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P58406

- HRH3_MOUSE

UniProt

P58406 - HRH3_MOUSE

Protein

Histamine H3 receptor

Gene

Hrh3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (16 Nov 2001)
      Previous versions | rss
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    Functioni

    The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist) By similarity.By similarity

    GO - Molecular functioni

    1. drug binding Source: Ensembl
    2. histamine receptor activity Source: Ensembl

    GO - Biological processi

    1. brain development Source: Ensembl
    2. drinking behavior Source: Ensembl
    3. eating behavior Source: Ensembl
    4. learning Source: Ensembl
    5. memory Source: Ensembl
    6. negative regulation of adenylate cyclase activity Source: Ensembl
    7. negative regulation of blood pressure Source: Ensembl
    8. negative regulation of gamma-aminobutyric acid secretion Source: Ensembl
    9. negative regulation of glutamate secretion Source: Ensembl
    10. negative regulation of serotonin secretion Source: Ensembl
    11. positive regulation of cytosolic calcium ion concentration Source: Ensembl
    12. positive regulation of epithelial cell proliferation Source: Ensembl
    13. regulation of neurotransmitter levels Source: InterPro
    14. regulation of norepinephrine secretion Source: Ensembl
    15. response to organic cyclic compound Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histamine H3 receptor
    Short name:
    H3R
    Short name:
    HH3R
    Gene namesi
    Name:Hrh3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:2139279. Hrh3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. myelin sheath Source: Ensembl
    3. neuron projection Source: Ensembl
    4. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 445445Histamine H3 receptorPRO_0000069691Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi11 – 111N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiP58406.

    PTM databases

    PhosphoSiteiP58406.

    Expressioni

    Gene expression databases

    BgeeiP58406.
    CleanExiMM_HRH3.
    GenevestigatoriP58406.

    Interactioni

    Structurei

    3D structure databases

    ProteinModelPortaliP58406.
    SMRiP58406. Positions 3-248, 352-427.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3939ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini61 – 7010CytoplasmicSequence Analysis
    Topological domaini92 – 10817ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini130 – 15627CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini178 – 19619ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini218 – 359142CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini381 – 39616ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini418 – 44528CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei40 – 6021Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei71 – 9121Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei109 – 12921Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei157 – 17721Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei197 – 21721Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei360 – 38021Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei397 – 41721Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi20 – 234Poly-Ala

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG289713.
    HOGENOMiHOG000048707.
    HOVERGENiHBG102132.
    InParanoidiP58406.
    KOiK04151.
    OrthoDBiEOG73804R.
    PhylomeDBiP58406.
    TreeFamiTF351747.

    Family and domain databases

    Gene3Di1.20.1070.10. 2 hits.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR003980. Histamine_H3_rcpt.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01471. HISTAMINEH3R.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P58406-1 [UniParc]FASTAAdd to Basket

    « Hide

    MERAPPDGLM NASGALAGEA AAAGGARGFS AAWTAVLAAL MALLIVATVL    50
    GNALVMLAFV ADSSLRTQNN FFLLNLAISD FLVGAFCIPL YVPYVLTGRW 100
    TFGRGLCKLW LVVDYLLCAS SVFNIVLISY DRFLSVTRAV SYRAQQGDTR 150
    RAVRKMALVW VLAFLLYGPA ILSWEYLSGG SSIPEGHCYA EFFYNWYFLI 200
    TASTLEFFTP FLSVTFFNLS IYLNIQRRTR LRLDGGREAG PEPPPDAQPS 250
    PPPAPPSCWG CWPKGHGEAM PLHRYGVGEA GPGVETGEAG LGGGSGGGAA 300
    ASPTSSSGSS SRGTERPRSL KRGSKPSASS ASLEKRMKMV SQSITQRFRL 350
    SRDKKVAKSL AIIVSIFGLC WAPYTLLMII RAACHGHCVP DYWYETSFWL 400
    LWANSAVNPV LYPLCHYSFR RAFTKLLCPQ KLKVQPHGSL EQCWK 445
    Length:445
    Mass (Da):48,541
    Last modified:November 16, 2001 - v1
    Checksum:iB8D406E29E1F3C5F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY044153 mRNA. Translation: AAK72406.1.
    CCDSiCCDS17169.1.
    RefSeqiNP_598610.1. NM_133849.3.
    UniGeneiMm.285360.

    Genome annotation databases

    EnsembliENSMUST00000056480; ENSMUSP00000049963; ENSMUSG00000039059.
    GeneIDi99296.
    KEGGimmu:99296.
    UCSCiuc008oij.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY044153 mRNA. Translation: AAK72406.1 .
    CCDSi CCDS17169.1.
    RefSeqi NP_598610.1. NM_133849.3.
    UniGenei Mm.285360.

    3D structure databases

    ProteinModelPortali P58406.
    SMRi P58406. Positions 3-248, 352-427.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi P58406.
    ChEMBLi CHEMBL3263.
    GuidetoPHARMACOLOGYi 264.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P58406.

    Proteomic databases

    PRIDEi P58406.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000056480 ; ENSMUSP00000049963 ; ENSMUSG00000039059 .
    GeneIDi 99296.
    KEGGi mmu:99296.
    UCSCi uc008oij.1. mouse.

    Organism-specific databases

    CTDi 11255.
    MGIi MGI:2139279. Hrh3.

    Phylogenomic databases

    eggNOGi NOG289713.
    HOGENOMi HOG000048707.
    HOVERGENi HBG102132.
    InParanoidi P58406.
    KOi K04151.
    OrthoDBi EOG73804R.
    PhylomeDBi P58406.
    TreeFami TF351747.

    Miscellaneous databases

    NextBioi 353867.
    PROi P58406.
    SOURCEi Search...

    Gene expression databases

    Bgeei P58406.
    CleanExi MM_HRH3.
    Genevestigatori P58406.

    Family and domain databases

    Gene3Di 1.20.1070.10. 2 hits.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR003980. Histamine_H3_rcpt.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01471. HISTAMINEH3R.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of mouse histamine H3 receptor."
      Coge F., Rique H., Levacher B., Leopold O., Guenin S.-P., Boutin J.A., Galizzi J.-P.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: CD-1.

    Entry informationi

    Entry nameiHRH3_MOUSE
    AccessioniPrimary (citable) accession number: P58406
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 16, 2001
    Last sequence update: November 16, 2001
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3