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P58406

- HRH3_MOUSE

UniProt

P58406 - HRH3_MOUSE

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Protein
Histamine H3 receptor
Gene
Hrh3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist) By similarity.

GO - Molecular functioni

  1. drug binding Source: Ensembl
  2. histamine receptor activity Source: Ensembl
Complete GO annotation...

GO - Biological processi

  1. brain development Source: Ensembl
  2. drinking behavior Source: Ensembl
  3. eating behavior Source: Ensembl
  4. learning Source: Ensembl
  5. memory Source: Ensembl
  6. negative regulation of adenylate cyclase activity Source: Ensembl
  7. negative regulation of blood pressure Source: Ensembl
  8. negative regulation of gamma-aminobutyric acid secretion Source: Ensembl
  9. negative regulation of glutamate secretion Source: Ensembl
  10. negative regulation of serotonin secretion Source: Ensembl
  11. positive regulation of cytosolic calcium ion concentration Source: Ensembl
  12. positive regulation of epithelial cell proliferation Source: Ensembl
  13. regulation of neurotransmitter levels Source: InterPro
  14. regulation of norepinephrine secretion Source: Ensembl
  15. response to organic cyclic compound Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Histamine H3 receptor
Short name:
H3R
Short name:
HH3R
Gene namesi
Name:Hrh3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:2139279. Hrh3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3939Extracellular Reviewed prediction
Add
BLAST
Transmembranei40 – 6021Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini61 – 7010Cytoplasmic Reviewed prediction
Transmembranei71 – 9121Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini92 – 10817Extracellular Reviewed prediction
Add
BLAST
Transmembranei109 – 12921Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini130 – 15627Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei157 – 17721Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini178 – 19619Extracellular Reviewed prediction
Add
BLAST
Transmembranei197 – 21721Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini218 – 359142Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei360 – 38021Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini381 – 39616Extracellular Reviewed prediction
Add
BLAST
Transmembranei397 – 41721Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini418 – 44528Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. myelin sheath Source: Ensembl
  3. neuron projection Source: Ensembl
  4. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 445445Histamine H3 receptor
PRO_0000069691Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi11 – 111N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP58406.

PTM databases

PhosphoSiteiP58406.

Expressioni

Gene expression databases

BgeeiP58406.
CleanExiMM_HRH3.
GenevestigatoriP58406.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliP58406.
SMRiP58406. Positions 3-248, 352-427.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi20 – 234Poly-Ala

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG289713.
HOGENOMiHOG000048707.
HOVERGENiHBG102132.
InParanoidiP58406.
KOiK04151.
OrthoDBiEOG73804R.
PhylomeDBiP58406.
TreeFamiTF351747.

Family and domain databases

Gene3Di1.20.1070.10. 2 hits.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003980. Histamine_H3_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01471. HISTAMINEH3R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P58406-1 [UniParc]FASTAAdd to Basket

« Hide

MERAPPDGLM NASGALAGEA AAAGGARGFS AAWTAVLAAL MALLIVATVL    50
GNALVMLAFV ADSSLRTQNN FFLLNLAISD FLVGAFCIPL YVPYVLTGRW 100
TFGRGLCKLW LVVDYLLCAS SVFNIVLISY DRFLSVTRAV SYRAQQGDTR 150
RAVRKMALVW VLAFLLYGPA ILSWEYLSGG SSIPEGHCYA EFFYNWYFLI 200
TASTLEFFTP FLSVTFFNLS IYLNIQRRTR LRLDGGREAG PEPPPDAQPS 250
PPPAPPSCWG CWPKGHGEAM PLHRYGVGEA GPGVETGEAG LGGGSGGGAA 300
ASPTSSSGSS SRGTERPRSL KRGSKPSASS ASLEKRMKMV SQSITQRFRL 350
SRDKKVAKSL AIIVSIFGLC WAPYTLLMII RAACHGHCVP DYWYETSFWL 400
LWANSAVNPV LYPLCHYSFR RAFTKLLCPQ KLKVQPHGSL EQCWK 445
Length:445
Mass (Da):48,541
Last modified:November 16, 2001 - v1
Checksum:iB8D406E29E1F3C5F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY044153 mRNA. Translation: AAK72406.1.
CCDSiCCDS17169.1.
RefSeqiNP_598610.1. NM_133849.3.
UniGeneiMm.285360.

Genome annotation databases

EnsembliENSMUST00000056480; ENSMUSP00000049963; ENSMUSG00000039059.
GeneIDi99296.
KEGGimmu:99296.
UCSCiuc008oij.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY044153 mRNA. Translation: AAK72406.1 .
CCDSi CCDS17169.1.
RefSeqi NP_598610.1. NM_133849.3.
UniGenei Mm.285360.

3D structure databases

ProteinModelPortali P58406.
SMRi P58406. Positions 3-248, 352-427.
ModBasei Search...

Chemistry

BindingDBi P58406.
ChEMBLi CHEMBL3263.
GuidetoPHARMACOLOGYi 264.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P58406.

Proteomic databases

PRIDEi P58406.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000056480 ; ENSMUSP00000049963 ; ENSMUSG00000039059 .
GeneIDi 99296.
KEGGi mmu:99296.
UCSCi uc008oij.1. mouse.

Organism-specific databases

CTDi 11255.
MGIi MGI:2139279. Hrh3.

Phylogenomic databases

eggNOGi NOG289713.
HOGENOMi HOG000048707.
HOVERGENi HBG102132.
InParanoidi P58406.
KOi K04151.
OrthoDBi EOG73804R.
PhylomeDBi P58406.
TreeFami TF351747.

Miscellaneous databases

NextBioi 353867.
PROi P58406.
SOURCEi Search...

Gene expression databases

Bgeei P58406.
CleanExi MM_HRH3.
Genevestigatori P58406.

Family and domain databases

Gene3Di 1.20.1070.10. 2 hits.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003980. Histamine_H3_rcpt.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR01471. HISTAMINEH3R.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning of mouse histamine H3 receptor."
    Coge F., Rique H., Levacher B., Leopold O., Guenin S.-P., Boutin J.A., Galizzi J.-P.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: CD-1.

Entry informationi

Entry nameiHRH3_MOUSE
AccessioniPrimary (citable) accession number: P58406
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: November 16, 2001
Last modified: July 9, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi