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P58312

- AT1A3_OREMO

UniProt

P58312 - AT1A3_OREMO

Protein

Sodium/potassium-transporting ATPase subunit alpha-3

Gene

atp1a3

Organism
Oreochromis mossambicus (Mozambique tilapia) (Tilapia mossambica)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (18 Oct 2001)
      Previous versions | rss
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    Functioni

    This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.

    Catalytic activityi

    ATP + H2O + Na+(In) + K+(Out) = ADP + phosphate + Na+(Out) + K+(In).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei363 – 36314-aspartylphosphate intermediateBy similarity
    Metal bindingi704 – 7041MagnesiumBy similarity
    Metal bindingi708 – 7081MagnesiumBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. sodium:potassium-exchanging ATPase activity Source: UniProtKB

    GO - Biological processi

    1. ATP biosynthetic process Source: InterPro
    2. sodium ion transmembrane transport Source: GOC

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Sodium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium/potassium-transporting ATPase subunit alpha-3 (EC:3.6.3.9)
    Short name:
    Na(+)/K(+) ATPase alpha-3 subunit
    Alternative name(s):
    Na(+)/K(+) ATPase alpha(III) subunit
    Sodium pump subunit alpha-3
    Gene namesi
    Name:atp1a3
    OrganismiOreochromis mossambicus (Mozambique tilapia) (Tilapia mossambica)
    Taxonomic identifieri8127 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaCichlomorphaeCichliformesCichlidaeAfrican cichlidsPseudocrenilabrinaeOreochrominiOreochromis

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum Source: UniProtKB
    2. Golgi apparatus Source: UniProtKB
    3. integral component of membrane Source: UniProtKB-KW
    4. plasma membrane Source: UniProtKB
    5. synapse Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10101010Sodium/potassium-transporting ATPase subunit alpha-3PRO_0000046302Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei930 – 9301Phosphoserine; by PKABy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiP58312.

    Interactioni

    Subunit structurei

    Composed of three subunits: alpha (catalytic), beta and gamma.

    Structurei

    3D structure databases

    ProteinModelPortaliP58312.
    SMRiP58312. Positions 17-1010.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 7474CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini96 – 11823ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini140 – 275136CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini296 – 30712ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini326 – 759434CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini780 – 78910ExtracellularSequence Analysis
    Topological domaini811 – 83020CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini854 – 90552ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini926 – 93813CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini958 – 97215ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini994 – 101017CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei75 – 9521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei119 – 13921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei276 – 29520HelicalSequence AnalysisAdd
    BLAST
    Transmembranei308 – 32518HelicalSequence AnalysisAdd
    BLAST
    Transmembranei760 – 77920HelicalSequence AnalysisAdd
    BLAST
    Transmembranei790 – 81021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei831 – 85323HelicalSequence AnalysisAdd
    BLAST
    Transmembranei906 – 92520HelicalSequence AnalysisAdd
    BLAST
    Transmembranei939 – 95719HelicalSequence AnalysisAdd
    BLAST
    Transmembranei973 – 99321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni69 – 713Interaction with phosphoinositide-3 kinaseBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi10 – 134Poly-Lys

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG004298.

    Family and domain databases

    Gene3Di1.20.1110.10. 2 hits.
    2.70.150.10. 2 hits.
    3.40.1110.10. 1 hit.
    InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
    IPR004014. ATPase_P-typ_cation-transptr_N.
    IPR023299. ATPase_P-typ_cyto_domN.
    IPR005775. ATPase_P-typ_Na/K_IIC.
    IPR018303. ATPase_P-typ_P_site.
    IPR023298. ATPase_P-typ_TM_dom.
    IPR008250. ATPase_P-typ_transduc_dom_A.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    [Graphical view]
    PfamiPF00689. Cation_ATPase_C. 1 hit.
    PF00690. Cation_ATPase_N. 1 hit.
    PF00122. E1-E2_ATPase. 1 hit.
    PF00702. Hydrolase. 1 hit.
    [Graphical view]
    PRINTSiPR00119. CATATPASE.
    SMARTiSM00831. Cation_ATPase_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF56784. SSF56784. 3 hits.
    SSF81660. SSF81660. 1 hit.
    TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
    TIGR01494. ATPase_P-type. 2 hits.
    PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P58312-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGDKDDRFPK KKKGGTKDMD ALKKEVPITE HKMSVEEVCR KFQTDVVQGL     50
    TNAKAAEFLL RDGPNALTPP PTTPEWVKFC RQLFGGFSIL LWTGAILCFL 100
    AYAIQAATED EPAGDNLYLG IVLTAVVVIT GCFSYFQEAK SSKIMESFKN 150
    MVPQQALVIR EGEKVQVNAE EVMAGDLIEV KGGDRIPADI RVTSAHGCKV 200
    DNSSLTGESE PQSRSPDCTH DNPLETRNIA FFSTNCVEGT ARGIVICTGD 250
    RTVMGRIATL TSGLETGKTP IAVEIEHFIH IITGVAVFLG VTFFILAIIL 300
    GYTWLKAVIF LIGIIVANVP EGLLATVTVC LTLTAKRMAK KNCLVKNLEA 350
    VETLGSTSTI CSDKTGTLTQ NRMTVAHMWF DNQIHEADTT EDQSGAAFDK 400
    SSVTWLSLSR VAPLCNRAQF KPRQDSVSIL KRDVAGDASE SALLKCIELS 450
    CGSVRMMRDK NKKVAEIPFN PTNKYQLSIH ETEDPNDNRY LLVMKGALER 500
    ILDRCSTIML QGKEQPMDEE MKEAFQNAYM ELGGLGERVL GFRHLLLPED 550
    QYPKGFAFDT DDVNFQTDNL CFVGLMSMID PPRAAVPDAV GKCRSAGIKV 600
    IMVTGDHPIT AKAIAKGVGI ISEGNETVED IAARLNIPVS QVNPRDAKAC 650
    VIHGSDLKDL SQDQMDDILR NHTEIVFART SPQQKLIIVE GCQRLGAIVA 700
    VTGDGVNDSP ALKKADIGVA MGISGSDVSK QAADMILLDD NFASIVTGVE 750
    EGRLIFDNLK KSIAYTLTSN IPEITPFLFF IIVNIPLALG TITILCIDLG 800
    TDMGSAISLA YETAESDIMK RQPRNPCRDK LVNERLISIA YGQIGMIQAL 850
    GGFFSYFVIL AENGFLPSQL VGIRLNWDDR SLNDLEDSYG QQWTYEQRKI 900
    VEFTCHTAFF VSIVVVQWAD LIICKTRRNS VFQQGMKNKI LIFGLFEETA 950
    LAAFLSYCPG MDVALRMYPL KPTWWFWAFP YSFLIFVYDE ARKLILCRNP 1000
    GGWVEKETYY 1010
    Length:1,010
    Mass (Da):111,507
    Last modified:October 18, 2001 - v1
    Checksum:i9FEDB07C7547F0D1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF109409 mRNA. Translation: AAF75108.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF109409 mRNA. Translation: AAF75108.1 .

    3D structure databases

    ProteinModelPortali P58312.
    SMRi P58312. Positions 17-1010.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P58312.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG004298.

    Family and domain databases

    Gene3Di 1.20.1110.10. 2 hits.
    2.70.150.10. 2 hits.
    3.40.1110.10. 1 hit.
    InterProi IPR006068. ATPase_P-typ_cation-transptr_C.
    IPR004014. ATPase_P-typ_cation-transptr_N.
    IPR023299. ATPase_P-typ_cyto_domN.
    IPR005775. ATPase_P-typ_Na/K_IIC.
    IPR018303. ATPase_P-typ_P_site.
    IPR023298. ATPase_P-typ_TM_dom.
    IPR008250. ATPase_P-typ_transduc_dom_A.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    [Graphical view ]
    Pfami PF00689. Cation_ATPase_C. 1 hit.
    PF00690. Cation_ATPase_N. 1 hit.
    PF00122. E1-E2_ATPase. 1 hit.
    PF00702. Hydrolase. 1 hit.
    [Graphical view ]
    PRINTSi PR00119. CATATPASE.
    SMARTi SM00831. Cation_ATPase_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56784. SSF56784. 3 hits.
    SSF81660. SSF81660. 1 hit.
    TIGRFAMsi TIGR01106. ATPase-IIC_X-K. 1 hit.
    TIGR01494. ATPase_P-type. 2 hits.
    PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Feng H.H., Leu J.H., Huang C.J., Hwang P.P.
      Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiAT1A3_OREMO
    AccessioniPrimary (citable) accession number: P58312
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 18, 2001
    Last sequence update: October 18, 2001
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3