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Protein

Striatin-4

Gene

Strn4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein.

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calmodulin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Striatin-4
Alternative name(s):
Zinedin
Gene namesi
Name:Strn4
Synonyms:Zin
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2142346. Strn4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000512401 – 760Striatin-4Add BLAST760

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei53PhosphoserineBy similarity1
Modified residuei206PhosphoserineCombined sources1
Modified residuei223PhosphoserineCombined sources1
Modified residuei276PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP58404.
PaxDbiP58404.
PeptideAtlasiP58404.
PRIDEiP58404.

PTM databases

iPTMnetiP58404.
PhosphoSitePlusiP58404.

Expressioni

Tissue specificityi

Mainly expressed in brain but is also expressed at low levels in the kidney.

Gene expression databases

BgeeiENSMUSG00000030374.
CleanExiMM_STRN4.
ExpressionAtlasiP58404. baseline and differential.
GenevisibleiP58404. MM.

Interactioni

Subunit structurei

Interacts with CTTNBP2; this interaction may regulate dendritic spine distribution of STRN4. Activation of glutamate receptors weakens the interaction with CTTNBP2 (By similarity). Interacts with CTTNBP2NL (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi220713. 1 interactor.
IntActiP58404. 1 interactor.
MINTiMINT-4135943.
STRINGi10090.ENSMUSP00000019220.

Structurei

3D structure databases

ProteinModelPortaliP58404.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati443 – 482WD 1Add BLAST40
Repeati496 – 535WD 2Add BLAST40
Repeati549 – 588WD 3Add BLAST40
Repeati595 – 635WD 4Add BLAST41
Repeati642 – 681WD 5Add BLAST40
Repeati684 – 723WD 6Add BLAST40
Repeati730 – 759WD 7Add BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni71 – 79Caveolin-bindingSequence analysis9
Regioni165 – 182Calmodulin-bindingSequence analysisAdd BLAST18

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili69 – 136Sequence analysisAdd BLAST68

Sequence similaritiesi

Belongs to the WD repeat striatin family.Curated
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0642. Eukaryota.
ENOG410XR31. LUCA.
GeneTreeiENSGT00520000055597.
HOGENOMiHOG000236343.
HOVERGENiHBG007117.
InParanoidiP58404.
KOiK17608.
OMAiIVRTESP.
OrthoDBiEOG091G0509.
TreeFamiTF313387.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR013258. Striatin_N.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08232. Striatin. 1 hit.
PF00400. WD40. 4 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P58404-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMEERAAAAV ASAASSCRPL GSGTAPNPTA AAPASSPAPG PGPVGKGGGG
60 70 80 90 100
GGSPGPTAGP EPLSLPGILH FIQHEWARFE AEKARWEAER AELQAQVAFL
110 120 130 140 150
QGERKGQENL KTDLVRRIKM LEYALKQERA KYHKLKFGTD LNQGEKKTDL
160 170 180 190 200
SEQVSNGPVE SVTLENSPLV WKEGRQLLRQ YLEEVGYTDT ILDMRSKRVR
210 220 230 240 250
SLLGRSLELN GAGEPVEGAP RASPGPGGLS GGESLLVKQI EEQIKRNAAG
260 270 280 290 300
KDGKERLGGS VLEQIPFLQN CEDEDSDEDD ELDSVQHKKQ RVRLPSKALV
310 320 330 340 350
PEMEDEDEED DSEDAINEFD FLGSGEDGEG SPDPRRCTSE GNPHELESRR
360 370 380 390 400
VKLQGILADL RDVDGLPPKV TVPPPGTPQP RPHEGSFGFS SDVFIMDTIG
410 420 430 440 450
GGEVSLGDLA DLTVTNDNDL SCDLSDSKDA FKKTWNPKFT LRSHYDGIRS
460 470 480 490 500
LAFHHSQSAL LTASEDGTLK LWNLQKAVTA KKNAALDVEP IHAFRAHRGP
510 520 530 540 550
VLAVTMGSNS EYCYSGGADA RIHSWKIPDL NMDPYDGYDP SVLSHVLEGH
560 570 580 590 600
GDAVWGLAFS PTSQRLASCS ADGTVRIWDP SSSGPSCLCT FPMDGEHGIP
610 620 630 640 650
TSVAFTSTEP AHVVASFRSG DTVLYDLEAG SALLTLESRG SSGPAQINQV
660 670 680 690 700
VSHPSQPLTI TAHDDRGIRF LDNRTGKSVH SMVAHLDAVT CLAVDPNGVF
710 720 730 740 750
LMSGSHDCSL RLWSLDNKTC VQEITAHRKK HEEAIHAVAC HPSKALIASA
760
GADALAKVFV
Length:760
Mass (Da):81,645
Last modified:July 27, 2011 - v2
Checksum:i230FA4855DFDE175
GO
Isoform 2 (identifier: P58404-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     385-391: Missing.

