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Protein

Probable cadmium-transporting ATPase

Gene

cadA

Organism
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Couples the hydrolysis of ATP with the export of cadmium.By similarity

Catalytic activityi

ATP + H2O + Cd2+(In) = ADP + phosphate + Cd2+(Out).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi17CadmiumPROSITE-ProRule annotation1
Metal bindingi20CadmiumPROSITE-ProRule annotation1
Active sitei3984-aspartylphosphate intermediateCurated1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processCadmium resistance, Ion transport, Transport
LigandATP-binding, Cadmium, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLMON169963:G1GTA-1165-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cadmium-transporting ATPaseCurated (EC:3.6.3.3By similarity)
Alternative name(s):
Cadmium-efflux ATPaseBy similarity
Gene namesi
Name:cadA
Ordered Locus Names:lmo1100
OrganismiListeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Taxonomic identifieri169963 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
Proteomesi
  • UP000000817 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei89 – 109HelicalSequence analysisAdd BLAST21
Transmembranei116 – 136HelicalSequence analysisAdd BLAST21
Transmembranei317 – 337HelicalSequence analysisAdd BLAST21
Transmembranei347 – 367HelicalSequence analysisAdd BLAST21
Transmembranei666 – 686HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000462461 – 707Probable cadmium-transporting ATPaseAdd BLAST707

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP58414

Interactioni

Protein-protein interaction databases

STRINGi169963.lmo1100

Structurei

3D structure databases

ProteinModelPortaliP58414
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 70HMAPROSITE-ProRule annotationAdd BLAST64

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C59 Bacteria
COG2217 LUCA
HOGENOMiHOG000250399
KOiK01534
OMAiHEHSHCE
PhylomeDBiP58414

Family and domain databases

CDDicd00371 HMA, 1 hit
Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 2 hits
InterProiView protein in InterPro
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR017969 Heavy-metal-associated_CS
IPR006121 HMA_dom
IPR036163 HMA_dom_sf
IPR027256 P-typ_ATPase_IB
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF00403 HMA, 1 hit
PRINTSiPR00941 CDATPASE
SUPFAMiSSF55008 SSF55008, 1 hit
SSF56784 SSF56784, 2 hits
SSF81653 SSF81653, 1 hit
SSF81665 SSF81665, 3 hits
TIGRFAMsiTIGR01525 ATPase-IB_hvy, 1 hit
TIGR01494 ATPase_P-type, 1 hit
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit
PS01047 HMA_1, 1 hit
PS50846 HMA_2, 1 hit

Sequencei

Sequence statusi: Complete.

P58414-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKASKQTTY RVDGMSCTNC AGKFEKNVKN LEGVTDAKVN FGAGKISVYG
60 70 80 90 100
ETSISQIEKA GAFENLRVTD EKDYSSKPAK KESFLKKNWH LVVSIIFIIL
110 120 130 140 150
AFISQNISGE DSTTTIILYV IAIVVGGFNL FKEGFANLIK LDFTMESLMT
160 170 180 190 200
IAIIGASIIG EWAEGSIVVI LFAFSEVLER YSMDKARQSI RSLMDIAPKE
210 220 230 240 250
ALIRRDDVEQ MIAVSDIQIG DIMIIKPGQK IAMDGVVIKG YSAINQSAIT
260 270 280 290 300
GESIPVEKKV DDEVFAGTLN EEGLLEVKVT KHVEDTTISK IIHLVEEAQG
310 320 330 340 350
ERAPAQAFVD KFAKYYTPTI MLIALLVVVV PPLFFGGDWD TWVYQGLSLL
360 370 380 390 400
VVGCPCSLVI STPVSIVSAI GNSAKNGVLV KGGIYLEEIG GLQAIAFDKT
410 420 430 440 450
GTLTKGKPVV TDFIPYSEHM DEQNSLSIIT ALETMSQHPL ASAIISKAMI
460 470 480 490 500
DNVDYKSIEI DNFSSITGKG VKGEVNGITY YIGSSKLFES SLEKSQSISQ
510 520 530 540 550
TYQSLQKQGK TAMLFGTESN ILAIIAVADE VRESSKEVIA QLHKLGIAHT
560 570 580 590 600
IMLTGDNNDT AQFIGKEIGV SDIKAELMPE DKLTYIKELK QTYGKVAMIG
610 620 630 640 650
DGVNDAPALA ASTVGIAMGG AGTDTALETA DVALMGDDLK KLPFIVNLSR
660 670 680 690 700
KTLKIIKQNI TFSLGIKLLA LLLVLPGWLT LWIAIVADMG ATLLVTLNGL

RLMKVKK
Length:707
Mass (Da):76,478
Last modified:December 5, 2001 - v1
Checksum:i484E9E04BDB2D71C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591977 Genomic DNA Translation: CAC99178.1
PIRiAD1212
RefSeqiNP_464625.1, NC_003210.1
WP_010989665.1, NC_003210.1

Genome annotation databases

EnsemblBacteriaiCAC99178; CAC99178; CAC99178
GeneIDi986725
KEGGilmo:lmo1100
PATRICifig|169963.11.peg.1131

Similar proteinsi

Entry informationi

Entry nameiCADA_LISMO
AccessioniPrimary (citable) accession number: P58414
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: December 5, 2001
Last modified: March 28, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health