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Protein

UTP--glucose-1-phosphate uridylyltransferase

Gene

cap4C

Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.

Pathwayi

GO - Molecular functioni

  1. UTP:glucose-1-phosphate uridylyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. capsule polysaccharide biosynthetic process Source: UniProtKB-UniPathway
  2. UDP-glucose metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Capsule biogenesis/degradation, Exopolysaccharide synthesis

Enzyme and pathway databases

BioCyciSPNE170187:GHGN-2153-MONOMER.
UniPathwayiUPA00215.
UPA00934.

Names & Taxonomyi

Protein namesi
Recommended name:
UTP--glucose-1-phosphate uridylyltransferase (EC:2.7.7.9)
Alternative name(s):
Alpha-D-glucosyl-1-phosphate uridylyltransferase
UDP-glucose pyrophosphorylase
Short name:
UDPGP
Uridine diphosphoglucose pyrophosphorylase
Gene namesi
Name:cap4C
Ordered Locus Names:SP_2092
OrganismiStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Taxonomic identifieri170187 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000585: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 299299UTP--glucose-1-phosphate uridylyltransferasePRO_0000201366Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi170187.SP_2092.

Structurei

3D structure databases

ProteinModelPortaliP58313.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDPGP type 2 family.Curated

Phylogenomic databases

eggNOGiCOG1210.
HOGENOMiHOG000283477.
KOiK00963.
OMAiTHMYGIA.
OrthoDBiEOG6Z9B3V.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR005771. GalU_uridylyltTrfase_bac/arc.
IPR005835. NTP_transferase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF00483. NTP_transferase. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR01099. galU. 1 hit.

Sequencei

Sequence statusi: Complete.

P58313-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTSKVRKAVI PAAGLGTRFL PATKALAKEM LPIVDKPTIQ FIVEEALKSG
60 70 80 90 100
IEDILVVTGK SKRSIEDHFD SNFELEYNLK EKGKTDLLKL VDKTTDMRLH
110 120 130 140 150
FIRQTHPRGL GDAVLQAKAF VGNEPFVVML GDDLMDITDE KAVPLTKQLM
160 170 180 190 200
DDYERTHAST IAVMPVPHDE VSAYGVIAPQ GEGKDGLYSV ETFVEKPAPE
210 220 230 240 250
DAPSDLAIIG RYLLTPEIFE ILEKQAPGAG NEIQLTDAID TLNKTQRVFA
260 270 280 290
REFKGARYDV GDKFGFMKTS IDYALKHPQV KDDLKNYLIQ LGKELTEKE
Length:299
Mass (Da):33,278
Last modified:October 18, 2001 - v1
Checksum:iE9D644167B4356C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005672 Genomic DNA. Translation: AAK76151.1.
PIRiF95244.
RefSeqiNP_346511.1. NC_003028.3.

Genome annotation databases

EnsemblBacteriaiAAK76151; AAK76151; SP_2092.
GeneIDi931965.
KEGGispn:SP_2092.
PATRICi19708769. VBIStrPne105772_2175.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005672 Genomic DNA. Translation: AAK76151.1.
PIRiF95244.
RefSeqiNP_346511.1. NC_003028.3.

3D structure databases

ProteinModelPortaliP58313.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi170187.SP_2092.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK76151; AAK76151; SP_2092.
GeneIDi931965.
KEGGispn:SP_2092.
PATRICi19708769. VBIStrPne105772_2175.

Phylogenomic databases

eggNOGiCOG1210.
HOGENOMiHOG000283477.
KOiK00963.
OMAiTHMYGIA.
OrthoDBiEOG6Z9B3V.

Enzyme and pathway databases

UniPathwayiUPA00215.
UPA00934.
BioCyciSPNE170187:GHGN-2153-MONOMER.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR005771. GalU_uridylyltTrfase_bac/arc.
IPR005835. NTP_transferase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF00483. NTP_transferase. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR01099. galU. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-334 / TIGR4.

Entry informationi

Entry nameiCAP4C_STRPN
AccessioniPrimary (citable) accession number: P58313
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: October 18, 2001
Last modified: January 7, 2015
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.