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Protein

Orexin receptor type 1

Gene

Hcrtr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Triggers an increase in cytoplasmic Ca2+ levels in response to orexin-A binding.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei36Important for responses to orexinBy similarity1
Binding sitei318AgonistBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-389397. Orexin and neuropeptides FF and QRFP bind to their respective receptors.
R-MMU-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Orexin receptor type 1
Short name:
Ox-1-R
Short name:
Ox1-R
Short name:
Ox1R
Alternative name(s):
Hypocretin receptor type 1
Gene namesi
Name:Hcrtr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2385650. Hcrtr1.

Subcellular locationi

  • Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 46ExtracellularBy similarityAdd BLAST46
Transmembranei47 – 67Helical; Name=1By similarityAdd BLAST21
Topological domaini68 – 82CytoplasmicBy similarityAdd BLAST15
Transmembranei83 – 105Helical; Name=2By similarityAdd BLAST23
Topological domaini106 – 119ExtracellularBy similarityAdd BLAST14
Transmembranei120 – 140Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini141 – 160CytoplasmicBy similarityAdd BLAST20
Transmembranei161 – 182Helical; Name=4By similarityAdd BLAST22
Topological domaini183 – 213ExtracellularBy similarityAdd BLAST31
Transmembranei214 – 235Helical; Name=5By similarityAdd BLAST22
Topological domaini236 – 298CytoplasmicBy similarityAdd BLAST63
Transmembranei299 – 321Helical; Name=6By similarityAdd BLAST23
Topological domaini322 – 336ExtracellularBy similarityAdd BLAST15
Transmembranei337 – 360Helical; Name=7By similarityAdd BLAST24
Topological domaini361 – 416CytoplasmicBy similarityAdd BLAST56

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2434819.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000699851 – 416Orexin receptor type 1Add BLAST416

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi119 ↔ 202By similarity
Glycosylationi194N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP58307.
PRIDEiP58307.

PTM databases

iPTMnetiP58307.
PhosphoSitePlusiP58307.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSMUSG00000028778.
CleanExiMM_HCRTR1.
GenevisibleiP58307. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030562.

Chemistry databases

BindingDBiP58307.

Structurei

3D structure databases

ProteinModelPortaliP58307.
SMRiP58307.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni26 – 41Required for response to orexin-ABy similarityAdd BLAST16

Domaini

The N-terminal region is required for orexin signaling.By similarity

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118781.
HOGENOMiHOG000230498.
HOVERGENiHBG101173.
InParanoidiP58307.
KOiK04238.
OMAiLMEPSAT.
OrthoDBiEOG091G0ZDG.
TreeFamiTF315303.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000204. Orexin_rcpt.
IPR004059. Orexin_rcpt_1.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01521. OREXIN1R.
PR01064. OREXINR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P58307-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPSATPGAQ PGVPTSSGEP FHLPPDYEDE FLRYLWRDYL YPKQYEWVLI
60 70 80 90 100
AAYVAVFLIA LVGNTLVCLA VWRNHHMRTV TNYFIVNLSL ADVLVTAICL
110 120 130 140 150
PASLLVDITE SWLFGQALCK VIPYLQAVSV SVAVLTLSFI ALDRWYAICH
160 170 180 190 200
PLLFKSTARR ARGSILGIWA VSLAVMVPQA AVMECSSVLP ELANRTRLFS
210 220 230 240 250
VCDEHWADEL YPKIYHSCFF IVTYLAPLGL MAMAYFQIFR KLWGRQIPGT
260 270 280 290 300
TSALVRNWKR PSEQLEAQHQ GLCTEPQPRA RAFLAEVKQM RARRKTAKML
310 320 330 340 350
MVVLLVFALC YLPISVLNVL KRVFGMFRQA SDREAVYACF TFSHWLVYAN
360 370 380 390 400
SAANPIIYNF LSGKFREQFK AAFSCCLPGL GPGSSARHKS LSLQSRCSVS
410
KVSEHVVLTT VTTVLS
Length:416
Mass (Da):46,781
Last modified:July 27, 2011 - v3
Checksum:iAB338FFCEF905E06
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti139F → V in AAK71326 (Ref. 5) Curated1
Sequence conflicti232A → G in AAR01326 (PubMed:15256537).Curated1
Sequence conflicti232A → G in AAK71326 (Ref. 5) Curated1
Sequence conflicti232A → G in AAO85111 (PubMed:12679517).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY336083 mRNA. Translation: AAR01326.1.
AK140137 mRNA. Translation: BAE24252.1.
AL606925 Genomic DNA. Translation: CAM45913.1.
CU207372, CU210846 Genomic DNA. Translation: CAQ51584.1.
CU210846, CU207372 Genomic DNA. Translation: CAQ51833.1.
BC119583 mRNA. Translation: AAI19584.1.
AF394596 mRNA. Translation: AAK71326.1.
AY255599 mRNA. Translation: AAO85111.1.
CCDSiCCDS18707.1.
RefSeqiNP_001156499.1. NM_001163027.1.
NP_945197.2. NM_198959.2.
XP_017175645.1. XM_017320156.1.
XP_017175646.1. XM_017320157.1.
UniGeneiMm.246595.

Genome annotation databases

EnsembliENSMUST00000030562; ENSMUSP00000030562; ENSMUSG00000028778.
ENSMUST00000119423; ENSMUSP00000112630; ENSMUSG00000028778.
ENSMUST00000120154; ENSMUSP00000113198; ENSMUSG00000028778.
ENSMUST00000164887; ENSMUSP00000127290; ENSMUSG00000028778.
GeneIDi230777.
KEGGimmu:230777.
UCSCiuc008uyx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY336083 mRNA. Translation: AAR01326.1.
AK140137 mRNA. Translation: BAE24252.1.
AL606925 Genomic DNA. Translation: CAM45913.1.
CU207372, CU210846 Genomic DNA. Translation: CAQ51584.1.
CU210846, CU207372 Genomic DNA. Translation: CAQ51833.1.
BC119583 mRNA. Translation: AAI19584.1.
AF394596 mRNA. Translation: AAK71326.1.
AY255599 mRNA. Translation: AAO85111.1.
CCDSiCCDS18707.1.
RefSeqiNP_001156499.1. NM_001163027.1.
NP_945197.2. NM_198959.2.
XP_017175645.1. XM_017320156.1.
XP_017175646.1. XM_017320157.1.
UniGeneiMm.246595.

3D structure databases

ProteinModelPortaliP58307.
SMRiP58307.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030562.

Chemistry databases

BindingDBiP58307.
ChEMBLiCHEMBL2434819.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP58307.
PhosphoSitePlusiP58307.

Proteomic databases

PaxDbiP58307.
PRIDEiP58307.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030562; ENSMUSP00000030562; ENSMUSG00000028778.
ENSMUST00000119423; ENSMUSP00000112630; ENSMUSG00000028778.
ENSMUST00000120154; ENSMUSP00000113198; ENSMUSG00000028778.
ENSMUST00000164887; ENSMUSP00000127290; ENSMUSG00000028778.
GeneIDi230777.
KEGGimmu:230777.
UCSCiuc008uyx.1. mouse.

Organism-specific databases

CTDi3061.
MGIiMGI:2385650. Hcrtr1.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118781.
HOGENOMiHOG000230498.
HOVERGENiHBG101173.
InParanoidiP58307.
KOiK04238.
OMAiLMEPSAT.
OrthoDBiEOG091G0ZDG.
TreeFamiTF315303.

Enzyme and pathway databases

ReactomeiR-MMU-389397. Orexin and neuropeptides FF and QRFP bind to their respective receptors.
R-MMU-416476. G alpha (q) signalling events.

Miscellaneous databases

PROiP58307.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028778.
CleanExiMM_HCRTR1.
GenevisibleiP58307. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000204. Orexin_rcpt.
IPR004059. Orexin_rcpt_1.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01521. OREXIN1R.
PR01064. OREXINR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOX1R_MOUSE
AccessioniPrimary (citable) accession number: P58307
Secondary accession number(s): Q0VDP5
, Q3USS9, Q6VNS3, Q80T45
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 124 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.