ID   CAD23_RAT               Reviewed;        3317 AA.
AC   P58365;
DT   16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   16-NOV-2001, sequence version 1.
DT   27-MAR-2024, entry version 128.
DE   RecName: Full=Cadherin-23;
DE   AltName: Full=Otocadherin;
DE   Flags: Precursor;
GN   Name=Cdh23;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley; TISSUE=Testis;
RX   PubMed=11597768; DOI=10.1016/s0169-328x(01)00218-2;
RA   Nakajima D., Nakayama M., Kikuno R., Hirosawa M., Nagase T., Ohara O.;
RT   "Identification of three novel non-classical cadherin genes through
RT   comprehensive analysis of large cDNAs.";
RL   Brain Res. Mol. Brain Res. 94:85-95(2001).
CC   -!- FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They
CC       preferentially interact with themselves in a homophilic manner in
CC       connecting cells. CDH23 is required for establishing and/or maintaining
CC       the proper organization of the stereocilia bundle of hair cells in the
CC       cochlea and the vestibule during late embryonic/early postnatal
CC       development. It is part of the functional network formed by USH1C,
CC       USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear
CC       hair cells. Required for normal hearing.
CC       {ECO:0000250|UniProtKB:Q9H251}.
CC   -!- SUBUNIT: antiparallel heterodimer with PCDH15 (By similarity).
CC       Interacts with USH1C and USH1G (By similarity).
CC       {ECO:0000250|UniProtKB:Q99PF4, ECO:0000250|UniProtKB:Q9H251}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9H251};
CC       Single-pass type I membrane protein {ECO:0000255}.
CC   -!- DOMAIN: Three calcium ions are usually bound at the interface of each
CC       cadherin domain and rigidify the connections, imparting a strong
CC       curvature to the full-length ectodomain.
CC       {ECO:0000250|UniProtKB:P12830}.
CC   -!- DOMAIN: Cadherin repeats 1 and 2 mediate calcium-dependent heterophilic
CC       interaction with PCDH15. {ECO:0000250|UniProtKB:Q99PF4}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB053447; BAB61904.1; -; mRNA.
DR   RefSeq; NP_446096.1; NM_053644.1.
DR   SMR; P58365; -.
DR   STRING; 10116.ENSRNOP00000048338; -.
DR   GlyCosmos; P58365; 42 sites, No reported glycans.
DR   GlyGen; P58365; 42 sites.
DR   iPTMnet; P58365; -.
DR   PhosphoSitePlus; P58365; -.
DR   PaxDb; 10116-ENSRNOP00000048338; -.
DR   GeneID; 114102; -.
DR   KEGG; rno:114102; -.
DR   UCSC; RGD:619760; rat.
DR   AGR; RGD:619760; -.
DR   CTD; 64072; -.
DR   RGD; 619760; Cdh23.
DR   eggNOG; KOG3594; Eukaryota.
DR   InParanoid; P58365; -.
DR   OrthoDB; 2961370at2759; -.
DR   PhylomeDB; P58365; -.
DR   PRO; PR:P58365; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0045177; C:apical part of cell; IDA:RGD.
DR   GO; GO:0005911; C:cell-cell junction; IBA:GO_Central.
DR   GO; GO:0005813; C:centrosome; ISO:RGD.
DR   GO; GO:0098683; C:cochlear hair cell ribbon synapse; ISO:RGD.
DR   GO; GO:0060091; C:kinocilium; ISO:RGD.
DR   GO; GO:0001917; C:photoreceptor inner segment; ISO:RGD.
DR   GO; GO:0098684; C:photoreceptor ribbon synapse; ISO:RGD.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032420; C:stereocilium; ISO:RGD.
DR   GO; GO:0032426; C:stereocilium tip; ISO:RGD.
DR   GO; GO:0045202; C:synapse; ISO:RGD.
DR   GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR   GO; GO:0008344; P:adult locomotory behavior; ISO:RGD.
DR   GO; GO:0060088; P:auditory receptor cell stereocilium organization; ISO:RGD.
DR   GO; GO:0006816; P:calcium ion transport; ISO:RGD.
DR   GO; GO:0098609; P:cell-cell adhesion; IBA:GO_Central.
DR   GO; GO:0090102; P:cochlea development; ISO:RGD.
DR   GO; GO:0050957; P:equilibrioception; ISO:RGD.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR   GO; GO:0042491; P:inner ear auditory receptor cell differentiation; ISO:RGD.
DR   GO; GO:0048839; P:inner ear development; ISO:RGD.
DR   GO; GO:0042472; P:inner ear morphogenesis; ISO:RGD.
DR   GO; GO:0060122; P:inner ear receptor cell stereocilium organization; ISO:RGD.
DR   GO; GO:0007626; P:locomotory behavior; ISO:RGD.
DR   GO; GO:0045494; P:photoreceptor cell maintenance; ISO:RGD.
DR   GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; ISO:RGD.
DR   GO; GO:0060013; P:righting reflex; ISO:RGD.
DR   GO; GO:0050953; P:sensory perception of light stimulus; ISO:RGD.
DR   GO; GO:0007605; P:sensory perception of sound; ISO:RGD.
DR   CDD; cd11304; Cadherin_repeat; 27.
DR   Gene3D; 2.60.40.60; Cadherins; 27.
DR   InterPro; IPR039808; Cadherin.
DR   InterPro; IPR002126; Cadherin-like_dom.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR020894; Cadherin_CS.
DR   PANTHER; PTHR24027; CADHERIN-23; 1.
DR   PANTHER; PTHR24027:SF445; CADHERIN-87A; 1.
DR   Pfam; PF00028; Cadherin; 24.
DR   PRINTS; PR00205; CADHERIN.
DR   SMART; SM00112; CA; 26.
DR   SUPFAM; SSF49313; Cadherin-like; 27.
DR   PROSITE; PS00232; CADHERIN_1; 17.
DR   PROSITE; PS50268; CADHERIN_2; 27.
PE   2: Evidence at transcript level;
KW   Calcium; Cell adhesion; Cell membrane; Glycoprotein; Hearing; Membrane;
KW   Metal-binding; Reference proteome; Repeat; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..3317
FT                   /note="Cadherin-23"
FT                   /id="PRO_0000003826"
FT   TOPO_DOM        24..3062
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        3063..3083
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        3084..3317
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          34..132
FT                   /note="Cadherin 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          133..236
FT                   /note="Cadherin 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          237..348
FT                   /note="Cadherin 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          349..458
FT                   /note="Cadherin 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          459..559
FT                   /note="Cadherin 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          560..669
FT                   /note="Cadherin 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          670..782
FT                   /note="Cadherin 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          777..888
FT                   /note="Cadherin 8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          889..993
FT                   /note="Cadherin 9"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          994..1100
FT                   /note="Cadherin 10"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          1101..1206
FT                   /note="Cadherin 11"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          1208..1311
FT                   /note="Cadherin 12"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          1312..1416
FT                   /note="Cadherin 13"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          1418..1525
FT                   /note="Cadherin 14"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          1527..1632
FT                   /note="Cadherin 15"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          1633..1742
FT                   /note="Cadherin 16"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          1743..1849
FT                   /note="Cadherin 17"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          1850..1957
FT                   /note="Cadherin 18"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          1958..2067
