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Protein

Striatin-4

Gene

Strn4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein.

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calmodulin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Striatin-4
Alternative name(s):
Zinedin
Gene namesi
Name:Strn4
Synonyms:Zin
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2142346. Strn4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 760760Striatin-4PRO_0000051240Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei53 – 531PhosphoserineBy similarity
Modified residuei206 – 2061PhosphoserineCombined sources
Modified residuei223 – 2231PhosphoserineCombined sources
Modified residuei276 – 2761PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP58404.
MaxQBiP58404.
PaxDbiP58404.
PeptideAtlasiP58404.
PRIDEiP58404.

PTM databases

iPTMnetiP58404.
PhosphoSiteiP58404.

Expressioni

Tissue specificityi

Mainly expressed in brain but is also expressed at low levels in the kidney.

Gene expression databases

BgeeiP58404.
CleanExiMM_STRN4.
ExpressionAtlasiP58404. baseline and differential.
GenevisibleiP58404. MM.

Interactioni

Subunit structurei

Interacts with CTTNBP2; this interaction may regulate dendritic spine distribution of STRN4. Activation of glutamate receptors weakens the interaction with CTTNBP2 (By similarity). Interacts with CTTNBP2NL (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi220713. 1 interaction.
IntActiP58404. 1 interaction.
MINTiMINT-4135943.
STRINGi10090.ENSMUSP00000019220.

Structurei

3D structure databases

ProteinModelPortaliP58404.
SMRiP58404. Positions 86-130, 385-759.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati443 – 48240WD 1Add
BLAST
Repeati496 – 53540WD 2Add
BLAST
Repeati549 – 58840WD 3Add
BLAST
Repeati595 – 63541WD 4Add
BLAST
Repeati642 – 68140WD 5Add
BLAST
Repeati684 – 72340WD 6Add
BLAST
Repeati730 – 75930WD 7Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni71 – 799Caveolin-bindingSequence analysis
Regioni165 – 18218Calmodulin-bindingSequence analysisAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili69 – 13668Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the WD repeat striatin family.Curated
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0642. Eukaryota.
ENOG410XR31. LUCA.
GeneTreeiENSGT00520000055597.
HOGENOMiHOG000236343.
HOVERGENiHBG007117.
InParanoidiP58404.
KOiK17608.
OMAiERAKHQK.
OrthoDBiEOG79KPDR.
TreeFamiTF313387.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR013258. Striatin_N.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08232. Striatin. 1 hit.
PF00400. WD40. 4 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P58404-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMEERAAAAV ASAASSCRPL GSGTAPNPTA AAPASSPAPG PGPVGKGGGG
60 70 80 90 100
GGSPGPTAGP EPLSLPGILH FIQHEWARFE AEKARWEAER AELQAQVAFL
110 120 130 140 150
QGERKGQENL KTDLVRRIKM LEYALKQERA KYHKLKFGTD LNQGEKKTDL
160 170 180 190 200
SEQVSNGPVE SVTLENSPLV WKEGRQLLRQ YLEEVGYTDT ILDMRSKRVR
210 220 230 240 250
SLLGRSLELN GAGEPVEGAP RASPGPGGLS GGESLLVKQI EEQIKRNAAG
260 270 280 290 300
KDGKERLGGS VLEQIPFLQN CEDEDSDEDD ELDSVQHKKQ RVRLPSKALV
310 320 330 340 350
PEMEDEDEED DSEDAINEFD FLGSGEDGEG SPDPRRCTSE GNPHELESRR
360 370 380 390 400
VKLQGILADL RDVDGLPPKV TVPPPGTPQP RPHEGSFGFS SDVFIMDTIG
410 420 430 440 450
GGEVSLGDLA DLTVTNDNDL SCDLSDSKDA FKKTWNPKFT LRSHYDGIRS
460 470 480 490 500
LAFHHSQSAL LTASEDGTLK LWNLQKAVTA KKNAALDVEP IHAFRAHRGP
510 520 530 540 550
VLAVTMGSNS EYCYSGGADA RIHSWKIPDL NMDPYDGYDP SVLSHVLEGH
560 570 580 590 600
GDAVWGLAFS PTSQRLASCS ADGTVRIWDP SSSGPSCLCT FPMDGEHGIP
610 620 630 640 650
TSVAFTSTEP AHVVASFRSG DTVLYDLEAG SALLTLESRG SSGPAQINQV
660 670 680 690 700
VSHPSQPLTI TAHDDRGIRF LDNRTGKSVH SMVAHLDAVT CLAVDPNGVF
710 720 730 740 750
LMSGSHDCSL RLWSLDNKTC VQEITAHRKK HEEAIHAVAC HPSKALIASA
760
GADALAKVFV
Length:760
Mass (Da):81,645
Last modified:July 27, 2011 - v2
Checksum:i230FA4855DFDE175
GO
Isoform 2 (identifier: P58404-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     385-391: Missing.

