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P58365

- CAD23_RAT

UniProt

P58365 - CAD23_RAT

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Protein

Cadherin-23

Gene
Cdh23
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing By similarity.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. detection of mechanical stimulus involved in sensory perception of sound Source: RGD
  2. homophilic cell adhesion Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell adhesion, Hearing

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-23
Alternative name(s):
Otocadherin
Gene namesi
Name:Cdh23
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi619760. Cdh23.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 30623039Extracellular Reviewed predictionAdd
BLAST
Transmembranei3063 – 308321Helical; Reviewed predictionAdd
BLAST
Topological domaini3084 – 3317234Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed predictionAdd
BLAST
Chaini24 – 33173294Cadherin-23PRO_0000003826Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi155 – 1551N-linked (GlcNAc...) Reviewed prediction
Glycosylationi206 – 2061N-linked (GlcNAc...) Reviewed prediction
Glycosylationi349 – 3491N-linked (GlcNAc...) Reviewed prediction
Glycosylationi391 – 3911N-linked (GlcNAc...) Reviewed prediction
Glycosylationi432 – 4321N-linked (GlcNAc...) Reviewed prediction
Glycosylationi464 – 4641N-linked (GlcNAc...) Reviewed prediction
Glycosylationi470 – 4701N-linked (GlcNAc...) Reviewed prediction
Glycosylationi600 – 6001N-linked (GlcNAc...) Reviewed prediction
Glycosylationi692 – 6921N-linked (GlcNAc...) Reviewed prediction
Glycosylationi763 – 7631N-linked (GlcNAc...) Reviewed prediction
Glycosylationi808 – 8081N-linked (GlcNAc...) Reviewed prediction
Glycosylationi825 – 8251N-linked (GlcNAc...) Reviewed prediction
Glycosylationi939 – 9391N-linked (GlcNAc...) Reviewed prediction
Glycosylationi999 – 9991N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1016 – 10161N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1169 – 11691N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1280 – 12801N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1313 – 13131N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1471 – 14711N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1532 – 15321N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1649 – 16491N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1665 – 16651N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1816 – 18161N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1855 – 18551N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1887 – 18871N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1900 – 19001N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2012 – 20121N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2048 – 20481N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2127 – 21271N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2166 – 21661N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2193 – 21931N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2261 – 22611N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2355 – 23551N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2367 – 23671N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2576 – 25761N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2614 – 26141N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2747 – 27471N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2806 – 28061N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2875 – 28751N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2894 – 28941N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2939 – 29391N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2979 – 29791N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP58365.
PRIDEiP58365.

PTM databases

PhosphoSiteiP58365.

Expressioni

Gene expression databases

GenevestigatoriP58365.

Interactioni

Subunit structurei

Interacts with USH1C and USH1G. antiparallel heterodimer with PCDH15 By similarity.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000049630.

Structurei

3D structure databases

ProteinModelPortaliP58365.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 13299Cadherin 1Add
BLAST
Domaini133 – 236104Cadherin 2Add
BLAST
Domaini237 – 348112Cadherin 3Add
BLAST
Domaini349 – 458110Cadherin 4Add
BLAST
Domaini459 – 559101Cadherin 5Add
BLAST
Domaini560 – 669110Cadherin 6Add
BLAST
Domaini670 – 782113Cadherin 7Add
BLAST
Domaini777 – 888112Cadherin 8Add
BLAST
Domaini889 – 993105Cadherin 9Add
BLAST
Domaini994 – 1100107Cadherin 10Add
BLAST
Domaini1101 – 1206106Cadherin 11Add
BLAST
Domaini1208 – 1311104Cadherin 12Add
BLAST
Domaini1312 – 1416105Cadherin 13Add
BLAST
Domaini1418 – 1525108Cadherin 14Add
BLAST
Domaini1527 – 1632106Cadherin 15Add
BLAST
Domaini1633 – 1742110Cadherin 16Add
BLAST
Domaini1743 – 1849107Cadherin 17Add
BLAST
Domaini1850 – 1957108Cadherin 18Add
BLAST
Domaini1958 – 2067110Cadherin 19Add
BLAST
Domaini2068 – 2172105Cadherin 20Add
BLAST
Domaini2173 – 2291119Cadherin 21Add
BLAST
Domaini2295 – 2400106Cadherin 22Add
BLAST
Domaini2401 – 2507107Cadherin 23Add
BLAST
Domaini2508 – 2609102Cadherin 24Add
BLAST
Domaini2612 – 2720109Cadherin 25Add
BLAST
Domaini2727 – 2844118Cadherin 26Add
BLAST
Domaini2845 – 2973129Cadherin 27Add
BLAST

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain By similarity.
Cadherin repeats 1 and 2 mediate calcium-dependent heterophilic interaction with PCDH15 By similarity.

Sequence similaritiesi

Contains 27 cadherin domains.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG12793.
HOGENOMiHOG000139588.
HOVERGENiHBG050768.
KOiK06813.
PhylomeDBiP58365.

Family and domain databases

Gene3Di2.60.40.60. 27 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
[Graphical view]
PfamiPF00028. Cadherin. 25 hits.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 26 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 27 hits.
PROSITEiPS00232. CADHERIN_1. 17 hits.
PS50268. CADHERIN_2. 27 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P58365-1 [UniParc]FASTAAdd to Basket

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MRHPPVTWCA MLWLLMLVSG SWGQVNRLPF FTNHFFDTYL LISEDTPVGS     50
SVTQLLARDM DNDPLVFGVS GEEASRFFAV EPDTGVVWLR QPLDRETKSE 100
FTVEFSVSDH QGVITRKVNI QVGDVNDNAP TFHNQPYSVR IPENTPVGTP 150
IFIVNATDPD LGAGGSVLYS FQPPSQFFAI DSARGIVTVI RELDYEVTQA 200
YQLTVNATDQ DKTRPLSTLA NLAIIITDVQ DMDPIFINLP YSTNIYEHSP 250
PGTTVRVITA VDQDKGRPRG IGYTIVSGNT NSIFALDYIS GALTLNGLLD 300
RENPLYSHGF ILTVKGTELN DDRSPSDATV TTTFNILVID INDNAPEFNS 350
SEYSVAITEL AQVGFALPLF IQVVDKDEGL NSMFEVYLVG NNSHHFIISP 400
TSVQGKADIR IRVAIPLDYE TVDRYDFDLF ANESVPDHVG YAKVKITLIN 450
ENDNRPIFSQ PLYNVSLYEN ITVGTSVLTV LATDNDVGTF GEVNYFFSDD 500
PDRFSLDKDT GLIMLIARLD YELIQRFTLT VIARDGGGEE TTGRVRINVL 550
DVNDNVPTFQ KDAYVGALRE NEPSVTQLVR LRATDEDSPP NNLITYSIVN 600
ASAFGSYFDI SVYEGYGVIS VSRPLDYEQI PNGLIYLTVM AKDAGNPPLY 650
STVPVTIEVF DENDNPPTFS KPAYFVSVVE NIMAGATVLF LNATDLDRSR 700
EYGQESIIYS LEGSSQFRIN ARSGEITTTS LLDRETKAEY ILIVRAVDGG 750
VGHNQKTGIA TVNVTLLDIN DNHPTWKDAP YYINLVEMTP PDSDVTTVVA 800
VDPDLGKNGT LVYSIQPPNK FYSLNSTTGK IRTTHVMLDR ENPDPVEAEL 850
MRKIIVSVTD CGRPPLKATS SATVFVNLLD LNDNDPTFQN LPFVAEVLEG 900
TPAGVSVYQV VAIDLDEGLN GLVSYRMQVG MPRMDFVINS TSGVVTTTAE 950
LDRERIAEYQ LRVVASDAGT PTKSSTSTLT IRVLDVNDET PTFFPAVYNV 1000
SVSEDVPREF RVVWLNCTDN DVGLNAELSY FITAGNVDGK FSVGYRDAVV 1050
RTVVGLDRET TAAYTLVLEA IDNVPVGKRR TGTATVFVTV LDVNDNRPIF 1100
LQSSYEASVP EDIPEGHSIV QLKATDADEG EFGRVWYRIL HGNHGNNFRL 1150
HVSSGLLVRG PRPLDRERNS SHVLMAEAYN HDLGPMRSSV RVIVYVEDVN 1200
DEAPVFTQQQ YNRLGLRETA GIGTSVIVVR ATDRDTGDGG LVNYRILSGA 1250
EGKFEIDEST GLIVTVDYLD YETKTSYLMN VSATDGAPPF NQGFCSVYVT 1300
LLNELDEAVQ FSNASYEAVI MENLALGTEI VRVQAYSIDN LNQITYRFDA 1350
YTSAQAKALF KIDAITGVIT VKGLVDREKG DFYTLTVVAD DGGPKVDSTV 1400
