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P58406 (HRH3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histamine H3 receptor

Short name=H3R
Short name=HH3R
Gene names
Name:Hrh3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length445 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist) By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processbrain development

Inferred from electronic annotation. Source: Ensembl

drinking behavior

Inferred from electronic annotation. Source: Ensembl

eating behavior

Inferred from electronic annotation. Source: Ensembl

learning

Inferred from electronic annotation. Source: Ensembl

memory

Inferred from electronic annotation. Source: Ensembl

negative regulation of adenylate cyclase activity

Inferred from electronic annotation. Source: Ensembl

negative regulation of blood pressure

Inferred from electronic annotation. Source: Ensembl

negative regulation of gamma-aminobutyric acid secretion

Inferred from electronic annotation. Source: Ensembl

negative regulation of glutamate secretion

Inferred from electronic annotation. Source: Ensembl

negative regulation of serotonin secretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of cytosolic calcium ion concentration

Inferred from electronic annotation. Source: Ensembl

positive regulation of epithelial cell proliferation

Inferred from electronic annotation. Source: Ensembl

regulation of neurotransmitter levels

Inferred from electronic annotation. Source: InterPro

regulation of norepinephrine secretion

Inferred from electronic annotation. Source: Ensembl

response to organic cyclic compound

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

myelin sheath

Inferred from electronic annotation. Source: Ensembl

neuron projection

Inferred from electronic annotation. Source: Ensembl

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functiondrug binding

Inferred from electronic annotation. Source: Ensembl

histamine receptor activity

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 445445Histamine H3 receptor
PRO_0000069691

Regions

Topological domain1 – 3939Extracellular Potential
Transmembrane40 – 6021Helical; Name=1; Potential
Topological domain61 – 7010Cytoplasmic Potential
Transmembrane71 – 9121Helical; Name=2; Potential
Topological domain92 – 10817Extracellular Potential
Transmembrane109 – 12921Helical; Name=3; Potential
Topological domain130 – 15627Cytoplasmic Potential
Transmembrane157 – 17721Helical; Name=4; Potential
Topological domain178 – 19619Extracellular Potential
Transmembrane197 – 21721Helical; Name=5; Potential
Topological domain218 – 359142Cytoplasmic Potential
Transmembrane360 – 38021Helical; Name=6; Potential
Topological domain381 – 39616Extracellular Potential
Transmembrane397 – 41721Helical; Name=7; Potential
Topological domain418 – 44528Cytoplasmic Potential
Compositional bias20 – 234Poly-Ala

Amino acid modifications

Glycosylation111N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P58406 [UniParc].

Last modified November 16, 2001. Version 1.
Checksum: B8D406E29E1F3C5F

FASTA44548,541
        10         20         30         40         50         60 
MERAPPDGLM NASGALAGEA AAAGGARGFS AAWTAVLAAL MALLIVATVL GNALVMLAFV 

        70         80         90        100        110        120 
ADSSLRTQNN FFLLNLAISD FLVGAFCIPL YVPYVLTGRW TFGRGLCKLW LVVDYLLCAS 

       130        140        150        160        170        180 
SVFNIVLISY DRFLSVTRAV SYRAQQGDTR RAVRKMALVW VLAFLLYGPA ILSWEYLSGG 

       190        200        210        220        230        240 
SSIPEGHCYA EFFYNWYFLI TASTLEFFTP FLSVTFFNLS IYLNIQRRTR LRLDGGREAG 

       250        260        270        280        290        300 
PEPPPDAQPS PPPAPPSCWG CWPKGHGEAM PLHRYGVGEA GPGVETGEAG LGGGSGGGAA 

       310        320        330        340        350        360 
ASPTSSSGSS SRGTERPRSL KRGSKPSASS ASLEKRMKMV SQSITQRFRL SRDKKVAKSL 

       370        380        390        400        410        420 
AIIVSIFGLC WAPYTLLMII RAACHGHCVP DYWYETSFWL LWANSAVNPV LYPLCHYSFR 

       430        440 
RAFTKLLCPQ KLKVQPHGSL EQCWK 

« Hide

References

[1]"Cloning of mouse histamine H3 receptor."
Coge F., Rique H., Levacher B., Leopold O., Guenin S.-P., Boutin J.A., Galizzi J.-P.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: CD-1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY044153 mRNA. Translation: AAK72406.1.
RefSeqNP_598610.1. NM_133849.3.
UniGeneMm.285360.

3D structure databases

ProteinModelPortalP58406.
SMRP58406. Positions 30-427.
ModBaseSearch...
MobiDBSearch...

Chemistry

BindingDBP58406.
ChEMBLCHEMBL3263.
GuidetoPHARMACOLOGY264.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP58406.

Proteomic databases

PRIDEP58406.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000056480; ENSMUSP00000049963; ENSMUSG00000039059.
GeneID99296.
KEGGmmu:99296.
UCSCuc008oij.1. mouse.

Organism-specific databases

CTD11255.
MGIMGI:2139279. Hrh3.

Phylogenomic databases

eggNOGNOG289713.
HOGENOMHOG000048707.
HOVERGENHBG102132.
InParanoidP58406.
KOK04151.
OrthoDBEOG73804R.
PhylomeDBP58406.
TreeFamTF351747.

Gene expression databases

BgeeP58406.
CleanExMM_HRH3.
GenevestigatorP58406.

Family and domain databases

Gene3D1.20.1070.10. 2 hits.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003980. Histamine_H3_rcpt.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01471. HISTAMINEH3R.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio353867.
PROP58406.
SOURCESearch...

Entry information

Entry nameHRH3_MOUSE
AccessionPrimary (citable) accession number: P58406
Entry history
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: November 16, 2001
Last modified: April 16, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries