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P58380

- FABI1_RHIME

UniProt

P58380 - FABI1_RHIME

Protein

Enoyl-[acyl-carrier-protein] reductase [NADH] 1

Gene

fabI1

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (16 Nov 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    An acyl-[acyl-carrier protein] + NAD+ = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei17 – 171NAD; via carbonyl oxygenBy similarity
    Binding sitei44 – 441NADBy similarity
    Binding sitei96 – 961NAD; via carbonyl oxygenBy similarity
    Active sitei149 – 1491Proton acceptorBy similarity
    Active sitei159 – 1591Proton acceptorBy similarity
    Binding sitei166 – 1661NADBy similarity
    Sitei207 – 2071Involved in acyl-ACP bindingBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi23 – 242NADBy similarity
    Nucleotide bindingi68 – 692NADBy similarity
    Nucleotide bindingi195 – 1995NADBy similarity

    GO - Molecular functioni

    1. enoyl-[acyl-carrier-protein] reductase (NADH) activity Source: UniProtKB-EC

    GO - Biological processi

    1. fatty acid biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciRETL1328306-WGS:GSTH-113-MONOMER.
    RETL1328306-WGS:GSTH-954-MONOMER.
    SMEL266834:GJF6-918-MONOMER.
    UniPathwayiUPA00094.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Enoyl-[acyl-carrier-protein] reductase [NADH] 1 (EC:1.3.1.9)
    Alternative name(s):
    NADH-dependent enoyl-ACP reductase 1
    Gene namesi
    Name:fabI1
    Ordered Locus Names:R00898
    ORF Names:SMc00005
    OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
    Taxonomic identifieri266834 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
    ProteomesiUP000001976: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 272272Enoyl-[acyl-carrier-protein] reductase [NADH] 1PRO_0000054905Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi266834.SMc00005.

    Structurei

    3D structure databases

    ProteinModelPortaliP58380.
    SMRiP58380. Positions 6-266.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0623.
    KOiK00208.
    OMAiTGEIHHV.
    OrthoDBiEOG6HF644.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR014358. Enoyl-ACP_Rdtase_NADH.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PIRSFiPIRSF000094. Enoyl-ACP_rdct. 1 hit.
    PRINTSiPR00081. GDHRDH.

    Sequencei

    Sequence statusi: Complete.

    P58380-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQASGLMNG KRGVIMGVAN NRSIAWGIAK ALAEAGAEIA LTWQGDALKK    50
    RVEPLAQELG AFMAGHCDVT DLATIDAVFS ALEEKWGKID FVVHAIAFSD 100
    KDELTGRYLD TSRDNFARTM DISVYSFTAV AARADRVMND GGSILTLTYY 150
    GAEKVMPHYN VMGVAKAALE ASVRYLAVDL GNRGIRVNAI SAGPIKTLAA 200
    SGIGDFRYIL KWNEYNAPLK RTVSIEEVGN SALYLLSDLS SGVTGEVHHV 250
    DSGYHTVGMK AVDAPDISVL KD 272
    Length:272
    Mass (Da):29,148
    Last modified:November 16, 2001 - v1
    Checksum:i1E0FA18A22CDBE36
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL591688 Genomic DNA. Translation: CAC45470.1.
    RefSeqiNP_385004.1. NC_003047.1.

    Genome annotation databases

    EnsemblBacteriaiCAC45470; CAC45470; SMc00005.
    GeneIDi1232539.
    KEGGisme:SMc00005.
    PATRICi23631061. VBISinMel96828_2294.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL591688 Genomic DNA. Translation: CAC45470.1 .
    RefSeqi NP_385004.1. NC_003047.1.

    3D structure databases

    ProteinModelPortali P58380.
    SMRi P58380. Positions 6-266.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 266834.SMc00005.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC45470 ; CAC45470 ; SMc00005 .
    GeneIDi 1232539.
    KEGGi sme:SMc00005.
    PATRICi 23631061. VBISinMel96828_2294.

    Phylogenomic databases

    eggNOGi COG0623.
    KOi K00208.
    OMAi TGEIHHV.
    OrthoDBi EOG6HF644.

    Enzyme and pathway databases

    UniPathwayi UPA00094 .
    BioCyci RETL1328306-WGS:GSTH-113-MONOMER.
    RETL1328306-WGS:GSTH-954-MONOMER.
    SMEL266834:GJF6-918-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR014358. Enoyl-ACP_Rdtase_NADH.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PIRSFi PIRSF000094. Enoyl-ACP_rdct. 1 hit.
    PRINTSi PR00081. GDHRDH.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1021.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1021.

    Entry informationi

    Entry nameiFABI1_RHIME
    AccessioniPrimary (citable) accession number: P58380
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 16, 2001
    Last sequence update: November 16, 2001
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3