 – 34321CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini365 – 38723ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini409 – 43426CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini456 – 48328ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini505 – 55955CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei221 – 24121Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei258 – 27821Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei302 – 32221Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei344 – 36421Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei388 – 40821Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei435 – 45521Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei484 – 50421Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini28 – 149122FZPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi507 – 5126Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family membersBy similarity
    Motifi557 – 5593PDZ-binding

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi152 – 1576Poly-Thr

    Domaini

    Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.By similarity
    The FZ domain is involved in binding with Wnt ligands.By similarity

    Sequence similaritiesi

    Contains 1 FZ (frizzled) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG006977.
    KOiK02375.

    Family and domain databases

    Gene3Di1.10.2000.10. 1 hit.
    InterProiIPR000539. Frizzled.
    IPR015526. Frizzled/SFRP.
    IPR020067. Frizzled_dom.
    IPR017981. GPCR_2-like.
    [Graphical view]
    PANTHERiPTHR11309. PTHR11309. 1 hit.
    PfamiPF01534. Frizzled. 1 hit.
    PF01392. Fz. 1 hit.
    [Graphical view]
    PRINTSiPR00489. FRIZZLED.
    SMARTiSM00063. FRI. 1 hit.
    [Graphical view]
    SUPFAMiSSF63501. SSF63501. 1 hit.
    PROSITEiPS50038. FZ. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P58421-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSFRSGVFA LSFVVLLLDY FAPAQAASKA IVCQEITVPM CKGIGYNHTY    50
    MPNQFNHDTQ DEAGMEVHQF WPLVVIQCSL DLKFFLCSMY TPICLPDYRK 100
    PLPPCRSVCE RAKAGCSPLM RKYGFAWPER MNCDRLPEHG DPDTLCMYYN 150
    WTETTTTLPP THPPKVKTPT SDCDGVCKCR EPFVSITRES HPLYNRIKTG 200
    QVPNCAMPCF QPYFTQDEKM FVTFWIGLWS ILCFISTFTT VATFLIDMER 250
    FRYPERPIIF LSACYLFVSI GYVVRLIVGH ENVACNKDHI HYETTGPALC 300
    TIVFLLIYFF GMASSIWWVI LTFTWFLAAG MKWGNEAIAS YSQYFHMAAW 350
    LIPSVKSIAV LALSSVDGDP VAGICYVGNQ NLDNLRGFVL APLVVYLFSG 400
    TMFLLAGFVS LFRIRSVIKQ GGTKTDKLEK LMIRIGIFSV LYTVPATIVV 450
    ACYIYEQHYR EHWEKTHNCS CPGDKQRYRP DYAVFMLKYL MCLVVGITSG 500
    VWIWSGKTLE SWKRFTGRCC RNSKPINASA YSEASRALTP RTGLSNLTLP 550
    HKQVPLSHV 559
    Length:559
    Mass (Da):63,518
    Last modified:December 5, 2001 - v1
    Checksum:i581EB243FCB954B7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF300716 mRNA. Translation: AAK51688.1.
    RefSeqiNP_001079217.1. NM_001085748.1.
    UniGeneiXl.11966.

    Genome annotation databases

    GeneIDi373834.
    KEGGixla:373834.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF300716 mRNA. Translation: AAK51688.1 .
    RefSeqi NP_001079217.1. NM_001085748.1.
    UniGenei Xl.11966.

    3D structure databases

    ProteinModelPortali P58421.
    SMRi P58421. Positions 31-149.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    GPCRDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 373834.
    KEGGi xla:373834.

    Organism-specific databases

    CTDi 7855.
    Xenbasei XB-GENE-865299. fzd5.

    Phylogenomic databases

    HOVERGENi HBG006977.
    KOi K02375.

    Family and domain databases

    Gene3Di 1.10.2000.10. 1 hit.
    InterProi IPR000539. Frizzled.
    IPR015526. Frizzled/SFRP.
    IPR020067. Frizzled_dom.
    IPR017981. GPCR_2-like.
    [Graphical view ]
    PANTHERi PTHR11309. PTHR11309. 1 hit.
    Pfami PF01534. Frizzled. 1 hit.
    PF01392. Fz. 1 hit.
    [Graphical view ]
    PRINTSi PR00489. FRIZZLED.
    SMARTi SM00063. FRI. 1 hit.
    [Graphical view ]
    SUPFAMi SSF63501. SSF63501. 1 hit.
    PROSITEi PS50038. FZ. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Xenopus frizzled-5: a frizzled family member expressed exclusively in the neural retina of the developing eye."
      Sumanas S., Ekker S.C.
      Mech. Dev. 103:133-136(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiFZD5_XENLA
    AccessioniPrimary (citable) accession number: P58421
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 5, 2001
    Last sequence update: December 5, 2001
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3