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Protein

Solute carrier family 2, facilitated glucose transporter member 2

Gene

SLC2A2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na+/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei347MonosaccharideBy similarity1
Binding sitei418MonosaccharideBy similarity1

GO - Molecular functioni

Keywordsi

Biological processSugar transport, Transport

Enzyme and pathway databases

ReactomeiR-BTA-189200 Cellular hexose transport
R-BTA-422356 Regulation of insulin secretion
R-BTA-8981373 Intestinal hexose absorption

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 2, facilitated glucose transporter member 2
Alternative name(s):
Glucose transporter type 2, liver
Short name:
GLUT-2
Gene namesi
Name:SLC2A2
Synonyms:GLUT2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 1

Organism-specific databases

VGNCiVGNC:34800 SLC2A2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10CytoplasmicSequence analysis10
Transmembranei11 – 31Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini32 – 96ExtracellularSequence analysisAdd BLAST65
Transmembranei97 – 117Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini118 – 122CytoplasmicSequence analysis5
Transmembranei123 – 143Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini144 – 157ExtracellularSequence analysisAdd BLAST14
Transmembranei158 – 178Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini179 – 191CytoplasmicSequence analysisAdd BLAST13
Transmembranei192 – 212Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini213 – 215ExtracellularSequence analysis3
Transmembranei216 – 236Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini237 – 301CytoplasmicSequence analysisAdd BLAST65
Transmembranei302 – 322Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini323 – 336ExtracellularSequence analysisAdd BLAST14
Transmembranei337 – 357Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini358 – 365CytoplasmicSequence analysis8
Transmembranei366 – 386Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini387 – 400ExtracellularSequence analysisAdd BLAST14
Transmembranei401 – 421Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini422 – 431CytoplasmicSequence analysis10
Transmembranei432 – 452Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini453 – 454ExtracellularSequence analysis2
Transmembranei455 – 475Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini476 – 510CytoplasmicSequence analysisAdd BLAST35

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000503451 – 510Solute carrier family 2, facilitated glucose transporter member 2Add BLAST510

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi62N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated; required for stability and retention at the cell surface of pancreatic beta cells.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP58351
PRIDEiP58351

Expressioni

Gene expression databases

BgeeiENSBTAG00000005386

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000050612

Structurei

3D structure databases

ProteinModelPortaliP58351
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni312 – 318Monosaccharide bindingBy similarity7

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0569 Eukaryota
COG0477 LUCA
GeneTreeiENSGT00760000119022
HOGENOMiHOG000202871
HOVERGENiHBG014816
InParanoidiP58351
KOiK07593
OMAiFQFGYDI
OrthoDBiEOG091G0A9K
TreeFamiTF313762

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR002440 Glc_transpt_2
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR003663 Sugar/inositol_transpt
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
PRINTSiPR01191 GLUCTRSPORT2
PR00171 SUGRTRNSPORT
SUPFAMiSSF103473 SSF103473, 3 hits
TIGRFAMsiTIGR00879 SP, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 1 hit
PS00217 SUGAR_TRANSPORT_2, 1 hit

Sequencei

Sequence statusi: Complete.

P58351-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEDKVTGTL VLAVFTAVLS SFQFGYDIGV INAPQQVIIT HYRHVLGVSL
60 70 80 90 100
DDRIAINNYA LNSTEELPTS LGDPTPVSWA EEETMTSASL ITMFWSLSVS
110 120 130 140 150
SFAVGGMIAS FFGGLLGDKL GRIKALLVAN ILSLVGALLM GFSKLGPSHI
160 170 180 190 200
LIISGRGISG LYCGLISGLI PMYIGEIAPT TLRGAIGALH QLAIVTGILI
210 220 230 240 250
SQIVGLDFIL GNHELWHILL GLSAVPAILQ CLLLFFCPES PRYLYIKLDE
260 270 280 290 300
EAKAKKSLKR LRGSDDITKD ITEMRKEREE ASNEKKVSII QLFTNASYRQ
310 320 330 340 350
PILVALMLHA AQQFSGINGI FYYSTSIFQT AGISQPVYAT IGVGAVNTVF
360 370 380 390 400
TAVSVFLVEK AGRRSLFLIG MSGMFVCAIF MSVGLVLLSK FPWMNYVSMT
410 420 430 440 450
AIFLFVSFFE IGPGPIPWFM VAEFFSQGPR PAALAIAAFS NWTGNFIIAL
460 470 480 490 500
CFQYIADFCG PYVFFLLLVW SWPLFCSHFL KFQKPKENPL RKSQQSSERR
510
GVQLKRQKLL
Length:510
Mass (Da):56,060
Last modified:February 10, 2009 - v2
Checksum:iC91767EF2C079617
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti258L → W in AAK63201 (PubMed:11599048).Curated1
Sequence conflicti278R → G in AAK63201 (PubMed:11599048).Curated1
Sequence conflicti395N → S in AAK63201 (PubMed:11599048).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC149324 mRNA Translation: AAI49325.1
AF308828 mRNA Translation: AAK63201.1
RefSeqiNP_001096692.1, NM_001103222.1
UniGeneiBt.13076

Genome annotation databases

EnsembliENSBTAT00000055725; ENSBTAP00000050612; ENSBTAG00000005386
GeneIDi282357
KEGGibta:282357

Similar proteinsi

Entry informationi

Entry nameiGTR2_BOVIN
AccessioniPrimary (citable) accession number: P58351
Secondary accession number(s): A6QPH3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: February 10, 2009
Last modified: March 28, 2018
This is version 105 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome