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P58312

- AT1A3_OREMO

UniProt

P58312 - AT1A3_OREMO

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Protein

Sodium/potassium-transporting ATPase subunit alpha-3

Gene
atp1a3
Organism
Oreochromis mossambicus (Mozambique tilapia) (Tilapia mossambica)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.

Catalytic activityi

ATP + H2O + Na+(In) + K+(Out) = ADP + phosphate + Na+(Out) + K+(In).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei363 – 36314-aspartylphosphate intermediate By similarity
Metal bindingi704 – 7041Magnesium By similarity
Metal bindingi708 – 7081Magnesium By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sodium:potassium-exchanging ATPase activity Source: UniProtKB

GO - Biological processi

  1. ATP biosynthetic process Source: InterPro
  2. sodium ion transmembrane transport Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit alpha-3 (EC:3.6.3.9)
Short name:
Na(+)/K(+) ATPase alpha-3 subunit
Alternative name(s):
Na(+)/K(+) ATPase alpha(III) subunit
Sodium pump subunit alpha-3
Gene namesi
Name:atp1a3
OrganismiOreochromis mossambicus (Mozambique tilapia) (Tilapia mossambica)
Taxonomic identifieri8127 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaCichlomorphaeCichliformesCichlidaeAfrican cichlidsPseudocrenilabrinaeOreochrominiOreochromis

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7474Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei75 – 9521Helical; Reviewed predictionAdd
BLAST
Topological domaini96 – 11823Extracellular Reviewed predictionAdd
BLAST
Transmembranei119 – 13921Helical; Reviewed predictionAdd
BLAST
Topological domaini140 – 275136Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei276 – 29520Helical; Reviewed predictionAdd
BLAST
Topological domaini296 – 30712Extracellular Reviewed predictionAdd
BLAST
Transmembranei308 – 32518Helical; Reviewed predictionAdd
BLAST
Topological domaini326 – 759434Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei760 – 77920Helical; Reviewed predictionAdd
BLAST
Topological domaini780 – 78910Extracellular Reviewed prediction
Transmembranei790 – 81021Helical; Reviewed predictionAdd
BLAST
Topological domaini811 – 83020Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei831 – 85323Helical; Reviewed predictionAdd
BLAST
Topological domaini854 – 90552Extracellular Reviewed predictionAdd
BLAST
Transmembranei906 – 92520Helical; Reviewed predictionAdd
BLAST
Topological domaini926 – 93813Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei939 – 95719Helical; Reviewed predictionAdd
BLAST
Topological domaini958 – 97215Extracellular Reviewed predictionAdd
BLAST
Transmembranei973 – 99321Helical; Reviewed predictionAdd
BLAST
Topological domaini994 – 101017Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB
  2. Golgi apparatus Source: UniProtKB
  3. integral component of membrane Source: UniProtKB-KW
  4. plasma membrane Source: UniProtKB
  5. synapse Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10101010Sodium/potassium-transporting ATPase subunit alpha-3PRO_0000046302Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei930 – 9301Phosphoserine; by PKA By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP58312.

Interactioni

Subunit structurei

Composed of three subunits: alpha (catalytic), beta and gamma.

Structurei

3D structure databases

ProteinModelPortaliP58312.
SMRiP58312. Positions 17-1010.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni69 – 713Interaction with phosphoinositide-3 kinase By similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi10 – 134Poly-Lys

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG004298.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR005775. ATPase_P-typ_Na/K_IIC.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSiPR00119. CATATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P58312-1 [UniParc]FASTAAdd to Basket

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MGDKDDRFPK KKKGGTKDMD ALKKEVPITE HKMSVEEVCR KFQTDVVQGL     50
TNAKAAEFLL RDGPNALTPP PTTPEWVKFC RQLFGGFSIL LWTGAILCFL 100
AYAIQAATED EPAGDNLYLG IVLTAVVVIT GCFSYFQEAK SSKIMESFKN 150
MVPQQALVIR EGEKVQVNAE EVMAGDLIEV KGGDRIPADI RVTSAHGCKV 200
DNSSLTGESE PQSRSPDCTH DNPLETRNIA FFSTNCVEGT ARGIVICTGD 250
RTVMGRIATL TSGLETGKTP IAVEIEHFIH IITGVAVFLG VTFFILAIIL 300
GYTWLKAVIF LIGIIVANVP EGLLATVTVC LTLTAKRMAK KNCLVKNLEA 350
VETLGSTSTI CSDKTGTLTQ NRMTVAHMWF DNQIHEADTT EDQSGAAFDK 400
SSVTWLSLSR VAPLCNRAQF KPRQDSVSIL KRDVAGDASE SALLKCIELS 450
CGSVRMMRDK NKKVAEIPFN PTNKYQLSIH ETEDPNDNRY LLVMKGALER 500
ILDRCSTIML QGKEQPMDEE MKEAFQNAYM ELGGLGERVL GFRHLLLPED 550
QYPKGFAFDT DDVNFQTDNL CFVGLMSMID PPRAAVPDAV GKCRSAGIKV 600
IMVTGDHPIT AKAIAKGVGI ISEGNETVED IAARLNIPVS QVNPRDAKAC 650
VIHGSDLKDL SQDQMDDILR NHTEIVFART SPQQKLIIVE GCQRLGAIVA 700
VTGDGVNDSP ALKKADIGVA MGISGSDVSK QAADMILLDD NFASIVTGVE 750
EGRLIFDNLK KSIAYTLTSN IPEITPFLFF IIVNIPLALG TITILCIDLG 800
TDMGSAISLA YETAESDIMK RQPRNPCRDK LVNERLISIA YGQIGMIQAL 850
GGFFSYFVIL AENGFLPSQL VGIRLNWDDR SLNDLEDSYG QQWTYEQRKI 900
VEFTCHTAFF VSIVVVQWAD LIICKTRRNS VFQQGMKNKI LIFGLFEETA 950
LAAFLSYCPG MDVALRMYPL KPTWWFWAFP YSFLIFVYDE ARKLILCRNP 1000
GGWVEKETYY 1010
Length:1,010
Mass (Da):111,507
Last modified:October 18, 2001 - v1
Checksum:i9FEDB07C7547F0D1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF109409 mRNA. Translation: AAF75108.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF109409 mRNA. Translation: AAF75108.1 .

3D structure databases

ProteinModelPortali P58312.
SMRi P58312. Positions 17-1010.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P58312.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG004298.

Family and domain databases

Gene3Di 1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProi IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR005775. ATPase_P-typ_Na/K_IIC.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view ]
Pfami PF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view ]
PRINTSi PR00119. CATATPASE.
SMARTi SM00831. Cation_ATPase_N. 1 hit.
[Graphical view ]
SUPFAMi SSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsi TIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Feng H.H., Leu J.H., Huang C.J., Hwang P.P.
    Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiAT1A3_OREMO
AccessioniPrimary (citable) accession number: P58312
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: October 18, 2001
Last modified: June 11, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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