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Reviewed, UniProtKB/Swiss-Prot P58341 (ATCU1_RHIME)

Last modified November 3, 2009. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Copper-transporting ATPase 1
    EC=3.6.3.4
Gene names
Name: actP1
Synonyms: actP
Ordered Locus Names: RA0548
ORF Names: SMa1013
Encoded onPlasmid pSymA (megaplasmid 1)
OrganismRhizobium meliloti (Sinorhizobium meliloti) [Complete proteome] [HAMAP]
Taxonomic identifier382 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Sinorhizobium/Ensifer group › Sinorhizobium

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Protein attributes

Sequence length826 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Involved in copper transport By similarity.

Catalytic activity

ATP + H2O + Cu2+(In) = ADP + phosphate + Cu2+(Out).

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the cation transport ATPase (P-type) family. Type IB subfamily.

Contains 2 HMA domains.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 826826Copper-transporting ATPase 1
PRO_0000046327

Regions

Transmembrane172 – 19221 Potential
Transmembrane209 – 22921 Potential
Transmembrane246 – 26621 Potential
Transmembrane270 – 29021 Potential
Transmembrane429 – 44921 Potential
Transmembrane457 – 47721 Potential
Transmembrane772 – 79221 Potential
Transmembrane795 – 81521 Potential
Domain16 – 8166HMA 1
Domain83 – 14866HMA 2

Sites

Active site51414-aspartylphosphate intermediate By similarity
Metal binding261Copper Potential
Metal binding291Copper Potential
Metal binding931Copper Potential
Metal binding961Copper Potential
Metal binding7131Magnesium By similarity
Metal binding7171Magnesium By similarity

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Sequences

Sequence LengthMass (Da)Tools
P58341-1 [UniParc].

Last modified November 2, 2001. Version 1.
Checksum: 91966D720D870F70

FASTA82686,285
        10         20         30         40         50         60 
MTAFTQIEKS AAVPAPTDFG IEGMTCASCV RRVEKAISAV PGVASATVNL ATERASVQFT 

        70         80         90        100        110        120 
GAPDTGGVLL AIEKAGYEPK VIIQEFGIEG MTCASCVSRV EKALRTVPGV ADASVNLATE 

       130        140        150        160        170        180 
KGTVRFVSGV DVAAIEAAVR DAGYDVRKAK ASGATAEPED RRELETRTLK RLVILSAVLT 

       190        200        210        220        230        240 
LPLFLVEMGS HFMPGVHEWI MENIGMRHNL YIQFALATAV LFGPGLRFFR KGVPNLLRWT 

       250        260        270        280        290        300 
PDMNSLVVLG TTAAWGYSVV ATFASGLLPS GTANVYYEAA AVIVTLILLG RYLEARAKGR 

       310        320        330        340        350        360 
TSQAIKRLLG LQPKTAFVAH GDEFVEIQIS DVVVGDVIRI RPGEKIPVDG TVLDGNSYVD 

       370        380        390        400        410        420 
ESMITGEPVP VQKAAGAEVV GGTINKNGSF TFRATKVGGD TLLAQIIKMV ETAQGSKLPI 

       430        440        450        460        470        480 
QALVDKVTAW FVPAVILVAV LTFAAWYVFG PSPALTFALV NAVAVLIIAC PCAMGLATPT 

       490        500        510        520        530        540 
SIMVGTGRAA ELGILFRKGE ALQSLREADV IALDKTGTLT KGRPELTDIV PADGFEADEV 

       550        560        570        580        590        600 
LSFVASLEAL SEHPIAEAIV SAAKSRGIAL VPATDFEATP GFGVRGAVSG LPVQVGADRA 

       610        620        630        640        650        660 
FSGVGIDVSP FVVEAERLGN SGKSPLYAAI DGRLAAIIAV SDPIKDTTPQ AIKALHDLGL 

       670        680        690        700        710        720 
KVAMITGDNR RTADAIARQL GIDEVVAEVL PDGKVDAVKR LREGGRKVAF IGDGINDAPA 

       730        740        750        760        770        780 
LTEADVGIAV GTGTDIAIES ADVVLMSGDL IGVPKAIALS KATIRNIKQN LFWAFAYNVS 

       790        800        810        820 
LVPVAAGVLY PLNGTLLSPI LAAAAMAMSS VFVLGNALRL RSVNPA

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References

[1]"Nucleotide sequence and predicted functions of the entire Sinorhizobium meliloti pSymA megaplasmid."
Barnett M.J., Fisher R.F., Jones T., Komp C., Abola A.P., Barloy-Hubler F., Bowser L., Capela D., Galibert F., Gouzy J., Gurjal M., Hong A., Huizar L., Hyman R.W., Kahn D., Kahn M.L., Kalman S., Keating D.H. expand/collapse author list , Palm C., Peck M.C., Surzycki R., Wells D.H., Yeh K.-C., Davis R.W., Federspiel N.A., Long S.R.
Proc. Natl. Acad. Sci. U.S.A. 98:9883-9888(2001) [PubMed: 11481432] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1021.

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Cross-references

Sequence databases

AE006469 Genomic DNA. Translation: AAK65206.1.
PIRD95330.
RefSeqNP_435794.1.

3D structure databases

HSSPHSSP built from PDB template 1JWW based on UniProtKB O32220.
ModBaseSearch...

Genome annotation databases

GeneID1235584.
GenomeReviewsGene locus RA0548 in contig AE006469_GR.
KEGGsme:SMa1013.
NMPDRfig|266834.1.peg.548.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMP58341.
OMAHEWIMEN.

Enzyme and pathway databases

BioCycSMEL266834:SMA1013-MON.
BRENDA3.6.3.4. 142.

Family and domain databases

InterProIPR008250. ATPase_P-typ_ATPase-assoc-reg.
IPR006403. ATPase_P-typ_cat/Cu-transptr.
IPR000695. ATPase_P-typ_H-transp.
IPR006416. ATPase_P-typ_heavy-metal.
IPR001757. ATPase_P-typ_ion-transptr.
IPR018303. ATPase_P-typ_P_site.
IPR006122. Cu_ion_bd.
IPR005834. Dehalogen-like_hydro.
IPR017969. Heavy-metal-associated_CS.
IPR006121. HeavyMe_transpt.
[Graphical view]
PANTHERPTHR11939. ATPase_P. 1 hit.
PfamPF00122. E1-E2_ATPase. 1 hit.
PF00403. HMA. 2 hits.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSPR00119. CATATPASE.
PR00120. HATPASE.
TIGRFAMsTIGR01511. ATPase-IB1_Cu. 1 hit.
TIGR01525. ATPase-IB_hvy. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
TIGR00003. Cu_ion_bd. 2 hits.
PROSITEPS00154. ATPASE_E1_E2. 1 hit.
PS01047. HMA_1. 2 hits.
PS50846. HMA_2. 2 hits.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameATCU1_RHIME
AccessionPrimary (citable) accession number: P58341
Entry history
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: November 2, 2001
Last modified: November 3, 2009
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents