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Reviewed, UniProtKB/Swiss-Prot P58314 (ALF1_PYRFU)

Last modified November 3, 2009. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Fructose-bisphosphate aldolase class 1
    EC=4.1.2.13
Alternative name(s):
    Fructose-biphosphate aldolase class I
      Short name=FBP aldolase
Gene names
Name: fba
Ordered Locus Names: PF1956
OrganismPyrococcus furiosus [Complete proteome] [HAMAP]
Taxonomic identifier2261 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus

Protein attributes

Sequence length281 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Catalytic activity

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Enzyme regulation

Activated by citrate.

Subunit structure

Homooctamer.

Subcellular location

Cytoplasm Probable.

Sequence similarities

Belongs to the deoC/fbaB aldolase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandSchiff base
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processglycolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionfructose-bisphosphate aldolase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 281281Fructose-bisphosphate aldolase class 1
PRO_0000138949

Sites

Active site1911Schiff-base intermediate with dihydroxyacetone-P

Experimental info

Mutagenesis1911K → A: Loss of activity. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P58314-1 [UniParc].

Last modified October 18, 2001. Version 1.
Checksum: 19637AD0DA8CBD2F

FASTA28131,135
        10         20         30         40         50         60 
MEAPQNVGIK RRLKRFFRRD GRALIFAMDH GFEHGPTDFE PVWEHVNPRV IIRKVVRAGI 

        70         80         90        100        110        120 
DGVMMLPGLA RIAGDEVKPE VGLMIKLTSK TNLRPKPEQL LQSQLGFVDD AIKLGADAIA 

       130        140        150        160        170        180 
ATVYWGSPQE DVMMRQFAEI VSYAHDLGYP VVQFAYPRGP YIDEKYGKKE DYRVVMYGAR 

       190        200        210        220        230        240 
AAAESGADMI KTYWTGSKET FAKVVEAAAG VPVLLSGGAK TENPVDFLKV VWEVIEAGGA 

       250        260        270        280 
GAVVGRNIFQ RENPEPMIKA LIRVIHRNED PEEAAKAEGL I 

« Hide

References

« Hide 'large scale' references
[1]"Archaeal fructose-1,6-bisphosphate aldolases constitute a new family of archaeal type class I aldolases."
Siebers B., Brinkmann H., Doerr C., Tjaden B., Lilie H., van der Oost J., Verhees C.H.
J. Biol. Chem. 276:28710-28718(2001) [PubMed: 11387336] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION, MUTAGENESIS OF LYS-191.
Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.
[2]"The complete sequence of the Pyrococcus furiosus genome."
Weiss R.B., Dunn D.M., Robb F.T., Brown J.R.
Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.

Cross-references

Sequence databases

AF368256 Genomic DNA. Translation: AAK83936.1.
AE009950 Genomic DNA. Translation: AAL82080.1.
RefSeqNP_579685.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID1469838.
GenomeReviewsGene locus PF1956 in contig AE009950_GR.
KEGGpfu:PF1956.
NMPDRfig|186497.1.peg.2008.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMP58314.
OMASGADMIK.

Enzyme and pathway databases

BioCycMetaCyc:MON-11810.
BRENDA4.1.2.13. 321.

Family and domain databases

InterProIPR013785. Aldolase_TIM.
IPR002915. DeoC/AroFGH_arch.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PfamPF01791. DeoC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALF1_PYRFU
AccessionPrimary (citable) accession number: P58314
Entry history
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: October 18, 2001
Last modified: November 3, 2009
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents