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P58308

- OX2R_MOUSE

UniProt

P58308 - OX2R_MOUSE

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Protein
Orexin receptor type 2
Gene
Hcrtr2, Mox2r
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides.

GO - Molecular functioni

  1. orexin receptor activity Source: MGI
  2. peptide hormone binding Source: Ensembl

GO - Biological processi

  1. circadian sleep/wake cycle process Source: InterPro
  2. feeding behavior Source: Ensembl
  3. neuropeptide signaling pathway Source: Ensembl
  4. phospholipase C-activating G-protein coupled receptor signaling pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_207651. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Orexin receptor type 2
Short name:
Ox-2-R
Short name:
Ox2-R
Short name:
Ox2R
Alternative name(s):
Hypocretin receptor type 2
Gene namesi
Name:Hcrtr2
Synonyms:Mox2r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:2680765. Hcrtr2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5454Extracellular Reviewed prediction
Add
BLAST
Transmembranei55 – 7521Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini76 – 8813Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei89 – 11022Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini111 – 12717Extracellular Reviewed prediction
Add
BLAST
Transmembranei128 – 15023Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini151 – 17222Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei173 – 19321Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini194 – 22431Extracellular Reviewed prediction
Add
BLAST
Transmembranei225 – 24723Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini248 – 30457Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei305 – 32723Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini328 – 34215Extracellular Reviewed prediction
Add
BLAST
Transmembranei343 – 36624Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini367 – 46094Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 460460Orexin receptor type 2
PRO_0000069990Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi14 – 141N-linked (GlcNAc...) Reviewed prediction
Glycosylationi22 – 221N-linked (GlcNAc...) Reviewed prediction
Glycosylationi202 – 2021N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP58308.

PTM databases

PhosphoSiteiP58308.

Expressioni

Tissue specificityi

Widely expressed. Isoform 2 not detected in skeletal muscle and kidney.1 Publication

Gene expression databases

ArrayExpressiP58308.
BgeeiP58308.
CleanExiMM_HCRTR2.
GenevestigatoriP58308.

Structurei

3D structure databases

ProteinModelPortaliP58308.
SMRiP58308. Positions 56-376.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG253280.
GeneTreeiENSGT00710000106558.
HOGENOMiHOG000230498.
HOVERGENiHBG101173.
InParanoidiP58308.
KOiK04239.
OMAiVHHRQED.
OrthoDBiEOG7CG72H.
PhylomeDBiP58308.
TreeFamiTF315303.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000204. Orexin_rcpt.
IPR004060. Orexin_rcpt_2.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
PF03827. Orexin_rec2. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01522. OREXIN2R.
PR01064. OREXINR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P58308-1) [UniParc]FASTAAdd to Basket

Also known as: 2b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSSTKLEDSL SRRNWSSASE LNETQEPFLN PTDYDDEEFL RYLWREYLHP    50
KEYEWVLIAG YIIVFVVALI GNVLVCVAVW KNHHMRTVTN YFIVNLSLAD 100
VLVTITCLPA TLVVDITETW FFGQSLCKVI PYLQTVSVSV SVLTLSCIAL 150
DRWYAICHPL MFKSTAKRAR NSIVVIWIVS CIIMIPQAIV MECSSMLPGL 200
ANKTTLFTVC DEHWGGEVYP KMYHICFFLV TYMAPLCLMI LAYLQIFRKL 250
WCRQIPGTSS VVQRKWKQQQ PVSQPRGSGQ QSKARISAVA AEIKQIRARR 300
KTARMLMVVL LVFAICYLPI SILNVLKRVF GMFTHTEDRE TVYAWFTFSH 350
WLVYANSAAN PIIYNFLSGK FREEFKAAFS CCLGVHHRQG DRLARGRTST 400
ESRKSLTTQI SNFDNVSKLS EHVVLTSIST LPAANGAGPL QNWYLQQGVP 450
SSLLSTWLEV 460
Length:460
Mass (Da):52,461
Last modified:May 30, 2003 - v2
Checksum:iD62A67C15BA67DCC
GO
Isoform 2 (identifier: P58308-2) [UniParc]FASTAAdd to Basket

Also known as: 2a

The sequence of this isoform differs from the canonical sequence as follows:
     444-460: Missing.

Show »
Length:443
Mass (Da):50,559
Checksum:i794736A669463283
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei444 – 46017Missing in isoform 2.
VSP_016466Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti201 – 2011A → T in AAK71327. 1 Publication
Sequence conflicti240 – 2401I → V in AAK71327. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY336084 mRNA. Translation: AAR01327.1.
AY336085 mRNA. Translation: AAR01328.1.
AY339390
, AY339383, AY339384, AY339385, AY339386, AY339387, AY339388, AY339389 Genomic DNA. Translation: AAR11293.1.
AY339389
, AY339383, AY339384, AY339385, AY339386, AY339387, AY339388 Genomic DNA. Translation: AAR11294.1.
AK038551 mRNA. Translation: BAC30039.1.
AK048781 mRNA. Translation: BAC33457.1.
AF394597 mRNA. Translation: AAK71327.1.
CCDSiCCDS23350.1. [P58308-1]
RefSeqiNP_945200.1. NM_198962.3. [P58308-1]
XP_006511328.1. XM_006511265.1. [P58308-1]
UniGeneiMm.335300.

Genome annotation databases

EnsembliENSMUST00000063140; ENSMUSP00000058230; ENSMUSG00000032360. [P58308-1]
ENSMUST00000184757; ENSMUSP00000139377; ENSMUSG00000032360. [P58308-2]
GeneIDi387285.
KEGGimmu:387285.
UCSCiuc009qsz.1. mouse. [P58308-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY336084 mRNA. Translation: AAR01327.1 .
AY336085 mRNA. Translation: AAR01328.1 .
AY339390
, AY339383 , AY339384 , AY339385 , AY339386 , AY339387 , AY339388 , AY339389 Genomic DNA. Translation: AAR11293.1 .
AY339389
, AY339383 , AY339384 , AY339385 , AY339386 , AY339387 , AY339388 Genomic DNA. Translation: AAR11294.1 .
AK038551 mRNA. Translation: BAC30039.1 .
AK048781 mRNA. Translation: BAC33457.1 .
AF394597 mRNA. Translation: AAK71327.1 .
CCDSi CCDS23350.1. [P58308-1 ]
RefSeqi NP_945200.1. NM_198962.3. [P58308-1 ]
XP_006511328.1. XM_006511265.1. [P58308-1 ]
UniGenei Mm.335300.

3D structure databases

ProteinModelPortali P58308.
SMRi P58308. Positions 56-376.
ModBasei Search...
MobiDBi Search...

Chemistry

ChEMBLi CHEMBL2434818.
GuidetoPHARMACOLOGYi 322.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P58308.

Proteomic databases

PRIDEi P58308.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000063140 ; ENSMUSP00000058230 ; ENSMUSG00000032360 . [P58308-1 ]
ENSMUST00000184757 ; ENSMUSP00000139377 ; ENSMUSG00000032360 . [P58308-2 ]
GeneIDi 387285.
KEGGi mmu:387285.
UCSCi uc009qsz.1. mouse. [P58308-1 ]

Organism-specific databases

CTDi 3062.
MGIi MGI:2680765. Hcrtr2.

Phylogenomic databases

eggNOGi NOG253280.
GeneTreei ENSGT00710000106558.
HOGENOMi HOG000230498.
HOVERGENi HBG101173.
InParanoidi P58308.
KOi K04239.
OMAi VHHRQED.
OrthoDBi EOG7CG72H.
PhylomeDBi P58308.
TreeFami TF315303.

Enzyme and pathway databases

Reactomei REACT_207651. G alpha (q) signalling events.

Miscellaneous databases

NextBioi 405814.
PROi P58308.
SOURCEi Search...

Gene expression databases

ArrayExpressi P58308.
Bgeei P58308.
CleanExi MM_HCRTR2.
Genevestigatori P58308.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000204. Orexin_rcpt.
IPR004060. Orexin_rcpt_2.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
PF03827. Orexin_rec2. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR01522. OREXIN2R.
PR01064. OREXINR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic organization of mouse orexin receptors: characterization of two novel tissue-specific splice variants."
    Chen J., Randeva H.S.
    Mol. Endocrinol. 18:2790-2804(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
    Strain: BALB/c.
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Cerebellum and Hypothalamus.
  3. "Cloning of mouse orexin receptors."
    Szendro P.I., Maevers K., Eichele G.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 100-311 (ISOFORMS 1/2).
    Strain: C57BL/6.
  4. "Hypocretin/orexin, sleep and narcolepsy."
    Hungs M., Mignot E.
    Bioessays 23:397-408(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  5. "To eat or to sleep? Orexin in the regulation of feeding and wakefulness."
    Willie J.T., Chemelli R.M., Sinton C.M., Yanagisawa M.
    Annu. Rev. Neurosci. 24:429-458(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiOX2R_MOUSE
AccessioniPrimary (citable) accession number: P58308
Secondary accession number(s): Q5SGC8, Q6VLX3, Q8BG12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: May 30, 2003
Last modified: September 3, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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