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P58381 (FABI2_RHIME) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Enoyl-[acyl-carrier-protein] reductase [NADH] 2

EC=1.3.1.9
Alternative name(s):
NADH-dependent enoyl-ACP reductase 2
Gene names
Name:fabI2
Ordered Locus Names:R00246
ORF Names:SMc00326
OrganismRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti) [Complete proteome] [HAMAP]
Taxonomic identifier266834 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium

Protein attributes

Sequence length268 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

An acyl-[acyl-carrier protein] + NAD+ = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH.

Pathway

Lipid metabolism; fatty acid biosynthesis.

Subcellular location

Cell inner membrane; Peripheral membrane protein By similarity.

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

Ontologies

Keywords
   Biological processFatty acid biosynthesis
Fatty acid metabolism
Lipid biosynthesis
Lipid metabolism
   Cellular componentCell inner membrane
Cell membrane
Membrane
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfatty acid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentplasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionenoyl-[acyl-carrier-protein] reductase (NADH) activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 268268Enoyl-[acyl-carrier-protein] reductase [NADH] 2
PRO_0000054906

Regions

Nucleotide binding20 – 212NAD By similarity
Nucleotide binding65 – 662NAD By similarity
Nucleotide binding192 – 1965NAD By similarity

Sites

Active site1461Proton acceptor By similarity
Active site1561Proton acceptor By similarity
Binding site141NAD; via carbonyl oxygen By similarity
Binding site411NAD By similarity
Binding site931NAD; via carbonyl oxygen By similarity
Binding site1631NAD By similarity
Site2041Involved in acyl-ACP binding By similarity

Sequences

Sequence LengthMass (Da)Tools
P58381 [UniParc].

Last modified November 16, 2001. Version 1.
Checksum: 83D2127C7D76628C

FASTA26828,672
        10         20         30         40         50         60 
MNGLMNGKRG LIMGVANSHS IAWGIAKSLA AQGAELAFTY QGEALGKRVK PLAAEVNSDF 

        70         80         90        100        110        120 
LLPCDVEDIG SVDAVVDAIK ERWGKLDFVV HAIGFSDKNE LKGLYADTTR DNFSRTMVIS 

       130        140        150        160        170        180 
CFSFTEIAKR AAELMSEGGT MLTLTYGGSM RVMPNYNVMG VAKAALEASV RYLAADYGSR 

       190        200        210        220        230        240 
GIRVNAISAG PIRTLAGAGI SDARAMLSWQ QKNSPLRRTV TIEDVGSSAL YLLSDLSRGV 

       250        260 
TGEIHYVDSG YNITSMPTLE ALRVADAD 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL591688 Genomic DNA. Translation: CAC41683.1.
RefSeqNP_384352.1. NC_003047.1.

3D structure databases

ProteinModelPortalP58381.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING266834.SMc00326.

Proteomic databases

PRIDEP58381.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC41683; CAC41683; SMc00326.
GeneID1231878.
KEGGsme:SMc00326.
PATRIC23629683. VBISinMel96828_1613.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0623.
KOK00208.
OMAAMEISAY.
OrthoDBEOG6HF644.

Enzyme and pathway databases

BioCycSMEL266834:GJF6-255-MONOMER.
UniPathwayUPA00094.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR014358. Enoyl-ACP_Rdtase_NADH.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PIRSFPIRSF000094. Enoyl-ACP_rdct. 1 hit.
PRINTSPR00081. GDHRDH.
ProtoNetSearch...

Entry information

Entry nameFABI2_RHIME
AccessionPrimary (citable) accession number: P58381
Entry history
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: November 16, 2001
Last modified: May 14, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways