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P58341 (ATCU1_RHIME) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Copper-transporting ATPase 1

EC=3.6.3.4
Gene names
Name:actP1
Synonyms:actP
Ordered Locus Names:RA0548
ORF Names:SMa1013
Encoded onPlasmid pSymA (megaplasmid 1)
OrganismRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti) [Complete proteome] [HAMAP]
Taxonomic identifier266834 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium

Protein attributes

Sequence length826 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in copper transport By similarity.

Catalytic activity

ATP + H2O + Cu2+(In) = ADP + phosphate + Cu2+(Out).

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily. [View classification]

Contains 2 HMA domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 826826Copper-transporting ATPase 1
PRO_0000046327

Regions

Transmembrane172 – 19221Helical; Potential
Transmembrane209 – 22921Helical; Potential
Transmembrane246 – 26621Helical; Potential
Transmembrane270 – 29021Helical; Potential
Transmembrane429 – 44921Helical; Potential
Transmembrane457 – 47721Helical; Potential
Transmembrane772 – 79221Helical; Potential
Transmembrane795 – 81521Helical; Potential
Domain16 – 8166HMA 1
Domain83 – 14866HMA 2

Sites

Active site51414-aspartylphosphate intermediate By similarity
Metal binding261Copper Potential
Metal binding291Copper Potential
Metal binding931Copper Potential
Metal binding961Copper Potential
Metal binding7131Magnesium By similarity
Metal binding7171Magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
P58341 [UniParc].

Last modified November 2, 2001. Version 1.
Checksum: 91966D720D870F70

FASTA82686,285
        10         20         30         40         50         60 
MTAFTQIEKS AAVPAPTDFG IEGMTCASCV RRVEKAISAV PGVASATVNL ATERASVQFT 

        70         80         90        100        110        120 
GAPDTGGVLL AIEKAGYEPK VIIQEFGIEG MTCASCVSRV EKALRTVPGV ADASVNLATE 

       130        140        150        160        170        180 
KGTVRFVSGV DVAAIEAAVR DAGYDVRKAK ASGATAEPED RRELETRTLK RLVILSAVLT 

       190        200        210        220        230        240 
LPLFLVEMGS HFMPGVHEWI MENIGMRHNL YIQFALATAV LFGPGLRFFR KGVPNLLRWT 

       250        260        270        280        290        300 
PDMNSLVVLG TTAAWGYSVV ATFASGLLPS GTANVYYEAA AVIVTLILLG RYLEARAKGR 

       310        320        330        340        350        360 
TSQAIKRLLG LQPKTAFVAH GDEFVEIQIS DVVVGDVIRI RPGEKIPVDG TVLDGNSYVD 

       370        380        390        400        410        420 
ESMITGEPVP VQKAAGAEVV GGTINKNGSF TFRATKVGGD TLLAQIIKMV ETAQGSKLPI 

       430        440        450        460        470        480 
QALVDKVTAW FVPAVILVAV LTFAAWYVFG PSPALTFALV NAVAVLIIAC PCAMGLATPT 

       490        500        510        520        530        540 
SIMVGTGRAA ELGILFRKGE ALQSLREADV IALDKTGTLT KGRPELTDIV PADGFEADEV 

       550        560        570        580        590        600 
LSFVASLEAL SEHPIAEAIV SAAKSRGIAL VPATDFEATP GFGVRGAVSG LPVQVGADRA 

       610        620        630        640        650        660 
FSGVGIDVSP FVVEAERLGN SGKSPLYAAI DGRLAAIIAV SDPIKDTTPQ AIKALHDLGL 

       670        680        690        700        710        720 
KVAMITGDNR RTADAIARQL GIDEVVAEVL PDGKVDAVKR LREGGRKVAF IGDGINDAPA 

       730        740        750        760        770        780 
LTEADVGIAV GTGTDIAIES ADVVLMSGDL IGVPKAIALS KATIRNIKQN LFWAFAYNVS 

       790        800        810        820 
LVPVAAGVLY PLNGTLLSPI LAAAAMAMSS VFVLGNALRL RSVNPA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE006469 Genomic DNA. Translation: AAK65206.1.
PIRD95330.
RefSeqNP_435794.1. NC_003037.1.

3D structure databases

ProteinModelPortalP58341.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1235584.
GenomeReviewsGene locus RA0548 in contig AE006469_GR.
KEGGsme:SMa1013.
NMPDRfig|266834.1.peg.548.
PATRIC23627570. VBISinMel96828_0564.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG507745.
OMAHEWIMEN.
ProtClustDBCLSK807623.

Enzyme and pathway databases

BioCycSMEL266834:SMA1013-MONOMER.

Family and domain databases

InterProIPR008250. ATPase_P-typ_ATPase-assoc-dom.
IPR006403. ATPase_P-typ_cat/Cu-transptr.
IPR023300. ATPase_P-typ_cyto_domA.
IPR023299. ATPase_P-typ_cyto_domN.
IPR000695. ATPase_P-typ_H-transp.
IPR006416. ATPase_P-typ_heavy-metal.
IPR001757. ATPase_P-typ_ion-transptr.
IPR018303. ATPase_P-typ_P_site.
IPR005834. Dehalogen-like_hydro.
IPR023214. HAD-like_dom.
IPR017969. Heavy-metal-associated_CS.
IPR006121. HeavyMe-assoc_HMA.
IPR006122. HMA_Cu_ion-bd.
[Graphical view]
Gene3DG3DSA:2.70.150.10. ATPase_P-typ_cyto_domA. 1 hit.
G3DSA:3.40.1110.10. ATPase_P-typ_cyto_domN. 1 hit.
G3DSA:3.40.50.1000. HAD-like_dom. 2 hits.
KOK01533.
PfamPF00122. E1-E2_ATPase. 1 hit.
PF00403. HMA. 2 hits.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSPR00119. CATATPASE.
PR00120. HATPASE.
SUPFAMSSF56784. HAD-like_dom. 1 hit.
SSF55008. HeavyMe_transpt. 2 hits.
TIGRFAMsTIGR01511. ATPase-IB1_Cu. 1 hit.
TIGR01525. ATPase-IB_hvy. 1 hit.
TIGR01494. ATPase_P-type. 1 hit.
TIGR00003. TIGR00003. 2 hits.
PROSITEPS00154. ATPASE_E1_E2. 1 hit.
PS01047. HMA_1. 2 hits.
PS50846. HMA_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameATCU1_RHIME
AccessionPrimary (citable) accession number: P58341
Entry history
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: November 2, 2001
Last modified: January 25, 2012
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families