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Protein

Neurexin-1-beta

Gene

NRXN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Neuronal cell surface protein that may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. May play a role in formation or maintenance of synaptic junctions. May mediate intracellular signaling. May play a role in angiogenesis (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi141Calcium1
Metal bindingi158Calcium; via carbonyl oxygen1
Metal bindingi240Calcium; via carbonyl oxygen1
Metal bindingi242Calcium1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAngiogenesis, Cell adhesion
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-6794361. Neurexins and neuroligins.
SIGNORiP58400.

Names & Taxonomyi

Protein namesi
Recommended name:
Neurexin-1-beta
Alternative name(s):
Neurexin I-beta
Gene namesi
Name:NRXN1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000179915.21.
HGNCiHGNC:8008. NRXN1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini51 – 396ExtracellularSequence analysisAdd BLAST346
Transmembranei397 – 417HelicalSequence analysisAdd BLAST21
Topological domaini418 – 472CytoplasmicSequence analysisAdd BLAST55

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi9378.
MalaCardsiNRXN1.
OpenTargetsiENSG00000179915.
Orphaneti106. Autism.
221150. Pitt-Hopkins-like syndrome.
3140. Schizophrenia.

Polymorphism and mutation databases

BioMutaiFSHR.
DMDMi322510054.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 50By similarityAdd BLAST50
ChainiPRO_000001949351 – 472Neurexin-1-betaAdd BLAST422

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi188N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Highly O-glycosylated and minor N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PeptideAtlasiP58400.
PRIDEiP58400.

PTM databases

iPTMnetiP58400.

Expressioni

Gene expression databases

BgeeiENSG00000179915.
CleanExiHS_NRXN1.
ExpressionAtlasiP58400. baseline and differential.
GenevisibleiP58400. HS.

Interactioni

Subunit structurei

The cytoplasmic C-terminal region binds to CASK. Binds NLGN1, NLGN2 and NLGN3, DAG1 (alpha-dystroglycan) and alpha-latrotoxin. Binding to neuroligins is calcium-dependent, and the binding preference ranks as follow: NLGN1 > NLGN4 >> NLGN3 > NLGN2 (By similarity). Interacts with CBLN2 and more weakly with CBLN4 (By similarity). Interacts with CBLN1; interaction is CBLN1 hexamer form-dependent; CBLN1-binding is calcium-independent; isoform 1b does not interact with CBLN1 (PubMed:27418511).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114779. 11 interactors.
DIPiDIP-46402N.

Structurei

Secondary structure

1472
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi91 – 103Combined sources13
Beta strandi112 – 123Combined sources12
Beta strandi126 – 135Combined sources10
Beta strandi142 – 148Combined sources7
Beta strandi151 – 160Combined sources10
Beta strandi163 – 166Combined sources4
Beta strandi174 – 176Combined sources3
Beta strandi178 – 185Combined sources8
Beta strandi188 – 196Combined sources9
Beta strandi199 – 201Combined sources3
Beta strandi244 – 250Combined sources7
Turni252 – 255Combined sources4
Beta strandi260 – 267Combined sources8
Helixi272 – 276Combined sources5
Turni277 – 279Combined sources3
Beta strandi283 – 290Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3B3QX-ray2.40E/F85-296[»]
ProteinModelPortaliP58400.
SMRiP58400.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP58400.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini91 – 289Laminin G-likePROSITE-ProRule annotationAdd BLAST199

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni205 – 234Essential for interaction with CBLN1; modulates interaction affinity with NLGN1, NLGN2 and NLGN3; prevents interaction with DAG1/alpha-dystroglycan; modulates interaction with alpha-latrotoxinBy similarity1 PublicationAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi9 – 29Gly-richPROSITE-ProRule annotationAdd BLAST21
Compositional biasi300 – 343Thr-richPROSITE-ProRule annotationAdd BLAST44
Compositional biasi404 – 407Poly-Ala4

Sequence similaritiesi

Belongs to the neurexin family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000118991.
HOGENOMiHOG000230482.
HOVERGENiHBG052670.

Family and domain databases

InterProiView protein in InterPro
IPR013320. ConA-like_dom.
IPR001791. Laminin_G.
IPR029824. Neurexin-1.
IPR003585. Neurexin-like.
IPR027789. Syndecan/Neurexin_dom.
PANTHERiPTHR10127:SF692. PTHR10127:SF692. 1 hit.
PfamiView protein in Pfam
PF02210. Laminin_G_2. 1 hit.
PF01034. Syndecan. 1 hit.
SMARTiView protein in SMART
SM00294. 4.1m. 1 hit.
SM00282. LamG. 1 hit.
SUPFAMiSSF49899. SSF49899. 2 hits.
PROSITEiView protein in PROSITE
PS50025. LAM_G_DOMAIN. 1 hit.

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

Note: A number of isoforms, alpha-type and beta-type are produced by alternative promoter usage. Beta-type isoforms differ from alpha-type isoforms in their N-terminus.
Isoform 1b (identifier: P58400-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYQRMLRCGA ELGSPGGGGG GGGGGGAGGR LALLWIVPLT LSGLLGVAWG
60 70 80 90 100
ASSLGAHHIH HFHGSSKHHS VPIAIYRSPA SLRGGHAGTT YIFSKGGGQI
110 120 130 140 150
TYKWPPNDRP STRADRLAIG FSTVQKEAVL VRVDSSSGLG DYLELHIHQG
160 170 180 190 200
KIGVKFNVGT DDIAIEESNA IINDGKYHVV RFTRSGGNAT LQVDSWPVIE
210 220 230 240 250
RYPAGNNDNE RLAIARQRIP YRLGRVVDEW LLDKGRQLTI FNSQATIIIG
260 270 280 290 300
GKEQGQPFQG QLSGLYYNGL KVLNMAAEND ANIAIVGNVR LVGEVPSSMT
310 320 330 340 350
TESTATAMQS EMSTSIMETT TTLATSTARR GKPPTKEPIS QTTDDILVAS
360 370 380 390 400
AECPSDDEDI DPCEPSSGGL ANPTRAGGRE PYPGSAEVIR ESSSTTGMVV
410 420 430 440 450
GIVAAAALCI LILLYAMYKY RNRDEGSYHV DESRNYISNS AQSNGAVVKE
460 470
KQPSSAKSSN KNKKNKDKEY YV
Length:472
Mass (Da):50,424
Last modified:August 30, 2017 - v3
Checksum:iC86516C0EB7A2D01
GO
Isoform 3b (identifier: P58400-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     205-234: Missing.

Show »
Length:442
Mass (Da):46,861
Checksum:i49A8DA1E2DEDA804
GO
Isoform 1a (identifier: Q9ULB1-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q9ULB1.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,477
Mass (Da):161,883
GO
Isoform 2a (identifier: Q9ULB1-2) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q9ULB1.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Produced by alternative splicing. No experimental confirmation available.
Length:1,496
Mass (Da):164,428
GO
Isoform 3a (identifier: Q9ULB1-3) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q9ULB1.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Produced by alternative splicing.
Length:1,547
Mass (Da):169,913
GO

Sequence cautioni

The sequence AF064842 differs from that shown. Reason: Frameshift at position 54.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti20G → R in AF064842 (PubMed:9921901).Curated1
Sequence conflicti46G → R in AF064842 (PubMed:9921901).Curated1
Sequence conflicti158V → I in AF064842 (PubMed:9921901).Curated1
Sequence conflicti288N → D in AF064842 (PubMed:9921901).Curated1
Sequence conflicti344D → G in AF064842 (PubMed:9921901).Curated1
Sequence conflicti415Y → C in AF064842 (PubMed:9921901).Curated1
Sequence conflicti418 – 420YKY → NKC in AF064842 (PubMed:9921901).Curated3

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_059057205 – 234Missing in isoform 3b. Add BLAST30

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF064842 mRNA. No translation available.
AC007462 Genomic DNA. No translation available.
AC007560 Genomic DNA. No translation available.
AC007680 Genomic DNA. No translation available.
AC007682 Genomic DNA. No translation available.
AC009234 Genomic DNA. No translation available.
AC010721 Genomic DNA. No translation available.
AC068715 Genomic DNA. No translation available.
AC068725 Genomic DNA. No translation available.
AC069550 Genomic DNA. No translation available.
AC078994 Genomic DNA. No translation available.
CCDSiCCDS1845.1. [P58400-2]
RefSeqiNP_001317021.1. NM_001330092.1.
NP_620072.1. NM_138735.4. [P58400-1]
UniGeneiHs.637685.

Genome annotation databases

EnsembliENST00000342183; ENSP00000341184; ENSG00000179915. [P58400-1]
ENST00000401710; ENSP00000385580; ENSG00000179915. [P58400-2]
GeneIDi9378.
UCSCiuc010fbp.4. human. [P58400-2]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiNRX1B_HUMAN
AccessioniPrimary (citable) accession number: P58400
Secondary accession number(s): E7ETA5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: August 30, 2017
Last modified: September 27, 2017
This is version 140 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families