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P58365

- CAD23_RAT

UniProt

P58365 - CAD23_RAT

Protein

Cadherin-23

Gene

Cdh23

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (16 Nov 2001)
      Previous versions | rss
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    Functioni

    Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing By similarity.By similarity

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. protein N-terminus binding Source: RGD

    GO - Biological processi

    1. homophilic cell adhesion Source: InterPro
    2. sensory perception of sound Source: UniProtKB-KW

    Keywords - Biological processi

    Cell adhesion, Hearing

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cadherin-23
    Alternative name(s):
    Otocadherin
    Gene namesi
    Name:Cdh23
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi619760. Cdh23.

    Subcellular locationi

    GO - Cellular componenti

    1. apical part of cell Source: RGD
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 33173294Cadherin-23PRO_0000003826Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi155 – 1551N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi206 – 2061N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi349 – 3491N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi391 – 3911N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi432 – 4321N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi464 – 4641N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi470 – 4701N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi600 – 6001N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi692 – 6921N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi763 – 7631N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi808 – 8081N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi825 – 8251N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi939 – 9391N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi999 – 9991N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1016 – 10161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1169 – 11691N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1280 – 12801N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1313 – 13131N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1471 – 14711N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1532 – 15321N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1649 – 16491N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1665 – 16651N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1816 – 18161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1855 – 18551N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1887 – 18871N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1900 – 19001N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2012 – 20121N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2048 – 20481N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2127 – 21271N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2166 – 21661N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2193 – 21931N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2261 – 22611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2355 – 23551N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2367 – 23671N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2576 – 25761N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2614 – 26141N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2747 – 27471N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2806 – 28061N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2875 – 28751N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2894 – 28941N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2939 – 29391N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2979 – 29791N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP58365.
    PRIDEiP58365.

    PTM databases

    PhosphoSiteiP58365.

    Expressioni

    Gene expression databases

    GenevestigatoriP58365.

    Interactioni

    Subunit structurei

    Interacts with USH1C and USH1G. antiparallel heterodimer with PCDH15 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000049630.

    Structurei

    3D structure databases

    ProteinModelPortaliP58365.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini24 – 30623039ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini3084 – 3317234CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei3063 – 308321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini34 – 13299Cadherin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini133 – 236104Cadherin 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini237 – 348112Cadherin 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini349 – 458110Cadherin 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini459 – 559101Cadherin 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini560 – 669110Cadherin 6PROSITE-ProRule annotationAdd
    BLAST
    Domaini670 – 782113Cadherin 7PROSITE-ProRule annotationAdd
    BLAST
    Domaini777 – 888112Cadherin 8PROSITE-ProRule annotationAdd
    BLAST
    Domaini889 – 993105Cadherin 9PROSITE-ProRule annotationAdd
    BLAST
    Domaini994 – 1100107Cadherin 10PROSITE-ProRule annotationAdd
    BLAST
    Domaini1101 – 1206106Cadherin 11PROSITE-ProRule annotationAdd
    BLAST
    Domaini1208 – 1311104Cadherin 12PROSITE-ProRule annotationAdd
    BLAST
    Domaini1312 – 1416105Cadherin 13PROSITE-ProRule annotationAdd
    BLAST
    Domaini1418 – 1525108Cadherin 14PROSITE-ProRule annotationAdd
    BLAST
    Domaini1527 – 1632106Cadherin 15PROSITE-ProRule annotationAdd
    BLAST
    Domaini1633 – 1742110Cadherin 16PROSITE-ProRule annotationAdd
    BLAST
    Domaini1743 – 1849107Cadherin 17PROSITE-ProRule annotationAdd
    BLAST
    Domaini1850 – 1957108Cadherin 18PROSITE-ProRule annotationAdd
    BLAST
    Domaini1958 – 2067110Cadherin 19PROSITE-ProRule annotationAdd
    BLAST
    Domaini2068 – 2172105Cadherin 20PROSITE-ProRule annotationAdd
    BLAST
    Domaini2173 – 2291119Cadherin 21PROSITE-ProRule annotationAdd
    BLAST
    Domaini2295 – 2400106Cadherin 22PROSITE-ProRule annotationAdd
    BLAST
    Domaini2401 – 2507107Cadherin 23PROSITE-ProRule annotationAdd
    BLAST
    Domaini2508 – 2609102Cadherin 24PROSITE-ProRule annotationAdd
    BLAST
    Domaini2612 – 2720109Cadherin 25PROSITE-ProRule annotationAdd
    BLAST
    Domaini2727 – 2844118Cadherin 26PROSITE-ProRule annotationAdd
    BLAST
    Domaini2845 – 2973129Cadherin 27PROSITE-ProRule annotationAdd
    BLAST

    Domaini

    Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity
    Cadherin repeats 1 and 2 mediate calcium-dependent heterophilic interaction with PCDH15.By similarity

    Sequence similaritiesi

    Contains 27 cadherin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG12793.
    HOGENOMiHOG000139588.
    HOVERGENiHBG050768.
    KOiK06813.
    PhylomeDBiP58365.

    Family and domain databases

    Gene3Di2.60.40.60. 27 hits.
    InterProiIPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    [Graphical view]
    PfamiPF00028. Cadherin. 25 hits.
    [Graphical view]
    PRINTSiPR00205. CADHERIN.
    SMARTiSM00112. CA. 26 hits.
    [Graphical view]
    SUPFAMiSSF49313. SSF49313. 27 hits.
    PROSITEiPS00232. CADHERIN_1. 17 hits.
    PS50268. CADHERIN_2. 27 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P58365-1 [UniParc]FASTAAdd to Basket

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    MRHPPVTWCA MLWLLMLVSG SWGQVNRLPF FTNHFFDTYL LISEDTPVGS     50
    SVTQLLARDM DNDPLVFGVS GEEASRFFAV EPDTGVVWLR QPLDRETKSE 100
    FTVEFSVSDH QGVITRKVNI QVGDVNDNAP TFHNQPYSVR IPENTPVGTP 150
    IFIVNATDPD LGAGGSVLYS FQPPSQFFAI DSARGIVTVI RELDYEVTQA 200
    YQLTVNATDQ DKTRPLSTLA NLAIIITDVQ DMDPIFINLP YSTNIYEHSP 250
    PGTTVRVITA VDQDKGRPRG IGYTIVSGNT NSIFALDYIS GALTLNGLLD 300
    RENPLYSHGF ILTVKGTELN DDRSPSDATV TTTFNILVID INDNAPEFNS 350
    SEYSVAITEL AQVGFALPLF IQVVDKDEGL NSMFEVYLVG NNSHHFIISP 400
    TSVQGKADIR IRVAIPLDYE TVDRYDFDLF ANESVPDHVG YAKVKITLIN 450
    ENDNRPIFSQ PLYNVSLYEN ITVGTSVLTV LATDNDVGTF GEVNYFFSDD 500
    PDRFSLDKDT GLIMLIARLD YELIQRFTLT VIARDGGGEE TTGRVRINVL 550
    DVNDNVPTFQ KDAYVGALRE NEPSVTQLVR LRATDEDSPP NNLITYSIVN 600
    ASAFGSYFDI SVYEGYGVIS VSRPLDYEQI PNGLIYLTVM AKDAGNPPLY 650
    STVPVTIEVF DENDNPPTFS KPAYFVSVVE NIMAGATVLF LNATDLDRSR 700
    EYGQESIIYS LEGSSQFRIN ARSGEITTTS LLDRETKAEY ILIVRAVDGG 750
    VGHNQKTGIA TVNVTLLDIN DNHPTWKDAP YYINLVEMTP PDSDVTTVVA 800
    VDPDLGKNGT LVYSIQPPNK FYSLNSTTGK IRTTHVMLDR ENPDPVEAEL 850
    MRKIIVSVTD CGRPPLKATS SATVFVNLLD LNDNDPTFQN LPFVAEVLEG 900
    TPAGVSVYQV VAIDLDEGLN GLVSYRMQVG MPRMDFVINS TSGVVTTTAE 950
    LDRERIAEYQ LRVVASDAGT PTKSSTSTLT IRVLDVNDET PTFFPAVYNV 1000
    SVSEDVPREF RVVWLNCTDN DVGLNAELSY FITAGNVDGK FSVGYRDAVV 1050
    RTVVGLDRET TAAYTLVLEA IDNVPVGKRR TGTATVFVTV LDVNDNRPIF 1100
    LQSSYEASVP EDIPEGHSIV QLKATDADEG EFGRVWYRIL HGNHGNNFRL 1150
    HVSSGLLVRG PRPLDRERNS SHVLMAEAYN HDLGPMRSSV RVIVYVEDVN 1200
    DEAPVFTQQQ YNRLGLRETA GIGTSVIVVR ATDRDTGDGG LVNYRILSGA 1250
    EGKFEIDEST GLIVTVDYLD YETKTSYLMN VSATDGAPPF NQGFCSVYVT 1300
    LLNELDEAVQ FSNASYEAVI MENLALGTEI VRVQAYSIDN LNQITYRFDA 1350
    YTSAQAKALF KIDAITGVIT VKGLVDREKG DFYTLTVVAD DGGPKVDSTV 1400
    KVYVTVLDEN DNSPRFDFTS DSAISVPEDC PVGQRVATVK ARDPDAGSNG 1450
    QVVFSLASGN IAGAFEIITS NDSIGEVFVA KPLDREELDH YILKIVASDR 1500
    GTPPRKKDHI LQVTILDVND NPPVIESPFG YNVSVNENVG GGTSVVQVRA 1550
    TDRDIGINSV LSYYITEGNE DMTFRMDRIS GEIATRPAPP DRERQNFYHL 1600
    VVTVEDEGTP TLSATTHVYV TIVDENDNAP VFQQPHYEVV LDEGPDTVNT 1650
    SLITVQALDL DEGPNGTVTY AIVAGNIINT FRINRRTGVI TAAKELDYEI 1700
    SHGRYTLIVT ATDQCPILSH RLTSTTTVLV NVNDINDNVP TFPRDYEGPF 1750
    DVTEGQPGPR VWTFLAHDRD SGPNGQVEYS VVDGDPLGEF VISPVEGVLR 1800
    VRKDVELDRE TIAFYNLTIC ARDRGVPPLS STMLVGIRVL DINDNDPVLL 1850
    NLPMNITISE NSPVSSFVAH VLASDADSGC NALLTFNITA GNRERAFFIN 1900
    ATTGIVTVNR PLDRERIPEY RLTVSVKDNP ENPRIARKDF DLLLVSLADE 1950
    NDNHPLFTEG TYQAEVMENS PAGTPLTVLN GPILALDADE DVYAVVTYQL 2000
    LGTHSDLFVI DNSTGVVTVR SGVIIDREAF SPPFLELLLL AEDVGQLNGT 2050
    AYLFITILDD NDNWPTFSPP AYTVHLLENC PPGFSVLQIT ATDEDSGLNG 2100
    ELVYRIEAGA QDRFLIHPVT GVIRVGNATI DREEQESYRL TVVATDRGTV 2150
    PLSGTATVTI LIDDINDSRP EFLNPIQTVS VLESTEPGTV IANVTAIDLD 2200
    LNPKLEYHIL SIVAKDDTDR LVPDQEDAFA VNINTGSVIV KSPLNRELVA 2250
    TYEVTLSVID NASDLPERSV SVPNAKLTVN ILDVNDNTPQ FKPFGITYYT 2300
    ERVLEGATPG TTLIAVAAVD PDKGLNGLIT YTLLDLIPPG YVQLEDSSAG 2350
    KVIANRTVDY EEVHWLNFTV RASDNGSPPR AAEIPVYLEI VDINDNNPIF 2400
    DQLSYQEAVF EDVAVGTVIL RVTATDADSG NFALIEYSLV DGEGKFAINP 2450
    NTGDIYVLSS LDREKKDHYI LTALAKDNPG DVASNRRENS VQVVIRVLDV 2500
    NDCRPQFSKP QFSTSVYENE PAGTSVITML ATDQDEGSNG QLTYSLEGPG 2550
    MEAFSVDMDS GLVTTQRPLQ SYERFNLTVV ATDGGEPPLW GTTMLLVEVI 2600
    DVNDNRPVFV RPPNGTILHI KEEIPLRSNV YEVYATDKDE GLNGAVRYSF 2650
    LKSTGNRDWE YFTIDPISGL IQTAQRLDRE KQAVYSLILV ASDLGQPVPY 2700
    ETMQPLQVAL EDIDDNEPLF VRPPKGSPQY QLLTVPEHSP RGTLVGNVTG 2750
    AVDADEGPNA IVYYFIAAGN EDKNFHLQPD GRLLVLRDLD RETEAIFSFI 2800
    VKASSNRSWT PPRGPSPALD LLTDLTLQEV RVVLEDINDQ PPRFTKAEYT 2850
    AGVATDAKVG SELIQVLALD ADIGNNSLVF YGILAIHYFR ALANDSEDVG 2900
    QVFTMGSVDG ILRTFDLFMA YSPGYFVVDI VARDLAGHND TAIIGIYILR 2950
    DDQRVKIVIN EIPDRVRGFE EEFIRLLSNI TGAIVNTDDV QFHVDMKGRV 3000
    NFAQTELLIH VVNRDTNRIL DVDRVIQMID ENKEQLRNLF RNYNVLDVQP 3050
    AISVQLPDDM SALQMAIIVL AILLFLAAML FVLMNWYYRT IHKRKLKAIV 3100
    AGSAGNRGFI DIMDMPNTNK YSFDGANPVW LDPFCRNLEL AAQAEHEDDL 3150
    PENLSEIADL WNSPTRTHGT FGREPAAVKP EDDRYLRAAI QEYDNIAKLG 3200
    QIIREGPIKL IHTDLEEEPG DHSPGQGSLR FRHKPPTELK GPDGIHIVHG 3250
    STGTLLATDL NSLPEDDQKG LDRSLETLTA SEATAFERNA RTESAKSTPL 3300
    HKLRDVIMES PLEITEL 3317
    Length:3,317
    Mass (Da):365,455
    Last modified:November 16, 2001 - v1
    Checksum:iCEF397A066BF0986
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB053447 mRNA. Translation: BAB61904.1.
    RefSeqiNP_446096.1. NM_053644.1.
    UniGeneiRn.208796.

    Genome annotation databases

    GeneIDi114102.
    KEGGirno:114102.
    UCSCiRGD:619760. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB053447 mRNA. Translation: BAB61904.1 .
    RefSeqi NP_446096.1. NM_053644.1.
    UniGenei Rn.208796.

    3D structure databases

    ProteinModelPortali P58365.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000049630.

    PTM databases

    PhosphoSitei P58365.

    Proteomic databases

    PaxDbi P58365.
    PRIDEi P58365.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 114102.
    KEGGi rno:114102.
    UCSCi RGD:619760. rat.

    Organism-specific databases

    CTDi 64072.
    RGDi 619760. Cdh23.

    Phylogenomic databases

    eggNOGi NOG12793.
    HOGENOMi HOG000139588.
    HOVERGENi HBG050768.
    KOi K06813.
    PhylomeDBi P58365.

    Miscellaneous databases

    NextBioi 618265.
    PROi P58365.

    Gene expression databases

    Genevestigatori P58365.

    Family and domain databases

    Gene3Di 2.60.40.60. 27 hits.
    InterProi IPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    [Graphical view ]
    Pfami PF00028. Cadherin. 25 hits.
    [Graphical view ]
    PRINTSi PR00205. CADHERIN.
    SMARTi SM00112. CA. 26 hits.
    [Graphical view ]
    SUPFAMi SSF49313. SSF49313. 27 hits.
    PROSITEi PS00232. CADHERIN_1. 17 hits.
    PS50268. CADHERIN_2. 27 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of three novel non-classical cadherin genes through comprehensive analysis of large cDNAs."
      Nakajima D., Nakayama M., Kikuno R., Hirosawa M., Nagase T., Ohara O.
      Brain Res. Mol. Brain Res. 94:85-95(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Testis.

    Entry informationi

    Entry nameiCAD23_RAT
    AccessioniPrimary (citable) accession number: P58365
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 16, 2001
    Last sequence update: November 16, 2001
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3