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P58421 (FZD5_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Frizzled-5

Short name=Fz-5
Short name=Xfz5
Gene names
Name:fzd5
Synonyms:fz5
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length559 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

Subcellular location

Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein By similarity.

Tissue specificity

Expressed in retina.

Developmental stage

First detected at the late neurula stage in retinal primordia. Throughout the tailbud stage, expressed exclusively in the neural retina within the optic vesicles. During tadpole stage, expression becomes restricted to the ciliary marginal zone.

Domain

Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway By similarity.

The FZ domain is involved in binding with Wnt ligands By similarity.

Sequence similarities

Belongs to the G-protein coupled receptor Fz/Smo family.

Contains 1 FZ (frizzled) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Chain27 – 559533Frizzled-5
PRO_0000012992

Regions

Topological domain27 – 220194Extracellular Potential
Transmembrane221 – 24121Helical; Name=1; Potential
Topological domain242 – 25716Cytoplasmic Potential
Transmembrane258 – 27821Helical; Name=2; Potential
Topological domain279 – 30123Extracellular Potential
Transmembrane302 – 32221Helical; Name=3; Potential
Topological domain323 – 34321Cytoplasmic Potential
Transmembrane344 – 36421Helical; Name=4; Potential
Topological domain365 – 38723Extracellular Potential
Transmembrane388 – 40821Helical; Name=5; Potential
Topological domain409 – 43426Cytoplasmic Potential
Transmembrane435 – 45521Helical; Name=6; Potential
Topological domain456 – 48328Extracellular Potential
Transmembrane484 – 50421Helical; Name=7; Potential
Topological domain505 – 55955Cytoplasmic Potential
Domain28 – 149122FZ
Motif507 – 5126Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members By similarity
Motif557 – 5593PDZ-binding
Compositional bias152 – 1576Poly-Thr

Amino acid modifications

Glycosylation471N-linked (GlcNAc...) Potential
Glycosylation1501N-linked (GlcNAc...) Potential
Glycosylation4681N-linked (GlcNAc...) Potential
Disulfide bond33 ↔ 94 By similarity
Disulfide bond41 ↔ 87 By similarity
Disulfide bond78 ↔ 116 By similarity
Disulfide bond105 ↔ 146 By similarity
Disulfide bond109 ↔ 133 By similarity

Sequences

Sequence LengthMass (Da)Tools
P58421 [UniParc].

Last modified December 5, 2001. Version 1.
Checksum: 581EB243FCB954B7

FASTA55963,518
        10         20         30         40         50         60 
MGSFRSGVFA LSFVVLLLDY FAPAQAASKA IVCQEITVPM CKGIGYNHTY MPNQFNHDTQ 

        70         80         90        100        110        120 
DEAGMEVHQF WPLVVIQCSL DLKFFLCSMY TPICLPDYRK PLPPCRSVCE RAKAGCSPLM 

       130        140        150        160        170        180 
RKYGFAWPER MNCDRLPEHG DPDTLCMYYN WTETTTTLPP THPPKVKTPT SDCDGVCKCR 

       190        200        210        220        230        240 
EPFVSITRES HPLYNRIKTG QVPNCAMPCF QPYFTQDEKM FVTFWIGLWS ILCFISTFTT 

       250        260        270        280        290        300 
VATFLIDMER FRYPERPIIF LSACYLFVSI GYVVRLIVGH ENVACNKDHI HYETTGPALC 

       310        320        330        340        350        360 
TIVFLLIYFF GMASSIWWVI LTFTWFLAAG MKWGNEAIAS YSQYFHMAAW LIPSVKSIAV 

       370        380        390        400        410        420 
LALSSVDGDP VAGICYVGNQ NLDNLRGFVL APLVVYLFSG TMFLLAGFVS LFRIRSVIKQ 

       430        440        450        460        470        480 
GGTKTDKLEK LMIRIGIFSV LYTVPATIVV ACYIYEQHYR EHWEKTHNCS CPGDKQRYRP 

       490        500        510        520        530        540 
DYAVFMLKYL MCLVVGITSG VWIWSGKTLE SWKRFTGRCC RNSKPINASA YSEASRALTP 

       550 
RTGLSNLTLP HKQVPLSHV 

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References

[1]"Xenopus frizzled-5: a frizzled family member expressed exclusively in the neural retina of the developing eye."
Sumanas S., Ekker S.C.
Mech. Dev. 103:133-136(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF300716 mRNA. Translation: AAK51688.1.
RefSeqNP_001079217.1. NM_001085748.1.
UniGeneXl.11966.

3D structure databases

ProteinModelPortalP58421.
SMRP58421. Positions 31-149.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

GPCRDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID373834.
KEGGxla:373834.

Organism-specific databases

CTD7855.
XenbaseXB-GENE-865299. fzd5.

Phylogenomic databases

HOVERGENHBG006977.
KOK02375.

Family and domain databases

Gene3D1.10.2000.10. 1 hit.
InterProIPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR017981. GPCR_2-like.
[Graphical view]
PANTHERPTHR11309. PTHR11309. 1 hit.
PfamPF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view]
PRINTSPR00489. FRIZZLED.
SMARTSM00063. FRI. 1 hit.
[Graphical view]
SUPFAMSSF63501. SSF63501. 1 hit.
PROSITEPS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFZD5_XENLA
AccessionPrimary (citable) accession number: P58421
Entry history
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: December 5, 2001
Last modified: June 11, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries