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P58407

- MDH_SULTO

UniProt

P58407 - MDH_SULTO

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Protein
Probable malate dehydrogenase
Gene
mdh, STK_18110
Organism
Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity.

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331NAD By similarity
Binding sitei82 – 821Substrate By similarity
Binding sitei88 – 881Substrate By similarity
Binding sitei95 – 951NAD By similarity
Binding sitei120 – 1201Substrate By similarity
Binding sitei148 – 1481Substrate By similarity
Active sitei172 – 1721Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi8 – 136NAD By similarity
Nucleotide bindingi118 – 1203NAD By similarity

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciSTOK273063:GJC7-2003-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable malate dehydrogenase (EC:1.1.1.37)
Gene namesi
Name:mdh
Ordered Locus Names:STK_18110
OrganismiSulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Taxonomic identifieri273063 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
ProteomesiUP000001015: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 308308Probable malate dehydrogenase
PRO_0000113494Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi273063.ST1811.

Structurei

3D structure databases

ProteinModelPortaliP58407.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000213793.
KOiK00024.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF56327. SSF56327. 1 hit.

Sequencei

Sequence statusi: Complete.

P58407-1 [UniParc]FASTAAdd to Basket

« Hide

MTKIAFIGVG KIGQTIAFNT IMDGYADEVM IYDIIPELPE KFEHELRHAL    50
ASKRLKVELL STNNLDDVAG ADIVVITAGK PRKPGMSRRD LFVDNAKIMM 100
DLANKLPKKN HGAVYIMVSN PVDMMASVFA RYSREFVIST GDQVETMRLR 150
AYIAKKLKIP VYRVNGFVGG EHGEDAVVLW STVTVNGKPF SEDLGVTKAE 200
VEDYVKKIPG EIIRVMGGTT WGPGTIIAEL IRAVALNENK VMSIATPRQF 250
EDEIIHVSVP TVVGSSIGPS LENLLDEKDR WNLMASMKDF YNVYKENLKH 300
LETSIQAQ 308
Length:308
Mass (Da):34,244
Last modified:November 16, 2001 - v1
Checksum:i6ECE66B30DD1ACEE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000023 Genomic DNA. Translation: BAB66902.2.
RefSeqiNP_377793.1. NC_003106.2.

Genome annotation databases

EnsemblBacteriaiBAB66902; BAB66902; STK_18110.
GeneIDi1459867.
KEGGisto:ST1811.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000023 Genomic DNA. Translation: BAB66902.2 .
RefSeqi NP_377793.1. NC_003106.2.

3D structure databases

ProteinModelPortali P58407.
ModBasei Search...

Protein-protein interaction databases

STRINGi 273063.ST1811.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB66902 ; BAB66902 ; STK_18110 .
GeneIDi 1459867.
KEGGi sto:ST1811.

Phylogenomic databases

eggNOGi COG0039.
HOGENOMi HOG000213793.
KOi K00024.

Enzyme and pathway databases

BioCyci STOK273063:GJC7-2003-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
PRINTSi PR00086. LLDHDRGNASE.
SUPFAMi SSF56327. SSF56327. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 16993 / JCM 10545 / NBRC 100140 / 7.

Entry informationi

Entry nameiMDH_SULTO
AccessioniPrimary (citable) accession number: P58407
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: November 16, 2001
Last modified: May 14, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi