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P58314

- ALF1_PYRFU

UniProt

P58314 - ALF1_PYRFU

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Protein
Fructose-bisphosphate aldolase class 1
Gene
fba, PF1956
Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Enzyme regulationi

Activated by citrate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei191 – 1911Schiff-base intermediate with dihydroxyacetone-P

GO - Molecular functioni

  1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-11810.
SABIO-RKP58314.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase class 1 (EC:4.1.2.13)
Alternative name(s):
Fructose-bisphosphate aldolase class I
Short name:
FBP aldolase
Gene namesi
Name:fba
Ordered Locus Names:PF1956
OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Taxonomic identifieri186497 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
ProteomesiUP000001013: Chromosome

Subcellular locationi

Cytoplasm Inferred

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi191 – 1911K → A: Loss of activity. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 281281Fructose-bisphosphate aldolase class 1
PRO_0000138949Add
BLAST

Proteomic databases

PRIDEiP58314.

Interactioni

Subunit structurei

Homooctamer.

Protein-protein interaction databases

STRINGi186497.PF1956.

Structurei

3D structure databases

ProteinModelPortaliP58314.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1830.
HOGENOMiHOG000224790.
KOiK11645.
OMAiATEGEYI.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR002915. DeoC/FbaB/lacD_aldolase.
[Graphical view]
PfamiPF01791. DeoC. 1 hit.
[Graphical view]
PIRSFiPIRSF038992. Aldolase_Ia. 1 hit.

Sequencei

Sequence statusi: Complete.

P58314-1 [UniParc]FASTAAdd to Basket

« Hide

MEAPQNVGIK RRLKRFFRRD GRALIFAMDH GFEHGPTDFE PVWEHVNPRV    50
IIRKVVRAGI DGVMMLPGLA RIAGDEVKPE VGLMIKLTSK TNLRPKPEQL 100
LQSQLGFVDD AIKLGADAIA ATVYWGSPQE DVMMRQFAEI VSYAHDLGYP 150
VVQFAYPRGP YIDEKYGKKE DYRVVMYGAR AAAESGADMI KTYWTGSKET 200
FAKVVEAAAG VPVLLSGGAK TENPVDFLKV VWEVIEAGGA GAVVGRNIFQ 250
RENPEPMIKA LIRVIHRNED PEEAAKAEGL I 281
Length:281
Mass (Da):31,135
Last modified:October 18, 2001 - v1
Checksum:i19637AD0DA8CBD2F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF368256 Genomic DNA. Translation: AAK83936.1.
AE009950 Genomic DNA. Translation: AAL82080.1.
RefSeqiNP_579685.1. NC_003413.1.
WP_011013098.1. NC_003413.1.

Genome annotation databases

EnsemblBacteriaiAAL82080; AAL82080; PF1956.
GeneIDi1469838.
KEGGipfu:PF1956.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF368256 Genomic DNA. Translation: AAK83936.1 .
AE009950 Genomic DNA. Translation: AAL82080.1 .
RefSeqi NP_579685.1. NC_003413.1.
WP_011013098.1. NC_003413.1.

3D structure databases

ProteinModelPortali P58314.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 186497.PF1956.

Proteomic databases

PRIDEi P58314.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL82080 ; AAL82080 ; PF1956 .
GeneIDi 1469838.
KEGGi pfu:PF1956.

Phylogenomic databases

eggNOGi COG1830.
HOGENOMi HOG000224790.
KOi K11645.
OMAi ATEGEYI.

Enzyme and pathway databases

BioCyci MetaCyc:MONOMER-11810.
SABIO-RK P58314.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR002915. DeoC/FbaB/lacD_aldolase.
[Graphical view ]
Pfami PF01791. DeoC. 1 hit.
[Graphical view ]
PIRSFi PIRSF038992. Aldolase_Ia. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Archaeal fructose-1,6-bisphosphate aldolases constitute a new family of archaeal type class I aldolases."
    Siebers B., Brinkmann H., Doerr C., Tjaden B., Lilie H., van der Oost J., Verhees C.H.
    J. Biol. Chem. 276:28710-28718(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION, MUTAGENESIS OF LYS-191.
    Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.
  2. "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P. horikoshii inferred from complete genomic sequences."
    Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M., DiRuggiero J., Robb F.T.
    Genetics 152:1299-1305(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.

Entry informationi

Entry nameiALF1_PYRFU
AccessioniPrimary (citable) accession number: P58314
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: October 18, 2001
Last modified: September 3, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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