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Protein

Striatin-3

Gene

Strn3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • negative regulation of intracellular estrogen receptor signaling pathway Source: RGD
  • negative regulation of transcription, DNA-templated Source: RGD
  • negative regulation of transcription by RNA polymerase II Source: RGD
  • positive regulation of transcription by RNA polymerase II Source: RGD
  • response to estradiol Source: RGD

Keywordsi

Molecular functionCalmodulin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Striatin-3
Alternative name(s):
Cell cycle autoantigen SG2NA
S/G2 antigen
Gene namesi
Name:Strn3
Synonyms:Gs2na, Sg2na
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi621827 Strn3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000512381 – 794Striatin-3Add BLAST794

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei149PhosphothreonineCombined sources1
Modified residuei200PhosphoserineBy similarity1
Modified residuei212PhosphoserineBy similarity1
Modified residuei227PhosphoserineCombined sources1
Modified residuei255PhosphoserineCombined sources1
Modified residuei332PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP58405
PRIDEiP58405

PTM databases

iPTMnetiP58405
PhosphoSitePlusiP58405

Expressioni

Gene expression databases

BgeeiENSRNOG00000060335
GenevisibleiP58405 RN

Interactioni

Subunit structurei

Interacts with protein phosphatase 2A (PP2A). Interacts with CDC42BPB.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi250366, 1 interactor
CORUMiP58405
IntActiP58405, 1 interactor
STRINGi10116.ENSRNOP00000007509

Structurei

3D structure databases

ProteinModelPortaliP58405
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati475 – 514WD 1Add BLAST40
Repeati528 – 567WD 2Add BLAST40
Repeati581 – 620WD 3Add BLAST40
Repeati676 – 715WD 4Add BLAST40
Repeati718 – 757WD 5Add BLAST40
Repeati764 – 794WD 6Add BLAST31

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni70 – 78Caveolin-bindingSequence analysis9
Regioni164 – 181Calmodulin-bindingSequence analysisAdd BLAST18

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili76 – 135Sequence analysisAdd BLAST60

Sequence similaritiesi

Belongs to the WD repeat striatin family.Curated

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0642 Eukaryota
ENOG410XR31 LUCA
GeneTreeiENSGT00520000055597
HOGENOMiHOG000236343
HOVERGENiHBG007117
InParanoidiP58405
KOiK17608
OMAiCTQEITS
OrthoDBiEOG091G0509
PhylomeDBiP58405
TreeFamiTF313387

Family and domain databases

Gene3Di2.130.10.10, 3 hits
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR013258 Striatin_N
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF08232 Striatin, 1 hit
PF00400 WD40, 5 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 4 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P58405-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDELAGGGGG QGMAVPPRPQ QGPGGNLSLP PGANGAPGGG GPPAAETAGP
60 70 80 90 100
PAGPELSRPQ QYTIPGILHY IQHEWARFEM ERAHWEVERA ELQARIAFLQ
110 120 130 140 150
GERKGQENLK KDLVRRIKML EYALKQERAK YHKLKYGTEL NQGDLKMPTF
160 170 180 190 200
ESEETKDAEA PPAQNSQLTW KQGRQLLRQY LQEVGYTDTI LDVRSQRVRS
210 220 230 240 250
LLGLSNSEPN GSIEAKNLEQ ILNGGESPKQ KGQEIKRPSG DVLETFNFLE
260 270 280 290 300
NADDSDEEEN DMIEGIPEGK DKLRIHKHKI GNEGLAADLT DDPDTEEALK
310 320 330 340 350
EFDFLVTAED GEGAGEARSS GDGTEWDKDD LSPTAEVWDV DQGLMSKLKE
360 370 380 390 400
QYKKERKGKR GAKRVNRTNL CDMITDLGDD ELPHIPSGII NQSRSASTRM
410 420 430 440 450
TDHEGSRAEE AEPITFPSGG GKSFIMGSDD VLLSVLGLGD LADLTVTNDA
460 470 480 490 500
DYSYDLPANK DALRKTWNPK YTLRSHFDGV RALAFHPVEP VLVTASEDHT
510 520 530 540 550
LKLWNLQKTV PAKKSASLDV EPIYTFRAHI GPVLSLAISS NGEQCFSGGI
560 570 580 590 600
DATIQWWNMP SPNVDPYDTY ESHVLAGTLV AHTDAVWGLA YSGIKNQLLS
610 620 630 640 650
CSADGTIRLW NPQEKLPCIC TYNGDKEHGI PTSVDFIGCD PAHMVTSFNT
660 670 680 690 700
GSAIIYDLET SQSLVMLSSQ VDSGLQSSNH INRVVSHPTL PVTITAHEDR
710 720 730 740 750
HIKFFDNKTG KMIHSMVAHL DAVTSLAVDP NGIYLMSGSH DCSIRLWNLD
760 770 780 790
SKTCVQEITA HRKKLDESIY DVAFHPSKAY IASAGADALA KVFV
Length:794
Mass (Da):87,111
Last modified:June 12, 2007 - v2
Checksum:i78B43BE6B92EF3C8
GO
Isoform 2 (identifier: P58405-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     9-9: G → GGQGMAVPPRPQQGRGG
     327-410: Missing.

Show »
Length:726
Mass (Da):79,204
Checksum:iCCA99583E7283201
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0261649G → GGQGMAVPPRPQQGRGG in isoform 2. 1 Publication1
Alternative sequenceiVSP_026165327 – 410Missing in isoform 2. 1 PublicationAdd BLAST84

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03048613 Genomic DNA No translation available.
AY026526 mRNA Translation: AAK07683.1
RefSeqiNP_001025068.1, NM_001029897.3 [P58405-1]
UniGeneiRn.8394

Genome annotation databases

EnsembliENSRNOT00000077578; ENSRNOP00000074395; ENSRNOG00000060335 [P58405-1]
GeneIDi114520
KEGGirno:114520
UCSCiRGD:621827 rat [P58405-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSTRN3_RAT
AccessioniPrimary (citable) accession number: P58405
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: June 12, 2007
Last modified: April 25, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health