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P58365

- CAD23_RAT

UniProt

P58365 - CAD23_RAT

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Protein

Cadherin-23

Gene

Cdh23

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing By similarity.By similarity

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. protein N-terminus binding Source: RGD

GO - Biological processi

  1. homophilic cell adhesion Source: InterPro
  2. sensory perception of sound Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell adhesion, Hearing

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-23
Alternative name(s):
Otocadherin
Gene namesi
Name:Cdh23
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi619760. Cdh23.

Subcellular locationi

GO - Cellular componenti

  1. apical part of cell Source: RGD
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 33173294Cadherin-23PRO_0000003826Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi155 – 1551N-linked (GlcNAc...)Sequence Analysis
Glycosylationi206 – 2061N-linked (GlcNAc...)Sequence Analysis
Glycosylationi349 – 3491N-linked (GlcNAc...)Sequence Analysis
Glycosylationi391 – 3911N-linked (GlcNAc...)Sequence Analysis
Glycosylationi432 – 4321N-linked (GlcNAc...)Sequence Analysis
Glycosylationi464 – 4641N-linked (GlcNAc...)Sequence Analysis
Glycosylationi470 – 4701N-linked (GlcNAc...)Sequence Analysis
Glycosylationi600 – 6001N-linked (GlcNAc...)Sequence Analysis
Glycosylationi692 – 6921N-linked (GlcNAc...)Sequence Analysis
Glycosylationi763 – 7631N-linked (GlcNAc...)Sequence Analysis
Glycosylationi808 – 8081N-linked (GlcNAc...)Sequence Analysis
Glycosylationi825 – 8251N-linked (GlcNAc...)Sequence Analysis
Glycosylationi939 – 9391N-linked (GlcNAc...)Sequence Analysis
Glycosylationi999 – 9991N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1016 – 10161N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1169 – 11691N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1280 – 12801N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1313 – 13131N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1471 – 14711N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1532 – 15321N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1649 – 16491N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1665 – 16651N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1816 – 18161N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1855 – 18551N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1887 – 18871N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1900 – 19001N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2012 – 20121N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2048 – 20481N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2127 – 21271N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2166 – 21661N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2193 – 21931N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2261 – 22611N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2355 – 23551N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2367 – 23671N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2576 – 25761N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2614 – 26141N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2747 – 27471N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2806 – 28061N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2875 – 28751N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2894 – 28941N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2939 – 29391N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2979 – 29791N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP58365.
PRIDEiP58365.

PTM databases

PhosphoSiteiP58365.

Expressioni

Gene expression databases

GenevestigatoriP58365.

Interactioni

Subunit structurei

Interacts with USH1C and USH1G. antiparallel heterodimer with PCDH15 By similarity.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000049630.

Structurei

3D structure databases

ProteinModelPortaliP58365.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 30623039ExtracellularSequence AnalysisAdd
BLAST
Topological domaini3084 – 3317234CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei3063 – 308321HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 13299Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini133 – 236104Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini237 – 348112Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini349 – 458110Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini459 – 559101Cadherin 5PROSITE-ProRule annotationAdd
BLAST
Domaini560 – 669110Cadherin 6PROSITE-ProRule annotationAdd
BLAST
Domaini670 – 782113Cadherin 7PROSITE-ProRule annotationAdd
BLAST
Domaini777 – 888112Cadherin 8PROSITE-ProRule annotationAdd
BLAST
Domaini889 – 993105Cadherin 9PROSITE-ProRule annotationAdd
BLAST
Domaini994 – 1100107Cadherin 10PROSITE-ProRule annotationAdd
BLAST
Domaini1101 – 1206106Cadherin 11PROSITE-ProRule annotationAdd
BLAST
Domaini1208 – 1311104Cadherin 12PROSITE-ProRule annotationAdd
BLAST
Domaini1312 – 1416105Cadherin 13PROSITE-ProRule annotationAdd
BLAST
Domaini1418 – 1525108Cadherin 14PROSITE-ProRule annotationAdd
BLAST
Domaini1527 – 1632106Cadherin 15PROSITE-ProRule annotationAdd
BLAST
Domaini1633 – 1742110Cadherin 16PROSITE-ProRule annotationAdd
BLAST
Domaini1743 – 1849107Cadherin 17PROSITE-ProRule annotationAdd
BLAST
Domaini1850 – 1957108Cadherin 18PROSITE-ProRule annotationAdd
BLAST
Domaini1958 – 2067110Cadherin 19PROSITE-ProRule annotationAdd
BLAST
Domaini2068 – 2172105Cadherin 20PROSITE-ProRule annotationAdd
BLAST
Domaini2173 – 2291119Cadherin 21PROSITE-ProRule annotationAdd
BLAST
Domaini2295 – 2400106Cadherin 22PROSITE-ProRule annotationAdd
BLAST
Domaini2401 – 2507107Cadherin 23PROSITE-ProRule annotationAdd
BLAST
Domaini2508 – 2609102Cadherin 24PROSITE-ProRule annotationAdd
BLAST
Domaini2612 – 2720109Cadherin 25PROSITE-ProRule annotationAdd
BLAST
Domaini2727 – 2844118Cadherin 26PROSITE-ProRule annotationAdd
BLAST
Domaini2845 – 2973129Cadherin 27PROSITE-ProRule annotationAdd
BLAST

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity
Cadherin repeats 1 and 2 mediate calcium-dependent heterophilic interaction with PCDH15.By similarity

Sequence similaritiesi

Contains 27 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG12793.
HOGENOMiHOG000139588.
HOVERGENiHBG050768.
InParanoidiP58365.
KOiK06813.
PhylomeDBiP58365.

Family and domain databases

Gene3Di2.60.40.60. 27 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
[Graphical view]
PfamiPF00028. Cadherin. 25 hits.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 26 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 27 hits.
PROSITEiPS00232. CADHERIN_1. 17 hits.
PS50268. CADHERIN_2. 27 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P58365-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MRHPPVTWCA MLWLLMLVSG SWGQVNRLPF FTNHFFDTYL LISEDTPVGS
60 70 80 90 100
SVTQLLARDM DNDPLVFGVS GEEASRFFAV EPDTGVVWLR QPLDRETKSE
110 120 130 140 150
FTVEFSVSDH QGVITRKVNI QVGDVNDNAP TFHNQPYSVR IPENTPVGTP
160 170 180 190 200
IFIVNATDPD LGAGGSVLYS FQPPSQFFAI DSARGIVTVI RELDYEVTQA
210 220 230 240 250
YQLTVNATDQ DKTRPLSTLA NLAIIITDVQ DMDPIFINLP YSTNIYEHSP
260 270 280 290 300
PGTTVRVITA VDQDKGRPRG IGYTIVSGNT NSIFALDYIS GALTLNGLLD
310 320 330 340 350
RENPLYSHGF ILTVKGTELN DDRSPSDATV TTTFNILVID INDNAPEFNS
360 370 380 390 400
SEYSVAITEL AQVGFALPLF IQVVDKDEGL NSMFEVYLVG NNSHHFIISP
410 420 430 440 450
TSVQGKADIR IRVAIPLDYE TVDRYDFDLF ANESVPDHVG YAKVKITLIN
460 470 480 490 500
ENDNRPIFSQ PLYNVSLYEN ITVGTSVLTV LATDNDVGTF GEVNYFFSDD
510 520 530 540 550
PDRFSLDKDT GLIMLIARLD YELIQRFTLT VIARDGGGEE TTGRVRINVL
560 570 580 590 600
DVNDNVPTFQ KDAYVGALRE NEPSVTQLVR LRATDEDSPP NNLITYSIVN
610 620 630 640 650
ASAFGSYFDI SVYEGYGVIS VSRPLDYEQI PNGLIYLTVM AKDAGNPPLY
660 670 680 690 700
STVPVTIEVF DENDNPPTFS KPAYFVSVVE NIMAGATVLF LNATDLDRSR
710 720 730 740 750
EYGQESIIYS LEGSSQFRIN ARSGEITTTS LLDRETKAEY ILIVRAVDGG
760 770 780 790 800
VGHNQKTGIA TVNVTLLDIN DNHPTWKDAP YYINLVEMTP PDSDVTTVVA
810 820 830 840 850
VDPDLGKNGT LVYSIQPPNK FYSLNSTTGK IRTTHVMLDR ENPDPVEAEL
860 870 880 890 900
MRKIIVSVTD CGRPPLKATS SATVFVNLLD LNDNDPTFQN LPFVAEVLEG
910 920 930 940 950
TPAGVSVYQV VAIDLDEGLN GLVSYRMQVG MPRMDFVINS TSGVVTTTAE
960 970 980 990 1000
LDRERIAEYQ LRVVASDAGT PTKSSTSTLT IRVLDVNDET PTFFPAVYNV
1010 1020 1030 1040 1050
SVSEDVPREF RVVWLNCTDN DVGLNAELSY FITAGNVDGK FSVGYRDAVV
1060 1070 1080 1090 1100
RTVVGLDRET TAAYTLVLEA IDNVPVGKRR TGTATVFVTV LDVNDNRPIF
1110 1120 1130 1140 1150
LQSSYEASVP EDIPEGHSIV QLKATDADEG EFGRVWYRIL HGNHGNNFRL
1160 1170 1180 1190 1200
HVSSGLLVRG PRPLDRERNS SHVLMAEAYN HDLGPMRSSV RVIVYVEDVN
1210 1220 1230 1240 1250
DEAPVFTQQQ YNRLGLRETA GIGTSVIVVR ATDRDTGDGG LVNYRILSGA
1260 1270 1280 1290 1300
EGKFEIDEST GLIVTVDYLD YETKTSYLMN VSATDGAPPF NQGFCSVYVT
1310 1320 1330 1340 1350
LLNELDEAVQ FSNASYEAVI MENLALGTEI VRVQAYSIDN LNQITYRFDA
1360 1370 1380 1390 1400
YTSAQAKALF KIDAITGVIT VKGLVDREKG DFYTLTVVAD DGGPKVDSTV
1410 1420 1430 1440 1450
KVYVTVLDEN DNSPRFDFTS DSAISVPEDC PVGQRVATVK ARDPDAGSNG
1460 1470 1480 1490 1500
QVVFSLASGN IAGAFEIITS NDSIGEVFVA KPLDREELDH YILKIVASDR
1510 1520 1530 1540 1550
GTPPRKKDHI LQVTILDVND NPPVIESPFG YNVSVNENVG GGTSVVQVRA
1560 1570 1580 1590 1600
TDRDIGINSV LSYYITEGNE DMTFRMDRIS GEIATRPAPP DRERQNFYHL
1610 1620 1630 1640 1650
VVTVEDEGTP TLSATTHVYV TIVDENDNAP VFQQPHYEVV LDEGPDTVNT
1660 1670 1680 1690 1700
SLITVQALDL DEGPNGTVTY AIVAGNIINT FRINRRTGVI TAAKELDYEI
1710 1720 1730 1740 1750
SHGRYTLIVT ATDQCPILSH RLTSTTTVLV NVNDINDNVP TFPRDYEGPF
1760 1770 1780 1790 1800
DVTEGQPGPR VWTFLAHDRD SGPNGQVEYS VVDGDPLGEF VISPVEGVLR
1810 1820 1830 1840 1850
VRKDVELDRE TIAFYNLTIC ARDRGVPPLS STMLVGIRVL DINDNDPVLL
1860 1870 1880 1890 1900
NLPMNITISE NSPVSSFVAH VLASDADSGC NALLTFNITA GNRERAFFIN
1910 1920 1930 1940 1950
ATTGIVTVNR PLDRERIPEY RLTVSVKDNP ENPRIARKDF DLLLVSLADE
1960 1970 1980 1990 2000
NDNHPLFTEG TYQAEVMENS PAGTPLTVLN GPILALDADE DVYAVVTYQL
2010 2020 2030 2040 2050
LGTHSDLFVI DNSTGVVTVR SGVIIDREAF SPPFLELLLL AEDVGQLNGT
2060 2070 2080 2090 2100
AYLFITILDD NDNWPTFSPP AYTVHLLENC PPGFSVLQIT ATDEDSGLNG
2110 2120 2130 2140 2150
ELVYRIEAGA QDRFLIHPVT GVIRVGNATI DREEQESYRL TVVATDRGTV
2160 2170 2180 2190 2200
PLSGTATVTI LIDDINDSRP EFLNPIQTVS VLESTEPGTV IANVTAIDLD
2210 2220 2230 2240 2250
LNPKLEYHIL SIVAKDDTDR LVPDQEDAFA VNINTGSVIV KSPLNRELVA
2260 2270 2280 2290 2300
TYEVTLSVID NASDLPERSV SVPNAKLTVN ILDVNDNTPQ FKPFGITYYT
2310 2320 2330 2340 2350
ERVLEGATPG TTLIAVAAVD PDKGLNGLIT YTLLDLIPPG YVQLEDSSAG
2360 2370 2380 2390 2400
KVIANRTVDY EEVHWLNFTV RASDNGSPPR AAEIPVYLEI VDINDNNPIF
2410 2420 2430 2440 2450
DQLSYQEAVF EDVAVGTVIL RVTATDADSG NFALIEYSLV DGEGKFAINP
2460 2470 2480 2490 2500
NTGDIYVLSS LDREKKDHYI LTALAKDNPG DVASNRRENS VQVVIRVLDV
2510 2520 2530 2540 2550
NDCRPQFSKP QFSTSVYENE PAGTSVITML ATDQDEGSNG QLTYSLEGPG
2560 2570 2580 2590 2600
MEAFSVDMDS GLVTTQRPLQ SYERFNLTVV ATDGGEPPLW GTTMLLVEVI
2610 2620 2630 2640 2650
DVNDNRPVFV RPPNGTILHI KEEIPLRSNV YEVYATDKDE GLNGAVRYSF
2660 2670 2680 2690 2700
LKSTGNRDWE YFTIDPISGL IQTAQRLDRE KQAVYSLILV ASDLGQPVPY
2710 2720 2730 2740 2750
ETMQPLQVAL EDIDDNEPLF VRPPKGSPQY QLLTVPEHSP RGTLVGNVTG
2760 2770 2780 2790 2800
AVDADEGPNA IVYYFIAAGN EDKNFHLQPD GRLLVLRDLD RETEAIFSFI
2810 2820 2830 2840 2850
VKASSNRSWT PPRGPSPALD LLTDLTLQEV RVVLEDINDQ PPRFTKAEYT
2860 2870 2880 2890 2900
AGVATDAKVG SELIQVLALD ADIGNNSLVF YGILAIHYFR ALANDSEDVG
2910 2920 2930 2940 2950
QVFTMGSVDG ILRTFDLFMA YSPGYFVVDI VARDLAGHND TAIIGIYILR
2960 2970 2980 2990 3000
DDQRVKIVIN EIPDRVRGFE EEFIRLLSNI TGAIVNTDDV QFHVDMKGRV
3010 3020 3030 3040 3050
NFAQTELLIH VVNRDTNRIL DVDRVIQMID ENKEQLRNLF RNYNVLDVQP
3060 3070 3080 3090 3100
AISVQLPDDM SALQMAIIVL AILLFLAAML FVLMNWYYRT IHKRKLKAIV
3110 3120 3130 3140 3150
AGSAGNRGFI DIMDMPNTNK YSFDGANPVW LDPFCRNLEL AAQAEHEDDL
3160 3170 3180 3190 3200
PENLSEIADL WNSPTRTHGT FGREPAAVKP EDDRYLRAAI QEYDNIAKLG
3210 3220 3230 3240 3250
QIIREGPIKL IHTDLEEEPG DHSPGQGSLR FRHKPPTELK GPDGIHIVHG
3260 3270 3280 3290 3300
STGTLLATDL NSLPEDDQKG LDRSLETLTA SEATAFERNA RTESAKSTPL
3310
HKLRDVIMES PLEITEL
Length:3,317
Mass (Da):365,455
Last modified:November 16, 2001 - v1
Checksum:iCEF397A066BF0986
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB053447 mRNA. Translation: BAB61904.1.
RefSeqiNP_446096.1. NM_053644.1.
UniGeneiRn.208796.

Genome annotation databases

GeneIDi114102.
KEGGirno:114102.
UCSCiRGD:619760. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB053447 mRNA. Translation: BAB61904.1 .
RefSeqi NP_446096.1. NM_053644.1.
UniGenei Rn.208796.

3D structure databases

ProteinModelPortali P58365.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000049630.

PTM databases

PhosphoSitei P58365.

Proteomic databases

PaxDbi P58365.
PRIDEi P58365.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 114102.
KEGGi rno:114102.
UCSCi RGD:619760. rat.

Organism-specific databases

CTDi 64072.
RGDi 619760. Cdh23.

Phylogenomic databases

eggNOGi NOG12793.
HOGENOMi HOG000139588.
HOVERGENi HBG050768.
InParanoidi P58365.
KOi K06813.
PhylomeDBi P58365.

Miscellaneous databases

NextBioi 618265.
PROi P58365.

Gene expression databases

Genevestigatori P58365.

Family and domain databases

Gene3Di 2.60.40.60. 27 hits.
InterProi IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
[Graphical view ]
Pfami PF00028. Cadherin. 25 hits.
[Graphical view ]
PRINTSi PR00205. CADHERIN.
SMARTi SM00112. CA. 26 hits.
[Graphical view ]
SUPFAMi SSF49313. SSF49313. 27 hits.
PROSITEi PS00232. CADHERIN_1. 17 hits.
PS50268. CADHERIN_2. 27 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of three novel non-classical cadherin genes through comprehensive analysis of large cDNAs."
    Nakajima D., Nakayama M., Kikuno R., Hirosawa M., Nagase T., Ohara O.
    Brain Res. Mol. Brain Res. 94:85-95(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Testis.

Entry informationi

Entry nameiCAD23_RAT
AccessioniPrimary (citable) accession number: P58365
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: November 16, 2001
Last modified: October 29, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3