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P58391

- KCNN3_MOUSE

UniProt

P58391 - KCNN3_MOUSE

Protein

Small conductance calcium-activated potassium channel protein 3

Gene

Kcnn3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 2 (16 Oct 2013)
      Previous versions | rss
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    Functioni

    Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin By similarity.By similarity

    GO - Molecular functioni

    1. calmodulin binding Source: RefGenome
    2. small conductance calcium-activated potassium channel activity Source: RefGenome

    GO - Biological processi

    1. potassium ion transmembrane transport Source: RefGenome

    Keywords - Molecular functioni

    Ion channel

    Keywords - Biological processi

    Ion transport, Transport

    Keywords - Ligandi

    Calmodulin-binding

    Enzyme and pathway databases

    ReactomeiREACT_199092. Ca2+ activated K+ channels.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Small conductance calcium-activated potassium channel protein 3
    Short name:
    SK3
    Short name:
    SKCa 3
    Short name:
    SKCa3
    Alternative name(s):
    KCa2.3
    Gene namesi
    Name:Kcnn3
    Synonyms:Sk3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:2153183. Kcnn3.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. integral component of membrane Source: UniProtKB-KW
    3. neuronal cell body Source: RefGenome
    4. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 732732Small conductance calcium-activated potassium channel protein 3PRO_0000155014Add
    BLAST

    Proteomic databases

    PaxDbiP58391.
    PRIDEiP58391.

    PTM databases

    PhosphoSiteiP58391.

    Expressioni

    Tissue specificityi

    Expressed at low levels in atrial and ventricular myocytes (at protein level).1 Publication

    Gene expression databases

    GenevestigatoriP58391.

    Interactioni

    Subunit structurei

    Heterooligomer. The complex is composed of 4 channel subunits each of which binds to a calmodulin subunit which regulates the channel activity through calcium-binding By similarity.By similarity

    Protein-protein interaction databases

    IntActiP58391. 2 interactions.
    MINTiMINT-4099712.
    STRINGi10090.ENSMUSP00000000811.

    Structurei

    3D structure databases

    ProteinModelPortaliP58391.
    SMRiP58391. Positions 473-675.
    ModBaseiSearch...
    MobiDBiSearch...

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei495 – 51521Pore-forming; Name=Segment H5Sequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei289 – 30921Helical; Name=Segment S1Sequence AnalysisAdd
    BLAST
    Transmembranei316 – 33621Helical; Name=Segment S2Sequence AnalysisAdd
    BLAST
    Transmembranei367 – 38721Helical; Name=Segment S3Sequence AnalysisAdd
    BLAST
    Transmembranei406 – 42621Helical; Name=Segment S4Sequence AnalysisAdd
    BLAST
    Transmembranei455 – 47521Helical; Name=Segment S5Sequence AnalysisAdd
    BLAST
    Transmembranei524 – 54421Helical; Name=Segment S6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni562 – 63877Calmodulin-bindingBy similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi19 – 6143Pro-richAdd
    BLAST
    Compositional biasi30 – 9566Gln-richAdd
    BLAST
    Compositional biasi684 – 6885Poly-Gln
    Compositional biasi728 – 7314Poly-Ser

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG320393.
    GeneTreeiENSGT00500000044784.
    HOVERGENiHBG052241.
    InParanoidiP58391.
    KOiK04944.
    OMAiVYNALFY.
    OrthoDBiEOG73FQMC.
    PhylomeDBiP58391.
    TreeFamiTF315015.

    Family and domain databases

    InterProiIPR013099. 2pore_dom_K_chnl_dom.
    IPR004178. CaM-bd_dom.
    IPR015449. K_chnl_Ca-activ_SK.
    [Graphical view]
    PANTHERiPTHR10153. PTHR10153. 1 hit.
    PfamiPF02888. CaMBD. 1 hit.
    PF07885. Ion_trans_2. 1 hit.
    PF03530. SK_channel. 1 hit.
    [Graphical view]
    PRINTSiPR01451. SKCHANNEL.
    SMARTiSM01053. CaMBD. 1 hit.
    [Graphical view]
    SUPFAMiSSF81327. SSF81327. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P58391-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDTSGHFHDS GVGDLDEDPK CPCPSSGDEQ QQQQQPPPPP APPAVPQQPP    50
    GPLLQPQPPQ PQQQQSQQQQ QQQSQQQQQQ APLHPLPQLA QLQSQLVHPG 100
    LLHSSPTAFR APTSANSTAI LHPSSRQGSQ LNLNDHLLGH SPSSTATSGP 150
    GGGSRHRQAS PLVHRRDSNP FTEIAMSSCK YSGGVMKPLS RLSASRRNLI 200
    EAEPEGQPLQ LFSPSNPPEI IISSREDNHA HQTLLHHPNA THNHQHAGTT 250
    AGSTTFPKAN KRKNQNIGYK LGHRRALFEK RKRLSDYALI FGMFGIVVMV 300
    IETELSWGLY SKDSMFSLAL KCLISLSTVI LLGLIIAYHT REVQLFVIDN 350
    GADDWRIAMT YERILYISLE MLVCAIHPIP GEYKFFWTAR LAFSYTPSRA 400
    EADVDIILSI PMFLRLYLIA RVMLLHSKLF TDASSRSIGA LNKINFNTRF 450
    VMKTLMTICP GTVLLVFSIS LWIIAAWTVR VCERYHDQQD VTSNFLGAMW 500
    LISITFLSIG YGDMVPHTYC GKGVCLLTGI MGAGCTALVV AVVARKLELT 550
    KAEKHVHNFM MDTQLTKRIK NAAANVLRET WLIYKHTKLL KKIDHAKVRK 600
    HQRKFLQAIH QLRGVKMEQR KLSDQANTLV DLSKMQNVMY DLITELNDRS 650
    EDLEKQIGSL ESKLEHLTAS FNSLPLLIAD TLRQQQQQLL TAFVEARGIS 700
    VAVGTSHAPP SDSPIGISST SFPTPYTSSS SC 732
    Length:732
    Mass (Da):81,333
    Last modified:October 16, 2013 - v2
    Checksum:i62347E83FFE9DC9B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti80 – 801Missing in AAK48902. (PubMed:11557517)Curated
    Sequence conflicti365 – 3651L → F in AAK48902. (PubMed:11557517)Curated
    Sequence conflicti574 – 5741A → T in AAK48902. (PubMed:11557517)Curated
    Sequence conflicti583 – 5831I → V in AAK48902. (PubMed:11557517)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF357241 mRNA. Translation: AAK48902.1.
    AK137738 mRNA. Translation: BAE23484.1.
    AC166364 Genomic DNA. No translation available.
    AC171273 Genomic DNA. No translation available.
    BC106769 mRNA. Translation: AAI06770.1.
    BC106770 mRNA. Translation: AAI06771.1.
    CCDSiCCDS38495.1.
    RefSeqiNP_536714.2. NM_080466.2.
    UniGeneiMm.120250.

    Genome annotation databases

    EnsembliENSMUST00000000811; ENSMUSP00000000811; ENSMUSG00000000794.
    GeneIDi140493.
    KEGGimmu:140493.
    UCSCiuc012cso.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF357241 mRNA. Translation: AAK48902.1 .
    AK137738 mRNA. Translation: BAE23484.1 .
    AC166364 Genomic DNA. No translation available.
    AC171273 Genomic DNA. No translation available.
    BC106769 mRNA. Translation: AAI06770.1 .
    BC106770 mRNA. Translation: AAI06771.1 .
    CCDSi CCDS38495.1.
    RefSeqi NP_536714.2. NM_080466.2.
    UniGenei Mm.120250.

    3D structure databases

    ProteinModelPortali P58391.
    SMRi P58391. Positions 473-675.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P58391. 2 interactions.
    MINTi MINT-4099712.
    STRINGi 10090.ENSMUSP00000000811.

    PTM databases

    PhosphoSitei P58391.

    Proteomic databases

    PaxDbi P58391.
    PRIDEi P58391.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000000811 ; ENSMUSP00000000811 ; ENSMUSG00000000794 .
    GeneIDi 140493.
    KEGGi mmu:140493.
    UCSCi uc012cso.1. mouse.

    Organism-specific databases

    CTDi 3782.
    MGIi MGI:2153183. Kcnn3.

    Phylogenomic databases

    eggNOGi NOG320393.
    GeneTreei ENSGT00500000044784.
    HOVERGENi HBG052241.
    InParanoidi P58391.
    KOi K04944.
    OMAi VYNALFY.
    OrthoDBi EOG73FQMC.
    PhylomeDBi P58391.
    TreeFami TF315015.

    Enzyme and pathway databases

    Reactomei REACT_199092. Ca2+ activated K+ channels.

    Miscellaneous databases

    NextBioi 369816.
    PROi P58391.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori P58391.

    Family and domain databases

    InterProi IPR013099. 2pore_dom_K_chnl_dom.
    IPR004178. CaM-bd_dom.
    IPR015449. K_chnl_Ca-activ_SK.
    [Graphical view ]
    PANTHERi PTHR10153. PTHR10153. 1 hit.
    Pfami PF02888. CaMBD. 1 hit.
    PF07885. Ion_trans_2. 1 hit.
    PF03530. SK_channel. 1 hit.
    [Graphical view ]
    PRINTSi PR01451. SKCHANNEL.
    SMARTi SM01053. CaMBD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81327. SSF81327. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular properties of small-conductance Ca2+-activated K+ channels expressed in murine colonic smooth muscle."
      Ro S., Hatton W.J., Koh S.D., Horowitz B.
      Am. J. Physiol. 281:G964-G973(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Colon.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Skin.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Differential expression of small-conductance Ca2+-activated K+ channels SK1, SK2, and SK3 in mouse atrial and ventricular myocytes."
      Tuteja D., Xu D., Timofeyev V., Lu L., Sharma D., Zhang Z., Xu Y., Nie L., Vazquez A.E., Young J.N., Glatter K.A., Chiamvimonvat N.
      Am. J. Physiol. 289:H2714-H2723(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiKCNN3_MOUSE
    AccessioniPrimary (citable) accession number: P58391
    Secondary accession number(s): Q3UUY9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 16, 2001
    Last sequence update: October 16, 2013
    Last modified: October 1, 2014
    This is version 95 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3