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P58321

- UCHL4_MOUSE

UniProt

P58321 - UCHL4_MOUSE

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Protein
Ubiquitin carboxyl-terminal hydrolase isozyme L4
Gene
Uchl4
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Ubiquitin-protein hydrolase is involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin.

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei95 – 951Nucleophile By similarity
Active sitei172 – 1721Proton donor By similarity
Sitei187 – 1871Important for enzyme activity By similarity

GO - Molecular functioni

  1. ubiquitin-specific protease activity Source: InterPro

GO - Biological processi

  1. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC12.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase isozyme L4 (EC:3.4.19.12)
Short name:
UCH-L4
Alternative name(s):
Ubiquitin thioesterase L4
Gene namesi
Name:Uchl4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:1890440. Uchl4.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 233233Ubiquitin carboxyl-terminal hydrolase isozyme L4
PRO_0000211064Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei133 – 1331Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP58321.
PaxDbiP58321.
PRIDEiP58321.

PTM databases

PhosphoSiteiP58321.

Expressioni

Tissue specificityi

Expressed in various tissues at low level.

Gene expression databases

BgeeiP58321.
CleanExiMM_UCHL4.
GenevestigatoriP58321.

Structurei

3D structure databases

ProteinModelPortaliP58321.
SMRiP58321. Positions 5-233.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni8 – 136Interaction with ubiquitin By similarity
Regioni222 – 2276Interaction with ubiquitin By similarity

Sequence similaritiesi

Belongs to the peptidase C12 family.

Phylogenomic databases

eggNOGiNOG327708.
GeneTreeiENSGT00510000046640.
HOGENOMiHOG000182400.
HOVERGENiHBG075483.
InParanoidiP58321.
KOiK05609.
OMAiYGMESEL.
OrthoDBiEOG7S7SFK.
PhylomeDBiP58321.
TreeFamiTF316166.

Family and domain databases

Gene3Di3.40.532.10. 1 hit.
InterProiIPR001578. Peptidase_C12_UCH.
[Graphical view]
PANTHERiPTHR10589. PTHR10589. 1 hit.
PfamiPF01088. Peptidase_C12. 1 hit.
[Graphical view]
PRINTSiPR00707. UBCTHYDRLASE.

Sequencei

Sequence statusi: Complete.

P58321-1 [UniParc]FASTAAdd to Basket

« Hide

MEGQRWLPLE ANPEVTNQFL KQLGLHPNWQ FVDVYGMESE LLSIIPRPVC    50
AVLLLFPITE KYEVFRTEEE EKIKSQGQDV TSSVYFMKQT ISNACGTIGT 100
IGLIHAIANN KDKVHFESGS TLKKFLEESV SMSPEERAKY LENYDAIRVT 150
HETSAHEGQT EAPSIDEKVD LHFIALVHVD GHLYELDGWK PFPINHGKTS 200
DETLLEDVIK VCKKFMERDP DELRFNAIAL SAA 233
Length:233
Mass (Da):26,450
Last modified:October 18, 2001 - v1
Checksum:i9D7899AD70C27819
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB035420 mRNA. Translation: BAB47122.1.
CCDSiCCDS23278.1.
PIRiJC7689.
RefSeqiNP_291085.1. NM_033607.1.
UniGeneiMm.390180.

Genome annotation databases

EnsembliENSMUST00000039011; ENSMUSP00000045208; ENSMUSG00000035337.
GeneIDi93841.
KEGGimmu:93841.
UCSCiuc009qbq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB035420 mRNA. Translation: BAB47122.1 .
CCDSi CCDS23278.1.
PIRi JC7689.
RefSeqi NP_291085.1. NM_033607.1.
UniGenei Mm.390180.

3D structure databases

ProteinModelPortali P58321.
SMRi P58321. Positions 5-233.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi C12.007.

PTM databases

PhosphoSitei P58321.

Proteomic databases

MaxQBi P58321.
PaxDbi P58321.
PRIDEi P58321.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000039011 ; ENSMUSP00000045208 ; ENSMUSG00000035337 .
GeneIDi 93841.
KEGGi mmu:93841.
UCSCi uc009qbq.1. mouse.

Organism-specific databases

CTDi 93841.
MGIi MGI:1890440. Uchl4.

Phylogenomic databases

eggNOGi NOG327708.
GeneTreei ENSGT00510000046640.
HOGENOMi HOG000182400.
HOVERGENi HBG075483.
InParanoidi P58321.
KOi K05609.
OMAi YGMESEL.
OrthoDBi EOG7S7SFK.
PhylomeDBi P58321.
TreeFami TF316166.

Miscellaneous databases

NextBioi 351701.
PROi P58321.
SOURCEi Search...

Gene expression databases

Bgeei P58321.
CleanExi MM_UCHL4.
Genevestigatori P58321.

Family and domain databases

Gene3Di 3.40.532.10. 1 hit.
InterProi IPR001578. Peptidase_C12_UCH.
[Graphical view ]
PANTHERi PTHR10589. PTHR10589. 1 hit.
Pfami PF01088. Peptidase_C12. 1 hit.
[Graphical view ]
PRINTSi PR00707. UBCTHYDRLASE.
ProtoNeti Search...

Publicationsi

  1. "Cloning, expression, and mapping of a mouse gene, Uchl4, highly homologous to human and mouse Uchl3."
    Osawa Y., Wang Y.-L., Osaka H., Aoki S., Wada K.
    Biochem. Biophys. Res. Commun. 283:627-633(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiUCHL4_MOUSE
AccessioniPrimary (citable) accession number: P58321
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: October 18, 2001
Last modified: July 9, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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