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P58401

- NRX2B_HUMAN

UniProt

P58401 - NRX2B_HUMAN

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Protein

Neurexin-2-beta

Gene

NRXN2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Neuronal cell surface protein that may be involved in cell recognition and cell adhesion.

GO - Molecular functioni

  1. cell adhesion molecule binding Source: BHF-UCL
  2. metal ion binding Source: InterPro
  3. neuroligin family protein binding Source: BHF-UCL

GO - Biological processi

  1. neuron cell-cell adhesion Source: BHF-UCL
  2. synaptic transmission Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Neurexin-2-beta
Alternative name(s):
Neurexin II-beta
Gene namesi
Name:NRXN2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:8009. NRXN2.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31787.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 5050By similarityAdd
BLAST
Chaini51 – 666616Neurexin-2-betaPRO_0000019497Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi190 – 1901N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP58401.

Expressioni

Gene expression databases

BgeeiP58401.
CleanExiHS_NRXN2.
ExpressionAtlasiP58401. baseline and differential.
GenevestigatoriP58401.

Interactioni

Subunit structurei

The cytoplasmic C-terminal region binds to CASK. Specific isoforms bind alpha-dystroglycan and neuroligins NLGN1, NLGN2 and NLGN3 (By similarity). Interacts with CBLN1, CBLN2 and, less avidly, with CBLN4 (By similarity).By similarity

Protein-protein interaction databases

BioGridi114780. 6 interactions.
IntActiP58401. 1 interaction.
MINTiMINT-7005058.
STRINGi9606.ENSP00000265459.

Structurei

3D structure databases

ProteinModelPortaliP58401.
SMRiP58401. Positions 91-294.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini51 – 590540ExtracellularSequence AnalysisAdd
BLAST
Topological domaini612 – 66655CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei591 – 61121HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini91 – 299209Laminin G-likePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi322 – 3254Poly-Thr
Compositional biasi328 – 3314Poly-Thr
Compositional biasi398 – 4014Poly-Pro
Compositional biasi598 – 6014Poly-Ala

Domaini

Alternative splicing in the laminin G-like domain regulates binding to alpha-dystroglycan.

Sequence similaritiesi

Belongs to the neurexin family.Curated
Contains 1 laminin G-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000118991.
HOGENOMiHOG000230482.
HOVERGENiHBG052670.
KOiK07377.
OMAiIRNQINI.
OrthoDBiEOG7XWPMM.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001791. Laminin_G.
IPR003585. Neurexin-like.
IPR027160. NRXN2.
IPR027789. Syndecan/Neurexin_dom.
[Graphical view]
PANTHERiPTHR10127:SF593. PTHR10127:SF593. 1 hit.
PfamiPF02210. Laminin_G_2. 1 hit.
PF01034. Syndecan. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
SM00282. LamG. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.
PROSITEiPS50025. LAM_G_DOMAIN. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative promoter usage and alternative splicing. Align

Note: A number of isoforms, alpha-type and beta-type are produced by alternative promoter usage. Beta-type isoforms differ from alpha-type isoforms in their N-terminus.

Isoform 1b (identifier: P58401-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPPGGSGPGG CPRRPPALAG PLPPPPPPPP PPLLPLLPLL LLLLLGAAEG
60 70 80 90 100
ARVSSSLSTT HHVHHFHSKH GTVPIAINRM PFLTRGGHAG TTYIFGKGGA
110 120 130 140 150
LITYTWPPND RPSTRMDRLA VGFSTHQRSA VLVRVDSASG LGDYLQLHID
160 170 180 190 200
QGTVGVIFNV GTDDITIDEP NAIVSDGKYH VVRFTRSGGN ATLQVDSWPV
210 220 230 240 250
NERYPAGNFD NERLAIARQR IPYRLGRVVD EWLLDKGRQL TIFNSQAAIK
260 270 280 290 300
IGGRDQGRPF QGQVSGLYYN GLKVLALAAE SDPNVRTEGH LRLVGEGPSV
310 320 330 340 350
LLSAETTATT LLADMATTIM ETTTTMATTT TRRGRSPTLR DSTTQNTDDL
360 370 380 390 400
LVASAECPSD DEDLEECEPS TGGELILPII TEDSLDPPPV ATRSPFVPPP
410 420 430 440 450
PTFYPFLTGV GATQDTLPPP AARRPPSGGP CQAERDDSDC EEPIEASGFA
460 470 480 490 500
SGEVFDSSLP PTDDEDFYTT FPLVTDRTTL LSPRKPAPRP NLRTDGATGA
510 520 530 540 550
PGVLFAPSAP APNLPAGKMN HRDPLQPLLE NPPLGPGAPT SFEPRRPPPL
560 570 580 590 600
RPGVTSAPGF PHLPTANPTG PGERGPPGAV EVIRESSSTT GMVVGIVAAA
610 620 630 640 650
ALCILILLYA MYKYRNRDEG SYQVDQSRNY ISNSAQSNGA VVKEKAPAAP
660
KTPSKAKKNK DKEYYV
Length:666
Mass (Da):70,927
Last modified:November 16, 2001 - v1
Checksum:iFD0B2FD353F63C6C
GO
Isoform 1a (identifier: Q9P2S2-1) [UniParc]FASTAAdd to Basket

