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Protein

Zinc finger protein 121

Gene

ZNF121

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri88 – 110C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri116 – 138C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri144 – 166C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri172 – 194C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri200 – 222C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri228 – 250C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri256 – 278C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri284 – 306C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri312 – 334C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri340 – 362C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri368 – 390C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 121
Alternative name(s):
Zinc finger protein 20
Gene namesi
Name:ZNF121
Synonyms:ZNF20
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000197961.11
HGNCiHGNC:12904 ZNF121
MIMi194628 gene
neXtProtiNX_P58317

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000197961
PharmGKBiPA37493

Polymorphism and mutation databases

BioMutaiZNF121
DMDMi152031766

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474081 – 390Zinc finger protein 121Add BLAST390

Proteomic databases

EPDiP58317
MaxQBiP58317
PaxDbiP58317
PeptideAtlasiP58317
PRIDEiP58317
ProteomicsDBi57059

PTM databases

iPTMnetiP58317
PhosphoSitePlusiP58317

Expressioni

Gene expression databases

BgeeiENSG00000197961
CleanExiHS_ZNF121
HS_ZNF20
ExpressionAtlasiP58317 baseline and differential
GenevisibleiP58317 HS

Organism-specific databases

HPAiHPA054961

Interactioni

Protein-protein interaction databases

BioGridi113474, 16 interactors
IntActiP58317, 8 interactors
STRINGi9606.ENSP00000326967

Structurei

3D structure databases

ProteinModelPortaliP58317
SMRiP58317
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri88 – 110C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri116 – 138C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri144 – 166C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri172 – 194C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri200 – 222C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri228 – 250C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri256 – 278C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri284 – 306C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri312 – 334C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri340 – 362C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri368 – 390C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144146
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiP58317
OMAiEELCDFM
OrthoDBiEOG091G02KC
PhylomeDBiP58317
TreeFamiTF341966

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 9 hits
SUPFAMiSSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 9 hits
PS50157 ZINC_FINGER_C2H2_2, 10 hits

Sequencei

Sequence statusi: Complete.

P58317-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEIHNGGEL CDFMENGEIF SEHSCLNAHM GTENTGDTYD CDEYGENFPM
60 70 80 90 100
LHNSAPAGET LSVLNQCRKA FSLPPNVHQR TWIGDKSFEY SDCEEAFVDQ
110 120 130 140 150
SHLQANRITH NGETLYEQKQ CGRAFTYSTS HAVSVKMHTV EKPYECKECG
160 170 180 190 200
KFFRYSSYLN SHMRTHTGEK PYECKECGKC FTVSSHLVEH VRIHTGEKPY
210 220 230 240 250
QCKECGRAFA GRSGLTKHVR IHTGEKPYEC NECGKAYNRF YLLTEHFKTH
260 270 280 290 300
TEEKPFECKV CGKSFRSSSC LKNHFRIHTG IKPYKCKECG KAFTVSSSLH
310 320 330 340 350
NHVKIHTGEK PYECKDCGKA FATSSQLIEH IRTHTGEKPY ICKECGKTFR
360 370 380 390
ASSHLQKHVR IHTGEKPYIC NECGKAYNRF YLLTKHLKTH
Length:390
Mass (Da):44,694
Last modified:July 10, 2007 - v2
Checksum:i5E824D279B5235EE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti96 – 97AF → NS in M99593 (PubMed:8468057).Curated2
Sequence conflicti212R → C in M99593 (PubMed:8468057).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008759 Genomic DNA No translation available.
M99593 Genomic DNA No translation available.
CCDSiCCDS32902.1
CCDS77228.1
PIRiA46017
RefSeqiNP_001008727.1, NM_001008727.3
NP_001295198.1, NM_001308269.1
XP_016882728.1, XM_017027239.1
UniGeneiHs.501537

Genome annotation databases

EnsembliENST00000320451; ENSP00000326967; ENSG00000197961
ENST00000586602; ENSP00000468643; ENSG00000197961
GeneIDi7675
KEGGihsa:7675
UCSCiuc010dwt.3 human

Similar proteinsi

Entry informationi

Entry nameiZN121_HUMAN
AccessioniPrimary (citable) accession number: P58317
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: July 10, 2007
Last modified: June 20, 2018
This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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