Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Small conductance calcium-activated potassium channel protein 3

Gene

KCNN3

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Calmodulin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Small conductance calcium-activated potassium channel protein 3
Short name:
SK3
Short name:
SKCa 3
Short name:
SKCa3
Alternative name(s):
KCa2.3
Gene namesi
Name:KCNN3
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei281 – 30121Helical; Name=Segment S1Sequence analysisAdd
BLAST
Transmembranei308 – 32821Helical; Name=Segment S2Sequence analysisAdd
BLAST
Transmembranei359 – 37921Helical; Name=Segment S3Sequence analysisAdd
BLAST
Transmembranei398 – 41821Helical; Name=Segment S4Sequence analysisAdd
BLAST
Transmembranei447 – 46721Helical; Name=Segment S5Sequence analysisAdd
BLAST
Intramembranei487 – 50721Pore-forming; Name=Segment H5Sequence analysisAdd
BLAST
Transmembranei516 – 53621Helical; Name=Segment S6Sequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 724724Small conductance calcium-activated potassium channel protein 3PRO_0000155015Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei160 – 1601PhosphoserineBy similarity
Modified residuei302 – 3021PhosphotyrosineBy similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Heterooligomer. The complex is composed of 4 channel subunits each of which binds to a calmodulin subunit which regulates the channel activity through calcium-binding (By similarity).By similarity

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliP58392.
SMRiP58392. Positions 537-667.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni554 – 63077Calmodulin-bindingBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi19 – 10587Pro-richAdd
BLAST
Compositional biasi30 – 8758Gln-richAdd
BLAST
Compositional biasi141 – 1466Poly-Gly
Compositional biasi676 – 6805Poly-Gln
Compositional biasi720 – 7234Poly-Ser

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG052241.
InParanoidiP58392.
KOiK04944.

Family and domain databases

InterProiIPR004178. CaM-bd_dom.
IPR015449. K_chnl_Ca-activ_SK.
IPR013099. K_chnl_dom.
[Graphical view]
PANTHERiPTHR10153. PTHR10153. 1 hit.
PfamiPF02888. CaMBD. 1 hit.
PF07885. Ion_trans_2. 1 hit.
PF03530. SK_channel. 1 hit.
[Graphical view]
PRINTSiPR01451. SKCHANNEL.
SMARTiSM01053. CaMBD. 1 hit.
[Graphical view]
SUPFAMiSSF81327. SSF81327. 1 hit.

Sequencei

Sequence statusi: Complete.

P58392-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTSGHFHDS GVGDLDEDPK CPCPSSGDEQ QQQQPPPPPP PPAPPAAPQQ
60 70 80 90 100
PPGPPLQPQP LQLQQQQQQQ QQQPPHPLSQ LAQLQSQPVH PGLLHSSPTA
110 120 130 140 150
FRAPPSSNST AILHPSSRQG SQLNLNDHLL GHSPSSTATS GPGGGGRHRQ
160 170 180 190 200
ASPLVHRRDS NPFTEIAMSS CKYSGGVMKP LSRLSASRRN LIEAEPEGQP
210 220 230 240 250
LQLFSPSNPP EIIISSREDN HAHQTLLHHP NATHNHQHAG TTASSTTFPK
260 270 280 290 300
ANKRKNQNIG YKLGHRRALF EKRKRLSDYA LIFGMFGIVV MVIETELSWG
310 320 330 340 350
LYSKDSMFSL ALKCLISLST IILLGLIIAY HTREVQLFVI DNGADDWRIA
360 370 380 390 400
MTYERILYIS LEMLVCAIHP IPGEYKFFWT ARLAFSYTPS RAEADVDIIL
410 420 430 440 450
SIPMFLRLYL IARVMLLHSK LFTDASSRSI GALNKINFNT RFVMKTLMTI
460 470 480 490 500
CPGTVLLVFS ISLWIIAAWT VRVCERYHDQ QDVTSNFLGA MWLISITFLS
510 520 530 540 550
IGYGDMVPHT YCGKGVCLLT GIMGAGCTAL VVAVVARKLE LTKAEKHVHN
560 570 580 590 600
FMMDTQLTKR IKNAAANVLR ETWLIYKHTK LLKKIDHAKV RKHQRKFLQA
610 620 630 640 650
IHQLRSVKME QRKLSDQANT LVDLSKMQNV MYDLITELND RSEDLEKQIG
660 670 680 690 700
SLESKLEHLT ASFNSLPLLI ADTLRQQQQQ LLSALMEARG VSVAVGTTHT
710 720
PLSDSPIGVS STSFPTPYTS SSSC
Length:724
Mass (Da):80,372
Last modified:November 16, 2001 - v1
Checksum:iAFB689A935B4196F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY038049 mRNA. Translation: AAK71498.1.
RefSeqiNP_999150.1. NM_213985.1.
UniGeneiSsc.5485.

Genome annotation databases

GeneIDi397045.
KEGGissc:397045.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY038049 mRNA. Translation: AAK71498.1.
RefSeqiNP_999150.1. NM_213985.1.
UniGeneiSsc.5485.

3D structure databases

ProteinModelPortaliP58392.
SMRiP58392. Positions 537-667.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi397045.
KEGGissc:397045.

Organism-specific databases

CTDi3782.

Phylogenomic databases

HOVERGENiHBG052241.
InParanoidiP58392.
KOiK04944.

Family and domain databases

InterProiIPR004178. CaM-bd_dom.
IPR015449. K_chnl_Ca-activ_SK.
IPR013099. K_chnl_dom.
[Graphical view]
PANTHERiPTHR10153. PTHR10153. 1 hit.
PfamiPF02888. CaMBD. 1 hit.
PF07885. Ion_trans_2. 1 hit.
PF03530. SK_channel. 1 hit.
[Graphical view]
PRINTSiPR01451. SKCHANNEL.
SMARTiSM01053. CaMBD. 1 hit.
[Graphical view]
SUPFAMiSSF81327. SSF81327. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Characterization of an apamin-sensitive small-conductance Ca(2+)-activated K(+) channel in porcine coronary artery endothelium: relevance to EDHF."
    Burnham M.P., Bychkov R., Feletou M., Richards G.R., Vanhoutte P.M., Weston A.H., Edwards G.
    Br. J. Pharmacol. 135:1133-1143(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Coronary artery.

Entry informationi

Entry nameiKCNN3_PIG
AccessioniPrimary (citable) accession number: P58392
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: November 16, 2001
Last modified: February 17, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.