Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P58381

- FABI2_RHIME

UniProt

P58381 - FABI2_RHIME

Protein

Enoyl-[acyl-carrier-protein] reductase [NADH] 2

Gene

fabI2

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (16 Nov 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    An acyl-[acyl-carrier protein] + NAD+ = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei14 – 141NAD; via carbonyl oxygenBy similarity
    Binding sitei41 – 411NADBy similarity
    Binding sitei93 – 931NAD; via carbonyl oxygenBy similarity
    Active sitei146 – 1461Proton acceptorBy similarity
    Active sitei156 – 1561Proton acceptorBy similarity
    Binding sitei163 – 1631NADBy similarity
    Sitei204 – 2041Involved in acyl-ACP bindingBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi20 – 212NADBy similarity
    Nucleotide bindingi65 – 662NADBy similarity
    Nucleotide bindingi192 – 1965NADBy similarity

    GO - Molecular functioni

    1. enoyl-[acyl-carrier-protein] reductase (NADH) activity Source: UniProtKB-EC

    GO - Biological processi

    1. fatty acid biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciSMEL266834:GJF6-255-MONOMER.
    UniPathwayiUPA00094.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Enoyl-[acyl-carrier-protein] reductase [NADH] 2 (EC:1.3.1.9)
    Alternative name(s):
    NADH-dependent enoyl-ACP reductase 2
    Gene namesi
    Name:fabI2
    Ordered Locus Names:R00246
    ORF Names:SMc00326
    OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
    Taxonomic identifieri266834 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
    ProteomesiUP000001976: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 268268Enoyl-[acyl-carrier-protein] reductase [NADH] 2PRO_0000054906Add
    BLAST

    Proteomic databases

    PRIDEiP58381.

    Interactioni

    Protein-protein interaction databases

    STRINGi266834.SMc00326.

    Structurei

    3D structure databases

    ProteinModelPortaliP58381.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0623.
    KOiK00208.
    OMAiAMEISAY.
    OrthoDBiEOG6HF644.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR014358. Enoyl-ACP_Rdtase_NADH.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PIRSFiPIRSF000094. Enoyl-ACP_rdct. 1 hit.
    PRINTSiPR00081. GDHRDH.

    Sequencei

    Sequence statusi: Complete.

    P58381-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNGLMNGKRG LIMGVANSHS IAWGIAKSLA AQGAELAFTY QGEALGKRVK    50
    PLAAEVNSDF LLPCDVEDIG SVDAVVDAIK ERWGKLDFVV HAIGFSDKNE 100
    LKGLYADTTR DNFSRTMVIS CFSFTEIAKR AAELMSEGGT MLTLTYGGSM 150
    RVMPNYNVMG VAKAALEASV RYLAADYGSR GIRVNAISAG PIRTLAGAGI 200
    SDARAMLSWQ QKNSPLRRTV TIEDVGSSAL YLLSDLSRGV TGEIHYVDSG 250
    YNITSMPTLE ALRVADAD 268
    Length:268
    Mass (Da):28,672
    Last modified:November 16, 2001 - v1
    Checksum:i83D2127C7D76628C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL591688 Genomic DNA. Translation: CAC41683.1.
    RefSeqiNP_384352.1. NC_003047.1.

    Genome annotation databases

    EnsemblBacteriaiCAC41683; CAC41683; SMc00326.
    GeneIDi1231878.
    KEGGisme:SMc00326.
    PATRICi23629683. VBISinMel96828_1613.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL591688 Genomic DNA. Translation: CAC41683.1 .
    RefSeqi NP_384352.1. NC_003047.1.

    3D structure databases

    ProteinModelPortali P58381.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 266834.SMc00326.

    Proteomic databases

    PRIDEi P58381.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC41683 ; CAC41683 ; SMc00326 .
    GeneIDi 1231878.
    KEGGi sme:SMc00326.
    PATRICi 23629683. VBISinMel96828_1613.

    Phylogenomic databases

    eggNOGi COG0623.
    KOi K00208.
    OMAi AMEISAY.
    OrthoDBi EOG6HF644.

    Enzyme and pathway databases

    UniPathwayi UPA00094 .
    BioCyci SMEL266834:GJF6-255-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR014358. Enoyl-ACP_Rdtase_NADH.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PIRSFi PIRSF000094. Enoyl-ACP_rdct. 1 hit.
    PRINTSi PR00081. GDHRDH.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1021.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1021.

    Entry informationi

    Entry nameiFABI2_RHIME
    AccessioniPrimary (citable) accession number: P58381
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 16, 2001
    Last sequence update: November 16, 2001
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3