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P58421

- FZD5_XENLA

UniProt

P58421 - FZD5_XENLA

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Protein
Frizzled-5
Gene
fzd5, fz5
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW

GO - Biological processi

  1. Wnt signaling pathway Source: UniProtKB-KW
  2. camera-type eye development Source: AgBase
  3. neuron development Source: AgBase
  4. regulation of cell differentiation Source: AgBase
  5. regulation of cell proliferation Source: AgBase
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Frizzled-5
Short name:
Fz-5
Short name:
Xfz5
Gene namesi
Name:fzd5
Synonyms:fz5
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-865299. fzd5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 220194Extracellular Reviewed prediction
Add
BLAST
Transmembranei221 – 24121Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini242 – 25716Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei258 – 27821Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini279 – 30123Extracellular Reviewed prediction
Add
BLAST
Transmembranei302 – 32221Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini323 – 34321Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei344 – 36421Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini365 – 38723Extracellular Reviewed prediction
Add
BLAST
Transmembranei388 – 40821Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini409 – 43426Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei435 – 45521Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini456 – 48328Extracellular Reviewed prediction
Add
BLAST
Transmembranei484 – 50421Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini505 – 55955Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626 Reviewed prediction
Add
BLAST
Chaini27 – 559533Frizzled-5
PRO_0000012992Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 94 By similarity
Disulfide bondi41 ↔ 87 By similarity
Glycosylationi47 – 471N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi78 ↔ 116 By similarity
Disulfide bondi105 ↔ 146 By similarity
Disulfide bondi109 ↔ 133 By similarity
Glycosylationi150 – 1501N-linked (GlcNAc...) Reviewed prediction
Glycosylationi468 – 4681N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Expressed in retina.

Developmental stagei

First detected at the late neurula stage in retinal primordia. Throughout the tailbud stage, expressed exclusively in the neural retina within the optic vesicles. During tadpole stage, expression becomes restricted to the ciliary marginal zone.

Structurei

3D structure databases

ProteinModelPortaliP58421.
SMRiP58421. Positions 31-149.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 149122FZ
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi507 – 5126Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members By similarity
Motifi557 – 5593PDZ-binding

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi152 – 1576Poly-Thr

Domaini

Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway By similarity.
The FZ domain is involved in binding with Wnt ligands By similarity.

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG006977.
KOiK02375.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiIPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR017981. GPCR_2-like.
[Graphical view]
PANTHERiPTHR11309. PTHR11309. 1 hit.
PfamiPF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view]
PRINTSiPR00489. FRIZZLED.
SMARTiSM00063. FRI. 1 hit.
[Graphical view]
SUPFAMiSSF63501. SSF63501. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P58421-1 [UniParc]FASTAAdd to Basket

« Hide

MGSFRSGVFA LSFVVLLLDY FAPAQAASKA IVCQEITVPM CKGIGYNHTY    50
MPNQFNHDTQ DEAGMEVHQF WPLVVIQCSL DLKFFLCSMY TPICLPDYRK 100
PLPPCRSVCE RAKAGCSPLM RKYGFAWPER MNCDRLPEHG DPDTLCMYYN 150
WTETTTTLPP THPPKVKTPT SDCDGVCKCR EPFVSITRES HPLYNRIKTG 200
QVPNCAMPCF QPYFTQDEKM FVTFWIGLWS ILCFISTFTT VATFLIDMER 250
FRYPERPIIF LSACYLFVSI GYVVRLIVGH ENVACNKDHI HYETTGPALC 300
TIVFLLIYFF GMASSIWWVI LTFTWFLAAG MKWGNEAIAS YSQYFHMAAW 350
LIPSVKSIAV LALSSVDGDP VAGICYVGNQ NLDNLRGFVL APLVVYLFSG 400
TMFLLAGFVS LFRIRSVIKQ GGTKTDKLEK LMIRIGIFSV LYTVPATIVV 450
ACYIYEQHYR EHWEKTHNCS CPGDKQRYRP DYAVFMLKYL MCLVVGITSG 500
VWIWSGKTLE SWKRFTGRCC RNSKPINASA YSEASRALTP RTGLSNLTLP 550
HKQVPLSHV 559
Length:559
Mass (Da):63,518
Last modified:December 5, 2001 - v1
Checksum:i581EB243FCB954B7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF300716 mRNA. Translation: AAK51688.1.
RefSeqiNP_001079217.1. NM_001085748.1.
UniGeneiXl.11966.

Genome annotation databases

GeneIDi373834.
KEGGixla:373834.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF300716 mRNA. Translation: AAK51688.1 .
RefSeqi NP_001079217.1. NM_001085748.1.
UniGenei Xl.11966.

3D structure databases

ProteinModelPortali P58421.
SMRi P58421. Positions 31-149.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

GPCRDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 373834.
KEGGi xla:373834.

Organism-specific databases

CTDi 7855.
Xenbasei XB-GENE-865299. fzd5.

Phylogenomic databases

HOVERGENi HBG006977.
KOi K02375.

Family and domain databases

Gene3Di 1.10.2000.10. 1 hit.
InterProi IPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR017981. GPCR_2-like.
[Graphical view ]
PANTHERi PTHR11309. PTHR11309. 1 hit.
Pfami PF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view ]
PRINTSi PR00489. FRIZZLED.
SMARTi SM00063. FRI. 1 hit.
[Graphical view ]
SUPFAMi SSF63501. SSF63501. 1 hit.
PROSITEi PS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Xenopus frizzled-5: a frizzled family member expressed exclusively in the neural retina of the developing eye."
    Sumanas S., Ekker S.C.
    Mech. Dev. 103:133-136(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiFZD5_XENLA
AccessioniPrimary (citable) accession number: P58421
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: December 5, 2001
Last modified: June 11, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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