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Protein

Zinc finger protein 121

Gene

ZNF121

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri88 – 11023C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri116 – 13823C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri144 – 16623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri172 – 19423C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri200 – 22223C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri228 – 25023C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri256 – 27823C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri284 – 30623C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri312 – 33423C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri340 – 36223C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri368 – 39023C2H2-type 11PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 121
Alternative name(s):
Zinc finger protein 20
Gene namesi
Name:ZNF121
Synonyms:ZNF20
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:12904. ZNF121.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37493.

Polymorphism and mutation databases

BioMutaiZNF121.
DMDMi152031766.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 390390Zinc finger protein 121PRO_0000047408Add
BLAST

Proteomic databases

EPDiP58317.
MaxQBiP58317.
PaxDbiP58317.
PRIDEiP58317.

PTM databases

iPTMnetiP58317.
PhosphoSiteiP58317.

Expressioni

Gene expression databases

BgeeiP58317.
CleanExiHS_ZNF121.
HS_ZNF20.
ExpressionAtlasiP58317. baseline and differential.
GenevisibleiP58317. HS.

Organism-specific databases

HPAiHPA054961.

Interactioni

Protein-protein interaction databases

BioGridi113474. 14 interactions.
IntActiP58317. 3 interactions.
STRINGi9606.ENSP00000326967.

Structurei

3D structure databases

ProteinModelPortaliP58317.
SMRiP58317. Positions 15-390.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 11 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri88 – 11023C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri116 – 13823C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri144 – 16623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri172 – 19423C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri200 – 22223C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri228 – 25023C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri256 – 27823C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri284 – 30623C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri312 – 33423C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri340 – 36223C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri368 – 39023C2H2-type 11PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063830.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP58317.
OMAiEELCDFM.
OrthoDBiEOG7KSX7Q.
PhylomeDBiP58317.
TreeFamiTF341966.

Family and domain databases

Gene3Di3.30.160.60. 10 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 5 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 9 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P58317-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEIHNGGEL CDFMENGEIF SEHSCLNAHM GTENTGDTYD CDEYGENFPM
60 70 80 90 100
LHNSAPAGET LSVLNQCRKA FSLPPNVHQR TWIGDKSFEY SDCEEAFVDQ
110 120 130 140 150
SHLQANRITH NGETLYEQKQ CGRAFTYSTS HAVSVKMHTV EKPYECKECG
160 170 180 190 200
KFFRYSSYLN SHMRTHTGEK PYECKECGKC FTVSSHLVEH VRIHTGEKPY
210 220 230 240 250
QCKECGRAFA GRSGLTKHVR IHTGEKPYEC NECGKAYNRF YLLTEHFKTH
260 270 280 290 300
TEEKPFECKV CGKSFRSSSC LKNHFRIHTG IKPYKCKECG KAFTVSSSLH
310 320 330 340 350
NHVKIHTGEK PYECKDCGKA FATSSQLIEH IRTHTGEKPY ICKECGKTFR
360 370 380 390
ASSHLQKHVR IHTGEKPYIC NECGKAYNRF YLLTKHLKTH
Length:390
Mass (Da):44,694
Last modified:July 10, 2007 - v2
Checksum:i5E824D279B5235EE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti96 – 972AF → NS in M99593 (PubMed:8468057).Curated
Sequence conflicti212 – 2121R → C in M99593 (PubMed:8468057).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008759 Genomic DNA. No translation available.
M99593 Genomic DNA. No translation available.
CCDSiCCDS32902.1.
CCDS77228.1.
PIRiA46017.
RefSeqiNP_001008727.1. NM_001008727.3.
NP_001295198.1. NM_001308269.1.
XP_005260119.1. XM_005260062.3.
UniGeneiHs.501537.

Genome annotation databases

EnsembliENST00000320451; ENSP00000326967; ENSG00000197961.
ENST00000586602; ENSP00000468643; ENSG00000197961.
GeneIDi7675.
KEGGihsa:7675.
UCSCiuc010dwt.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008759 Genomic DNA. No translation available.
M99593 Genomic DNA. No translation available.
CCDSiCCDS32902.1.
CCDS77228.1.
PIRiA46017.
RefSeqiNP_001008727.1. NM_001008727.3.
NP_001295198.1. NM_001308269.1.
XP_005260119.1. XM_005260062.3.
UniGeneiHs.501537.

3D structure databases

ProteinModelPortaliP58317.
SMRiP58317. Positions 15-390.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113474. 14 interactions.
IntActiP58317. 3 interactions.
STRINGi9606.ENSP00000326967.

PTM databases

iPTMnetiP58317.
PhosphoSiteiP58317.

Polymorphism and mutation databases

BioMutaiZNF121.
DMDMi152031766.

Proteomic databases

EPDiP58317.
MaxQBiP58317.
PaxDbiP58317.
PRIDEiP58317.

Protocols and materials databases

DNASUi7675.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000320451; ENSP00000326967; ENSG00000197961.
ENST00000586602; ENSP00000468643; ENSG00000197961.
GeneIDi7675.
KEGGihsa:7675.
UCSCiuc010dwt.3. human.

Organism-specific databases

CTDi7675.
GeneCardsiZNF121.
HGNCiHGNC:12904. ZNF121.
HPAiHPA054961.
MIMi194628. gene.
neXtProtiNX_P58317.
PharmGKBiPA37493.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063830.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP58317.
OMAiEELCDFM.
OrthoDBiEOG7KSX7Q.
PhylomeDBiP58317.
TreeFamiTF341966.

Miscellaneous databases

GenomeRNAii7675.
PROiP58317.
SOURCEiSearch...

Gene expression databases

BgeeiP58317.
CleanExiHS_ZNF121.
HS_ZNF20.
ExpressionAtlasiP58317. baseline and differential.
GenevisibleiP58317. HS.

Family and domain databases

Gene3Di3.30.160.60. 10 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 5 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 9 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "A novel zinc finger cDNA with a polymorphic pentanucleotide repeat (ATTTT)n maps on human chromosome 19p."
    Chen H., Kalaitsidaki M., Warren A.C., Avramopoulos D., Antonarakis S.E.
    Genomics 15:621-625(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 96-390.

Entry informationi

Entry nameiZN121_HUMAN
AccessioniPrimary (citable) accession number: P58317
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: July 10, 2007
Last modified: June 8, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.