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Protein

Neurexophilin-1

Gene

NXPH1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors.Curated

Enzyme and pathway databases

SIGNORiP58417.

Names & Taxonomyi

Protein namesi
Recommended name:
Neurexophilin-1
Gene namesi
Name:NXPH1
Synonyms:NPH1
ORF Names:Nbla00697
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:20693. NXPH1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134961263.

Polymorphism and mutation databases

BioMutaiNXPH1.
DMDMi17433155.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 271250Neurexophilin-1PRO_0000020059Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi23 – 231N-linked (GlcNAc...)Sequence analysis
Glycosylationi68 – 681N-linked (GlcNAc...)Sequence analysis
Glycosylationi93 – 931N-linked (GlcNAc...)Sequence analysis
Glycosylationi146 – 1461N-linked (GlcNAc...)Sequence analysis
Glycosylationi156 – 1561N-linked (GlcNAc...)Sequence analysis
Glycosylationi162 – 1621N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiP58417.
PaxDbiP58417.
PeptideAtlasiP58417.
PRIDEiP58417.

PTM databases

iPTMnetiP58417.
PhosphoSiteiP58417.

Expressioni

Gene expression databases

BgeeiP58417.
CleanExiHS_NXPH1.
ExpressionAtlasiP58417. baseline and differential.
GenevisibleiP58417. HS.

Organism-specific databases

HPAiHPA020062.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000384551.

Structurei

3D structure databases

ProteinModelPortaliP58417.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni22 – 9776IIAdd
BLAST
Regioni98 – 17679IIIAdd
BLAST
Regioni177 – 1859IV (linker domain)
Regioni186 – 27186V (Cys-rich)Add
BLAST

Sequence similaritiesi

Belongs to the neurexophilin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IJV8. Eukaryota.
ENOG410YYWH. LUCA.
HOGENOMiHOG000261694.
HOVERGENiHBG052706.
InParanoidiP58417.
KOiK16656.
OMAiFQVTCAN.
OrthoDBiEOG7SBNPB.
PhylomeDBiP58417.
TreeFamiTF333047.

Family and domain databases

InterProiIPR010450. Nxph.
IPR026845. NXPH/NXPE.
[Graphical view]
PANTHERiPTHR17103. PTHR17103. 1 hit.
PfamiPF06312. Neurexophilin. 1 hit.
[Graphical view]
PIRSFiPIRSF038019. Neurexophilin. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P58417-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQAACWYVLF LLQPTVYLVT CANLTNGGKS ELLKSGSSKS TLKHIWTESS
60 70 80 90 100
KDLSISRLLS QTFRGKENDT DLDLRYDTPE PYSEQDLWDW LRNSTDLQEP
110 120 130 140 150
RPRAKRRPIV KTGKFKKMFG WGDFHSNIKT VKLNLLITGK IVDHGNGTFS
160 170 180 190 200
VYFRHNSTGQ GNVSVSLVPP TKIVEFDLAQ QTVIDAKDSK SFNCRIEYEK
210 220 230 240 250
VDKATKNTLC NYDPSKTCYQ EQTQSHVSWL CSKPFKVICI YISFYSTDYK
260 270
LVQKVCPDYN YHSDTPYFPS G
Length:271
Mass (Da):31,082
Last modified:December 5, 2001 - v1
Checksum:i140C6C7DE1126B27
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti146 – 1461N → S in BAC03713 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB047362 mRNA. Translation: BAB69044.1.
AK091655 mRNA. Translation: BAC03713.1.
AC004457 Genomic DNA. No translation available.
AC004613 Genomic DNA. No translation available.
AC004861 Genomic DNA. No translation available.
BC047505 mRNA. Translation: AAH47505.1.
CCDSiCCDS47540.1.
RefSeqiNP_689958.1. NM_152745.2.
UniGeneiHs.487564.

Genome annotation databases

EnsembliENST00000405863; ENSP00000384551; ENSG00000122584.
GeneIDi30010.
KEGGihsa:30010.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB047362 mRNA. Translation: BAB69044.1.
AK091655 mRNA. Translation: BAC03713.1.
AC004457 Genomic DNA. No translation available.
AC004613 Genomic DNA. No translation available.
AC004861 Genomic DNA. No translation available.
BC047505 mRNA. Translation: AAH47505.1.
CCDSiCCDS47540.1.
RefSeqiNP_689958.1. NM_152745.2.
UniGeneiHs.487564.

3D structure databases

ProteinModelPortaliP58417.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000384551.

PTM databases

iPTMnetiP58417.
PhosphoSiteiP58417.

Polymorphism and mutation databases

BioMutaiNXPH1.
DMDMi17433155.

Proteomic databases

EPDiP58417.
PaxDbiP58417.
PeptideAtlasiP58417.
PRIDEiP58417.

Protocols and materials databases

DNASUi30010.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000405863; ENSP00000384551; ENSG00000122584.
GeneIDi30010.
KEGGihsa:30010.

Organism-specific databases

CTDi30010.
GeneCardsiNXPH1.
HGNCiHGNC:20693. NXPH1.
HPAiHPA020062.
MIMi604639. gene.
neXtProtiNX_P58417.
PharmGKBiPA134961263.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJV8. Eukaryota.
ENOG410YYWH. LUCA.
HOGENOMiHOG000261694.
HOVERGENiHBG052706.
InParanoidiP58417.
KOiK16656.
OMAiFQVTCAN.
OrthoDBiEOG7SBNPB.
PhylomeDBiP58417.
TreeFamiTF333047.

Enzyme and pathway databases

SIGNORiP58417.

Miscellaneous databases

GeneWikiiNXPH1.
GenomeRNAii30010.
PROiP58417.
SOURCEiSearch...

Gene expression databases

BgeeiP58417.
CleanExiHS_NXPH1.
ExpressionAtlasiP58417. baseline and differential.
GenevisibleiP58417. HS.

Family and domain databases

InterProiIPR010450. Nxph.
IPR026845. NXPH/NXPE.
[Graphical view]
PANTHERiPTHR17103. PTHR17103. 1 hit.
PfamiPF06312. Neurexophilin. 1 hit.
[Graphical view]
PIRSFiPIRSF038019. Neurexophilin. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma."
    Ohira M., Morohashi A., Nakamura Y., Isogai E., Furuya K., Hamano S., Machida T., Aoyama M., Fukumura M., Miyazaki K., Suzuki Y., Sugano S., Hirato J., Nakagawara A.
    Cancer Lett. 197:63-68(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Neuroblastoma.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiNXPH1_HUMAN
AccessioniPrimary (citable) accession number: P58417
Secondary accession number(s): Q8NB31
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: December 5, 2001
Last modified: July 6, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.