The sequence of this isoform can be found in the external entry Q9P2S2.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,712
Mass (Da):184,982
GO
Isoform 2a (identifier: Q9P2S2-2) [UniParc]FASTAAdd to Basket

Also known as: Alpha-2B

The sequence of this isoform can be found in the external entry Q9P2S2.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,642
Mass (Da):177,293
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP001092 Genomic DNA. No translation available.
AC044790 Genomic DNA. No translation available.
CCDSiCCDS8078.1. [P58401-1]
RefSeqiNP_620063.1. NM_138734.2. [P58401-1]
UniGeneiHs.372938.

Genome annotation databases

EnsembliENST00000301894; ENSP00000301894; ENSG00000110076. [P58401-1]
GeneIDi9379.
KEGGihsa:9379.
UCSCiuc001oao.3. human. [P58401-1]

Polymorphism databases

DMDMi17368287.

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP001092 Genomic DNA. No translation available.
AC044790 Genomic DNA. No translation available.
CCDSi CCDS8078.1. [P58401-1 ]
RefSeqi NP_620063.1. NM_138734.2. [P58401-1 ]
UniGenei Hs.372938.

3D structure databases

ProteinModelPortali P58401.
SMRi P58401. Positions 91-294.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114780. 6 interactions.
IntActi P58401. 1 interaction.
MINTi MINT-7005058.
STRINGi 9606.ENSP00000265459.

Polymorphism databases

DMDMi 17368287.

Proteomic databases

PRIDEi P58401.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000301894 ; ENSP00000301894 ; ENSG00000110076 . [P58401-1 ]
GeneIDi 9379.
KEGGi hsa:9379.
UCSCi uc001oao.3. human. [P58401-1 ]

Organism-specific databases

CTDi 9379.
GeneCardsi GC11M064373.
HGNCi HGNC:8009. NRXN2.
MIMi 600566. gene.
neXtProti NX_P58401.
PharmGKBi PA31787.
GenAtlasi Search...

Phylogenomic databases

GeneTreei ENSGT00760000118991.
HOGENOMi HOG000230482.
HOVERGENi HBG052670.
KOi K07377.
OMAi IRNQINI.
OrthoDBi EOG7XWPMM.

Miscellaneous databases

ChiTaRSi NRXN2. human.
GeneWikii NRXN2.
GenomeRNAii 9379.
NextBioi 35140.
SOURCEi Search...

Gene expression databases

Bgeei P58401.
CleanExi HS_NRXN2.
ExpressionAtlasi P58401. baseline and differential.
Genevestigatori P58401.

Family and domain databases

Gene3Di 2.60.120.200. 1 hit.
InterProi IPR013320. ConA-like_dom.
IPR001791. Laminin_G.
IPR003585. Neurexin-like.
IPR027160. NRXN2.
IPR027789. Syndecan/Neurexin_dom.
[Graphical view ]
PANTHERi PTHR10127:SF593. PTHR10127:SF593. 1 hit.
Pfami PF02210. Laminin_G_2. 1 hit.
PF01034. Syndecan. 1 hit.
[Graphical view ]
SMARTi SM00294. 4.1m. 1 hit.
SM00282. LamG. 1 hit.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 2 hits.
PROSITEi PS50025. LAM_G_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Sequencing of human neurexin II gene."
    Rowen L., Madan A., Qin S., Baradarani L., Birditt B., Bloom S., Burke J., Dors M., Fleetwood P., Kaur A., Madan A., Nesbitt R., Pate D., Hood L.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 90-666.

Entry informationi

Entry nameiNRX2B_HUMAN
AccessioniPrimary (citable) accession number: P58401
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: November 16, 2001
Last modified: October 29, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3