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P58401

- NRX2B_HUMAN

UniProt

P58401 - NRX2B_HUMAN

Protein

Neurexin-2-beta

Gene

NRXN2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (16 Nov 2001)
      Previous versions | rss
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    Functioni

    Neuronal cell surface protein that may be involved in cell recognition and cell adhesion.

    GO - Molecular functioni

    1. cell adhesion molecule binding Source: BHF-UCL
    2. metal ion binding Source: InterPro
    3. neuroligin family protein binding Source: BHF-UCL

    GO - Biological processi

    1. neuron cell-cell adhesion Source: BHF-UCL
    2. synaptic transmission Source: InterPro

    Keywords - Biological processi

    Cell adhesion

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neurexin-2-beta
    Alternative name(s):
    Neurexin II-beta
    Gene namesi
    Name:NRXN2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:8009. NRXN2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31787.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 5050By similarityAdd
    BLAST
    Chaini51 – 666616Neurexin-2-betaPRO_0000019497Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi190 – 1901N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiP58401.

    Expressioni

    Gene expression databases

    ArrayExpressiP58401.
    BgeeiP58401.
    CleanExiHS_NRXN2.
    GenevestigatoriP58401.

    Interactioni

    Subunit structurei

    The cytoplasmic C-terminal region binds to CASK. Specific isoforms bind alpha-dystroglycan and neuroligins NLGN1, NLGN2 and NLGN3 By similarity. Interacts with CBLN1, CBLN2 and, less avidly, with CBLN4 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi114780. 6 interactions.
    IntActiP58401. 1 interaction.
    MINTiMINT-7005058.
    STRINGi9606.ENSP00000265459.

    Structurei

    3D structure databases

    ProteinModelPortaliP58401.
    SMRiP58401. Positions 91-294.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini51 – 590540ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini612 – 66655CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei591 – 61121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini91 – 299209Laminin G-likePROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi322 – 3254Poly-Thr
    Compositional biasi328 – 3314Poly-Thr
    Compositional biasi398 – 4014Poly-Pro
    Compositional biasi598 – 6014Poly-Ala

    Domaini

    Alternative splicing in the laminin G-like domain regulates binding to alpha-dystroglycan.

    Sequence similaritiesi

    Belongs to the neurexin family.Curated
    Contains 1 laminin G-like domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOGENOMiHOG000230482.
    HOVERGENiHBG052670.
    KOiK07377.
    OMAiIRNQINI.
    OrthoDBiEOG7XWPMM.

    Family and domain databases

    Gene3Di2.60.120.200. 1 hit.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR001791. Laminin_G.
    IPR003585. Neurexin-like.
    IPR027160. NRXN2.
    IPR027789. Syndecan/Neurexin_dom.
    [Graphical view]
    PANTHERiPTHR10127:SF593. PTHR10127:SF593. 1 hit.
    PfamiPF02210. Laminin_G_2. 1 hit.
    PF01034. Syndecan. 1 hit.
    [Graphical view]
    SMARTiSM00294. 4.1m. 1 hit.
    SM00282. LamG. 1 hit.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 2 hits.
    PROSITEiPS50025. LAM_G_DOMAIN. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative promoter usage and alternative splicing. Align

    Note: A number of isoforms, alpha-type and beta-type are produced by alternative promoter usage. Beta-type isoforms differ from alpha-type isoforms in their N-terminus.

    Isoform 1b (identifier: P58401-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPPGGSGPGG CPRRPPALAG PLPPPPPPPP PPLLPLLPLL LLLLLGAAEG    50
    ARVSSSLSTT HHVHHFHSKH GTVPIAINRM PFLTRGGHAG TTYIFGKGGA 100
    LITYTWPPND RPSTRMDRLA VGFSTHQRSA VLVRVDSASG LGDYLQLHID 150
    QGTVGVIFNV GTDDITIDEP NAIVSDGKYH VVRFTRSGGN ATLQVDSWPV 200
    NERYPAGNFD NERLAIARQR IPYRLGRVVD EWLLDKGRQL TIFNSQAAIK 250
    IGGRDQGRPF QGQVSGLYYN GLKVLALAAE SDPNVRTEGH LRLVGEGPSV 300
    LLSAETTATT LLADMATTIM ETTTTMATTT TRRGRSPTLR DSTTQNTDDL 350
    LVASAECPSD DEDLEECEPS TGGELILPII TEDSLDPPPV ATRSPFVPPP 400
    PTFYPFLTGV GATQDTLPPP AARRPPSGGP CQAERDDSDC EEPIEASGFA 450
    SGEVFDSSLP PTDDEDFYTT FPLVTDRTTL LSPRKPAPRP NLRTDGATGA 500
    PGVLFAPSAP APNLPAGKMN HRDPLQPLLE NPPLGPGAPT SFEPRRPPPL 550
    RPGVTSAPGF PHLPTANPTG PGERGPPGAV EVIRESSSTT GMVVGIVAAA 600
    ALCILILLYA MYKYRNRDEG SYQVDQSRNY ISNSAQSNGA VVKEKAPAAP 650
    KTPSKAKKNK DKEYYV 666
    Length:666
    Mass (Da):70,927
    Last modified:November 16, 2001 - v1
    Checksum:iFD0B2FD353F63C6C
    GO
    Isoform 1a (identifier: Q9P2S2-1) [UniParc]FASTAAdd to Basket

