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P58308

- OX2R_MOUSE

UniProt

P58308 - OX2R_MOUSE

Protein

Orexin receptor type 2

Gene

Hcrtr2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 2 (30 May 2003)
      Previous versions | rss
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    Functioni

    Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides.

    GO - Molecular functioni

    1. orexin receptor activity Source: MGI
    2. peptide hormone binding Source: Ensembl

    GO - Biological processi

    1. circadian sleep/wake cycle process Source: InterPro
    2. feeding behavior Source: Ensembl
    3. neuropeptide signaling pathway Source: Ensembl
    4. phospholipase C-activating G-protein coupled receptor signaling pathway Source: MGI

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_207651. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Orexin receptor type 2
    Short name:
    Ox-2-R
    Short name:
    Ox2-R
    Short name:
    Ox2R
    Alternative name(s):
    Hypocretin receptor type 2
    Gene namesi
    Name:Hcrtr2
    Synonyms:Mox2r
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:2680765. Hcrtr2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 460460Orexin receptor type 2PRO_0000069990Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi14 – 141N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi22 – 221N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi202 – 2021N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiP58308.

    PTM databases

    PhosphoSiteiP58308.

    Expressioni

    Tissue specificityi

    Widely expressed. Isoform 2 not detected in skeletal muscle and kidney.1 Publication

    Gene expression databases

    ArrayExpressiP58308.
    BgeeiP58308.
    CleanExiMM_HCRTR2.
    GenevestigatoriP58308.

    Structurei

    3D structure databases

    ProteinModelPortaliP58308.
    SMRiP58308. Positions 56-376.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5454ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini76 – 8813CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini111 – 12717ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini151 – 17222CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini194 – 22431ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini248 – 30457CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini328 – 34215ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini367 – 46094CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei55 – 7521Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei89 – 11022Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei128 – 15023Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei173 – 19321Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei225 – 24723Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei305 – 32723Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei343 – 36624Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG253280.
    GeneTreeiENSGT00710000106558.
    HOGENOMiHOG000230498.
    HOVERGENiHBG101173.
    InParanoidiP58308.
    KOiK04239.
    OMAiVHHRQED.
    OrthoDBiEOG7CG72H.
    PhylomeDBiP58308.
    TreeFamiTF315303.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000204. Orexin_rcpt.
    IPR004060. Orexin_rcpt_2.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    PF03827. Orexin_rec2. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01522. OREXIN2R.
    PR01064. OREXINR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P58308-1) [UniParc]FASTAAdd to Basket

    Also known as: 2b

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSSTKLEDSL SRRNWSSASE LNETQEPFLN PTDYDDEEFL RYLWREYLHP    50
    KEYEWVLIAG YIIVFVVALI GNVLVCVAVW KNHHMRTVTN YFIVNLSLAD 100
    VLVTITCLPA TLVVDITETW FFGQSLCKVI PYLQTVSVSV SVLTLSCIAL 150
    DRWYAICHPL MFKSTAKRAR NSIVVIWIVS CIIMIPQAIV MECSSMLPGL 200
    ANKTTLFTVC DEHWGGEVYP KMYHICFFLV TYMAPLCLMI LAYLQIFRKL 250
    WCRQIPGTSS VVQRKWKQQQ PVSQPRGSGQ QSKARISAVA AEIKQIRARR 300
    KTARMLMVVL LVFAICYLPI SILNVLKRVF GMFTHTEDRE TVYAWFTFSH 350
    WLVYANSAAN PIIYNFLSGK FREEFKAAFS CCLGVHHRQG DRLARGRTST 400
    ESRKSLTTQI SNFDNVSKLS EHVVLTSIST LPAANGAGPL QNWYLQQGVP 450
    SSLLSTWLEV 460
    Length:460
    Mass (Da):52,461
    Last modified:May 30, 2003 - v2
    Checksum:iD62A67C15BA67DCC
    GO
    Isoform 2 (identifier: P58308-2) [UniParc]FASTAAdd to Basket

    Also known as: 2a

    The sequence of this isoform differs from the canonical sequence as follows:
         444-460: Missing.

    Show »
    Length:443
    Mass (Da):50,559
    Checksum:i794736A669463283
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti201 – 2011A → T in AAK71327. 1 PublicationCurated
    Sequence conflicti240 – 2401I → V in AAK71327. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei444 – 46017Missing in isoform 2. 1 PublicationVSP_016466Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY336084 mRNA. Translation: AAR01327.1.
    AY336085 mRNA. Translation: AAR01328.1.
    AY339390
    , AY339383, AY339384, AY339385, AY339386, AY339387, AY339388, AY339389 Genomic DNA. Translation: AAR11293.1.
    AY339389
    , AY339383, AY339384, AY339385, AY339386, AY339387, AY339388 Genomic DNA. Translation: AAR11294.1.
    AK038551 mRNA. Translation: BAC30039.1.
    AK048781 mRNA. Translation: BAC33457.1.
    AF394597 mRNA. Translation: AAK71327.1.
    CCDSiCCDS23350.1. [P58308-1]
    RefSeqiNP_945200.1. NM_198962.3. [P58308-1]
    XP_006511328.1. XM_006511265.1. [P58308-1]
    UniGeneiMm.335300.

    Genome annotation databases

    EnsembliENSMUST00000063140; ENSMUSP00000058230; ENSMUSG00000032360. [P58308-1]
    ENSMUST00000184757; ENSMUSP00000139377; ENSMUSG00000032360. [P58308-2]
    GeneIDi387285.
    KEGGimmu:387285.
    UCSCiuc009qsz.1. mouse. [P58308-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY336084 mRNA. Translation: AAR01327.1 .
    AY336085 mRNA. Translation: AAR01328.1 .
    AY339390
    , AY339383 , AY339384 , AY339385 , AY339386 , AY339387 , AY339388 , AY339389 Genomic DNA. Translation: AAR11293.1 .
    AY339389
    , AY339383 , AY339384 , AY339385 , AY339386 , AY339387 , AY339388 Genomic DNA. Translation: AAR11294.1 .
    AK038551 mRNA. Translation: BAC30039.1 .
    AK048781 mRNA. Translation: BAC33457.1 .
    AF394597 mRNA. Translation: AAK71327.1 .
    CCDSi CCDS23350.1. [P58308-1 ]
    RefSeqi NP_945200.1. NM_198962.3. [P58308-1 ]
    XP_006511328.1. XM_006511265.1. [P58308-1 ]
    UniGenei Mm.335300.

    3D structure databases

    ProteinModelPortali P58308.
    SMRi P58308. Positions 56-376.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    ChEMBLi CHEMBL2434818.
    GuidetoPHARMACOLOGYi 322.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P58308.

    Proteomic databases

    PRIDEi P58308.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000063140 ; ENSMUSP00000058230 ; ENSMUSG00000032360 . [P58308-1 ]
    ENSMUST00000184757 ; ENSMUSP00000139377 ; ENSMUSG00000032360 . [P58308-2 ]
    GeneIDi 387285.
    KEGGi mmu:387285.
    UCSCi uc009qsz.1. mouse. [P58308-1 ]

    Organism-specific databases

    CTDi 3062.
    MGIi MGI:2680765. Hcrtr2.

    Phylogenomic databases

    eggNOGi NOG253280.
    GeneTreei ENSGT00710000106558.
    HOGENOMi HOG000230498.
    HOVERGENi HBG101173.
    InParanoidi P58308.
    KOi K04239.
    OMAi VHHRQED.
    OrthoDBi EOG7CG72H.
    PhylomeDBi P58308.
    TreeFami TF315303.

    Enzyme and pathway databases

    Reactomei REACT_207651. G alpha (q) signalling events.

    Miscellaneous databases

    NextBioi 405814.
    PROi P58308.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P58308.
    Bgeei P58308.
    CleanExi MM_HCRTR2.
    Genevestigatori P58308.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000204. Orexin_rcpt.
    IPR004060. Orexin_rcpt_2.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    PF03827. Orexin_rec2. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01522. OREXIN2R.
    PR01064. OREXINR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic organization of mouse orexin receptors: characterization of two novel tissue-specific splice variants."
      Chen J., Randeva H.S.
      Mol. Endocrinol. 18:2790-2804(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
      Strain: BALB/c.
      Tissue: Brain.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Cerebellum and Hypothalamus.
    3. "Cloning of mouse orexin receptors."
      Szendro P.I., Maevers K., Eichele G.
      Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 100-311 (ISOFORMS 1/2).
      Strain: C57BL/6.
    4. "Hypocretin/orexin, sleep and narcolepsy."
      Hungs M., Mignot E.
      Bioessays 23:397-408(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    5. "To eat or to sleep? Orexin in the regulation of feeding and wakefulness."
      Willie J.T., Chemelli R.M., Sinton C.M., Yanagisawa M.
      Annu. Rev. Neurosci. 24:429-458(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry nameiOX2R_MOUSE
    AccessioniPrimary (citable) accession number: P58308
    Secondary accession number(s): Q5SGC8, Q6VLX3, Q8BG12
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2001
    Last sequence update: May 30, 2003
    Last modified: October 1, 2014
    This is version 106 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3