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Protein

Neurexin-1-beta

Gene

NRXN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Neuronal cell surface protein that may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. May play a role in formation or maintenance of synaptic junctions. May mediate intracellular signaling. May play a role in angiogenesis (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi141Calcium1
Metal bindingi158Calcium; via carbonyl oxygen1
Metal bindingi210Calcium; via carbonyl oxygen1
Metal bindingi212Calcium1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Angiogenesis, Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000179915-MONOMER.
ReactomeiR-HSA-6794361. Interactions of neurexins and neuroligins at synapses.
SIGNORiP58400.

Names & Taxonomyi

Protein namesi
Recommended name:
Neurexin-1-beta
Alternative name(s):
Neurexin I-beta
Gene namesi
Name:NRXN1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:8008. NRXN1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini51 – 363ExtracellularSequence analysisAdd BLAST313
Transmembranei364 – 386HelicalSequence analysisAdd BLAST23
Topological domaini387 – 442CytoplasmicSequence analysisAdd BLAST56

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi9378.
MalaCardsiNRXN1.
OpenTargetsiENSG00000179915.
Orphaneti106. Autism.
221150. Pitt-Hopkins-like syndrome.
3140. Schizophrenia.

Polymorphism and mutation databases

BioMutaiFSHR.
DMDMi322510054.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 50By similarityAdd BLAST50
ChainiPRO_000001949351 – 442Neurexin-1-betaAdd BLAST392

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi188N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Highly O-glycosylated and minor N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PeptideAtlasiP58400.
PRIDEiP58400.

PTM databases

iPTMnetiP58400.

Expressioni

Gene expression databases

BgeeiENSG00000179915.
CleanExiHS_NRXN1.
ExpressionAtlasiP58400. baseline and differential.
GenevisibleiP58400. HS.

Organism-specific databases

HPAiCAB009373.

Interactioni

Subunit structurei

The cytoplasmic C-terminal region binds to CASK. Isoforms Beta 4b bind neuroligins NLGN1, NLGN2 and NLGN3, alpha-dystroglycan and alpha-latrotoxin. Binding to neuroligins is calcium-dependent, and the binding preference ranks as follow: NLGN1 > NLGN4 >> NLGN3 > NLGN2 (By similarity). Interacts with CBLN1, CBLN2 and more weakly with CBLN4. CBLN1-binding is calcium-independent (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114779. 11 interactors.
DIPiDIP-46402N.

Structurei

Secondary structure

1442
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi91 – 103Combined sources13
Beta strandi112 – 123Combined sources12
Beta strandi126 – 135Combined sources10
Beta strandi142 – 148Combined sources7
Beta strandi151 – 160Combined sources10
Beta strandi163 – 166Combined sources4
Beta strandi174 – 176Combined sources3
Beta strandi178 – 185Combined sources8
Beta strandi188 – 196Combined sources9
Beta strandi199 – 201Combined sources3
Beta strandi214 – 220Combined sources7
Turni222 – 225Combined sources4
Beta strandi230 – 237Combined sources8
Helixi242 – 246Combined sources5
Turni247 – 249Combined sources3
Beta strandi253 – 260Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3B3QX-ray2.40E/F85-266[»]
ProteinModelPortaliP58400.
SMRiP58400.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP58400.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini91 – 259Laminin G-likePROSITE-ProRule annotationAdd BLAST169

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi289 – 292Poly-Thr4
Compositional biasi374 – 377Poly-Ala4

Sequence similaritiesi

Belongs to the neurexin family.Curated
Contains 1 laminin G-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000118991.
HOGENOMiHOG000230482.
HOVERGENiHBG052670.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001791. Laminin_G.
IPR029824. Neurexin-1.
IPR003585. Neurexin-like.
IPR027789. Syndecan/Neurexin_dom.
[Graphical view]
PANTHERiPTHR10127:SF565. PTHR10127:SF565. 2 hits.
PfamiPF02210. Laminin_G_2. 1 hit.
PF01034. Syndecan. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
SM00282. LamG. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50025. LAM_G_DOMAIN. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

Note: A number of isoforms, alpha-type and beta-type are produced by alternative promoter usage. Beta-type isoforms differ from alpha-type isoforms in their N-terminus.
Isoform 1b (identifier: P58400-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYQRMLRCGA ELGSPGGGGG GGGGGGAGGR LALLWIVPLT LSGLLGVAWG
60 70 80 90 100
ASSLGAHHIH HFHGSSKHHS VPIAIYRSPA SLRGGHAGTT YIFSKGGGQI
110 120 130 140 150
TYKWPPNDRP STRADRLAIG FSTVQKEAVL VRVDSSSGLG DYLELHIHQG
160 170 180 190 200
KIGVKFNVGT DDIAIEESNA IINDGKYHVV RFTRSGGNAT LQVDSWPVIE
210 220 230 240 250
RYPAGRQLTI FNSQATIIIG GKEQGQPFQG QLSGLYYNGL KVLNMAAEND
260 270 280 290 300
ANIAIVGNVR LVGEVPSSMT TESTATAMQS EMSTSIMETT TTLATSTARR
310 320 330 340 350
GKPPTKEPIS QTTDDILVAS AECPSDDEDI DPCEPSSGGL ANPTRAGGRE
360 370 380 390 400
PYPGSAEVIR ESSSTTGMVV GIVAAAALCI LILLYAMYKY RNRDEGSYHV
410 420 430 440
DESRNYISNS AQSNGAVVKE KQPSSAKSSN KNKKNKDKEY YV
Length:442
Mass (Da):46,861
Last modified:February 8, 2011 - v2
Checksum:i49A8DA1E2DEDA804
GO
Isoform 1a (identifier: Q9ULB1-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q9ULB1.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,477
Mass (Da):161,883
GO
Isoform 2a (identifier: Q9ULB1-2) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q9ULB1.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Produced by alternative splicing. No experimental confirmation available.
Length:1,496
Mass (Da):164,428
GO
Isoform 3a (identifier: Q9ULB1-3) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q9ULB1.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Produced by alternative splicing.
Length:1,547
Mass (Da):169,913
GO

Sequence cautioni

The sequence AF064842 differs from that shown. Reason: Frameshift at position 54.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti20G → R in AF064842 (PubMed:9921901).Curated1
Sequence conflicti46G → R in AF064842 (PubMed:9921901).Curated1
Sequence conflicti158V → I in AF064842 (PubMed:9921901).Curated1
Sequence conflicti258N → D in AF064842 (PubMed:9921901).Curated1
Sequence conflicti314D → G in AF064842 (PubMed:9921901).Curated1
Sequence conflicti385Y → C in AF064842 (PubMed:9921901).Curated1
Sequence conflicti388 – 390YKY → NKC in AF064842 (PubMed:9921901).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF064842 mRNA. No translation available.
AC068725 Genomic DNA. No translation available.
AC069550 Genomic DNA. No translation available.
AC078994 Genomic DNA. No translation available.
CCDSiCCDS1845.1. [P58400-1]
RefSeqiNP_620072.1. NM_138735.4. [P58400-1]
UniGeneiHs.637685.

Genome annotation databases

EnsembliENST00000342183; ENSP00000341184; ENSG00000179915. [P58400-1]
GeneIDi9378.
UCSCiuc010fbp.4. human. [P58400-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF064842 mRNA. No translation available.
AC068725 Genomic DNA. No translation available.
AC069550 Genomic DNA. No translation available.
AC078994 Genomic DNA. No translation available.
CCDSiCCDS1845.1. [P58400-1]
RefSeqiNP_620072.1. NM_138735.4. [P58400-1]
UniGeneiHs.637685.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3B3QX-ray2.40E/F85-266[»]
ProteinModelPortaliP58400.
SMRiP58400.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114779. 11 interactors.
DIPiDIP-46402N.

PTM databases

iPTMnetiP58400.

Polymorphism and mutation databases

BioMutaiFSHR.
DMDMi322510054.

Proteomic databases

PeptideAtlasiP58400.
PRIDEiP58400.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342183; ENSP00000341184; ENSG00000179915. [P58400-1]
GeneIDi9378.
UCSCiuc010fbp.4. human. [P58400-1]

Organism-specific databases

CTDi9378.
DisGeNETi9378.
GeneCardsiNRXN1.
HGNCiHGNC:8008. NRXN1.
HPAiCAB009373.
MalaCardsiNRXN1.
MIMi600565. gene.
neXtProtiNX_P58400.
OpenTargetsiENSG00000179915.
Orphaneti106. Autism.
221150. Pitt-Hopkins-like syndrome.
3140. Schizophrenia.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000118991.
HOGENOMiHOG000230482.
HOVERGENiHBG052670.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000179915-MONOMER.
ReactomeiR-HSA-6794361. Interactions of neurexins and neuroligins at synapses.
SIGNORiP58400.

Miscellaneous databases

ChiTaRSiNRXN1. human.
EvolutionaryTraceiP58400.
GeneWikiiNRXN1.
GenomeRNAii9378.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000179915.
CleanExiHS_NRXN1.
ExpressionAtlasiP58400. baseline and differential.
GenevisibleiP58400. HS.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001791. Laminin_G.
IPR029824. Neurexin-1.
IPR003585. Neurexin-like.
IPR027789. Syndecan/Neurexin_dom.
[Graphical view]
PANTHERiPTHR10127:SF565. PTHR10127:SF565. 2 hits.
PfamiPF02210. Laminin_G_2. 1 hit.
PF01034. Syndecan. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
SM00282. LamG. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50025. LAM_G_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNRX1B_HUMAN
AccessioniPrimary (citable) accession number: P58400
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: February 8, 2011
Last modified: November 30, 2016
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.