P58313 (CAP4C_STRPN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
UTP--glucose-1-phosphate uridylyltransferase
EC=2.7.7.9

Alternative name(s):
Alpha-D-glucosyl-1-phosphate uridylyltransferase
UDP-glucose pyrophosphorylase
Short name=UDPGP
Uridine diphosphoglucose pyrophosphorylase

Gene names

Name:	cap4C
Ordered Locus Names:	SP_2092

Organism

Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) [Complete proteome] [HAMAP]

Taxonomic identifier

170187 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus › Streptococcus pneumoniae

Protein attributes

Sequence length	299 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.
Pathway	Carbohydrate metabolism; nucleotide-sugar metabolism. Capsule biogenesis; capsule polysaccharide biosynthesis.
Sequence similarities	Belongs to the UDPGP type 2 family.

Ontologies

Keywords
Biological process	Capsule biogenesis/degradation Exopolysaccharide synthesis
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	UDP-glucose metabolic process Inferred from electronic annotation. Source: InterPro capsule polysaccharide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	UTP:glucose-1-phosphate uridylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 299	299	UTP--glucose-1-phosphate uridylyltransferase		PRO_0000201366

Sequences

	Sequence		Length	Mass (Da)
	P58313 [UniParc]. Last modified October 18, 2001. Version 1. Checksum: E9D644167B4356C3	FASTA	299	33,278
	10 20 30 40 50 60 MTSKVRKAVI PAAGLGTRFL PATKALAKEM LPIVDKPTIQ FIVEEALKSG IEDILVVTGK 70 80 90 100 110 120 SKRSIEDHFD SNFELEYNLK EKGKTDLLKL VDKTTDMRLH FIRQTHPRGL GDAVLQAKAF 130 140 150 160 170 180 VGNEPFVVML GDDLMDITDE KAVPLTKQLM DDYERTHAST IAVMPVPHDE VSAYGVIAPQ 190 200 210 220 230 240 GEGKDGLYSV ETFVEKPAPE DAPSDLAIIG RYLLTPEIFE ILEKQAPGAG NEIQLTDAID 250 260 270 280 290 TLNKTQRVFA REFKGARYDV GDKFGFMKTS IDYALKHPQV KDDLKNYLIQ LGKELTEKE

References

[1]

"Complete genome sequence of a virulent isolate of Streptococcus pneumoniae." Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D., Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J., Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D., Umayam L.A., White O., Salzberg S.L. , Lewis M.R., Radune D., Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L., McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T., Hickey E.K., Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C., Dougherty B.A., Morrison D.A., Hollingshead S.K., Fraser C.M. Science 293:498-506(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-334 / TIGR4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE005672 Genomic DNA. Translation: AAK76151.1.
PIR	F95244.
RefSeq	NP_346511.1. NC_003028.3.
3D structure databases
ProteinModelPortal	P58313.
ModBase	Search...
Protein-protein interaction databases
STRING	170187.SP_2092.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAK76151; AAK76151; SP_2092.
GeneID	931965.
KEGG	spn:SP_2092.
PATRIC	19708769. VBIStrPne105772_2175.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1210.
HOGENOM	HOG000283477.
KO	K00963.
OMA	YIVREAI.
ProtClustDB	CLSK877010.
Enzyme and pathway databases
UniPathway	UPA00215. UPA00934.
Family and domain databases
InterPro	IPR005771. GalU_uridylyltTrfase_bac/arc. IPR005835. NTP_transferase. [Graphical view]
Pfam	PF00483. NTP_transferase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01099. galU. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CAP4C_STRPN

Accession

Primary (citable) accession number: P58313

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 18, 2001
Last sequence update:	October 18, 2001
Last modified:	May 1, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program