Show »
Length:753
Mass (Da):80,975
Checksum:i2B9BD0879C0AB224
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 91A → P in AAH80283 (PubMed:15489334).Curated
Sequence conflicti594 – 5941D → A in AAL07439 (PubMed:10748158).Curated
Sequence conflicti594 – 5941D → A in AAH04025 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei385 – 3917Missing in isoform 2. 1 PublicationVSP_013815

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF414080 mRNA. Translation: AAL07439.1.
AC148981 Genomic DNA. No translation available.
BC004025 mRNA. Translation: AAH04025.1.
BC080283 mRNA. Translation: AAH80283.1.
CCDSiCCDS39786.1. [P58404-1]
CCDS39787.1. [P58404-2]
RefSeqiNP_001034967.1. NM_001039878.2. [P58404-2]
NP_598550.2. NM_133789.3. [P58404-1]
UniGeneiMm.21612.

Genome annotation databases

EnsembliENSMUST00000019220; ENSMUSP00000019220; ENSMUSG00000030374. [P58404-1]
ENSMUST00000108495; ENSMUSP00000104135; ENSMUSG00000030374. [P58404-2]
GeneIDi97387.
KEGGimmu:97387.
UCSCiuc009fie.2. mouse. [P58404-2]
uc009fif.2. mouse. [P58404-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF414080 mRNA. Translation: AAL07439.1.
AC148981 Genomic DNA. No translation available.
BC004025 mRNA. Translation: AAH04025.1.
BC080283 mRNA. Translation: AAH80283.1.
CCDSiCCDS39786.1. [P58404-1]
CCDS39787.1. [P58404-2]
RefSeqiNP_001034967.1. NM_001039878.2. [P58404-2]
NP_598550.2. NM_133789.3. [P58404-1]
UniGeneiMm.21612.

3D structure databases

ProteinModelPortaliP58404.
SMRiP58404. Positions 86-130, 385-759.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi220713. 1 interaction.
IntActiP58404. 1 interaction.
MINTiMINT-4135943.
STRINGi10090.ENSMUSP00000019220.

PTM databases

iPTMnetiP58404.
PhosphoSiteiP58404.

Proteomic databases

EPDiP58404.
MaxQBiP58404.
PaxDbiP58404.
PeptideAtlasiP58404.
PRIDEiP58404.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019220; ENSMUSP00000019220; ENSMUSG00000030374. [P58404-1]
ENSMUST00000108495; ENSMUSP00000104135; ENSMUSG00000030374. [P58404-2]
GeneIDi97387.
KEGGimmu:97387.
UCSCiuc009fie.2. mouse. [P58404-2]
uc009fif.2. mouse. [P58404-1]

Organism-specific databases

CTDi29888.
MGIiMGI:2142346. Strn4.

Phylogenomic databases

eggNOGiKOG0642. Eukaryota.
ENOG410XR31. LUCA.
GeneTreeiENSGT00520000055597.
HOGENOMiHOG000236343.
HOVERGENiHBG007117.
InParanoidiP58404.
KOiK17608.
OMAiERAKHQK.
OrthoDBiEOG79KPDR.
TreeFamiTF313387.

Miscellaneous databases

ChiTaRSiStrn4. mouse.
PROiP58404.
SOURCEiSearch...

Gene expression databases

BgeeiP58404.
CleanExiMM_STRN4.
ExpressionAtlasiP58404. baseline and differential.
GenevisibleiP58404. MM.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR013258. Striatin_N.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08232. Striatin. 1 hit.
PF00400. WD40. 4 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Zinedin, SG2NA, and striatin are calmodulin-binding, WD repeat proteins principally expressed in the brain."
    Castets F., Rakitina T., Gaillard S., Moqrich A., Mattei M.-G., Monneron A.
    J. Biol. Chem. 275:19970-19977(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J and Czech II.
    Tissue: Mammary tumor.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-206, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic brain.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-206, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-206; SER-223 AND SER-276, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiSTRN4_MOUSE
AccessioniPrimary (citable) accession number: P58404
Secondary accession number(s): E9QKX6, Q68EF5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: July 27, 2011
Last modified: July 6, 2016
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The name 'Zinedin' probably originates from the name of the famous soccer player from Marseille (Zinedine Zidane).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.