ID   HRH3_MOUSE              Reviewed;         445 AA.
AC   P58406;
DT   16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   16-NOV-2001, sequence version 1.
DT   27-MAR-2024, entry version 154.
DE   RecName: Full=Histamine H3 receptor;
DE            Short=H3R;
DE            Short=HH3R;
GN   Name=Hrh3;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=CD-1;
RA   Coge F., Rique H., Levacher B., Leopold O., Guenin S.-P., Boutin J.A.,
RA   Galizzi J.-P.;
RT   "Cloning of mouse histamine H3 receptor.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-439, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: The H3 subclass of histamine receptors could mediate the
CC       histamine signals in CNS and peripheral nervous system. Signals through
CC       the inhibition of adenylate cyclase and displays high constitutive
CC       activity (spontaneous activity in the absence of agonist) (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; AY044153; AAK72406.1; -; mRNA.
DR   CCDS; CCDS17169.1; -.
DR   RefSeq; NP_598610.1; NM_133849.3.
DR   AlphaFoldDB; P58406; -.
DR   SMR; P58406; -.
DR   STRING; 10090.ENSMUSP00000049963; -.
DR   BindingDB; P58406; -.
DR   ChEMBL; CHEMBL3263; -.
DR   DrugCentral; P58406; -.
DR   GuidetoPHARMACOLOGY; 264; -.
DR   GlyCosmos; P58406; 1 site, No reported glycans.
DR   GlyGen; P58406; 1 site.
DR   iPTMnet; P58406; -.
DR   PhosphoSitePlus; P58406; -.
DR   SwissPalm; P58406; -.
DR   PaxDb; 10090-ENSMUSP00000049963; -.
DR   ProteomicsDB; 267018; -.
DR   Antibodypedia; 14714; 561 antibodies from 36 providers.
DR   DNASU; 99296; -.
DR   Ensembl; ENSMUST00000056480.10; ENSMUSP00000049963.4; ENSMUSG00000039059.12.
DR   GeneID; 99296; -.
DR   KEGG; mmu:99296; -.
DR   UCSC; uc008oij.2; mouse.
DR   AGR; MGI:2139279; -.
DR   CTD; 11255; -.
DR   MGI; MGI:2139279; Hrh3.
DR   VEuPathDB; HostDB:ENSMUSG00000039059; -.
DR   eggNOG; KOG3656; Eukaryota.
DR   GeneTree; ENSGT00940000161502; -.
DR   InParanoid; P58406; -.
DR   OMA; DIFHEVH; -.
DR   OrthoDB; 5405331at2759; -.
DR   PhylomeDB; P58406; -.
DR   TreeFam; TF351747; -.
DR   Reactome; R-MMU-390650; Histamine receptors.
DR   BioGRID-ORCS; 99296; 3 hits in 77 CRISPR screens.
DR   PRO; PR:P58406; -.
DR   Proteomes; UP000000589; Chromosome 2.
DR   RNAct; P58406; Protein.
DR   Bgee; ENSMUSG00000039059; Expressed in superior frontal gyrus and 56 other cell types or tissues.
DR   ExpressionAtlas; P58406; baseline and differential.
DR   GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0045202; C:synapse; IBA:GO_Central.
DR   GO; GO:0043176; F:amine binding; ISO:MGI.
DR   GO; GO:0016907; F:G protein-coupled acetylcholine receptor activity; IBA:GO_Central.
DR   GO; GO:0004993; F:G protein-coupled serotonin receptor activity; IBA:GO_Central.
DR   GO; GO:1901363; F:heterocyclic compound binding; ISO:MGI.
DR   GO; GO:0004969; F:histamine receptor activity; IEA:InterPro.
DR   GO; GO:0097159; F:organic cyclic compound binding; ISO:MGI.
DR   GO; GO:0007197; P:adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0046058; P:cAMP metabolic process; ISO:MGI.
DR   GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR   GO; GO:0050890; P:cognition; ISO:MGI.
DR   GO; GO:0042756; P:drinking behavior; ISO:MGI.
DR   GO; GO:0042755; P:eating behavior; ISO:MGI.
DR   GO; GO:0007187; P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; IBA:GO_Central.
DR   GO; GO:0007612; P:learning; ISO:MGI.
DR   GO; GO:0007613; P:memory; ISO:MGI.
DR   GO; GO:0045776; P:negative regulation of blood pressure; ISO:MGI.
DR   GO; GO:0014053; P:negative regulation of gamma-aminobutyric acid secretion; ISO:MGI.
DR   GO; GO:0014050; P:negative regulation of glutamate secretion; ISO:MGI.
DR   GO; GO:0014063; P:negative regulation of serotonin secretion; ISO:MGI.
DR   GO; GO:0090238; P:positive regulation of arachidonic acid secretion; ISO:MGI.
DR   GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; ISO:MGI.
DR   GO; GO:0050679; P:positive regulation of epithelial cell proliferation; ISO:MGI.
DR   GO; GO:0014061; P:regulation of norepinephrine secretion; ISO:MGI.
DR   GO; GO:1904321; P:response to forskolin; ISO:MGI.
DR   GO; GO:0014070; P:response to organic cyclic compound; ISO:MGI.
DR   CDD; cd15296; 7tmA_Histamine_H3R; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR041998; 7tmA_HRH3.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR003980; Histamine_H3_rcpt.
DR   PANTHER; PTHR24247; 5-HYDROXYTRYPTAMINE RECEPTOR; 1.
DR   PANTHER; PTHR24247:SF194; HISTAMINE H3 RECEPTOR; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR01471; HISTAMINEH3R.
DR   SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   Genevisible; P58406; MM.
PE   1: Evidence at protein level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Phosphoprotein; Receptor; Reference proteome; Transducer;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..445
FT                   /note="Histamine H3 receptor"
FT                   /id="PRO_0000069691"
FT   TOPO_DOM        1..39
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        40..60
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        61..70
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        71..91
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        92..108
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        109..129
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        130..156
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        157..177
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        178..196
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        197..217
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        218..359
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        360..380
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        381..396
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        397..417
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        418..445
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          234..259
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          273..336
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        242..259
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        299..314
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         439
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:21183079"
FT   CARBOHYD        11
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        107..188
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   445 AA;  48541 MW;  B8D406E29E1F3C5F CRC64;
     MERAPPDGLM NASGALAGEA AAAGGARGFS AAWTAVLAAL MALLIVATVL GNALVMLAFV
     ADSSLRTQNN FFLLNLAISD FLVGAFCIPL YVPYVLTGRW TFGRGLCKLW LVVDYLLCAS
     SVFNIVLISY DRFLSVTRAV SYRAQQGDTR RAVRKMALVW VLAFLLYGPA ILSWEYLSGG
     SSIPEGHCYA EFFYNWYFLI TASTLEFFTP FLSVTFFNLS IYLNIQRRTR LRLDGGREAG
     PEPPPDAQPS PPPAPPSCWG CWPKGHGEAM PLHRYGVGEA GPGVETGEAG LGGGSGGGAA
     ASPTSSSGSS SRGTERPRSL KRGSKPSASS ASLEKRMKMV SQSITQRFRL SRDKKVAKSL
     AIIVSIFGLC WAPYTLLMII RAACHGHCVP DYWYETSFWL LWANSAVNPV LYPLCHYSFR
     RAFTKLLCPQ KLKVQPHGSL EQCWK
//