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P58400 (NRX1B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neurexin-1-beta
Alternative name(s):
Neurexin I-beta
Gene names
Name:NRXN1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length442 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Neuronal cell surface protein that may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. May play a role in formation or maintenance of synaptic junctions. May mediate intracellular signaling. May play a role in angiogenesis By similarity.

Subunit structure

The cytoplasmic C-terminal region binds to CASK. Isoforms Beta 4b bind neuroligins NLGN1, NLGN2 and NLGN3, alpha-dystroglycan and alpha-latrotoxin. Binding to neuroligins is calcium-dependent, and the binding preference ranks as follow: NLGN1 > NLGN4 >> NLGN3 > NLGN2 By similarity. Interacts with CBLN1, CBLN2 and more weakly with CBLN4. CBLN1-binding is calcium-independent By similarity.

Subcellular location

Cell membrane; Single-pass type I membrane protein. Cell junctionsynapse. Note: Localized on the pre-synaptic membrane By similarity.

Post-translational modification

Highly O-glycosylated and minor N-glycosylated By similarity.

Sequence similarities

Belongs to the neurexin family.

Contains 1 laminin G-like domain.

Sequence caution

The sequence AF064842 differs from that shown. Reason: Frameshift at position 54.

Ontologies

Keywords
   Biological processAngiogenesis
Cell adhesion
   Cellular componentCell junction
Cell membrane
Membrane
Synapse
   Coding sequence diversityAlternative promoter usage
Alternative splicing
   DomainSignal
Transmembrane
Transmembrane helix
   LigandCalcium
Metal-binding
   PTMGlycoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processN-methyl-D-aspartate receptor clustering

Inferred from sequence or structural similarity. Source: BHF-UCL

adult behavior

Inferred from mutant phenotype PubMed 17034946. Source: BHF-UCL

angiogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

calcium-dependent cell-cell adhesion

Inferred from sequence or structural similarity. Source: BHF-UCL

cerebellar granule cell differentiation

Inferred from sequence or structural similarity. Source: BHF-UCL

establishment of protein localization

Inferred from sequence or structural similarity. Source: BHF-UCL

gamma-aminobutyric acid receptor clustering

Inferred from sequence or structural similarity. Source: BHF-UCL

gephyrin clustering

Inferred from sequence or structural similarity. Source: BHF-UCL

guanylate kinase-associated protein clustering

Inferred from sequence or structural similarity. Source: BHF-UCL

heterophilic cell-cell adhesion

Inferred from sequence or structural similarity. Source: BHF-UCL

learning

Inferred from mutant phenotype PubMed 17034946. Source: BHF-UCL

negative regulation of filopodium assembly

Inferred from sequence or structural similarity. Source: BHF-UCL

neuroligin clustering

Inferred from sequence or structural similarity. Source: BHF-UCL

neuron cell-cell adhesion

Inferred from sequence or structural similarity. Source: BHF-UCL

neuronal signal transduction

Traceable author statement PubMed 15797875. Source: BHF-UCL

neurotransmitter secretion

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of establishment of protein localization to plasma membrane

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of excitatory postsynaptic membrane potential

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of synapse maturation

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of synaptic transmission, glutamatergic

Inferred from sequence or structural similarity. Source: BHF-UCL

postsynaptic density protein 95 clustering

Inferred from sequence or structural similarity. Source: BHF-UCL

postsynaptic membrane assembly

Inferred from sequence or structural similarity. Source: BHF-UCL

presynaptic membrane assembly

Inferred from sequence or structural similarity. Source: BHF-UCL

protein localization to synapse

Inferred from sequence or structural similarity. Source: BHF-UCL

receptor localization to synapse

Inferred from sequence or structural similarity. Source: BHF-UCL

regulation of N-methyl-D-aspartate selective glutamate receptor activity

Inferred from sequence or structural similarity. Source: BHF-UCL

regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity

Inferred from sequence or structural similarity. Source: BHF-UCL

social behavior

Inferred from mutant phenotype PubMed 17034946. Source: BHF-UCL

synapse assembly

Inferred from sequence or structural similarity. Source: BHF-UCL

synaptic transmission

Inferred from sequence or structural similarity. Source: BHF-UCL

synaptic vesicle clustering

Inferred from sequence or structural similarity. Source: BHF-UCL

vocalization behavior

Inferred from mutant phenotype PubMed 17034946. Source: BHF-UCL

   Cellular_componentaxonal growth cone

Inferred from sequence or structural similarity. Source: BHF-UCL

cell junction

Inferred from electronic annotation. Source: UniProtKB-KW

cell surface

Inferred from sequence or structural similarity. Source: BHF-UCL

endocytic vesicle

Inferred from sequence or structural similarity. Source: BHF-UCL

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from sequence or structural similarity. Source: BHF-UCL

presynaptic membrane

Traceable author statement PubMed 15797875. Source: BHF-UCL

   Molecular_functioncalcium channel regulator activity

Inferred from sequence or structural similarity. Source: BHF-UCL

calcium-dependent protein binding

Inferred from sequence or structural similarity. Source: BHF-UCL

cell adhesion molecule binding

Inferred from sequence or structural similarity. Source: BHF-UCL

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

neuroligin family protein binding

Inferred from sequence or structural similarity. Source: BHF-UCL

receptor binding

Inferred from sequence or structural similarity. Source: BHF-UCL

Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative promoter usage and alternative splicing. [Align] [Select]

Note: A number of isoforms, alpha-type and beta-type are produced by alternative promoter usage. Beta-type isoforms differ from alpha-type isoforms in their N-terminus.
Isoform 1b (identifier: P58400-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 1a (identifier: Q9ULB1-1)

The sequence of this isoform can be found in the external entry Q9ULB1.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Isoform 2a (identifier: Q9ULB1-2)

The sequence of this isoform can be found in the external entry Q9ULB1.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Produced by alternative splicing. No experimental confirmation available.
Isoform 3a (identifier: Q9ULB1-3)

The sequence of this isoform can be found in the external entry Q9ULB1.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Produced by alternative splicing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 5050 By similarity
Chain51 – 442392Neurexin-1-beta
PRO_0000019493

Regions

Topological domain51 – 363313Extracellular Potential
Transmembrane364 – 38623Helical; Potential
Topological domain387 – 44256Cytoplasmic Potential
Domain91 – 259169Laminin G-like
Compositional bias289 – 2924Poly-Thr
Compositional bias374 – 3774Poly-Ala

Sites

Metal binding1411Calcium
Metal binding1581Calcium; via carbonyl oxygen
Metal binding2101Calcium; via carbonyl oxygen
Metal binding2121Calcium

Amino acid modifications

Glycosylation1881N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict201G → R in AF064842. Ref.1
Sequence conflict461G → R in AF064842. Ref.1
Sequence conflict1581V → I in AF064842. Ref.1
Sequence conflict2581N → D in AF064842. Ref.1
Sequence conflict3141D → G in AF064842. Ref.1
Sequence conflict3851Y → C in AF064842. Ref.1
Sequence conflict388 – 3903YKY → NKC in AF064842. Ref.1

Secondary structure

................................ 442
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1b [UniParc].

Last modified February 8, 2011. Version 2.
Checksum: 49A8DA1E2DEDA804

FASTA44246,861
        10         20         30         40         50         60 
MYQRMLRCGA ELGSPGGGGG GGGGGGAGGR LALLWIVPLT LSGLLGVAWG ASSLGAHHIH 

        70         80         90        100        110        120 
HFHGSSKHHS VPIAIYRSPA SLRGGHAGTT YIFSKGGGQI TYKWPPNDRP STRADRLAIG 

       130        140        150        160        170        180 
FSTVQKEAVL VRVDSSSGLG DYLELHIHQG KIGVKFNVGT DDIAIEESNA IINDGKYHVV 

       190        200        210        220        230        240 
RFTRSGGNAT LQVDSWPVIE RYPAGRQLTI FNSQATIIIG GKEQGQPFQG QLSGLYYNGL 

       250        260        270        280        290        300 
KVLNMAAEND ANIAIVGNVR LVGEVPSSMT TESTATAMQS EMSTSIMETT TTLATSTARR 

       310        320        330        340        350        360 
GKPPTKEPIS QTTDDILVAS AECPSDDEDI DPCEPSSGGL ANPTRAGGRE PYPGSAEVIR 

       370        380        390        400        410        420 
ESSSTTGMVV GIVAAAALCI LILLYAMYKY RNRDEGSYHV DESRNYISNS AQSNGAVVKE 

       430        440 
KQPSSAKSSN KNKKNKDKEY YV 

« Hide

Isoform 1a [UniParc].

See Q9ULB1.

Isoform 2a [UniParc].

See Q9ULB1.

Isoform 3a [UniParc].

See Q9ULB1.

References

« Hide 'large scale' references
[1]"CCG repeats in cDNAs from human brain."
Kleiderlein J.J., Nisson P.E., Jessee J., Li W.B., Becker K.G., Derby M.L., Ross C.A., Margolis R.L.
Hum. Genet. 103:666-673(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1B).
Tissue: Brain.
[2]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Structural basis for synaptic adhesion mediated by neuroligin-neurexin interactions."
Chen X., Liu H., Shim A.H., Focia P.J., He X.
Nat. Struct. Mol. Biol. 15:50-56(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 85-266 IN COMPLEX WITH MOUSE NLRG1, CALCIUM-BINDING SITES.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF064842 mRNA. No translation available.
AC068725 Genomic DNA. No translation available.
AC069550 Genomic DNA. No translation available.
AC078994 Genomic DNA. No translation available.
CCDSCCDS1845.1. [P58400-1]
RefSeqNP_620072.1. NM_138735.2. [P58400-1]
UniGeneHs.637685.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3B3QX-ray2.40E/F85-266[»]
ProteinModelPortalP58400.
SMRP58400. Positions 88-263.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114779. 11 interactions.
DIPDIP-46402N.
STRING9606.ENSP00000385142.

Polymorphism databases

DMDM322510054.

Proteomic databases

PRIDEP58400.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000342183; ENSP00000341184; ENSG00000179915. [P58400-1]
GeneID9378.
KEGGhsa:9378.
UCSCuc010fbp.3. human. [P58400-1]

Organism-specific databases

CTD9378.
GeneCardsGC02M050145.
HGNCHGNC:8008. NRXN1.
MIM600565. gene.
neXtProtNX_P58400.
Orphanet106. Autism.
221150. Pitt-Hopkins-like syndrome.
3140. Schizophrenia.
GenAtlasSearch...

Phylogenomic databases

HOGENOMHOG000230482.
HOVERGENHBG052670.
KOK07377.

Gene expression databases

ArrayExpressP58400.
BgeeP58400.
CleanExHS_NRXN1.
GenevestigatorP58400.

Family and domain databases

Gene3D2.60.120.200. 1 hit.
InterProIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR001791. Laminin_G.
IPR003585. Neurexin-like.
IPR027789. Syndecan/Neurexin_dom.
[Graphical view]
PfamPF02210. Laminin_G_2. 1 hit.
PF01034. Syndecan. 1 hit.
[Graphical view]
SMARTSM00294. 4.1m. 1 hit.
SM00282. LamG. 1 hit.
[Graphical view]
SUPFAMSSF49899. SSF49899. 1 hit.
PROSITEPS50025. LAM_G_DOMAIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSNRXN1. human.
EvolutionaryTraceP58400.
GeneWikiNRXN1.
GenomeRNAi9378.
NextBio35134.
PROP58400.
SOURCESearch...

Entry information

Entry nameNRX1B_HUMAN
AccessionPrimary (citable) accession number: P58400
Entry history
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: February 8, 2011
Last modified: July 9, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM