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P58401 (NRX2B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neurexin-2-beta
Alternative name(s):
Neurexin II-beta
Gene names
Name:NRXN2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length666 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Neuronal cell surface protein that may be involved in cell recognition and cell adhesion.

Subunit structure

The cytoplasmic C-terminal region binds to CASK. Specific isoforms bind alpha-dystroglycan and neuroligins NLGN1, NLGN2 and NLGN3 By similarity. Interacts with CBLN1, CBLN2 and, less avidly, with CBLN4 By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein Potential.

Domain

Alternative splicing in the laminin G-like domain regulates binding to alpha-dystroglycan.

Sequence similarities

Belongs to the neurexin family.

Contains 1 laminin G-like domain.

Ontologies

Alternative products

This entry describes 3 isoforms produced by alternative promoter usage and alternative splicing. [Align] [Select]

Note: A number of isoforms, alpha-type and beta-type are produced by alternative promoter usage. Beta-type isoforms differ from alpha-type isoforms in their N-terminus.
Isoform 1b (identifier: P58401-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 1a (identifier: Q9P2S2-1)

The sequence of this isoform can be found in the external entry Q9P2S2.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Isoform 2a (identifier: Q9P2S2-2)

Also known as: Alpha-2B;

The sequence of this isoform can be found in the external entry Q9P2S2.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 5050 By similarity
Chain51 – 666616Neurexin-2-beta
PRO_0000019497

Regions

Topological domain51 – 590540Extracellular Potential
Transmembrane591 – 61121Helical; Potential
Topological domain612 – 66655Cytoplasmic Potential
Domain91 – 299209Laminin G-like
Compositional bias322 – 3254Poly-Thr
Compositional bias328 – 3314Poly-Thr
Compositional bias398 – 4014Poly-Pro
Compositional bias598 – 6014Poly-Ala

Amino acid modifications

Glycosylation1901N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Isoform 1b [UniParc].

Last modified November 16, 2001. Version 1.
Checksum: FD0B2FD353F63C6C

FASTA66670,927
        10         20         30         40         50         60 
MPPGGSGPGG CPRRPPALAG PLPPPPPPPP PPLLPLLPLL LLLLLGAAEG ARVSSSLSTT 

        70         80         90        100        110        120 
HHVHHFHSKH GTVPIAINRM PFLTRGGHAG TTYIFGKGGA LITYTWPPND RPSTRMDRLA 

       130        140        150        160        170        180 
VGFSTHQRSA VLVRVDSASG LGDYLQLHID QGTVGVIFNV GTDDITIDEP NAIVSDGKYH 

       190        200        210        220        230        240 
VVRFTRSGGN ATLQVDSWPV NERYPAGNFD NERLAIARQR IPYRLGRVVD EWLLDKGRQL 

       250        260        270        280        290        300 
TIFNSQAAIK IGGRDQGRPF QGQVSGLYYN GLKVLALAAE SDPNVRTEGH LRLVGEGPSV 

       310        320        330        340        350        360 
LLSAETTATT LLADMATTIM ETTTTMATTT TRRGRSPTLR DSTTQNTDDL LVASAECPSD 

       370        380        390        400        410        420 
DEDLEECEPS TGGELILPII TEDSLDPPPV ATRSPFVPPP PTFYPFLTGV GATQDTLPPP 

       430        440        450        460        470        480 
AARRPPSGGP CQAERDDSDC EEPIEASGFA SGEVFDSSLP PTDDEDFYTT FPLVTDRTTL 

       490        500        510        520        530        540 
LSPRKPAPRP NLRTDGATGA PGVLFAPSAP APNLPAGKMN HRDPLQPLLE NPPLGPGAPT 

       550        560        570        580        590        600 
SFEPRRPPPL RPGVTSAPGF PHLPTANPTG PGERGPPGAV EVIRESSSTT GMVVGIVAAA 

       610        620        630        640        650        660 
ALCILILLYA MYKYRNRDEG SYQVDQSRNY ISNSAQSNGA VVKEKAPAAP KTPSKAKKNK 


DKEYYV 

« Hide

Isoform 1a [UniParc].

See Q9P2S2.

Isoform 2a (Alpha-2B) [UniParc].

See Q9P2S2.

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP001092 Genomic DNA. No translation available.
AC044790 Genomic DNA. No translation available.
CCDSCCDS8078.1. [P58401-1]
RefSeqNP_620063.1. NM_138734.2. [P58401-1]
UniGeneHs.372938.

3D structure databases

ProteinModelPortalP58401.
SMRP58401. Positions 91-294.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114780. 6 interactions.
IntActP58401. 1 interaction.
MINTMINT-7005058.
STRING9606.ENSP00000265459.

Polymorphism databases

DMDM17368287.

Proteomic databases

PRIDEP58401.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000301894; ENSP00000301894; ENSG00000110076. [P58401-1]
GeneID9379.
KEGGhsa:9379.
UCSCuc001oao.3. human. [P58401-1]

Organism-specific databases

CTD9379.
GeneCardsGC11M064373.
HGNCHGNC:8009. NRXN2.
MIM600566. gene.
neXtProtNX_P58401.
PharmGKBPA31787.
GenAtlasSearch...

Phylogenomic databases

HOGENOMHOG000230482.
HOVERGENHBG052670.
KOK07377.
OMAIRNQINI.
OrthoDBEOG7XWPMM.

Gene expression databases

ArrayExpressP58401.
BgeeP58401.
CleanExHS_NRXN2.
GenevestigatorP58401.

Family and domain databases

Gene3D2.60.120.200. 1 hit.
InterProIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR001791. Laminin_G.
IPR003585. Neurexin-like.
IPR027160. NRXN2.
IPR027789. Syndecan/Neurexin_dom.
[Graphical view]
PANTHERPTHR10127:SF593. PTHR10127:SF593. 1 hit.
PfamPF02210. Laminin_G_2. 1 hit.
PF01034. Syndecan. 1 hit.
[Graphical view]
SMARTSM00294. 4.1m. 1 hit.
SM00282. LamG. 1 hit.
[Graphical view]
SUPFAMSSF49899. SSF49899. 2 hits.
PROSITEPS50025. LAM_G_DOMAIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSNRXN2. human.
GeneWikiNRXN2.
GenomeRNAi9379.
NextBio35140.
SOURCESearch...

Entry information

Entry nameNRX2B_HUMAN
AccessionPrimary (citable) accession number: P58401
Entry history
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: November 16, 2001
Last modified: July 9, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM