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Protein

Membrane-associated transporter protein

Gene

Slc45a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Melanocyte differentiation antigen. May transport substances required for melanin biosynthesis (By similarity).By similarity

GO - Molecular functioni

  • sucrose:proton symporter activity Source: MGI

GO - Biological processi

  • developmental pigmentation Source: MGI
  • melanin biosynthetic process Source: UniProtKB-KW
  • response to stimulus Source: UniProtKB-KW
  • sucrose transport Source: MGI
  • visual perception Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Melanin biosynthesis, Sensory transduction, Vision

Enzyme and pathway databases

ReactomeiR-MMU-5662702. Melanin biosynthesis.

Protein family/group databases

TCDBi2.A.2.4.14. the glycoside-pentoside-hexuronide (gph):cation symporter family.

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane-associated transporter protein
Alternative name(s):
Melanoma antigen AIM1
Short name:
Protein AIM-1
Protein underwhite
Solute carrier family 45 member 2
Gene namesi
Name:Slc45a2
Synonyms:Aim1, Matp, uw
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2153040. Slc45a2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 45CytoplasmicSequence analysisAdd BLAST45
Transmembranei46 – 66Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini67 – 68ExtracellularSequence analysis2
Transmembranei69 – 89Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini90 – 105CytoplasmicSequence analysisAdd BLAST16
Transmembranei106 – 126Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini127 – 138ExtracellularSequence analysisAdd BLAST12
Transmembranei139 – 159Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini160 – 184CytoplasmicSequence analysisAdd BLAST25
Transmembranei185 – 205Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini206 – 216ExtracellularSequence analysisAdd BLAST11
Transmembranei217 – 237Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini238 – 318CytoplasmicSequence analysisAdd BLAST81
Transmembranei319 – 339Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini340 – 366ExtracellularSequence analysisAdd BLAST27
Transmembranei367 – 387Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini388 – 398CytoplasmicSequence analysisAdd BLAST11
Transmembranei399 – 419Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini420 – 425ExtracellularSequence analysis6
Transmembranei426 – 446Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini447 – 477CytoplasmicSequence analysisAdd BLAST31
Transmembranei478 – 498Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini499 – 504ExtracellularSequence analysis6
Transmembranei505 – 525Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini526 – 530CytoplasmicSequence analysis5

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Defects in Slc45a2 are the cause of the UW-dbr phenotype that results in loss of nearly all pigmentation in the homozygous state.

Keywords - Diseasei

Albinism, Disease mutation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001225181 – 530Membrane-associated transporter proteinAdd BLAST530

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi356N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP58355.
PRIDEiP58355.

PTM databases

iPTMnetiP58355.
PhosphoSitePlusiP58355.

Expressioni

Tissue specificityi

Melanocytes, eyes, kidney and uterus.

Gene expression databases

BgeeiENSMUSG00000022243.
CleanExiMM_SLC45A2.
ExpressionAtlasiP58355. baseline and differential.
GenevisibleiP58355. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022851.

Structurei

3D structure databases

ProteinModelPortaliP58355.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0637. Eukaryota.
ENOG410XPTR. LUCA.
GeneTreeiENSGT00390000018882.
HOGENOMiHOG000128553.
HOVERGENiHBG018570.
InParanoidiP58355.
KOiK15378.
OMAiTSFGVMS.
OrthoDBiEOG091G05H5.
PhylomeDBiP58355.
TreeFamiTF325412.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.

Sequencei

Sequence statusi: Complete.

P58355-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGSNGPTDT HTYQSLAEDC PFGSVEQPKR STGRLVMHSM AMFGREFCYA
60 70 80 90 100
VEAAYVTPVL LSVGLPKSLY SMVWLLSPIL GFLLQPVVGS ASDHCRARWG
110 120 130 140 150
RRRPYILTLA IMMLLGMALY LNGDAVVSAL VANPRQKLIW AISITMVGVV
160 170 180 190 200
LFDFSADFID GPIKAYLFDV CSHQDKEKGL HYHALFTGFG GALGYILGAI
210 220 230 240 250
DWVHLDLGRL LGTEFQVMFF FSALVLILCF ITHLCSIPEA PLRDAATDPP
260 270 280 290 300
SQQDPQGSSL SASGMHEYGS IEKVKNGGAD TEQPVQEWKN KKPSGQSQRT
310 320 330 340 350
MSMKSLLRAL VNMPSHYRCL CVSHLIGWTA FLSNMLFFTD FMGQIVYHGD
360 370 380 390 400
PYGAHNSTEF LIYERGVEVG CWGLCINSVF SSVYSYFQKA MVSYIGLKGL
410 420 430 440 450
YFMGYLLFGL GTGFIGLFPN VYSTLVLCSM FGVMSSTLYT VPFNLIAEYH
460 470 480 490 500
REEEKEKGQE APGGPDNQGR GKGVDCAALT CMVQLAQILV GGGLGFLVNM
510 520 530
AGSVVVVVIT ASAVSLIGCC FVALFVRYVD
Length:530
Mass (Da):57,961
Last modified:November 16, 2001 - v1
Checksum:iF4EDEAD07916D9FC
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti153D → N in UW-dbr. 1 Publication1
Natural varianti435S → P in UW-dbr. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF360357 mRNA. Translation: AAK81713.1.
AK029155 mRNA. Translation: BAC26330.1.
CCDSiCCDS27382.1.
RefSeqiNP_444307.1. NM_053077.3.
UniGeneiMm.138278.

Genome annotation databases

EnsembliENSMUST00000117100; ENSMUSP00000112408; ENSMUSG00000022243.
GeneIDi22293.
KEGGimmu:22293.
UCSCiuc007vgx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF360357 mRNA. Translation: AAK81713.1.
AK029155 mRNA. Translation: BAC26330.1.
CCDSiCCDS27382.1.
RefSeqiNP_444307.1. NM_053077.3.
UniGeneiMm.138278.

3D structure databases

ProteinModelPortaliP58355.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022851.

Protein family/group databases

TCDBi2.A.2.4.14. the glycoside-pentoside-hexuronide (gph):cation symporter family.

PTM databases

iPTMnetiP58355.
PhosphoSitePlusiP58355.

Proteomic databases

PaxDbiP58355.
PRIDEiP58355.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000117100; ENSMUSP00000112408; ENSMUSG00000022243.
GeneIDi22293.
KEGGimmu:22293.
UCSCiuc007vgx.1. mouse.

Organism-specific databases

CTDi51151.
MGIiMGI:2153040. Slc45a2.

Phylogenomic databases

eggNOGiKOG0637. Eukaryota.
ENOG410XPTR. LUCA.
GeneTreeiENSGT00390000018882.
HOGENOMiHOG000128553.
HOVERGENiHBG018570.
InParanoidiP58355.
KOiK15378.
OMAiTSFGVMS.
OrthoDBiEOG091G05H5.
PhylomeDBiP58355.
TreeFamiTF325412.

Enzyme and pathway databases

ReactomeiR-MMU-5662702. Melanin biosynthesis.

Miscellaneous databases

ChiTaRSiSlc45a2. mouse.
PROiP58355.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022243.
CleanExiMM_SLC45A2.
ExpressionAtlasiP58355. baseline and differential.
GenevisibleiP58355. MM.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiS45A2_MOUSE
AccessioniPrimary (citable) accession number: P58355
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: November 16, 2001
Last modified: November 30, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.