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Protein

Krueppel-like factor 16

Gene

Klf16

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor that binds GC and GT boxes in the D1A, D2 and D3 dopamine receptor promoters and displaces Sp1 and Sp3 from these sequences. It modulates dopaminergic transmission in the brain by repressing or activating transcription from several different promoters depending on cellular context.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri126 – 150C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri156 – 180C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri186 – 208C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • DNA binding Source: MGI
  • DNA binding transcription factor activity Source: MGI
  • metal ion binding Source: UniProtKB-KW
  • RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB
  • transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB

GO - Biological processi

  • dopamine receptor signaling pathway Source: MGI
  • negative regulation of transcription by RNA polymerase II Source: NTNU_SB
  • regulation of transcription by RNA polymerase II Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Krueppel-like factor 16
Alternative name(s):
Basic transcription element-binding protein 4
Short name:
BTE-binding protein 4
Dopamine receptor-regulating factor
Transcription factor BTEB4
Gene namesi
Name:Klf16
Synonyms:Bteb4, Drrf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2153049. Klf16.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000471591 – 251Krueppel-like factor 16Add BLAST251

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei103PhosphoserineCombined sources1
Modified residuei151PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP58334.
MaxQBiP58334.
PaxDbiP58334.
PRIDEiP58334.

PTM databases

iPTMnetiP58334.
PhosphoSitePlusiP58334.

Expressioni

Tissue specificityi

High expression in brain; olfactory tubercle, olfactory bulb, nucleus accumbens, striatum, hippocampal CA1 region, amygdala, dentate gyrus and frontal cortex. Moderate expression in hippocampal CA2-3 regions, piriform cortex, septum, and distinct thalamic nuclei. Low expression in the cerebellum.

Gene expression databases

BgeeiENSMUSG00000035397.
CleanExiMM_KLF16.
ExpressionAtlasiP58334. baseline and differential.
GenevisibleiP58334. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048825.

Structurei

3D structure databases

ProteinModelPortaliP58334.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi3 – 136Ala/Pro-richAdd BLAST134
Compositional biasi103 – 116Ser-richAdd BLAST14
Compositional biasi223 – 248Pro/Ser-richAdd BLAST26

Domaini

The Ala/Pro-rich domain may contain discrete activation and repression subdomains and also can mediate protein-protein interactions.

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri126 – 150C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri156 – 180C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri186 – 208C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118984.
HOGENOMiHOG000233575.
HOVERGENiHBG050746.
InParanoidiP58334.
KOiK09208.
OMAiPMSAYSE.
OrthoDBiEOG091G1BN0.
PhylomeDBiP58334.
TreeFamiTF351003.

Family and domain databases

InterProiView protein in InterPro
IPR036236. Znf_C2H2_sf.
IPR013087. Znf_C2H2_type.
SMARTiView protein in SMART
SM00355. ZnF_C2H2. 3 hits.
SUPFAMiSSF57667. SSF57667. 2 hits.
PROSITEiView protein in PROSITE
PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.

Sequencei

Sequence statusi: Complete.

P58334-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAAVACVDY FAADVLMAIS SGAVVHRGRP GPEGAGPAAG LDVRATRREA
60 70 80 90 100
TPPGTPGAPP PPATAPGPGG ATAAPHLLAA SILADLRGGP VVATAASTAG
110 120 130 140 150
GTSPVSSSSA ASSPSSGRAP GAAKSHRCPF HGCAKAYYKS SHLKSHLRTH
160 170 180 190 200
TGERPFACDW PGCDKKFARS DELARHHRTH TGEKRFPCPL CTKRFTRSDH
210 220 230 240 250
LTKHARRHPG FRPELLRRPG ARSVSPSDSL PCSLAGSPTP SPVPSPAPAG

L
Length:251
Mass (Da):25,652
Last modified:August 16, 2004 - v2
Checksum:i3F0D7739BF7B1FA4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF283891 mRNA. Translation: AAK66968.1.
AK044577 mRNA. Translation: BAC31987.1.
AK154524 mRNA. Translation: BAE32651.1.
CCDSiCCDS24026.1.
RefSeqiNP_510962.2. NM_078477.2.
UniGeneiMm.41513.

Genome annotation databases

EnsembliENSMUST00000038558; ENSMUSP00000048825; ENSMUSG00000035397.
GeneIDi118445.
KEGGimmu:118445.
UCSCiuc007gdt.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiKLF16_MOUSE
AccessioniPrimary (citable) accession number: P58334
Secondary accession number(s): Q3U3Y4, Q8C8S2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: August 16, 2004
Last modified: March 28, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome