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P58355

- S45A2_MOUSE

UniProt

P58355 - S45A2_MOUSE

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Protein
Membrane-associated transporter protein
Gene
Slc45a2, Aim1, Matp, uw
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Melanocyte differentiation antigen. May transport substances required for melanin biosynthesis By similarity.

GO - Biological processi

  1. developmental pigmentation Source: MGI
  2. melanin biosynthetic process Source: UniProtKB-KW
  3. response to stimulus Source: UniProtKB-KW
  4. visual perception Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Melanin biosynthesis, Sensory transduction, Vision

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane-associated transporter protein
Alternative name(s):
Melanoma antigen AIM1
Short name:
Protein AIM-1
Protein underwhite
Solute carrier family 45 member 2
Gene namesi
Name:Slc45a2
Synonyms:Aim1, Matp, uw
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:2153040. Slc45a2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4545Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei46 – 6621Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini67 – 682Extracellular Reviewed prediction
Transmembranei69 – 8921Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini90 – 10516Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei106 – 12621Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini127 – 13812Extracellular Reviewed prediction
Add
BLAST
Transmembranei139 – 15921Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini160 – 18425Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei185 – 20521Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini206 – 21611Extracellular Reviewed prediction
Add
BLAST
Transmembranei217 – 23721Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini238 – 31881Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei319 – 33921Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini340 – 36627Extracellular Reviewed prediction
Add
BLAST
Transmembranei367 – 38721Helical; Name=8; Reviewed prediction
Add
BLAST
Topological domaini388 – 39811Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei399 – 41921Helical; Name=9; Reviewed prediction
Add
BLAST
Topological domaini420 – 4256Extracellular Reviewed prediction
Transmembranei426 – 44621Helical; Name=10; Reviewed prediction
Add
BLAST
Topological domaini447 – 47731Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei478 – 49821Helical; Name=11; Reviewed prediction
Add
BLAST
Topological domaini499 – 5046Extracellular Reviewed prediction
Transmembranei505 – 52521Helical; Name=12; Reviewed prediction
Add
BLAST
Topological domaini526 – 5305Cytoplasmic Reviewed prediction

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. melanosome membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Defects in Slc45a2 are the cause of the UW-dbr phenotype that results in loss of nearly all pigmentation in the homozygous state.

Keywords - Diseasei

Albinism, Disease mutation

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 530530Membrane-associated transporter protein
PRO_0000122518Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi356 – 3561N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP58355.

PTM databases

PhosphoSiteiP58355.

Expressioni

Tissue specificityi

Melanocytes, eyes, kidney and uterus.

Gene expression databases

BgeeiP58355.
CleanExiMM_SLC45A2.
GenevestigatoriP58355.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022851.

Structurei

3D structure databases

ProteinModelPortaliP58355.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG317436.
HOGENOMiHOG000128553.
HOVERGENiHBG018570.
InParanoidiP58355.
KOiK15378.
OMAiMGGNSGQ.
PhylomeDBiP58355.
TreeFamiTF325412.

Family and domain databases

InterProiIPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.

Sequencei

Sequence statusi: Complete.

P58355-1 [UniParc]FASTAAdd to Basket

« Hide

MSGSNGPTDT HTYQSLAEDC PFGSVEQPKR STGRLVMHSM AMFGREFCYA    50
VEAAYVTPVL LSVGLPKSLY SMVWLLSPIL GFLLQPVVGS ASDHCRARWG 100
RRRPYILTLA IMMLLGMALY LNGDAVVSAL VANPRQKLIW AISITMVGVV 150
LFDFSADFID GPIKAYLFDV CSHQDKEKGL HYHALFTGFG GALGYILGAI 200
DWVHLDLGRL LGTEFQVMFF FSALVLILCF ITHLCSIPEA PLRDAATDPP 250
SQQDPQGSSL SASGMHEYGS IEKVKNGGAD TEQPVQEWKN KKPSGQSQRT 300
MSMKSLLRAL VNMPSHYRCL CVSHLIGWTA FLSNMLFFTD FMGQIVYHGD 350
PYGAHNSTEF LIYERGVEVG CWGLCINSVF SSVYSYFQKA MVSYIGLKGL 400
YFMGYLLFGL GTGFIGLFPN VYSTLVLCSM FGVMSSTLYT VPFNLIAEYH 450
REEEKEKGQE APGGPDNQGR GKGVDCAALT CMVQLAQILV GGGLGFLVNM 500
AGSVVVVVIT ASAVSLIGCC FVALFVRYVD 530
Length:530
Mass (Da):57,961
Last modified:November 16, 2001 - v1
Checksum:iF4EDEAD07916D9FC
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti153 – 1531D → N in UW-dbr. 1 Publication
Natural varianti435 – 4351S → P in UW-dbr. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF360357 mRNA. Translation: AAK81713.1.
AK029155 mRNA. Translation: BAC26330.1.
CCDSiCCDS27382.1.
RefSeqiNP_444307.1. NM_053077.3.
XP_006520111.1. XM_006520048.1.
UniGeneiMm.138278.

Genome annotation databases

EnsembliENSMUST00000022851; ENSMUSP00000022851; ENSMUSG00000022243.
GeneIDi22293.
KEGGimmu:22293.
UCSCiuc007vgx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF360357 mRNA. Translation: AAK81713.1 .
AK029155 mRNA. Translation: BAC26330.1 .
CCDSi CCDS27382.1.
RefSeqi NP_444307.1. NM_053077.3.
XP_006520111.1. XM_006520048.1.
UniGenei Mm.138278.

3D structure databases

ProteinModelPortali P58355.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000022851.

PTM databases

PhosphoSitei P58355.

Proteomic databases

PRIDEi P58355.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000022851 ; ENSMUSP00000022851 ; ENSMUSG00000022243 .
GeneIDi 22293.
KEGGi mmu:22293.
UCSCi uc007vgx.1. mouse.

Organism-specific databases

CTDi 51151.
MGIi MGI:2153040. Slc45a2.

Phylogenomic databases

eggNOGi NOG317436.
HOGENOMi HOG000128553.
HOVERGENi HBG018570.
InParanoidi P58355.
KOi K15378.
OMAi MGGNSGQ.
PhylomeDBi P58355.
TreeFami TF325412.

Miscellaneous databases

ChiTaRSi SLC45A2. mouse.
NextBioi 302439.
PROi P58355.
SOURCEi Search...

Gene expression databases

Bgeei P58355.
CleanExi MM_SLC45A2.
Genevestigatori P58355.

Family and domain databases

InterProi IPR016196. MFS_dom_general_subst_transpt.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mutations in the gene encoding B, a novel transporter protein, reduce melanin content in medaka."
    Fukamachi S., Shimada A., Shima A.
    Nat. Genet. 28:381-385(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ddY.
    Tissue: Eye, Kidney and Uterus.
  2. "Mutations in the human orthologue of the mouse underwhite gene (uw) underlie a new form of oculocutaneous albinism, OCA4."
    Newton J.M., Cohen-Barak O., Hagiwara N., Gardner J.M., Davisson M.T., King R.A., Brilliant M.H.
    Am. J. Hum. Genet. 69:981-988(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS UW-DBR ASN-153 AND PRO-435.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Skin.

Entry informationi

Entry nameiS45A2_MOUSE
AccessioniPrimary (citable) accession number: P58355
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: November 16, 2001
Last modified: July 9, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi