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P58380 (FABI1_RHIME) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Enoyl-[acyl-carrier-protein] reductase [NADH] 1

EC=1.3.1.9
Alternative name(s):
NADH-dependent enoyl-ACP reductase 1
Gene names
Name:fabI1
Ordered Locus Names:R00898
ORF Names:SMc00005
OrganismRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti) [Complete proteome] [HAMAP]
Taxonomic identifier266834 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium

Protein attributes

Sequence length272 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

An acyl-[acyl-carrier protein] + NAD+ = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH.

Pathway

Lipid metabolism; fatty acid biosynthesis.

Subcellular location

Cell inner membrane; Peripheral membrane protein By similarity.

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

Ontologies

Keywords
   Biological processFatty acid biosynthesis
Fatty acid metabolism
Lipid biosynthesis
Lipid metabolism
   Cellular componentCell inner membrane
Cell membrane
Membrane
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfatty acid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentplasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionenoyl-[acyl-carrier-protein] reductase (NADH) activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 272272Enoyl-[acyl-carrier-protein] reductase [NADH] 1
PRO_0000054905

Regions

Nucleotide binding23 – 242NAD By similarity
Nucleotide binding68 – 692NAD By similarity
Nucleotide binding195 – 1995NAD By similarity

Sites

Active site1491Proton acceptor By similarity
Active site1591Proton acceptor By similarity
Binding site171NAD; via carbonyl oxygen By similarity
Binding site441NAD By similarity
Binding site961NAD; via carbonyl oxygen By similarity
Binding site1661NAD By similarity
Site2071Involved in acyl-ACP binding By similarity

Sequences

Sequence LengthMass (Da)Tools
P58380 [UniParc].

Last modified November 16, 2001. Version 1.
Checksum: 1E0FA18A22CDBE36

FASTA27229,148
        10         20         30         40         50         60 
MAQASGLMNG KRGVIMGVAN NRSIAWGIAK ALAEAGAEIA LTWQGDALKK RVEPLAQELG 

        70         80         90        100        110        120 
AFMAGHCDVT DLATIDAVFS ALEEKWGKID FVVHAIAFSD KDELTGRYLD TSRDNFARTM 

       130        140        150        160        170        180 
DISVYSFTAV AARADRVMND GGSILTLTYY GAEKVMPHYN VMGVAKAALE ASVRYLAVDL 

       190        200        210        220        230        240 
GNRGIRVNAI SAGPIKTLAA SGIGDFRYIL KWNEYNAPLK RTVSIEEVGN SALYLLSDLS 

       250        260        270 
SGVTGEVHHV DSGYHTVGMK AVDAPDISVL KD 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL591688 Genomic DNA. Translation: CAC45470.1.
RefSeqNP_385004.1. NC_003047.1.

3D structure databases

ProteinModelPortalP58380.
SMRP58380. Positions 6-266.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING266834.SMc00005.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC45470; CAC45470; SMc00005.
GeneID1232539.
KEGGsme:SMc00005.
PATRIC23631061. VBISinMel96828_2294.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0623.
KOK00208.
OMATGEIHHV.
OrthoDBEOG6HF644.

Enzyme and pathway databases

BioCycRETL1328306-WGS:GSTH-113-MONOMER.
RETL1328306-WGS:GSTH-954-MONOMER.
SMEL266834:GJF6-918-MONOMER.
UniPathwayUPA00094.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR014358. Enoyl-ACP_Rdtase_NADH.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PIRSFPIRSF000094. Enoyl-ACP_rdct. 1 hit.
PRINTSPR00081. GDHRDH.
ProtoNetSearch...

Entry information

Entry nameFABI1_RHIME
AccessionPrimary (citable) accession number: P58380
Entry history
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: November 16, 2001
Last modified: July 9, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways