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Protein

Histamine H3 receptor

Gene

Hrh3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist) (By similarity).By similarity

GO - Molecular functioni

  1. drug binding Source: Ensembl
  2. histamine receptor activity Source: Ensembl

GO - Biological processi

  1. brain development Source: Ensembl
  2. drinking behavior Source: Ensembl
  3. eating behavior Source: Ensembl
  4. learning Source: Ensembl
  5. memory Source: Ensembl
  6. negative regulation of adenylate cyclase activity Source: Ensembl
  7. negative regulation of blood pressure Source: Ensembl
  8. negative regulation of gamma-aminobutyric acid secretion Source: Ensembl
  9. negative regulation of glutamate secretion Source: Ensembl
  10. negative regulation of serotonin secretion Source: Ensembl
  11. positive regulation of cytosolic calcium ion concentration Source: Ensembl
  12. positive regulation of epithelial cell proliferation Source: Ensembl
  13. regulation of neurotransmitter levels Source: InterPro
  14. regulation of norepinephrine secretion Source: Ensembl
  15. response to organic cyclic compound Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_331048. G alpha (i) signalling events.
REACT_346351. Histamine receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Histamine H3 receptor
Short name:
H3R
Short name:
HH3R
Gene namesi
Name:Hrh3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2139279. Hrh3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3939ExtracellularSequence AnalysisAdd
BLAST
Transmembranei40 – 6021Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini61 – 7010CytoplasmicSequence Analysis
Transmembranei71 – 9121Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini92 – 10817ExtracellularSequence AnalysisAdd
BLAST
Transmembranei109 – 12921Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini130 – 15627CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei157 – 17721Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini178 – 19619ExtracellularSequence AnalysisAdd
BLAST
Transmembranei197 – 21721Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini218 – 359142CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei360 – 38021Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini381 – 39616ExtracellularSequence AnalysisAdd
BLAST
Transmembranei397 – 41721Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini418 – 44528CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. myelin sheath Source: Ensembl
  3. neuron projection Source: Ensembl
  4. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 445445Histamine H3 receptorPRO_0000069691Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi11 – 111N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP58406.

PTM databases

PhosphoSiteiP58406.

Expressioni

Gene expression databases

BgeeiP58406.
CleanExiMM_HRH3.
ExpressionAtlasiP58406. baseline and differential.
GenevestigatoriP58406.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliP58406.
SMRiP58406. Positions 3-248, 352-427.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi20 – 234Poly-Ala

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG289713.
HOGENOMiHOG000048707.
HOVERGENiHBG102132.
InParanoidiP58406.
KOiK04151.
OrthoDBiEOG73804R.
PhylomeDBiP58406.
TreeFamiTF351747.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003980. Histamine_H3_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01471. HISTAMINEH3R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P58406-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERAPPDGLM NASGALAGEA AAAGGARGFS AAWTAVLAAL MALLIVATVL
60 70 80 90 100
GNALVMLAFV ADSSLRTQNN FFLLNLAISD FLVGAFCIPL YVPYVLTGRW
110 120 130 140 150
TFGRGLCKLW LVVDYLLCAS SVFNIVLISY DRFLSVTRAV SYRAQQGDTR
160 170 180 190 200
RAVRKMALVW VLAFLLYGPA ILSWEYLSGG SSIPEGHCYA EFFYNWYFLI
210 220 230 240 250
TASTLEFFTP FLSVTFFNLS IYLNIQRRTR LRLDGGREAG PEPPPDAQPS
260 270 280 290 300
PPPAPPSCWG CWPKGHGEAM PLHRYGVGEA GPGVETGEAG LGGGSGGGAA
310 320 330 340 350
ASPTSSSGSS SRGTERPRSL KRGSKPSASS ASLEKRMKMV SQSITQRFRL
360 370 380 390 400
SRDKKVAKSL AIIVSIFGLC WAPYTLLMII RAACHGHCVP DYWYETSFWL
410 420 430 440
LWANSAVNPV LYPLCHYSFR RAFTKLLCPQ KLKVQPHGSL EQCWK
Length:445
Mass (Da):48,541
Last modified:November 16, 2001 - v1
Checksum:iB8D406E29E1F3C5F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY044153 mRNA. Translation: AAK72406.1.
CCDSiCCDS17169.1.
RefSeqiNP_598610.1. NM_133849.3.
UniGeneiMm.285360.

Genome annotation databases

EnsembliENSMUST00000056480; ENSMUSP00000049963; ENSMUSG00000039059.
GeneIDi99296.
KEGGimmu:99296.
UCSCiuc008oij.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY044153 mRNA. Translation: AAK72406.1.
CCDSiCCDS17169.1.
RefSeqiNP_598610.1. NM_133849.3.
UniGeneiMm.285360.

3D structure databases

ProteinModelPortaliP58406.
SMRiP58406. Positions 3-248, 352-427.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiP58406.
ChEMBLiCHEMBL3263.
GuidetoPHARMACOLOGYi264.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP58406.

Proteomic databases

PRIDEiP58406.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000056480; ENSMUSP00000049963; ENSMUSG00000039059.
GeneIDi99296.
KEGGimmu:99296.
UCSCiuc008oij.1. mouse.

Organism-specific databases

CTDi11255.
MGIiMGI:2139279. Hrh3.

Phylogenomic databases

eggNOGiNOG289713.
HOGENOMiHOG000048707.
HOVERGENiHBG102132.
InParanoidiP58406.
KOiK04151.
OrthoDBiEOG73804R.
PhylomeDBiP58406.
TreeFamiTF351747.

Enzyme and pathway databases

ReactomeiREACT_331048. G alpha (i) signalling events.
REACT_346351. Histamine receptors.

Miscellaneous databases

NextBioi353867.
PROiP58406.
SOURCEiSearch...

Gene expression databases

BgeeiP58406.
CleanExiMM_HRH3.
ExpressionAtlasiP58406. baseline and differential.
GenevestigatoriP58406.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003980. Histamine_H3_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01471. HISTAMINEH3R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning of mouse histamine H3 receptor."
    Coge F., Rique H., Levacher B., Leopold O., Guenin S.-P., Boutin J.A., Galizzi J.-P.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: CD-1.

Entry informationi

Entry nameiHRH3_MOUSE
AccessioniPrimary (citable) accession number: P58406
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: November 16, 2001
Last modified: April 1, 2015
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.