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Protein

Solute carrier family 2, facilitated glucose transporter member 5

Gene

SLC2A5

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a fructose transporter that has only low activity with other monosaccharides. Can mediate the uptake of deoxyglucose, but with low efficiency. Essential for fructose uptake in the small intestine. Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose. Required for the development of high blood pressure in response to high dietary fructose intake.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei32 – 321FructoseBy similarity
Binding sitei167 – 1671FructoseBy similarity
Binding sitei288 – 2881FructoseBy similarity
Binding sitei387 – 3871FructoseBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 2, facilitated glucose transporter member 5
Alternative name(s):
Fructose transporter
Glucose transporter type 5, small intestine
Short name:
GLUT-5
Gene namesi
Name:SLC2A5
Synonyms:GLUT5
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1818Cytoplasmic1 PublicationAdd
BLAST
Transmembranei19 – 3921Helical; Name=11 PublicationAdd
BLAST
Topological domaini40 – 6829Extracellular1 PublicationAdd
BLAST
Transmembranei69 – 9123Helical; Name=21 PublicationAdd
BLAST
Topological domaini92 – 987Cytoplasmic1 Publication
Transmembranei99 – 11921Helical; Name=31 PublicationAdd
BLAST
Topological domaini120 – 1267Extracellular1 Publication
Transmembranei127 – 14923Helical; Name=41 PublicationAdd
BLAST
Topological domaini150 – 16112Cytoplasmic1 PublicationAdd
BLAST
Transmembranei162 – 18221Helical; Name=51 PublicationAdd
BLAST
Topological domaini183 – 19210Extracellular1 Publication
Transmembranei193 – 21321Helical; Name=61 PublicationAdd
BLAST
Topological domaini214 – 27764Cytoplasmic1 PublicationAdd
BLAST
Transmembranei278 – 29821Helical; Name=71 PublicationAdd
BLAST
Topological domaini299 – 31315Extracellular1 PublicationAdd
BLAST
Transmembranei314 – 33421Helical; Name=81 PublicationAdd
BLAST
Topological domaini335 – 3428Cytoplasmic1 Publication
Transmembranei343 – 36321Helical; Name=91 PublicationAdd
BLAST
Topological domaini364 – 3718Extracellular1 Publication
Transmembranei372 – 39423Helical; Name=101 PublicationAdd
BLAST
Topological domaini395 – 41218Cytoplasmic1 PublicationAdd
BLAST
Transmembranei413 – 43321Helical; Name=111 PublicationAdd
BLAST
Topological domaini434 – 4396Extracellular1 Publication
Transmembranei440 – 46021Helical; Name=121 PublicationAdd
BLAST
Topological domaini461 – 50141Cytoplasmic1 PublicationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 501501Solute carrier family 2, facilitated glucose transporter member 5PRO_0000050367Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Glycosylationi51 – 511N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Acetylation, Glycoprotein

Proteomic databases

PaxDbiP58353.
PRIDEiP58353.

Expressioni

Gene expression databases

BgeeiENSBTAG00000034323.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000045621.

Structurei

Secondary structure

1
501
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi20 – 234Combined sources
Helixi28 – 3710Combined sources
Turni38 – 403Combined sources
Helixi43 – 5513Combined sources
Helixi64 – 8724Combined sources
Helixi89 – 935Combined sources
Helixi98 – 10811Combined sources
Helixi110 – 1178Combined sources
Turni119 – 1213Combined sources
Helixi124 – 1274Combined sources
Helixi129 – 15325Combined sources
Beta strandi156 – 1583Combined sources
Helixi160 – 1623Combined sources
Helixi165 – 17915Combined sources
Turni183 – 1864Combined sources
Turni189 – 1913Combined sources
Helixi192 – 1976Combined sources
Helixi198 – 2003Combined sources
Helixi201 – 2099Combined sources
Helixi210 – 2123Combined sources
Helixi217 – 2226Combined sources
Helixi227 – 2348Combined sources
Helixi246 – 2505Combined sources
Helixi253 – 2608Combined sources
Helixi266 – 2705Combined sources
Beta strandi272 – 2743Combined sources
Helixi275 – 28915Combined sources
Helixi294 – 30512Combined sources
Turni306 – 3083Combined sources
Helixi313 – 33826Combined sources
Helixi341 – 36222Combined sources
Turni367 – 3704Combined sources
Helixi371 – 38717Combined sources
Turni388 – 3936Combined sources
Helixi394 – 4029Combined sources
Turni405 – 4073Combined sources
Helixi408 – 43629Combined sources
Helixi438 – 4403Combined sources
Helixi443 – 45816Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4YB9X-ray3.20D1-473[»]
ProteinModelPortaliP58353.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni296 – 2983Fructose bindingBy similarity
Regioni419 – 4202Fructose bindingBy similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0569. Eukaryota.
COG0477. LUCA.
HOGENOMiHOG000202871.
HOVERGENiHBG014816.
InParanoidiP58353.
KOiK08143.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002442. Fru_transpt_5.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR01194. GLUCTRSPORT5.
PR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P58353-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPQDPVKRE GRLTPVIVLA TLIAAFGSSF QYGYNVAAIN SPSEFMKDFY
60 70 80 90 100
NYTYYDRVGE YMNEFYLTLL WSVTVSMFPF GGFLGSLMVG PLVNNLGRKG
110 120 130 140 150
TLLFNNIFSI VPALLMGFSE LAKSFEMIIV ARVLVGICAG LSSNVVPMYL
160 170 180 190 200
GELAPKNWRG ALGVVPQLFI TIGILVAQIF GLRSLLANEE GWPILLGLTG
210 220 230 240 250
IPAVLQLLFL PFFPESPRYL LIQKKDEAAA KSALRRLRGW HDVDAEIEEI
260 270 280 290 300
LEEDRAEKAV GFISVLKLFK MRSLRWQVIS IIVLMAGQQL SGVNAIYYYA
310 320 330 340 350
DQIYLSAGVN EDDVQYVTAG TGAVNVLITV CAIFVVELMG RRFLLLLGFS
360 370 380 390 400
VCFTACCVLT GALALQDVIS WMPYVSIACV ISYVIGHALG PSPIPALLVT
410 420 430 440 450
EIFLQSSRPA AYMVAGTVHW LSNFTVGLVF PFIQVGLGAY SFVIFAVICL
460 470 480 490 500
LTTVYIFLII PETKSKTFIE INRIFIKMNK VPGVHPEKEE LKEFPPSTAR

Q
Length:501
Mass (Da):55,393
Last modified:February 5, 2008 - v2
Checksum:i6752DA90FFFDC3F3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti255 – 2551R → E in AAK63203 (PubMed:11599048).Curated
Sequence conflicti353 – 3531F → L in AAK63203 (PubMed:11599048).Curated
Sequence conflicti454 – 4541V → I in AAK63203 (PubMed:11599048).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC151530 mRNA. Translation: AAI51531.1.
AF308830 mRNA. Translation: AAK63203.1.
RefSeqiNP_001094512.1. NM_001101042.2.
UniGeneiBt.19805.

Genome annotation databases

GeneIDi282868.
KEGGibta:282868.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC151530 mRNA. Translation: AAI51531.1.
AF308830 mRNA. Translation: AAK63203.1.
RefSeqiNP_001094512.1. NM_001101042.2.
UniGeneiBt.19805.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4YB9X-ray3.20D1-473[»]
ProteinModelPortaliP58353.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000045621.

Proteomic databases

PaxDbiP58353.
PRIDEiP58353.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi282868.
KEGGibta:282868.

Organism-specific databases

CTDi6518.

Phylogenomic databases

eggNOGiKOG0569. Eukaryota.
COG0477. LUCA.
HOGENOMiHOG000202871.
HOVERGENiHBG014816.
InParanoidiP58353.
KOiK08143.

Gene expression databases

BgeeiENSBTAG00000034323.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002442. Fru_transpt_5.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR01194. GLUCTRSPORT5.
PR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGTR5_BOVIN
AccessioniPrimary (citable) accession number: P58353
Secondary accession number(s): A7MBF2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: February 5, 2008
Last modified: September 7, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.