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Protein

Solute carrier family 2, facilitated glucose transporter member 5

Gene

SLC2A5

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a fructose transporter that has only low activity with other monosaccharides. Can mediate the uptake of deoxyglucose, but with low efficiency. Essential for fructose uptake in the small intestine. Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose. Required for the development of high blood pressure in response to high dietary fructose intake.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei32FructoseBy similarity1
Binding sitei167FructoseBy similarity1
Binding sitei288FructoseBy similarity1
Binding sitei387FructoseBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 2, facilitated glucose transporter member 5
Alternative name(s):
Fructose transporter
Glucose transporter type 5, small intestine
Short name:
GLUT-5
Gene namesi
Name:SLC2A5
Synonyms:GLUT5
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 18Cytoplasmic1 PublicationAdd BLAST18
Transmembranei19 – 39Helical; Name=11 PublicationAdd BLAST21
Topological domaini40 – 68Extracellular1 PublicationAdd BLAST29
Transmembranei69 – 91Helical; Name=21 PublicationAdd BLAST23
Topological domaini92 – 98Cytoplasmic1 Publication7
Transmembranei99 – 119Helical; Name=31 PublicationAdd BLAST21
Topological domaini120 – 126Extracellular1 Publication7
Transmembranei127 – 149Helical; Name=41 PublicationAdd BLAST23
Topological domaini150 – 161Cytoplasmic1 PublicationAdd BLAST12
Transmembranei162 – 182Helical; Name=51 PublicationAdd BLAST21
Topological domaini183 – 192Extracellular1 Publication10
Transmembranei193 – 213Helical; Name=61 PublicationAdd BLAST21
Topological domaini214 – 277Cytoplasmic1 PublicationAdd BLAST64
Transmembranei278 – 298Helical; Name=71 PublicationAdd BLAST21
Topological domaini299 – 313Extracellular1 PublicationAdd BLAST15
Transmembranei314 – 334Helical; Name=81 PublicationAdd BLAST21
Topological domaini335 – 342Cytoplasmic1 Publication8
Transmembranei343 – 363Helical; Name=91 PublicationAdd BLAST21
Topological domaini364 – 371Extracellular1 Publication8
Transmembranei372 – 394Helical; Name=101 PublicationAdd BLAST23
Topological domaini395 – 412Cytoplasmic1 PublicationAdd BLAST18
Transmembranei413 – 433Helical; Name=111 PublicationAdd BLAST21
Topological domaini434 – 439Extracellular1 Publication6
Transmembranei440 – 460Helical; Name=121 PublicationAdd BLAST21
Topological domaini461 – 501Cytoplasmic1 PublicationAdd BLAST41

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000503671 – 501Solute carrier family 2, facilitated glucose transporter member 5Add BLAST501

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Glycosylationi51N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Acetylation, Glycoprotein

Proteomic databases

PaxDbiP58353.
PRIDEiP58353.

Expressioni

Gene expression databases

BgeeiENSBTAG00000034323.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000045621.

Structurei

Secondary structure

1501
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi20 – 23Combined sources4
Helixi28 – 37Combined sources10
Turni38 – 40Combined sources3
Helixi43 – 55Combined sources13
Helixi64 – 87Combined sources24
Helixi89 – 93Combined sources5
Helixi98 – 108Combined sources11
Helixi110 – 117Combined sources8
Turni119 – 121Combined sources3
Helixi124 – 127Combined sources4
Helixi129 – 153Combined sources25
Beta strandi156 – 158Combined sources3
Helixi160 – 162Combined sources3
Helixi165 – 179Combined sources15
Turni183 – 186Combined sources4
Turni189 – 191Combined sources3
Helixi192 – 197Combined sources6
Helixi198 – 200Combined sources3
Helixi201 – 209Combined sources9
Helixi210 – 212Combined sources3
Helixi217 – 222Combined sources6
Helixi227 – 234Combined sources8
Helixi246 – 250Combined sources5
Helixi253 – 260Combined sources8
Helixi266 – 270Combined sources5
Beta strandi272 – 274Combined sources3
Helixi275 – 289Combined sources15
Helixi294 – 305Combined sources12
Turni306 – 308Combined sources3
Helixi313 – 338Combined sources26
Helixi341 – 362Combined sources22
Turni367 – 370Combined sources4
Helixi371 – 387Combined sources17
Turni388 – 393Combined sources6
Helixi394 – 402Combined sources9
Turni405 – 407Combined sources3
Helixi408 – 436Combined sources29
Helixi438 – 440Combined sources3
Helixi443 – 458Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4YB9X-ray3.20D1-473[»]
ProteinModelPortaliP58353.
SMRiP58353.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni296 – 298Fructose bindingBy similarity3
Regioni419 – 420Fructose bindingBy similarity2

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0569. Eukaryota.
COG0477. LUCA.
HOGENOMiHOG000202871.
HOVERGENiHBG014816.
InParanoidiP58353.
KOiK08143.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002442. Fru_transpt_5.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR01194. GLUCTRSPORT5.
PR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P58353-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPQDPVKRE GRLTPVIVLA TLIAAFGSSF QYGYNVAAIN SPSEFMKDFY
60 70 80 90 100
NYTYYDRVGE YMNEFYLTLL WSVTVSMFPF GGFLGSLMVG PLVNNLGRKG
110 120 130 140 150
TLLFNNIFSI VPALLMGFSE LAKSFEMIIV ARVLVGICAG LSSNVVPMYL
160 170 180 190 200
GELAPKNWRG ALGVVPQLFI TIGILVAQIF GLRSLLANEE GWPILLGLTG
210 220 230 240 250
IPAVLQLLFL PFFPESPRYL LIQKKDEAAA KSALRRLRGW HDVDAEIEEI
260 270 280 290 300
LEEDRAEKAV GFISVLKLFK MRSLRWQVIS IIVLMAGQQL SGVNAIYYYA
310 320 330 340 350
DQIYLSAGVN EDDVQYVTAG TGAVNVLITV CAIFVVELMG RRFLLLLGFS
360 370 380 390 400
VCFTACCVLT GALALQDVIS WMPYVSIACV ISYVIGHALG PSPIPALLVT
410 420 430 440 450
EIFLQSSRPA AYMVAGTVHW LSNFTVGLVF PFIQVGLGAY SFVIFAVICL
460 470 480 490 500
LTTVYIFLII PETKSKTFIE INRIFIKMNK VPGVHPEKEE LKEFPPSTAR

Q
Length:501
Mass (Da):55,393
Last modified:February 5, 2008 - v2
Checksum:i6752DA90FFFDC3F3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti255R → E in AAK63203 (PubMed:11599048).Curated1
Sequence conflicti353F → L in AAK63203 (PubMed:11599048).Curated1
Sequence conflicti454V → I in AAK63203 (PubMed:11599048).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC151530 mRNA. Translation: AAI51531.1.
AF308830 mRNA. Translation: AAK63203.1.
RefSeqiNP_001094512.1. NM_001101042.2.
UniGeneiBt.19805.

Genome annotation databases

GeneIDi282868.
KEGGibta:282868.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC151530 mRNA. Translation: AAI51531.1.
AF308830 mRNA. Translation: AAK63203.1.
RefSeqiNP_001094512.1. NM_001101042.2.
UniGeneiBt.19805.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4YB9X-ray3.20D1-473[»]
ProteinModelPortaliP58353.
SMRiP58353.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000045621.

Proteomic databases

PaxDbiP58353.
PRIDEiP58353.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi282868.
KEGGibta:282868.

Organism-specific databases

CTDi6518.

Phylogenomic databases

eggNOGiKOG0569. Eukaryota.
COG0477. LUCA.
HOGENOMiHOG000202871.
HOVERGENiHBG014816.
InParanoidiP58353.
KOiK08143.

Gene expression databases

BgeeiENSBTAG00000034323.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002442. Fru_transpt_5.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR01194. GLUCTRSPORT5.
PR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGTR5_BOVIN
AccessioniPrimary (citable) accession number: P58353
Secondary accession number(s): A7MBF2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: February 5, 2008
Last modified: November 30, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.