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Protein

Striatin-3

Gene

Strn3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • negative regulation of intracellular estrogen receptor signaling pathway Source: RGD
  • negative regulation of transcription, DNA-templated Source: RGD
  • negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  • positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  • response to estradiol Source: RGD
Complete GO annotation...

Keywords - Ligandi

Calmodulin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Striatin-3
Alternative name(s):
Cell cycle autoantigen SG2NA
S/G2 antigen
Gene namesi
Name:Strn3
Synonyms:Gs2na, Sg2na
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi621827. Strn3.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: RGD
  • dendrite Source: RGD
  • Golgi apparatus Source: Ensembl
  • neuronal cell body Source: RGD
  • nucleoplasm Source: Ensembl
  • plasma membrane Source: Ensembl
  • protein complex Source: RGD
  • protein phosphatase type 2A complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 794794Striatin-3PRO_0000051238Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei149 – 1491PhosphothreonineCombined sources
Modified residuei200 – 2001PhosphoserineBy similarity
Modified residuei212 – 2121PhosphoserineBy similarity
Modified residuei227 – 2271PhosphoserineCombined sources
Modified residuei255 – 2551PhosphoserineCombined sources
Modified residuei332 – 3321PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP58405.
PRIDEiP58405.

PTM databases

iPTMnetiP58405.
PhosphoSiteiP58405.

Expressioni

Gene expression databases

GenevisibleiP58405. RN.

Interactioni

Subunit structurei

Interacts with protein phosphatase 2A (PP2A). Interacts with CDC42BPB.By similarity

GO - Molecular functioni

  • protein complex binding Source: RGD

Protein-protein interaction databases

BioGridi250366. 1 interaction.
IntActiP58405. 1 interaction.
MINTiMINT-1775849.
STRINGi10116.ENSRNOP00000007509.

Structurei

3D structure databases

ProteinModelPortaliP58405.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati475 – 51440WD 1Add
BLAST
Repeati528 – 56740WD 2Add
BLAST
Repeati581 – 62040WD 3Add
BLAST
Repeati676 – 71540WD 4Add
BLAST
Repeati718 – 75740WD 5Add
BLAST
Repeati764 – 79431WD 6Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni70 – 789Caveolin-bindingSequence analysis
Regioni164 – 18118Calmodulin-bindingSequence analysisAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili76 – 13560Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the WD repeat striatin family.Curated
Contains 6 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0642. Eukaryota.
ENOG410XR31. LUCA.
GeneTreeiENSGT00520000055597.
HOGENOMiHOG000236343.
HOVERGENiHBG007117.
InParanoidiP58405.
KOiK17608.
OMAiDDTDVKM.
OrthoDBiEOG79KPDR.
PhylomeDBiP58405.
TreeFamiTF313387.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR013258. Striatin_N.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08232. Striatin. 1 hit.
PF00400. WD40. 5 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P58405-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDELAGGGGG QGMAVPPRPQ QGPGGNLSLP PGANGAPGGG GPPAAETAGP
60 70 80 90 100
PAGPELSRPQ QYTIPGILHY IQHEWARFEM ERAHWEVERA ELQARIAFLQ
110 120 130 140 150
GERKGQENLK KDLVRRIKML EYALKQERAK YHKLKYGTEL NQGDLKMPTF
160 170 180 190 200
ESEETKDAEA PPAQNSQLTW KQGRQLLRQY LQEVGYTDTI LDVRSQRVRS
210 220 230 240 250
LLGLSNSEPN GSIEAKNLEQ ILNGGESPKQ KGQEIKRPSG DVLETFNFLE
260 270 280 290 300
NADDSDEEEN DMIEGIPEGK DKLRIHKHKI GNEGLAADLT DDPDTEEALK
310 320 330 340 350
EFDFLVTAED GEGAGEARSS GDGTEWDKDD LSPTAEVWDV DQGLMSKLKE
360 370 380 390 400
QYKKERKGKR GAKRVNRTNL CDMITDLGDD ELPHIPSGII NQSRSASTRM
410 420 430 440 450
TDHEGSRAEE AEPITFPSGG GKSFIMGSDD VLLSVLGLGD LADLTVTNDA
460 470 480 490 500
DYSYDLPANK DALRKTWNPK YTLRSHFDGV RALAFHPVEP VLVTASEDHT
510 520 530 540 550
LKLWNLQKTV PAKKSASLDV EPIYTFRAHI GPVLSLAISS NGEQCFSGGI
560 570 580 590 600
DATIQWWNMP SPNVDPYDTY ESHVLAGTLV AHTDAVWGLA YSGIKNQLLS
610 620 630 640 650
CSADGTIRLW NPQEKLPCIC TYNGDKEHGI PTSVDFIGCD PAHMVTSFNT
660 670 680 690 700
GSAIIYDLET SQSLVMLSSQ VDSGLQSSNH INRVVSHPTL PVTITAHEDR
710 720 730 740 750
HIKFFDNKTG KMIHSMVAHL DAVTSLAVDP NGIYLMSGSH DCSIRLWNLD
760 770 780 790
SKTCVQEITA HRKKLDESIY DVAFHPSKAY IASAGADALA KVFV
Length:794
Mass (Da):87,111
Last modified:June 12, 2007 - v2
Checksum:i78B43BE6B92EF3C8
GO
Isoform 2 (identifier: P58405-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     9-9: G → GGQGMAVPPRPQQGRGG
     327-410: Missing.