    The sequence of this isoform can be found in the external entry Q9P2S2.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
    Length:1,712
    Mass (Da):184,982
    GO
    Isoform 2a (identifier: Q9P2S2-2) [UniParc]FASTAAdd to Basket

    Also known as: Alpha-2B

    The sequence of this isoform can be found in the external entry Q9P2S2.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
    Length:1,642
    Mass (Da):177,293
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP001092 Genomic DNA. No translation available.
    AC044790 Genomic DNA. No translation available.
    CCDSiCCDS8078.1. [P58401-1]
    RefSeqiNP_620063.1. NM_138734.2. [P58401-1]
    UniGeneiHs.372938.

    Genome annotation databases

    EnsembliENST00000301894; ENSP00000301894; ENSG00000110076. [P58401-1]
    GeneIDi9379.
    KEGGihsa:9379.
    UCSCiuc001oao.3. human. [P58401-1]

    Polymorphism databases

    DMDMi17368287.

    Keywords - Coding sequence diversityi

    Alternative promoter usage, Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP001092 Genomic DNA. No translation available.
    AC044790 Genomic DNA. No translation available.
    CCDSi CCDS8078.1. [P58401-1 ]
    RefSeqi NP_620063.1. NM_138734.2. [P58401-1 ]
    UniGenei Hs.372938.

    3D structure databases

    ProteinModelPortali P58401.
    SMRi P58401. Positions 91-294.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114780. 6 interactions.
    IntActi P58401. 1 interaction.
    MINTi MINT-7005058.
    STRINGi 9606.ENSP00000265459.

    Polymorphism databases

    DMDMi 17368287.

    Proteomic databases

    PRIDEi P58401.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000301894 ; ENSP00000301894 ; ENSG00000110076 . [P58401-1 ]
    GeneIDi 9379.
    KEGGi hsa:9379.
    UCSCi uc001oao.3. human. [P58401-1 ]

    Organism-specific databases

    CTDi 9379.
    GeneCardsi GC11M064373.
    HGNCi HGNC:8009. NRXN2.
    MIMi 600566. gene.
    neXtProti NX_P58401.
    PharmGKBi PA31787.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000230482.
    HOVERGENi HBG052670.
    KOi K07377.
    OMAi IRNQINI.
    OrthoDBi EOG7XWPMM.

    Miscellaneous databases

    ChiTaRSi NRXN2. human.
    GeneWikii NRXN2.
    GenomeRNAii 9379.
    NextBioi 35140.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P58401.
    Bgeei P58401.
    CleanExi HS_NRXN2.
    Genevestigatori P58401.

    Family and domain databases

    Gene3Di 2.60.120.200. 1 hit.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR001791. Laminin_G.
    IPR003585. Neurexin-like.
    IPR027160. NRXN2.
    IPR027789. Syndecan/Neurexin_dom.
    [Graphical view ]
    PANTHERi PTHR10127:SF593. PTHR10127:SF593. 1 hit.
    Pfami PF02210. Laminin_G_2. 1 hit.
    PF01034. Syndecan. 1 hit.
    [Graphical view ]
    SMARTi SM00294. 4.1m. 1 hit.
    SM00282. LamG. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 2 hits.
    PROSITEi PS50025. LAM_G_DOMAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Sequencing of human neurexin II gene."
      Rowen L., Madan A., Qin S., Baradarani L., Birditt B., Bloom S., Burke J., Dors M., Fleetwood P., Kaur A., Madan A., Nesbitt R., Pate D., Hood L.
      Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 90-666.

    Entry informationi

    Entry nameiNRX2B_HUMAN
    AccessioniPrimary (citable) accession number: P58401
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 16, 2001
    Last sequence update: November 16, 2001
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3