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P58407

- MDH_SULTO

UniProt

P58407 - MDH_SULTO

Protein

Probable malate dehydrogenase

Gene

mdh

Organism
Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (16 Nov 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible oxidation of malate to oxaloacetate.By similarity

    Catalytic activityi

    (S)-malate + NAD+ = oxaloacetate + NADH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei33 – 331NADBy similarity
    Binding sitei82 – 821SubstrateBy similarity
    Binding sitei88 – 881SubstrateBy similarity
    Binding sitei95 – 951NADBy similarity
    Binding sitei120 – 1201SubstrateBy similarity
    Binding sitei148 – 1481SubstrateBy similarity
    Active sitei172 – 1721Proton acceptorBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi8 – 136NADBy similarity
    Nucleotide bindingi118 – 1203NADBy similarity

    GO - Molecular functioni

    1. L-malate dehydrogenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciSTOK273063:GJC7-2003-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable malate dehydrogenase (EC:1.1.1.37)
    Gene namesi
    Name:mdh
    Ordered Locus Names:STK_18110
    OrganismiSulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
    Taxonomic identifieri273063 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
    ProteomesiUP000001015: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 308308Probable malate dehydrogenasePRO_0000113494Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi273063.ST1811.

    Structurei

    3D structure databases

    ProteinModelPortaliP58407.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH/MDH superfamily. MDH type 3 family.Curated

    Phylogenomic databases

    eggNOGiCOG0039.
    HOGENOMiHOG000213793.
    KOiK00024.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    InterProiIPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11540. PTHR11540. 1 hit.
    PfamiPF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSiPR00086. LLDHDRGNASE.
    SUPFAMiSSF56327. SSF56327. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P58407-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTKIAFIGVG KIGQTIAFNT IMDGYADEVM IYDIIPELPE KFEHELRHAL    50
    ASKRLKVELL STNNLDDVAG ADIVVITAGK PRKPGMSRRD LFVDNAKIMM 100
    DLANKLPKKN HGAVYIMVSN PVDMMASVFA RYSREFVIST GDQVETMRLR 150
    AYIAKKLKIP VYRVNGFVGG EHGEDAVVLW STVTVNGKPF SEDLGVTKAE 200
    VEDYVKKIPG EIIRVMGGTT WGPGTIIAEL IRAVALNENK VMSIATPRQF 250
    EDEIIHVSVP TVVGSSIGPS LENLLDEKDR WNLMASMKDF YNVYKENLKH 300
    LETSIQAQ 308
    Length:308
    Mass (Da):34,244
    Last modified:November 16, 2001 - v1
    Checksum:i6ECE66B30DD1ACEE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000023 Genomic DNA. Translation: BAB66902.2.
    RefSeqiNP_377793.1. NC_003106.2.

    Genome annotation databases

    EnsemblBacteriaiBAB66902; BAB66902; STK_18110.
    GeneIDi1459867.
    KEGGisto:ST1811.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000023 Genomic DNA. Translation: BAB66902.2 .
    RefSeqi NP_377793.1. NC_003106.2.

    3D structure databases

    ProteinModelPortali P58407.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 273063.ST1811.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB66902 ; BAB66902 ; STK_18110 .
    GeneIDi 1459867.
    KEGGi sto:ST1811.

    Phylogenomic databases

    eggNOGi COG0039.
    HOGENOMi HOG000213793.
    KOi K00024.

    Enzyme and pathway databases

    BioCyci STOK273063:GJC7-2003-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    InterProi IPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11540. PTHR11540. 1 hit.
    Pfami PF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSi PR00086. LLDHDRGNASE.
    SUPFAMi SSF56327. SSF56327. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 16993 / JCM 10545 / NBRC 100140 / 7.

    Entry informationi

    Entry nameiMDH_SULTO
    AccessioniPrimary (citable) accession number: P58407
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 16, 2001
    Last sequence update: November 16, 2001
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3