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Protein

Probable cadmium-transporting ATPase

Gene

cadA

Organism
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

This electroneutral antiporter ejects one cadmium ion while accumulating two protons by an energy-dependent efflux mechanism.By similarity

Catalytic activityi

ATP + H2O + Cd2+(In) = ADP + phosphate + Cd2+(Out).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi17CadmiumPROSITE-ProRule annotation1
Metal bindingi20CadmiumPROSITE-ProRule annotation1
Active sitei3984-aspartylphosphate intermediateCurated1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antiport, Cadmium resistance, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Cadmium, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cadmium-transporting ATPase (EC:3.6.3.3)
Alternative name(s):
Cadmium efflux ATPase
Gene namesi
Name:cadA
Ordered Locus Names:lmo1100
OrganismiListeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Taxonomic identifieri169963 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
Proteomesi
  • UP000000817 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei89 – 109HelicalSequence analysisAdd BLAST21
Transmembranei116 – 136HelicalSequence analysisAdd BLAST21
Transmembranei317 – 337HelicalSequence analysisAdd BLAST21
Transmembranei347 – 367HelicalSequence analysisAdd BLAST21
Transmembranei666 – 686HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000462461 – 707Probable cadmium-transporting ATPaseAdd BLAST707

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP58414.

Interactioni

Protein-protein interaction databases

STRINGi169963.lmo1100.

Structurei

3D structure databases

ProteinModelPortaliP58414.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 70HMAPROSITE-ProRule annotationAdd BLAST64

Sequence similaritiesi

Contains 1 HMA domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C59. Bacteria.
COG2217. LUCA.
HOGENOMiHOG000250399.
KOiK01534.
OMAiIPFYKKH.
PhylomeDBiP58414.

Family and domain databases

CDDicd00371. HMA. 1 hit.
Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 2 hits.
3.40.50.1000. 1 hit.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR017969. Heavy-metal-associated_CS.
IPR006121. HMA_dom.
IPR027256. P-typ_ATPase_IB.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF00403. HMA. 1 hit.
[Graphical view]
PRINTSiPR00941. CDATPASE.
SUPFAMiSSF55008. SSF55008. 1 hit.
SSF56784. SSF56784. 2 hits.
TIGRFAMsiTIGR01525. ATPase-IB_hvy. 1 hit.
TIGR01494. ATPase_P-type. 1 hit.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
PS01047. HMA_1. 1 hit.
PS50846. HMA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P58414-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKASKQTTY RVDGMSCTNC AGKFEKNVKN LEGVTDAKVN FGAGKISVYG
60 70 80 90 100
ETSISQIEKA GAFENLRVTD EKDYSSKPAK KESFLKKNWH LVVSIIFIIL
110 120 130 140 150
AFISQNISGE DSTTTIILYV IAIVVGGFNL FKEGFANLIK LDFTMESLMT
160 170 180 190 200
IAIIGASIIG EWAEGSIVVI LFAFSEVLER YSMDKARQSI RSLMDIAPKE
210 220 230 240 250
ALIRRDDVEQ MIAVSDIQIG DIMIIKPGQK IAMDGVVIKG YSAINQSAIT
260 270 280 290 300
GESIPVEKKV DDEVFAGTLN EEGLLEVKVT KHVEDTTISK IIHLVEEAQG
310 320 330 340 350
ERAPAQAFVD KFAKYYTPTI MLIALLVVVV PPLFFGGDWD TWVYQGLSLL
360 370 380 390 400
VVGCPCSLVI STPVSIVSAI GNSAKNGVLV KGGIYLEEIG GLQAIAFDKT
410 420 430 440 450
GTLTKGKPVV TDFIPYSEHM DEQNSLSIIT ALETMSQHPL ASAIISKAMI
460 470 480 490 500
DNVDYKSIEI DNFSSITGKG VKGEVNGITY YIGSSKLFES SLEKSQSISQ
510 520 530 540 550
TYQSLQKQGK TAMLFGTESN ILAIIAVADE VRESSKEVIA QLHKLGIAHT
560 570 580 590 600
IMLTGDNNDT AQFIGKEIGV SDIKAELMPE DKLTYIKELK QTYGKVAMIG
610 620 630 640 650
DGVNDAPALA ASTVGIAMGG AGTDTALETA DVALMGDDLK KLPFIVNLSR
660 670 680 690 700
KTLKIIKQNI TFSLGIKLLA LLLVLPGWLT LWIAIVADMG ATLLVTLNGL

RLMKVKK
Length:707
Mass (Da):76,478
Last modified:December 5, 2001 - v1
Checksum:i484E9E04BDB2D71C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591977 Genomic DNA. Translation: CAC99178.1.
PIRiAD1212.
RefSeqiNP_464625.1. NC_003210.1.
WP_010989665.1. NC_003210.1.

Genome annotation databases

EnsemblBacteriaiCAC99178; CAC99178; CAC99178.
GeneIDi986725.
KEGGilmo:lmo1100.
PATRICi20311307. VBILisMon69206_1131.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591977 Genomic DNA. Translation: CAC99178.1.
PIRiAD1212.
RefSeqiNP_464625.1. NC_003210.1.
WP_010989665.1. NC_003210.1.

3D structure databases

ProteinModelPortaliP58414.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi169963.lmo1100.

Proteomic databases

PaxDbiP58414.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC99178; CAC99178; CAC99178.
GeneIDi986725.
KEGGilmo:lmo1100.
PATRICi20311307. VBILisMon69206_1131.

Phylogenomic databases

eggNOGiENOG4105C59. Bacteria.
COG2217. LUCA.
HOGENOMiHOG000250399.
KOiK01534.
OMAiIPFYKKH.
PhylomeDBiP58414.

Family and domain databases

CDDicd00371. HMA. 1 hit.
Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 2 hits.
3.40.50.1000. 1 hit.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR017969. Heavy-metal-associated_CS.
IPR006121. HMA_dom.
IPR027256. P-typ_ATPase_IB.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF00403. HMA. 1 hit.
[Graphical view]
PRINTSiPR00941. CDATPASE.
SUPFAMiSSF55008. SSF55008. 1 hit.
SSF56784. SSF56784. 2 hits.
TIGRFAMsiTIGR01525. ATPase-IB_hvy. 1 hit.
TIGR01494. ATPase_P-type. 1 hit.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
PS01047. HMA_1. 1 hit.
PS50846. HMA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCADA_LISMO
AccessioniPrimary (citable) accession number: P58414
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: December 5, 2001
Last modified: November 30, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.