Show »
Length:726
Mass (Da):79,204
Checksum:iCCA99583E7283201
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei9 – 91G → GGQGMAVPPRPQQGRGG in isoform 2. 1 PublicationVSP_026164
Alternative sequencei327 – 41084Missing in isoform 2. 1 PublicationVSP_026165Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03048613 Genomic DNA. No translation available.
AY026526 mRNA. Translation: AAK07683.1.
RefSeqiNP_001025068.1. NM_001029897.3. [P58405-1]
UniGeneiRn.8394.

Genome annotation databases

EnsembliENSRNOT00000077578; ENSRNOP00000074395; ENSRNOG00000060335. [P58405-1]
GeneIDi114520.
KEGGirno:114520.
UCSCiRGD:621827. rat. [P58405-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03048613 Genomic DNA. No translation available.
AY026526 mRNA. Translation: AAK07683.1.
RefSeqiNP_001025068.1. NM_001029897.3. [P58405-1]
UniGeneiRn.8394.

3D structure databases

ProteinModelPortaliP58405.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi250366. 1 interaction.
IntActiP58405. 1 interaction.
MINTiMINT-1775849.
STRINGi10116.ENSRNOP00000007509.

PTM databases

iPTMnetiP58405.
PhosphoSiteiP58405.

Proteomic databases

PaxDbiP58405.
PRIDEiP58405.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000077578; ENSRNOP00000074395; ENSRNOG00000060335. [P58405-1]
GeneIDi114520.
KEGGirno:114520.
UCSCiRGD:621827. rat. [P58405-1]

Organism-specific databases

CTDi29966.
RGDi621827. Strn3.

Phylogenomic databases

eggNOGiKOG0642. Eukaryota.
ENOG410XR31. LUCA.
GeneTreeiENSGT00520000055597.
HOGENOMiHOG000236343.
HOVERGENiHBG007117.
InParanoidiP58405.
KOiK17608.
OMAiDDTDVKM.
OrthoDBiEOG79KPDR.
PhylomeDBiP58405.
TreeFamiTF313387.

Miscellaneous databases

PROiP58405.

Gene expression databases

GenevisibleiP58405. RN.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR013258. Striatin_N.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08232. Striatin. 1 hit.
PF00400. WD40. 5 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  2. "Rat SG2NA gene partial sequence."
    Long X., Bigsby R.M., Nephew K.P.
    Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-529 (ISOFORM 2).
    Strain: Sprague-Dawley.
  3. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-149; SER-227; SER-255 AND SER-332, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSTRN3_RAT
AccessioniPrimary (citable) accession number: P58405
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: June 12, 2007
Last modified: July 6, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.