FT                   /note="Cadherin 19"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          2068..2172
FT                   /note="Cadherin 20"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          2173..2291
FT                   /note="Cadherin 21"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          2295..2400
FT                   /note="Cadherin 22"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          2401..2507
FT                   /note="Cadherin 23"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          2508..2609
FT                   /note="Cadherin 24"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          2612..2720
FT                   /note="Cadherin 25"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          2727..2844
FT                   /note="Cadherin 26"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          2845..2973
FT                   /note="Cadherin 27"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   CARBOHYD        155
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        206
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        349
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        391
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        432
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        464
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        470
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        600
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        692
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        763
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        808
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        825
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        939
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        999
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1016
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1169
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1280
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1313
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1471
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1532
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1649
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1665
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1816
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1855
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1887
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1900
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        2012
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        2048
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        2127
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        2166
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        2193
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        2261
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        2355
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        2367
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        2576
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        2614
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        2747
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        2806
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        2875
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        2894
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        2939
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        2979
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   3317 AA;  365455 MW;  CEF397A066BF0986 CRC64;
     MRHPPVTWCA MLWLLMLVSG SWGQVNRLPF FTNHFFDTYL LISEDTPVGS SVTQLLARDM
     DNDPLVFGVS GEEASRFFAV EPDTGVVWLR QPLDRETKSE FTVEFSVSDH QGVITRKVNI
     QVGDVNDNAP TFHNQPYSVR IPENTPVGTP IFIVNATDPD LGAGGSVLYS FQPPSQFFAI
     DSARGIVTVI RELDYEVTQA YQLTVNATDQ DKTRPLSTLA NLAIIITDVQ DMDPIFINLP
     YSTNIYEHSP PGTTVRVITA VDQDKGRPRG IGYTIVSGNT NSIFALDYIS GALTLNGLLD
     RENPLYSHGF ILTVKGTELN DDRSPSDATV TTTFNILVID INDNAPEFNS SEYSVAITEL
     AQVGFALPLF IQVVDKDEGL NSMFEVYLVG NNSHHFIISP TSVQGKADIR IRVAIPLDYE
     TVDRYDFDLF ANESVPDHVG YAKVKITLIN ENDNRPIFSQ PLYNVSLYEN ITVGTSVLTV
     LATDNDVGTF GEVNYFFSDD PDRFSLDKDT GLIMLIARLD YELIQRFTLT VIARDGGGEE
     TTGRVRINVL DVNDNVPTFQ KDAYVGALRE NEPSVTQLVR LRATDEDSPP NNLITYSIVN
     ASAFGSYFDI SVYEGYGVIS VSRPLDYEQI PNGLIYLTVM AKDAGNPPLY STVPVTIEVF
     DENDNPPTFS KPAYFVSVVE NIMAGATVLF LNATDLDRSR EYGQESIIYS LEGSSQFRIN
     ARSGEITTTS LLDRETKAEY ILIVRAVDGG VGHNQKTGIA TVNVTLLDIN DNHPTWKDAP
     YYINLVEMTP PDSDVTTVVA VDPDLGKNGT LVYSIQPPNK FYSLNSTTGK IRTTHVMLDR
     ENPDPVEAEL MRKIIVSVTD CGRPPLKATS SATVFVNLLD LNDNDPTFQN LPFVAEVLEG
     TPAGVSVYQV VAIDLDEGLN GLVSYRMQVG MPRMDFVINS TSGVVTTTAE LDRERIAEYQ
     LRVVASDAGT PTKSSTSTLT IRVLDVNDET PTFFPAVYNV SVSEDVPREF RVVWLNCTDN
     DVGLNAELSY FITAGNVDGK FSVGYRDAVV RTVVGLDRET TAAYTLVLEA IDNVPVGKRR
     TGTATVFVTV LDVNDNRPIF LQSSYEASVP EDIPEGHSIV QLKATDADEG EFGRVWYRIL
     HGNHGNNFRL HVSSGLLVRG PRPLDRERNS SHVLMAEAYN HDLGPMRSSV RVIVYVEDVN
     DEAPVFTQQQ YNRLGLRETA GIGTSVIVVR ATDRDTGDGG LVNYRILSGA EGKFEIDEST
     GLIVTVDYLD YETKTSYLMN VSATDGAPPF NQGFCSVYVT LLNELDEAVQ FSNASYEAVI
     MENLALGTEI VRVQAYSIDN LNQITYRFDA YTSAQAKALF KIDAITGVIT VKGLVDREKG
     DFYTLTVVAD DGGPKVDSTV KVYVTVLDEN DNSPRFDFTS DSAISVPEDC PVGQRVATVK
     ARDPDAGSNG QVVFSLASGN IAGAFEIITS NDSIGEVFVA KPLDREELDH YILKIVASDR
     GTPPRKKDHI LQVTILDVND NPPVIESPFG YNVSVNENVG GGTSVVQVRA TDRDIGINSV
     LSYYITEGNE DMTFRMDRIS GEIATRPAPP DRERQNFYHL VVTVEDEGTP TLSATTHVYV
     TIVDENDNAP VFQQPHYEVV LDEGPDTVNT SLITVQALDL DEGPNGTVTY AIVAGNIINT
     FRINRRTGVI TAAKELDYEI SHGRYTLIVT ATDQCPILSH RLTSTTTVLV NVNDINDNVP
     TFPRDYEGPF DVTEGQPGPR VWTFLAHDRD SGPNGQVEYS VVDGDPLGEF VISPVEGVLR
     VRKDVELDRE TIAFYNLTIC ARDRGVPPLS STMLVGIRVL DINDNDPVLL NLPMNITISE
     NSPVSSFVAH VLASDADSGC NALLTFNITA GNRERAFFIN ATTGIVTVNR PLDRERIPEY
     RLTVSVKDNP ENPRIARKDF DLLLVSLADE NDNHPLFTEG TYQAEVMENS PAGTPLTVLN
     GPILALDADE DVYAVVTYQL LGTHSDLFVI DNSTGVVTVR SGVIIDREAF SPPFLELLLL
     AEDVGQLNGT AYLFITILDD NDNWPTFSPP AYTVHLLENC PPGFSVLQIT ATDEDSGLNG
     ELVYRIEAGA QDRFLIHPVT GVIRVGNATI DREEQESYRL TVVATDRGTV PLSGTATVTI
     LIDDINDSRP EFLNPIQTVS VLESTEPGTV IANVTAIDLD LNPKLEYHIL SIVAKDDTDR
     LVPDQEDAFA VNINTGSVIV KSPLNRELVA TYEVTLSVID NASDLPERSV SVPNAKLTVN
     ILDVNDNTPQ FKPFGITYYT ERVLEGATPG TTLIAVAAVD PDKGLNGLIT YTLLDLIPPG
     YVQLEDSSAG KVIANRTVDY EEVHWLNFTV RASDNGSPPR AAEIPVYLEI VDINDNNPIF
     DQLSYQEAVF EDVAVGTVIL RVTATDADSG NFALIEYSLV DGEGKFAINP NTGDIYVLSS
     LDREKKDHYI LTALAKDNPG DVASNRRENS VQVVIRVLDV NDCRPQFSKP QFSTSVYENE
     PAGTSVITML ATDQDEGSNG QLTYSLEGPG MEAFSVDMDS GLVTTQRPLQ SYERFNLTVV
     ATDGGEPPLW GTTMLLVEVI DVNDNRPVFV RPPNGTILHI KEEIPLRSNV YEVYATDKDE
     GLNGAVRYSF LKSTGNRDWE YFTIDPISGL IQTAQRLDRE KQAVYSLILV ASDLGQPVPY
     ETMQPLQVAL EDIDDNEPLF VRPPKGSPQY QLLTVPEHSP RGTLVGNVTG AVDADEGPNA
     IVYYFIAAGN EDKNFHLQPD GRLLVLRDLD RETEAIFSFI VKASSNRSWT PPRGPSPALD
     LLTDLTLQEV RVVLEDINDQ PPRFTKAEYT AGVATDAKVG SELIQVLALD ADIGNNSLVF
     YGILAIHYFR ALANDSEDVG QVFTMGSVDG ILRTFDLFMA YSPGYFVVDI VARDLAGHND
     TAIIGIYILR DDQRVKIVIN EIPDRVRGFE EEFIRLLSNI TGAIVNTDDV QFHVDMKGRV
     NFAQTELLIH VVNRDTNRIL DVDRVIQMID ENKEQLRNLF RNYNVLDVQP AISVQLPDDM
     SALQMAIIVL AILLFLAAML FVLMNWYYRT IHKRKLKAIV AGSAGNRGFI DIMDMPNTNK
     YSFDGANPVW LDPFCRNLEL AAQAEHEDDL PENLSEIADL WNSPTRTHGT FGREPAAVKP
     EDDRYLRAAI QEYDNIAKLG QIIREGPIKL IHTDLEEEPG DHSPGQGSLR FRHKPPTELK
     GPDGIHIVHG STGTLLATDL NSLPEDDQKG LDRSLETLTA SEATAFERNA RTESAKSTPL
     HKLRDVIMES PLEITEL
//