Show »
Length:753
Mass (Da):80,975
Checksum:i2B9BD0879C0AB224
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9A → P in AAH80283 (PubMed:15489334).Curated1
Sequence conflicti594D → A in AAL07439 (PubMed:10748158).Curated1
Sequence conflicti594D → A in AAH04025 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_013815385 – 391Missing in isoform 2. 1 Publication7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF414080 mRNA. Translation: AAL07439.1.
AC148981 Genomic DNA. No translation available.
BC004025 mRNA. Translation: AAH04025.1.
BC080283 mRNA. Translation: AAH80283.1.
CCDSiCCDS39786.1. [P58404-1]
CCDS39787.1. [P58404-2]
RefSeqiNP_001034967.1. NM_001039878.2. [P58404-2]
NP_598550.2. NM_133789.3. [P58404-1]
UniGeneiMm.21612.

Genome annotation databases

EnsembliENSMUST00000019220; ENSMUSP00000019220; ENSMUSG00000030374. [P58404-1]
ENSMUST00000108495; ENSMUSP00000104135; ENSMUSG00000030374. [P58404-2]
GeneIDi97387.
KEGGimmu:97387.
UCSCiuc009fie.2. mouse. [P58404-2]
uc009fif.2. mouse. [P58404-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF414080 mRNA. Translation: AAL07439.1.
AC148981 Genomic DNA. No translation available.
BC004025 mRNA. Translation: AAH04025.1.
BC080283 mRNA. Translation: AAH80283.1.
CCDSiCCDS39786.1. [P58404-1]
CCDS39787.1. [P58404-2]
RefSeqiNP_001034967.1. NM_001039878.2. [P58404-2]
NP_598550.2. NM_133789.3. [P58404-1]
UniGeneiMm.21612.

3D structure databases

ProteinModelPortaliP58404.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi220713. 1 interactor.
IntActiP58404. 1 interactor.
MINTiMINT-4135943.
STRINGi10090.ENSMUSP00000019220.

PTM databases

iPTMnetiP58404.
PhosphoSitePlusiP58404.

Proteomic databases

MaxQBiP58404.
PaxDbiP58404.
PeptideAtlasiP58404.
PRIDEiP58404.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019220; ENSMUSP00000019220; ENSMUSG00000030374. [P58404-1]
ENSMUST00000108495; ENSMUSP00000104135; ENSMUSG00000030374. [P58404-2]
GeneIDi97387.
KEGGimmu:97387.
UCSCiuc009fie.2. mouse. [P58404-2]
uc009fif.2. mouse. [P58404-1]

Organism-specific databases

CTDi29888.
MGIiMGI:2142346. Strn4.

Phylogenomic databases

eggNOGiKOG0642. Eukaryota.
ENOG410XR31. LUCA.
GeneTreeiENSGT00520000055597.
HOGENOMiHOG000236343.
HOVERGENiHBG007117.
InParanoidiP58404.
KOiK17608.
OMAiIVRTESP.
OrthoDBiEOG091G0509.
TreeFamiTF313387.

Miscellaneous databases

ChiTaRSiStrn4. mouse.
PROiP58404.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030374.
CleanExiMM_STRN4.
ExpressionAtlasiP58404. baseline and differential.
GenevisibleiP58404. MM.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR013258. Striatin_N.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08232. Striatin. 1 hit.
PF00400. WD40. 4 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSTRN4_MOUSE
AccessioniPrimary (citable) accession number: P58404
Secondary accession number(s): E9QKX6, Q68EF5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: July 27, 2011
Last modified: November 30, 2016
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The name 'Zinedin' probably originates from the name of the famous soccer player from Marseille (Zinedine Zidane).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.