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P58407 (MDH_SULTO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable malate dehydrogenase

EC=1.1.1.37
Gene names
Name:mdh
Ordered Locus Names:STK_18110
OrganismSulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) [Complete proteome] [HAMAP]
Taxonomic identifier273063 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus

Protein attributes

Sequence length308 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity.

Catalytic activity

(S)-malate + NAD+ = oxaloacetate + NADH.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the LDH/MDH superfamily. MDH type 3 family.

Ontologies

Keywords
   Biological processTricarboxylic acid cycle
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcellular carbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

tricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionL-malate dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 308308Probable malate dehydrogenase
PRO_0000113494

Regions

Nucleotide binding8 – 136NAD By similarity
Nucleotide binding118 – 1203NAD By similarity

Sites

Active site1721Proton acceptor By similarity
Binding site331NAD By similarity
Binding site821Substrate By similarity
Binding site881Substrate By similarity
Binding site951NAD By similarity
Binding site1201Substrate By similarity
Binding site1481Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P58407 [UniParc].

Last modified November 16, 2001. Version 1.
Checksum: 6ECE66B30DD1ACEE

FASTA30834,244
        10         20         30         40         50         60 
MTKIAFIGVG KIGQTIAFNT IMDGYADEVM IYDIIPELPE KFEHELRHAL ASKRLKVELL 

        70         80         90        100        110        120 
STNNLDDVAG ADIVVITAGK PRKPGMSRRD LFVDNAKIMM DLANKLPKKN HGAVYIMVSN 

       130        140        150        160        170        180 
PVDMMASVFA RYSREFVIST GDQVETMRLR AYIAKKLKIP VYRVNGFVGG EHGEDAVVLW 

       190        200        210        220        230        240 
STVTVNGKPF SEDLGVTKAE VEDYVKKIPG EIIRVMGGTT WGPGTIIAEL IRAVALNENK 

       250        260        270        280        290        300 
VMSIATPRQF EDEIIHVSVP TVVGSSIGPS LENLLDEKDR WNLMASMKDF YNVYKENLKH 


LETSIQAQ 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000023 Genomic DNA. Translation: BAB66902.2.
RefSeqNP_377793.1. NC_003106.2.

3D structure databases

ProteinModelPortalP58407.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING273063.ST1811.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB66902; BAB66902; STK_18110.
GeneID1459867.
KEGGsto:ST1811.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0039.
HOGENOMHOG000213793.
KOK00024.
ProtClustDBCLSK883804.

Enzyme and pathway databases

BioCycSTOK273063:GJC7-2003-MONOMER.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11540. PTHR11540. 1 hit.
PfamPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSPR00086. LLDHDRGNASE.
SUPFAMSSF56327. SSF56327. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMDH_SULTO
AccessionPrimary (citable) accession number: P58407
Entry history
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: November 16, 2001
Last modified: February 19, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families