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P58365 (CAD23_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Cadherin-23
Alternative name(s):
Otocadherin
Gene names
Name:Cdh23
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length3317 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing By similarity.

Subunit structure

Interacts with USH1C and USH1G. antiparallel heterodimer with PCDH15 By similarity.

Subcellular location

Cell membrane; Single-pass type I membrane protein By similarity.

Domain

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain By similarity.

Cadherin repeats 1 and 2 mediate calcium-dependent heterophilic interaction with PCDH15 By similarity.

Sequence similarities

Contains 27 cadherin domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 33173294Cadherin-23
PRO_0000003826

Regions

Topological domain24 – 30623039Extracellular Potential
Transmembrane3063 – 308321Helical; Potential
Topological domain3084 – 3317234Cytoplasmic Potential
Domain34 – 13299Cadherin 1
Domain133 – 236104Cadherin 2
Domain237 – 348112Cadherin 3
Domain349 – 458110Cadherin 4
Domain459 – 559101Cadherin 5
Domain560 – 669110Cadherin 6
Domain670 – 782113Cadherin 7
Domain777 – 888112Cadherin 8
Domain889 – 993105Cadherin 9
Domain994 – 1100107Cadherin 10
Domain1101 – 1206106Cadherin 11
Domain1208 – 1311104Cadherin 12
Domain1312 – 1416105Cadherin 13
Domain1418 – 1525108Cadherin 14
Domain1527 – 1632106Cadherin 15
Domain1633 – 1742110Cadherin 16
Domain1743 – 1849107Cadherin 17
Domain1850 – 1957108Cadherin 18
Domain1958 – 2067110Cadherin 19
Domain2068 – 2172105Cadherin 20
Domain2173 – 2291119Cadherin 21
Domain2295 – 2400106Cadherin 22
Domain2401 – 2507107Cadherin 23
Domain2508 – 2609102Cadherin 24
Domain2612 – 2720109Cadherin 25
Domain2727 – 2844118Cadherin 26
Domain2845 – 2973129Cadherin 27

Amino acid modifications

Glycosylation1551N-linked (GlcNAc...) Potential
Glycosylation2061N-linked (GlcNAc...) Potential
Glycosylation3491N-linked (GlcNAc...) Potential
Glycosylation3911N-linked (GlcNAc...) Potential
Glycosylation4321N-linked (GlcNAc...) Potential
Glycosylation4641N-linked (GlcNAc...) Potential
Glycosylation4701N-linked (GlcNAc...) Potential
Glycosylation6001N-linked (GlcNAc...) Potential
Glycosylation6921N-linked (GlcNAc...) Potential
Glycosylation7631N-linked (GlcNAc...) Potential
Glycosylation8081N-linked (GlcNAc...) Potential
Glycosylation8251N-linked (GlcNAc...) Potential
Glycosylation9391N-linked (GlcNAc...) Potential
Glycosylation9991N-linked (GlcNAc...) Potential
Glycosylation10161N-linked (GlcNAc...) Potential
Glycosylation11691N-linked (GlcNAc...) Potential
Glycosylation12801N-linked (GlcNAc...) Potential
Glycosylation13131N-linked (GlcNAc...) Potential
Glycosylation14711N-linked (GlcNAc...) Potential
Glycosylation15321N-linked (GlcNAc...) Potential
Glycosylation16491N-linked (GlcNAc...) Potential
Glycosylation16651N-linked (GlcNAc...) Potential
Glycosylation18161N-linked (GlcNAc...) Potential
Glycosylation18551N-linked (GlcNAc...) Potential
Glycosylation18871N-linked (GlcNAc...) Potential
Glycosylation19001N-linked (GlcNAc...) Potential
Glycosylation20121N-linked (GlcNAc...) Potential
Glycosylation20481N-linked (GlcNAc...) Potential
Glycosylation21271N-linked (GlcNAc...) Potential
Glycosylation21661N-linked (GlcNAc...) Potential
Glycosylation21931N-linked (GlcNAc...) Potential
Glycosylation22611N-linked (GlcNAc...) Potential
Glycosylation23551N-linked (GlcNAc...) Potential
Glycosylation23671N-linked (GlcNAc...) Potential
Glycosylation25761N-linked (GlcNAc...) Potential
Glycosylation26141N-linked (GlcNAc...) Potential
Glycosylation27471N-linked (GlcNAc...) Potential
Glycosylation28061N-linked (GlcNAc...) Potential
Glycosylation28751N-linked (GlcNAc...) Potential
Glycosylation28941N-linked (GlcNAc...) Potential
Glycosylation29391N-linked (GlcNAc...) Potential
Glycosylation29791N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P58365 [UniParc].

Last modified November 16, 2001. Version 1.
Checksum: CEF397A066BF0986

FASTA3,317365,455
        10         20         30         40         50         60 
MRHPPVTWCA MLWLLMLVSG SWGQVNRLPF FTNHFFDTYL LISEDTPVGS SVTQLLARDM 

        70         80         90        100        110        120 
DNDPLVFGVS GEEASRFFAV EPDTGVVWLR QPLDRETKSE FTVEFSVSDH QGVITRKVNI 

       130        140        150        160        170        180 
QVGDVNDNAP TFHNQPYSVR IPENTPVGTP IFIVNATDPD LGAGGSVLYS FQPPSQFFAI 

       190        200        210        220        230        240 
DSARGIVTVI RELDYEVTQA YQLTVNATDQ DKTRPLSTLA NLAIIITDVQ DMDPIFINLP 

       250        260        270        280        290        300 
YSTNIYEHSP PGTTVRVITA VDQDKGRPRG IGYTIVSGNT NSIFALDYIS GALTLNGLLD 

       310        320        330        340        350        360 
RENPLYSHGF ILTVKGTELN DDRSPSDATV TTTFNILVID INDNAPEFNS SEYSVAITEL 

       370        380        390        400        410        420 
AQVGFALPLF IQVVDKDEGL NSMFEVYLVG NNSHHFIISP TSVQGKADIR IRVAIPLDYE 

       430        440        450        460        470        480 
TVDRYDFDLF ANESVPDHVG YAKVKITLIN ENDNRPIFSQ PLYNVSLYEN ITVGTSVLTV 

       490        500        510        520        530        540 
LATDNDVGTF GEVNYFFSDD PDRFSLDKDT GLIMLIARLD YELIQRFTLT VIARDGGGEE 

       550        560        570        580        590        600 
TTGRVRINVL DVNDNVPTFQ KDAYVGALRE NEPSVTQLVR LRATDEDSPP NNLITYSIVN 

       610        620        630        640        650        660 
ASAFGSYFDI SVYEGYGVIS VSRPLDYEQI PNGLIYLTVM AKDAGNPPLY STVPVTIEVF 

       670        680        690        700        710        720 
DENDNPPTFS KPAYFVSVVE NIMAGATVLF LNATDLDRSR EYGQESIIYS LEGSSQFRIN 

       730        740        750        760        770        780 
ARSGEITTTS LLDRETKAEY ILIVRAVDGG VGHNQKTGIA TVNVTLLDIN DNHPTWKDAP 

       790        800        810        820        830        840 
YYINLVEMTP PDSDVTTVVA VDPDLGKNGT LVYSIQPPNK FYSLNSTTGK IRTTHVMLDR 

       850        860        870        880        890        900 
ENPDPVEAEL MRKIIVSVTD CGRPPLKATS SATVFVNLLD LNDNDPTFQN LPFVAEVLEG 

       910        920        930        940        950        960 
TPAGVSVYQV VAIDLDEGLN GLVSYRMQVG MPRMDFVINS TSGVVTTTAE LDRERIAEYQ 

       970        980        990       1000       1010       1020 
LRVVASDAGT PTKSSTSTLT IRVLDVNDET PTFFPAVYNV SVSEDVPREF RVVWLNCTDN 

      1030       1040       1050       1060       1070       1080 
DVGLNAELSY FITAGNVDGK FSVGYRDAVV RTVVGLDRET TAAYTLVLEA IDNVPVGKRR 

      1090       1100       1110       1120       1130       1140 
TGTATVFVTV LDVNDNRPIF LQSSYEASVP EDIPEGHSIV QLKATDADEG EFGRVWYRIL 

      1150       1160       1170       1180       1190       1200 
HGNHGNNFRL HVSSGLLVRG PRPLDRERNS SHVLMAEAYN HDLGPMRSSV RVIVYVEDVN 

      1210       1220       1230       1240       1250       1260 
DEAPVFTQQQ YNRLGLRETA GIGTSVIVVR ATDRDTGDGG LVNYRILSGA EGKFEIDEST 

      1270       1280       1290       1300       1310       1320 
GLIVTVDYLD YETKTSYLMN VSATDGAPPF NQGFCSVYVT LLNELDEAVQ FSNASYEAVI 

      1330       1340       1350       1360       1370       1380 
MENLALGTEI VRVQAYSIDN LNQITYRFDA YTSAQAKALF KIDAITGVIT VKGLVDREKG 

      1390       1400       1410       1420       1430       1440 
DFYTLTVVAD DGGPKVDSTV KVYVTVLDEN DNSPRFDFTS DSAISVPEDC PVGQRVATVK 

      1450       1460       1470       1480       1490       1500 
ARDPDAGSNG QVVFSLASGN IAGAFEIITS NDSIGEVFVA KPLDREELDH YILKIVASDR 

      1510       1520       1530       1540       1550       1560 
GTPPRKKDHI LQVTILDVND NPPVIESPFG YNVSVNENVG GGTSVVQVRA TDRDIGINSV 

      1570       1580       1590       1600       1610       1620 
LSYYITEGNE DMTFRMDRIS GEIATRPAPP DRERQNFYHL VVTVEDEGTP TLSATTHVYV 

      1630       1640       1650       1660       1670       1680 
TIVDENDNAP VFQQPHYEVV LDEGPDTVNT SLITVQALDL DEGPNGTVTY AIVAGNIINT 

      1690       1700       1710       1720       1730       1740 
FRINRRTGVI TAAKELDYEI SHGRYTLIVT ATDQCPILSH RLTSTTTVLV NVNDINDNVP 

      1750       1760       1770       1780       1790       1800 
TFPRDYEGPF DVTEGQPGPR VWTFLAHDRD SGPNGQVEYS VVDGDPLGEF VISPVEGVLR 

      1810       1820       1830       1840       1850       1860 
VRKDVELDRE TIAFYNLTIC ARDRGVPPLS STMLVGIRVL DINDNDPVLL NLPMNITISE 

      1870       1880       1890       1900       1910       1920 
NSPVSSFVAH VLASDADSGC NALLTFNITA GNRERAFFIN ATTGIVTVNR PLDRERIPEY 

      1930       1940       1950       1960       1970       1980 
RLTVSVKDNP ENPRIARKDF DLLLVSLADE NDNHPLFTEG TYQAEVMENS PAGTPLTVLN 

      1990       2000       2010       2020       2030       2040 
GPILALDADE DVYAVVTYQL LGTHSDLFVI DNSTGVVTVR SGVIIDREAF SPPFLELLLL 

      2050       2060       2070       2080       2090       2100 
AEDVGQLNGT AYLFITILDD NDNWPTFSPP AYTVHLLENC PPGFSVLQIT ATDEDSGLNG 

      2110       2120       2130       2140       2150       2160 
ELVYRIEAGA QDRFLIHPVT GVIRVGNATI DREEQESYRL TVVATDRGTV PLSGTATVTI 

      2170       2180       2190       2200       2210       2220 
LIDDINDSRP EFLNPIQTVS VLESTEPGTV IANVTAIDLD LNPKLEYHIL SIVAKDDTDR 

      2230       2240       2250       2260       2270       2280 
LVPDQEDAFA VNINTGSVIV KSPLNRELVA TYEVTLSVID NASDLPERSV SVPNAKLTVN 

      2290       2300       2310       2320       2330       2340 
ILDVNDNTPQ FKPFGITYYT ERVLEGATPG TTLIAVAAVD PDKGLNGLIT YTLLDLIPPG 

      2350       2360       2370       2380       2390       2400 
YVQLEDSSAG KVIANRTVDY EEVHWLNFTV RASDNGSPPR AAEIPVYLEI VDINDNNPIF 

      2410       2420       2430       2440       2450       2460 
DQLSYQEAVF EDVAVGTVIL RVTATDADSG NFALIEYSLV DGEGKFAINP NTGDIYVLSS 

      2470       2480       2490       2500       2510       2520 
LDREKKDHYI LTALAKDNPG DVASNRRENS VQVVIRVLDV NDCRPQFSKP QFSTSVYENE 

      2530       2540       2550       2560       2570       2580 
PAGTSVITML ATDQDEGSNG QLTYSLEGPG MEAFSVDMDS GLVTTQRPLQ SYERFNLTVV 

      2590       2600       2610       2620       2630       2640 
ATDGGEPPLW GTTMLLVEVI DVNDNRPVFV RPPNGTILHI KEEIPLRSNV YEVYATDKDE 

      2650       2660       2670       2680       2690       2700 
GLNGAVRYSF LKSTGNRDWE YFTIDPISGL IQTAQRLDRE KQAVYSLILV ASDLGQPVPY 

      2710       2720       2730       2740       2750       2760 
ETMQPLQVAL EDIDDNEPLF VRPPKGSPQY QLLTVPEHSP RGTLVGNVTG AVDADEGPNA 

      2770       2780       2790       2800       2810       2820 
IVYYFIAAGN EDKNFHLQPD GRLLVLRDLD RETEAIFSFI VKASSNRSWT PPRGPSPALD 

      2830       2840       2850       2860       2870       2880 
LLTDLTLQEV RVVLEDINDQ PPRFTKAEYT AGVATDAKVG SELIQVLALD ADIGNNSLVF 

      2890       2900       2910       2920       2930       2940 
YGILAIHYFR ALANDSEDVG QVFTMGSVDG ILRTFDLFMA YSPGYFVVDI VARDLAGHND 

      2950       2960       2970       2980       2990       3000 
TAIIGIYILR DDQRVKIVIN EIPDRVRGFE EEFIRLLSNI TGAIVNTDDV QFHVDMKGRV 

      3010       3020       3030       3040       3050       3060 
NFAQTELLIH VVNRDTNRIL DVDRVIQMID ENKEQLRNLF RNYNVLDVQP AISVQLPDDM 

      3070       3080       3090       3100       3110       3120 
SALQMAIIVL AILLFLAAML FVLMNWYYRT IHKRKLKAIV AGSAGNRGFI DIMDMPNTNK 

      3130       3140       3150       3160       3170       3180 
YSFDGANPVW LDPFCRNLEL AAQAEHEDDL PENLSEIADL WNSPTRTHGT FGREPAAVKP 

      3190       3200       3210       3220       3230       3240 
EDDRYLRAAI QEYDNIAKLG QIIREGPIKL IHTDLEEEPG DHSPGQGSLR FRHKPPTELK 

      3250       3260       3270       3280       3290       3300 
GPDGIHIVHG STGTLLATDL NSLPEDDQKG LDRSLETLTA SEATAFERNA RTESAKSTPL 

      3310 
HKLRDVIMES PLEITEL 

« Hide

References

[1]"Identification of three novel non-classical cadherin genes through comprehensive analysis of large cDNAs."
Nakajima D., Nakayama M., Kikuno R., Hirosawa M., Nagase T., Ohara O.
Brain Res. Mol. Brain Res. 94:85-95(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB053447 mRNA. Translation: BAB61904.1.
RefSeqNP_446096.1. NM_053644.1.
UniGeneRn.208796.

3D structure databases

ProteinModelPortalP58365.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000049630.

PTM databases

PhosphoSiteP58365.

Proteomic databases

PaxDbP58365.
PRIDEP58365.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID114102.
KEGGrno:114102.
UCSCRGD:619760. rat.

Organism-specific databases

CTD64072.
RGD619760. Cdh23.

Phylogenomic databases

eggNOGNOG12793.
HOGENOMHOG000139588.
HOVERGENHBG050768.
KOK06813.
PhylomeDBP58365.

Gene expression databases

GenevestigatorP58365.

Family and domain databases

Gene3D2.60.40.60. 27 hits.
InterProIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
[Graphical view]
PfamPF00028. Cadherin. 25 hits.
[Graphical view]
PRINTSPR00205. CADHERIN.
SMARTSM00112. CA. 26 hits.
[Graphical view]
SUPFAMSSF49313. SSF49313. 27 hits.
PROSITEPS00232. CADHERIN_1. 17 hits.
PS50268. CADHERIN_2. 27 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio618265.
PROP58365.

Entry information

Entry nameCAD23_RAT
AccessionPrimary (citable) accession number: P58365
Entry history
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: November 16, 2001
Last modified: April 16, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families