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Protein

Neurexophilin-1

Gene

NXPH1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors.Curated

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000122584-MONOMER.
SIGNORiP58417.

Names & Taxonomyi

Protein namesi
Recommended name:
Neurexophilin-1
Gene namesi
Name:NXPH1
Synonyms:NPH1
ORF Names:Nbla00697
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:20693. NXPH1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi30010.
OpenTargetsiENSG00000122584.
PharmGKBiPA134961263.

Polymorphism and mutation databases

BioMutaiNXPH1.
DMDMi17433155.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000002005922 – 271Neurexophilin-1Add BLAST250

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi23N-linked (GlcNAc...)Sequence analysis1
Glycosylationi68N-linked (GlcNAc...)Sequence analysis1
Glycosylationi93N-linked (GlcNAc...)Sequence analysis1
Glycosylationi146N-linked (GlcNAc...)Sequence analysis1
Glycosylationi156N-linked (GlcNAc...)Sequence analysis1
Glycosylationi162N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP58417.
PeptideAtlasiP58417.
PRIDEiP58417.

PTM databases

iPTMnetiP58417.
PhosphoSitePlusiP58417.

Expressioni

Gene expression databases

BgeeiENSG00000122584.
CleanExiHS_NXPH1.
ExpressionAtlasiP58417. baseline and differential.
GenevisibleiP58417. HS.

Organism-specific databases

HPAiHPA020062.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9606.ENSP00000384551.

Structurei

3D structure databases

ProteinModelPortaliP58417.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni22 – 97IIAdd BLAST76
Regioni98 – 176IIIAdd BLAST79
Regioni177 – 185IV (linker domain)9
Regioni186 – 271V (Cys-rich)Add BLAST86

Sequence similaritiesi

Belongs to the neurexophilin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IJV8. Eukaryota.
ENOG410YYWH. LUCA.
GeneTreeiENSGT00390000015950.
HOGENOMiHOG000261694.
HOVERGENiHBG052706.
InParanoidiP58417.
KOiK16656.
OMAiFQVTCAN.
OrthoDBiEOG091G0GC5.
PhylomeDBiP58417.
TreeFamiTF333047.

Family and domain databases

InterProiIPR010450. Nxph.
IPR026845. NXPH/NXPE.
[Graphical view]
PANTHERiPTHR17103. PTHR17103. 1 hit.
PfamiPF06312. Neurexophilin. 1 hit.
[Graphical view]
PIRSFiPIRSF038019. Neurexophilin. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P58417-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQAACWYVLF LLQPTVYLVT CANLTNGGKS ELLKSGSSKS TLKHIWTESS
60 70 80 90 100
KDLSISRLLS QTFRGKENDT DLDLRYDTPE PYSEQDLWDW LRNSTDLQEP
110 120 130 140 150
RPRAKRRPIV KTGKFKKMFG WGDFHSNIKT VKLNLLITGK IVDHGNGTFS
160 170 180 190 200
VYFRHNSTGQ GNVSVSLVPP TKIVEFDLAQ QTVIDAKDSK SFNCRIEYEK
210 220 230 240 250
VDKATKNTLC NYDPSKTCYQ EQTQSHVSWL CSKPFKVICI YISFYSTDYK
260 270
LVQKVCPDYN YHSDTPYFPS G
Length:271
Mass (Da):31,082
Last modified:December 5, 2001 - v1
Checksum:i140C6C7DE1126B27
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti146N → S in BAC03713 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB047362 mRNA. Translation: BAB69044.1.
AK091655 mRNA. Translation: BAC03713.1.
AC004457 Genomic DNA. No translation available.
AC004613 Genomic DNA. No translation available.
AC004861 Genomic DNA. No translation available.
BC047505 mRNA. Translation: AAH47505.1.
CCDSiCCDS47540.1.
RefSeqiNP_689958.1. NM_152745.2.
UniGeneiHs.487564.

Genome annotation databases

EnsembliENST00000405863; ENSP00000384551; ENSG00000122584.
GeneIDi30010.
KEGGihsa:30010.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB047362 mRNA. Translation: BAB69044.1.
AK091655 mRNA. Translation: BAC03713.1.
AC004457 Genomic DNA. No translation available.
AC004613 Genomic DNA. No translation available.
AC004861 Genomic DNA. No translation available.
BC047505 mRNA. Translation: AAH47505.1.
CCDSiCCDS47540.1.
RefSeqiNP_689958.1. NM_152745.2.
UniGeneiHs.487564.

3D structure databases

ProteinModelPortaliP58417.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000384551.

PTM databases

iPTMnetiP58417.
PhosphoSitePlusiP58417.

Polymorphism and mutation databases

BioMutaiNXPH1.
DMDMi17433155.

Proteomic databases

PaxDbiP58417.
PeptideAtlasiP58417.
PRIDEiP58417.

Protocols and materials databases

DNASUi30010.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000405863; ENSP00000384551; ENSG00000122584.
GeneIDi30010.
KEGGihsa:30010.

Organism-specific databases

CTDi30010.
DisGeNETi30010.
GeneCardsiNXPH1.
HGNCiHGNC:20693. NXPH1.
HPAiHPA020062.
MIMi604639. gene.
neXtProtiNX_P58417.
OpenTargetsiENSG00000122584.
PharmGKBiPA134961263.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJV8. Eukaryota.
ENOG410YYWH. LUCA.
GeneTreeiENSGT00390000015950.
HOGENOMiHOG000261694.
HOVERGENiHBG052706.
InParanoidiP58417.
KOiK16656.
OMAiFQVTCAN.
OrthoDBiEOG091G0GC5.
PhylomeDBiP58417.
TreeFamiTF333047.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000122584-MONOMER.
SIGNORiP58417.

Miscellaneous databases

GeneWikiiNXPH1.
GenomeRNAii30010.
PROiP58417.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000122584.
CleanExiHS_NXPH1.
ExpressionAtlasiP58417. baseline and differential.
GenevisibleiP58417. HS.

Family and domain databases

InterProiIPR010450. Nxph.
IPR026845. NXPH/NXPE.
[Graphical view]
PANTHERiPTHR17103. PTHR17103. 1 hit.
PfamiPF06312. Neurexophilin. 1 hit.
[Graphical view]
PIRSFiPIRSF038019. Neurexophilin. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNXPH1_HUMAN
AccessioniPrimary (citable) accession number: P58417
Secondary accession number(s): Q8NB31
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: December 5, 2001
Last modified: November 2, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.