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P58308 (OX2R_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orexin receptor type 2

Short name=Ox-2-R
Short name=Ox2-R
Short name=Ox2R
Alternative name(s):
Hypocretin receptor type 2
Gene names
Name:Hcrtr2
Synonyms:Mox2r
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length460 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Widely expressed. Isoform 2 not detected in skeletal muscle and kidney. Ref.1

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P58308-1)

Also known as: 2b;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P58308-2)

Also known as: 2a;

The sequence of this isoform differs from the canonical sequence as follows:
     444-460: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 460460Orexin receptor type 2
PRO_0000069990

Regions

Topological domain1 – 5454Extracellular Potential
Transmembrane55 – 7521Helical; Name=1; Potential
Topological domain76 – 8813Cytoplasmic Potential
Transmembrane89 – 11022Helical; Name=2; Potential
Topological domain111 – 12717Extracellular Potential
Transmembrane128 – 15023Helical; Name=3; Potential
Topological domain151 – 17222Cytoplasmic Potential
Transmembrane173 – 19321Helical; Name=4; Potential
Topological domain194 – 22431Extracellular Potential
Transmembrane225 – 24723Helical; Name=5; Potential
Topological domain248 – 30457Cytoplasmic Potential
Transmembrane305 – 32723Helical; Name=6; Potential
Topological domain328 – 34215Extracellular Potential
Transmembrane343 – 36624Helical; Name=7; Potential
Topological domain367 – 46094Cytoplasmic Potential

Amino acid modifications

Glycosylation141N-linked (GlcNAc...) Potential
Glycosylation221N-linked (GlcNAc...) Potential
Glycosylation2021N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence444 – 46017Missing in isoform 2.
VSP_016466

Experimental info

Sequence conflict2011A → T in AAK71327. Ref.3
Sequence conflict2401I → V in AAK71327. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (2b) [UniParc].

Last modified May 30, 2003. Version 2.
Checksum: D62A67C15BA67DCC

FASTA46052,461
        10         20         30         40         50         60 
MSSTKLEDSL SRRNWSSASE LNETQEPFLN PTDYDDEEFL RYLWREYLHP KEYEWVLIAG 

        70         80         90        100        110        120 
YIIVFVVALI GNVLVCVAVW KNHHMRTVTN YFIVNLSLAD VLVTITCLPA TLVVDITETW 

       130        140        150        160        170        180 
FFGQSLCKVI PYLQTVSVSV SVLTLSCIAL DRWYAICHPL MFKSTAKRAR NSIVVIWIVS 

       190        200        210        220        230        240 
CIIMIPQAIV MECSSMLPGL ANKTTLFTVC DEHWGGEVYP KMYHICFFLV TYMAPLCLMI 

       250        260        270        280        290        300 
LAYLQIFRKL WCRQIPGTSS VVQRKWKQQQ PVSQPRGSGQ QSKARISAVA AEIKQIRARR 

       310        320        330        340        350        360 
KTARMLMVVL LVFAICYLPI SILNVLKRVF GMFTHTEDRE TVYAWFTFSH WLVYANSAAN 

       370        380        390        400        410        420 
PIIYNFLSGK FREEFKAAFS CCLGVHHRQG DRLARGRTST ESRKSLTTQI SNFDNVSKLS 

       430        440        450        460 
EHVVLTSIST LPAANGAGPL QNWYLQQGVP SSLLSTWLEV 

« Hide

Isoform 2 (2a) [UniParc].

Checksum: 794736A669463283
Show »

FASTA44350,559

References

« Hide 'large scale' references
[1]"Genomic organization of mouse orexin receptors: characterization of two novel tissue-specific splice variants."
Chen J., Randeva H.S.
Mol. Endocrinol. 18:2790-2804(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
Strain: BALB/c.
Tissue: Brain.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: C57BL/6J.
Tissue: Cerebellum and Hypothalamus.
[3]"Cloning of mouse orexin receptors."
Szendro P.I., Maevers K., Eichele G.
Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 100-311 (ISOFORMS 1/2).
Strain: C57BL/6.
[4]"Hypocretin/orexin, sleep and narcolepsy."
Hungs M., Mignot E.
Bioessays 23:397-408(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[5]"To eat or to sleep? Orexin in the regulation of feeding and wakefulness."
Willie J.T., Chemelli R.M., Sinton C.M., Yanagisawa M.
Annu. Rev. Neurosci. 24:429-458(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY336084 mRNA. Translation: AAR01327.1.
AY336085 mRNA. Translation: AAR01328.1.
AY339390 expand/collapse EMBL AC list , AY339383, AY339384, AY339385, AY339386, AY339387, AY339388, AY339389 Genomic DNA. Translation: AAR11293.1.
AY339389 expand/collapse EMBL AC list , AY339383, AY339384, AY339385, AY339386, AY339387, AY339388 Genomic DNA. Translation: AAR11294.1.
AK038551 mRNA. Translation: BAC30039.1.
AK048781 mRNA. Translation: BAC33457.1.
AF394597 mRNA. Translation: AAK71327.1.
CCDSCCDS23350.1. [P58308-1]
RefSeqNP_945200.1. NM_198962.3. [P58308-1]
XP_006511328.1. XM_006511265.1. [P58308-1]
UniGeneMm.335300.

3D structure databases

ProteinModelPortalP58308.
SMRP58308. Positions 56-376.
ModBaseSearch...
MobiDBSearch...

Chemistry

ChEMBLCHEMBL2434818.
GuidetoPHARMACOLOGY322.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP58308.

Proteomic databases

PRIDEP58308.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000063140; ENSMUSP00000058230; ENSMUSG00000032360. [P58308-1]
ENSMUST00000184757; ENSMUSP00000139377; ENSMUSG00000032360. [P58308-2]
GeneID387285.
KEGGmmu:387285.
UCSCuc009qsz.1. mouse. [P58308-1]

Organism-specific databases

CTD3062.
MGIMGI:2680765. Hcrtr2.

Phylogenomic databases

eggNOGNOG253280.
GeneTreeENSGT00710000106558.
HOGENOMHOG000230498.
HOVERGENHBG101173.
InParanoidP58308.
KOK04239.
OMAVHHRQED.
OrthoDBEOG7CG72H.
PhylomeDBP58308.
TreeFamTF315303.

Gene expression databases

ArrayExpressP58308.
BgeeP58308.
CleanExMM_HCRTR2.
GenevestigatorP58308.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000204. Orexin_rcpt.
IPR004060. Orexin_rcpt_2.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
PF03827. Orexin_rec2. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01522. OREXIN2R.
PR01064. OREXINR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio405814.
PROP58308.
SOURCESearch...

Entry information

Entry nameOX2R_MOUSE
AccessionPrimary (citable) accession number: P58308
Secondary accession number(s): Q5SGC8, Q6VLX3, Q8BG12
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: May 30, 2003
Last modified: July 9, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries