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Protein

Solute carrier family 2, facilitated glucose transporter member 2

Gene

SLC2A2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na+/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei347 – 3471MonosaccharideBy similarity
Binding sitei418 – 4181MonosaccharideBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

ReactomeiR-BTA-189200. Hexose transport.
R-BTA-422356. Regulation of insulin secretion.
R-BTA-428790. Facilitative Na+-independent glucose transporters.
R-BTA-70153. Glucose transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 2, facilitated glucose transporter member 2
Alternative name(s):
Glucose transporter type 2, liver
Short name:
GLUT-2
Gene namesi
Name:SLC2A2
Synonyms:GLUT2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 1

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010CytoplasmicSequence analysis
Transmembranei11 – 3121Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini32 – 9665ExtracellularSequence analysisAdd
BLAST
Transmembranei97 – 11721Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini118 – 1225CytoplasmicSequence analysis
Transmembranei123 – 14321Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini144 – 15714ExtracellularSequence analysisAdd
BLAST
Transmembranei158 – 17821Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini179 – 19113CytoplasmicSequence analysisAdd
BLAST
Transmembranei192 – 21221Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini213 – 2153ExtracellularSequence analysis
Transmembranei216 – 23621Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini237 – 30165CytoplasmicSequence analysisAdd
BLAST
Transmembranei302 – 32221Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini323 – 33614ExtracellularSequence analysisAdd
BLAST
Transmembranei337 – 35721Helical; Name=8Sequence analysisAdd
BLAST
Topological domaini358 – 3658CytoplasmicSequence analysis
Transmembranei366 – 38621Helical; Name=9Sequence analysisAdd
BLAST
Topological domaini387 – 40014ExtracellularSequence analysisAdd
BLAST
Transmembranei401 – 42121Helical; Name=10Sequence analysisAdd
BLAST
Topological domaini422 – 43110CytoplasmicSequence analysis
Transmembranei432 – 45221Helical; Name=11Sequence analysisAdd
BLAST
Topological domaini453 – 4542ExtracellularSequence analysis
Transmembranei455 – 47521Helical; Name=12Sequence analysisAdd
BLAST
Topological domaini476 – 51035CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 510510Solute carrier family 2, facilitated glucose transporter member 2PRO_0000050345Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi62 – 621N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

N-glycosylated; required for stability and retention at the cell surface of pancreatic beta cells.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP58351.

Expressioni

Gene expression databases

BgeeiENSBTAG00000005386.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000050612.

Structurei

3D structure databases

ProteinModelPortaliP58351.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni312 – 3187Monosaccharide bindingBy similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0569. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00760000119022.
HOGENOMiHOG000202871.
HOVERGENiHBG014816.
InParanoidiP58351.
KOiK07593.
OMAiETEGSAH.
OrthoDBiEOG091G0A9K.
TreeFamiTF313762.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002440. Glc_transpt_2.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR01191. GLUCTRSPORT2.
PR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P58351-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEDKVTGTL VLAVFTAVLS SFQFGYDIGV INAPQQVIIT HYRHVLGVSL
60 70 80 90 100
DDRIAINNYA LNSTEELPTS LGDPTPVSWA EEETMTSASL ITMFWSLSVS
110 120 130 140 150
SFAVGGMIAS FFGGLLGDKL GRIKALLVAN ILSLVGALLM GFSKLGPSHI
160 170 180 190 200
LIISGRGISG LYCGLISGLI PMYIGEIAPT TLRGAIGALH QLAIVTGILI
210 220 230 240 250
SQIVGLDFIL GNHELWHILL GLSAVPAILQ CLLLFFCPES PRYLYIKLDE
260 270 280 290 300
EAKAKKSLKR LRGSDDITKD ITEMRKEREE ASNEKKVSII QLFTNASYRQ
310 320 330 340 350
PILVALMLHA AQQFSGINGI FYYSTSIFQT AGISQPVYAT IGVGAVNTVF
360 370 380 390 400
TAVSVFLVEK AGRRSLFLIG MSGMFVCAIF MSVGLVLLSK FPWMNYVSMT
410 420 430 440 450
AIFLFVSFFE IGPGPIPWFM VAEFFSQGPR PAALAIAAFS NWTGNFIIAL
460 470 480 490 500
CFQYIADFCG PYVFFLLLVW SWPLFCSHFL KFQKPKENPL RKSQQSSERR
510
GVQLKRQKLL
Length:510
Mass (Da):56,060
Last modified:February 10, 2009 - v2
Checksum:iC91767EF2C079617
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti258 – 2581L → W in AAK63201 (PubMed:11599048).Curated
Sequence conflicti278 – 2781R → G in AAK63201 (PubMed:11599048).Curated
Sequence conflicti395 – 3951N → S in AAK63201 (PubMed:11599048).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC149324 mRNA. Translation: AAI49325.1.
AF308828 mRNA. Translation: AAK63201.1.
RefSeqiNP_001096692.1. NM_001103222.1.
UniGeneiBt.13076.

Genome annotation databases

EnsembliENSBTAT00000055725; ENSBTAP00000050612; ENSBTAG00000005386.
GeneIDi282357.
KEGGibta:282357.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC149324 mRNA. Translation: AAI49325.1.
AF308828 mRNA. Translation: AAK63201.1.
RefSeqiNP_001096692.1. NM_001103222.1.
UniGeneiBt.13076.

3D structure databases

ProteinModelPortaliP58351.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000050612.

Proteomic databases

PaxDbiP58351.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000055725; ENSBTAP00000050612; ENSBTAG00000005386.
GeneIDi282357.
KEGGibta:282357.

Organism-specific databases

CTDi6514.

Phylogenomic databases

eggNOGiKOG0569. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00760000119022.
HOGENOMiHOG000202871.
HOVERGENiHBG014816.
InParanoidiP58351.
KOiK07593.
OMAiETEGSAH.
OrthoDBiEOG091G0A9K.
TreeFamiTF313762.

Enzyme and pathway databases

ReactomeiR-BTA-189200. Hexose transport.
R-BTA-422356. Regulation of insulin secretion.
R-BTA-428790. Facilitative Na+-independent glucose transporters.
R-BTA-70153. Glucose transport.

Gene expression databases

BgeeiENSBTAG00000005386.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002440. Glc_transpt_2.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR01191. GLUCTRSPORT2.
PR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGTR2_BOVIN
AccessioniPrimary (citable) accession number: P58351
Secondary accession number(s): A6QPH3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: February 10, 2009
Last modified: September 7, 2016
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.