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P58312

- AT1A3_OREMO

UniProt

P58312 - AT1A3_OREMO

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Protein

Sodium/potassium-transporting ATPase subunit alpha-3

Gene

atp1a3

Organism
Oreochromis mossambicus (Mozambique tilapia) (Tilapia mossambica)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.

Catalytic activityi

ATP + H2O + Na+(In) + K+(Out) = ADP + phosphate + Na+(Out) + K+(In).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei363 – 36314-aspartylphosphate intermediateBy similarity
Metal bindingi704 – 7041MagnesiumBy similarity
Metal bindingi708 – 7081MagnesiumBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sodium:potassium-exchanging ATPase activity Source: UniProtKB

GO - Biological processi

  1. ATP biosynthetic process Source: InterPro
  2. sodium ion transmembrane transport Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit alpha-3 (EC:3.6.3.9)
Short name:
Na(+)/K(+) ATPase alpha-3 subunit
Alternative name(s):
Na(+)/K(+) ATPase alpha(III) subunit
Sodium pump subunit alpha-3
Gene namesi
Name:atp1a3
OrganismiOreochromis mossambicus (Mozambique tilapia) (Tilapia mossambica)
Taxonomic identifieri8127 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaCichlomorphaeCichliformesCichlidaeAfrican cichlidsPseudocrenilabrinaeOreochrominiOreochromis

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB
  2. Golgi apparatus Source: UniProtKB
  3. integral component of membrane Source: UniProtKB-KW
  4. plasma membrane Source: UniProtKB
  5. synapse Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10101010Sodium/potassium-transporting ATPase subunit alpha-3PRO_0000046302Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei930 – 9301Phosphoserine; by PKABy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP58312.

Interactioni

Subunit structurei

Composed of three subunits: alpha (catalytic), beta and gamma.

Structurei

3D structure databases

ProteinModelPortaliP58312.
SMRiP58312. Positions 17-1010.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7474CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini96 – 11823ExtracellularSequence AnalysisAdd
BLAST
Topological domaini140 – 275136CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini296 – 30712ExtracellularSequence AnalysisAdd
BLAST
Topological domaini326 – 759434CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini780 – 78910ExtracellularSequence Analysis
Topological domaini811 – 83020CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini854 – 90552ExtracellularSequence AnalysisAdd
BLAST
Topological domaini926 – 93813CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini958 – 97215ExtracellularSequence AnalysisAdd
BLAST
Topological domaini994 – 101017CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei75 – 9521HelicalSequence AnalysisAdd
BLAST
Transmembranei119 – 13921HelicalSequence AnalysisAdd
BLAST
Transmembranei276 – 29520HelicalSequence AnalysisAdd
BLAST
Transmembranei308 – 32518HelicalSequence AnalysisAdd
BLAST
Transmembranei760 – 77920HelicalSequence AnalysisAdd
BLAST
Transmembranei790 – 81021HelicalSequence AnalysisAdd
BLAST
Transmembranei831 – 85323HelicalSequence AnalysisAdd
BLAST
Transmembranei906 – 92520HelicalSequence AnalysisAdd
BLAST
Transmembranei939 – 95719HelicalSequence AnalysisAdd
BLAST
Transmembranei973 – 99321HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni69 – 713Interaction with phosphoinositide-3 kinaseBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi10 – 134Poly-Lys

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG004298.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR005775. ATPase_P-typ_Na/K_IIC.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSiPR00119. CATATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P58312-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGDKDDRFPK KKKGGTKDMD ALKKEVPITE HKMSVEEVCR KFQTDVVQGL
60 70 80 90 100
TNAKAAEFLL RDGPNALTPP PTTPEWVKFC RQLFGGFSIL LWTGAILCFL
110 120 130 140 150
AYAIQAATED EPAGDNLYLG IVLTAVVVIT GCFSYFQEAK SSKIMESFKN
160 170 180 190 200
MVPQQALVIR EGEKVQVNAE EVMAGDLIEV KGGDRIPADI RVTSAHGCKV
210 220 230 240 250
DNSSLTGESE PQSRSPDCTH DNPLETRNIA FFSTNCVEGT ARGIVICTGD
260 270 280 290 300
RTVMGRIATL TSGLETGKTP IAVEIEHFIH IITGVAVFLG VTFFILAIIL
310 320 330 340 350
GYTWLKAVIF LIGIIVANVP EGLLATVTVC LTLTAKRMAK KNCLVKNLEA
360 370 380 390 400
VETLGSTSTI CSDKTGTLTQ NRMTVAHMWF DNQIHEADTT EDQSGAAFDK
410 420 430 440 450
SSVTWLSLSR VAPLCNRAQF KPRQDSVSIL KRDVAGDASE SALLKCIELS
460 470 480 490 500
CGSVRMMRDK NKKVAEIPFN PTNKYQLSIH ETEDPNDNRY LLVMKGALER
510 520 530 540 550
ILDRCSTIML QGKEQPMDEE MKEAFQNAYM ELGGLGERVL GFRHLLLPED
560 570 580 590 600
QYPKGFAFDT DDVNFQTDNL CFVGLMSMID PPRAAVPDAV GKCRSAGIKV
610 620 630 640 650
IMVTGDHPIT AKAIAKGVGI ISEGNETVED IAARLNIPVS QVNPRDAKAC
660 670 680 690 700
VIHGSDLKDL SQDQMDDILR NHTEIVFART SPQQKLIIVE GCQRLGAIVA
710 720 730 740 750
VTGDGVNDSP ALKKADIGVA MGISGSDVSK QAADMILLDD NFASIVTGVE
760 770 780 790 800
EGRLIFDNLK KSIAYTLTSN IPEITPFLFF IIVNIPLALG TITILCIDLG
810 820 830 840 850
TDMGSAISLA YETAESDIMK RQPRNPCRDK LVNERLISIA YGQIGMIQAL
860 870 880 890 900
GGFFSYFVIL AENGFLPSQL VGIRLNWDDR SLNDLEDSYG QQWTYEQRKI
910 920 930 940 950
VEFTCHTAFF VSIVVVQWAD LIICKTRRNS VFQQGMKNKI LIFGLFEETA
960 970 980 990 1000
LAAFLSYCPG MDVALRMYPL KPTWWFWAFP YSFLIFVYDE ARKLILCRNP
1010
GGWVEKETYY
Length:1,010
Mass (Da):111,507
Last modified:October 18, 2001 - v1
Checksum:i9FEDB07C7547F0D1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF109409 mRNA. Translation: AAF75108.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF109409 mRNA. Translation: AAF75108.1 .

3D structure databases

ProteinModelPortali P58312.
SMRi P58312. Positions 17-1010.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P58312.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG004298.

Family and domain databases

Gene3Di 1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProi IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR005775. ATPase_P-typ_Na/K_IIC.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view ]
Pfami PF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view ]
PRINTSi PR00119. CATATPASE.
SMARTi SM00831. Cation_ATPase_N. 1 hit.
[Graphical view ]
SUPFAMi SSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsi TIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Feng H.H., Leu J.H., Huang C.J., Hwang P.P.
    Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiAT1A3_OREMO
AccessioniPrimary (citable) accession number: P58312
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: October 18, 2001
Last modified: October 1, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3