KVYVTVLDEN DNSPRFDFTS DSAISVPEDC PVGQRVATVK ARDPDAGSNG 1450
QVVFSLASGN IAGAFEIITS NDSIGEVFVA KPLDREELDH YILKIVASDR 1500
GTPPRKKDHI LQVTILDVND NPPVIESPFG YNVSVNENVG GGTSVVQVRA 1550
TDRDIGINSV LSYYITEGNE DMTFRMDRIS GEIATRPAPP DRERQNFYHL 1600
VVTVEDEGTP TLSATTHVYV TIVDENDNAP VFQQPHYEVV LDEGPDTVNT 1650
SLITVQALDL DEGPNGTVTY AIVAGNIINT FRINRRTGVI TAAKELDYEI 1700
SHGRYTLIVT ATDQCPILSH RLTSTTTVLV NVNDINDNVP TFPRDYEGPF 1750
DVTEGQPGPR VWTFLAHDRD SGPNGQVEYS VVDGDPLGEF VISPVEGVLR 1800
VRKDVELDRE TIAFYNLTIC ARDRGVPPLS STMLVGIRVL DINDNDPVLL 1850
NLPMNITISE NSPVSSFVAH VLASDADSGC NALLTFNITA GNRERAFFIN 1900
ATTGIVTVNR PLDRERIPEY RLTVSVKDNP ENPRIARKDF DLLLVSLADE 1950
NDNHPLFTEG TYQAEVMENS PAGTPLTVLN GPILALDADE DVYAVVTYQL 2000
LGTHSDLFVI DNSTGVVTVR SGVIIDREAF SPPFLELLLL AEDVGQLNGT 2050
AYLFITILDD NDNWPTFSPP AYTVHLLENC PPGFSVLQIT ATDEDSGLNG 2100
ELVYRIEAGA QDRFLIHPVT GVIRVGNATI DREEQESYRL TVVATDRGTV 2150
PLSGTATVTI LIDDINDSRP EFLNPIQTVS VLESTEPGTV IANVTAIDLD 2200
LNPKLEYHIL SIVAKDDTDR LVPDQEDAFA VNINTGSVIV KSPLNRELVA 2250
TYEVTLSVID NASDLPERSV SVPNAKLTVN ILDVNDNTPQ FKPFGITYYT 2300
ERVLEGATPG TTLIAVAAVD PDKGLNGLIT YTLLDLIPPG YVQLEDSSAG 2350
KVIANRTVDY EEVHWLNFTV RASDNGSPPR AAEIPVYLEI VDINDNNPIF 2400
DQLSYQEAVF EDVAVGTVIL RVTATDADSG NFALIEYSLV DGEGKFAINP 2450
NTGDIYVLSS LDREKKDHYI LTALAKDNPG DVASNRRENS VQVVIRVLDV 2500
NDCRPQFSKP QFSTSVYENE PAGTSVITML ATDQDEGSNG QLTYSLEGPG 2550
MEAFSVDMDS GLVTTQRPLQ SYERFNLTVV ATDGGEPPLW GTTMLLVEVI 2600
DVNDNRPVFV RPPNGTILHI KEEIPLRSNV YEVYATDKDE GLNGAVRYSF 2650
LKSTGNRDWE YFTIDPISGL IQTAQRLDRE KQAVYSLILV ASDLGQPVPY 2700
ETMQPLQVAL EDIDDNEPLF VRPPKGSPQY QLLTVPEHSP RGTLVGNVTG 2750
AVDADEGPNA IVYYFIAAGN EDKNFHLQPD GRLLVLRDLD RETEAIFSFI 2800
VKASSNRSWT PPRGPSPALD LLTDLTLQEV RVVLEDINDQ PPRFTKAEYT 2850
AGVATDAKVG SELIQVLALD ADIGNNSLVF YGILAIHYFR ALANDSEDVG 2900
QVFTMGSVDG ILRTFDLFMA YSPGYFVVDI VARDLAGHND TAIIGIYILR 2950
DDQRVKIVIN EIPDRVRGFE EEFIRLLSNI TGAIVNTDDV QFHVDMKGRV 3000
NFAQTELLIH VVNRDTNRIL DVDRVIQMID ENKEQLRNLF RNYNVLDVQP 3050
AISVQLPDDM SALQMAIIVL AILLFLAAML FVLMNWYYRT IHKRKLKAIV 3100
AGSAGNRGFI DIMDMPNTNK YSFDGANPVW LDPFCRNLEL AAQAEHEDDL 3150
PENLSEIADL WNSPTRTHGT FGREPAAVKP EDDRYLRAAI QEYDNIAKLG 3200
QIIREGPIKL IHTDLEEEPG DHSPGQGSLR FRHKPPTELK GPDGIHIVHG 3250
STGTLLATDL NSLPEDDQKG LDRSLETLTA SEATAFERNA RTESAKSTPL 3300
HKLRDVIMES PLEITEL 3317
Length:3,317
Mass (Da):365,455
Last modified:November 16, 2001 - v1
Checksum:iCEF397A066BF0986
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB053447 mRNA. Translation: BAB61904.1.
RefSeqiNP_446096.1. NM_053644.1.
UniGeneiRn.208796.

Genome annotation databases

GeneIDi114102.
KEGGirno:114102.
UCSCiRGD:619760. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB053447 mRNA. Translation: BAB61904.1 .
RefSeqi NP_446096.1. NM_053644.1.
UniGenei Rn.208796.

3D structure databases

ProteinModelPortali P58365.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000049630.

PTM databases

PhosphoSitei P58365.

Proteomic databases

PaxDbi P58365.
PRIDEi P58365.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 114102.
KEGGi rno:114102.
UCSCi RGD:619760. rat.

Organism-specific databases

CTDi 64072.
RGDi 619760. Cdh23.

Phylogenomic databases

eggNOGi NOG12793.
HOGENOMi HOG000139588.
HOVERGENi HBG050768.
KOi K06813.
PhylomeDBi P58365.

Miscellaneous databases

NextBioi 618265.
PROi P58365.

Gene expression databases

Genevestigatori P58365.

Family and domain databases

Gene3Di 2.60.40.60. 27 hits.
InterProi IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
[Graphical view ]
Pfami PF00028. Cadherin. 25 hits.
[Graphical view ]
PRINTSi PR00205. CADHERIN.
SMARTi SM00112. CA. 26 hits.
[Graphical view ]
SUPFAMi SSF49313. SSF49313. 27 hits.
PROSITEi PS00232. CADHERIN_1. 17 hits.
PS50268. CADHERIN_2. 27 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of three novel non-classical cadherin genes through comprehensive analysis of large cDNAs."
    Nakajima D., Nakayama M., Kikuno R., Hirosawa M., Nagase T., Ohara O.
    Brain Res. Mol. Brain Res. 94:85-95(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Testis.

Entry informationi

Entry nameiCAD23_RAT
AccessioniPrimary (citable) accession number: P58365
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: November 16, 2001
Last modified: April 16, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi