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Protein

Orexin receptor type 1

Gene

Hcrtr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-389397. Orexin and neuropeptides FF and QRFP bind to their respective receptors.
R-MMU-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Orexin receptor type 1
Short name:
Ox-1-R
Short name:
Ox1-R
Short name:
Ox1R
Alternative name(s):
Hypocretin receptor type 1
Gene namesi
Name:Hcrtr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2385650. Hcrtr1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4646ExtracellularSequence analysisAdd
BLAST
Transmembranei47 – 6721Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini68 – 8316CytoplasmicSequence analysisAdd
BLAST
Transmembranei84 – 10421Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini105 – 12016ExtracellularSequence analysisAdd
BLAST
Transmembranei121 – 14121Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini142 – 16221CytoplasmicSequence analysisAdd
BLAST
Transmembranei163 – 18321Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini184 – 21835ExtracellularSequence analysisAdd
BLAST
Transmembranei219 – 23921Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini240 – 29960CytoplasmicSequence analysisAdd
BLAST
Transmembranei300 – 32021Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini321 – 33616ExtracellularSequence analysisAdd
BLAST
Transmembranei337 – 35721Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini358 – 41659CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2434819.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 416416Orexin receptor type 1PRO_0000069985Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi194 – 1941N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP58307.
PRIDEiP58307.

PTM databases

iPTMnetiP58307.
PhosphoSiteiP58307.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiP58307.
CleanExiMM_HCRTR1.
GenevisibleiP58307. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030562.

Chemistry

BindingDBiP58307.

Structurei

3D structure databases

ProteinModelPortaliP58307.
SMRiP58307. Positions 16-404.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118781.
HOGENOMiHOG000230498.
HOVERGENiHBG101173.
InParanoidiP58307.
KOiK04238.
OMAiLMEPSAT.
OrthoDBiEOG7CG72H.
TreeFamiTF315303.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000204. Orexin_rcpt.
IPR004059. Orexin_rcpt_1.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01521. OREXIN1R.
PR01064. OREXINR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P58307-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPSATPGAQ PGVPTSSGEP FHLPPDYEDE FLRYLWRDYL YPKQYEWVLI
60 70 80 90 100
AAYVAVFLIA LVGNTLVCLA VWRNHHMRTV TNYFIVNLSL ADVLVTAICL
110 120 130 140 150
PASLLVDITE SWLFGQALCK VIPYLQAVSV SVAVLTLSFI ALDRWYAICH
160 170 180 190 200
PLLFKSTARR ARGSILGIWA VSLAVMVPQA AVMECSSVLP ELANRTRLFS
210 220 230 240 250
VCDEHWADEL YPKIYHSCFF IVTYLAPLGL MAMAYFQIFR KLWGRQIPGT
260 270 280 290 300
TSALVRNWKR PSEQLEAQHQ GLCTEPQPRA RAFLAEVKQM RARRKTAKML
310 320 330 340 350
MVVLLVFALC YLPISVLNVL KRVFGMFRQA SDREAVYACF TFSHWLVYAN
360 370 380 390 400
SAANPIIYNF LSGKFREQFK AAFSCCLPGL GPGSSARHKS LSLQSRCSVS
410
KVSEHVVLTT VTTVLS
Length:416
Mass (Da):46,781
Last modified:July 27, 2011 - v3
Checksum:iAB338FFCEF905E06
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti139 – 1391F → V in AAK71326 (Ref. 5) Curated
Sequence conflicti232 – 2321A → G in AAR01326 (PubMed:15256537).Curated
Sequence conflicti232 – 2321A → G in AAK71326 (Ref. 5) Curated
Sequence conflicti232 – 2321A → G in AAO85111 (PubMed:12679517).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY336083 mRNA. Translation: AAR01326.1.
AK140137 mRNA. Translation: BAE24252.1.
AL606925 Genomic DNA. Translation: CAM45913.1.
CU207372, CU210846 Genomic DNA. Translation: CAQ51584.1.
CU210846, CU207372 Genomic DNA. Translation: CAQ51833.1.
BC119583 mRNA. Translation: AAI19584.1.
AF394596 mRNA. Translation: AAK71326.1.
AY255599 mRNA. Translation: AAO85111.1.
CCDSiCCDS18707.1.
RefSeqiNP_001156499.1. NM_001163027.1.
NP_945197.2. NM_198959.2.
XP_011238819.1. XM_011240517.1.
XP_011238820.1. XM_011240518.1.
XP_011249538.1. XM_011251236.1.
XP_011249539.1. XM_011251237.1.
UniGeneiMm.246595.

Genome annotation databases

EnsembliENSMUST00000030562; ENSMUSP00000030562; ENSMUSG00000028778.
ENSMUST00000119423; ENSMUSP00000112630; ENSMUSG00000028778.
ENSMUST00000120154; ENSMUSP00000113198; ENSMUSG00000028778.
ENSMUST00000164887; ENSMUSP00000127290; ENSMUSG00000028778.
GeneIDi230777.
KEGGimmu:230777.
UCSCiuc008uyx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY336083 mRNA. Translation: AAR01326.1.
AK140137 mRNA. Translation: BAE24252.1.
AL606925 Genomic DNA. Translation: CAM45913.1.
CU207372, CU210846 Genomic DNA. Translation: CAQ51584.1.
CU210846, CU207372 Genomic DNA. Translation: CAQ51833.1.
BC119583 mRNA. Translation: AAI19584.1.
AF394596 mRNA. Translation: AAK71326.1.
AY255599 mRNA. Translation: AAO85111.1.
CCDSiCCDS18707.1.
RefSeqiNP_001156499.1. NM_001163027.1.
NP_945197.2. NM_198959.2.
XP_011238819.1. XM_011240517.1.
XP_011238820.1. XM_011240518.1.
XP_011249538.1. XM_011251236.1.
XP_011249539.1. XM_011251237.1.
UniGeneiMm.246595.

3D structure databases

ProteinModelPortaliP58307.
SMRiP58307. Positions 16-404.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030562.

Chemistry

BindingDBiP58307.
ChEMBLiCHEMBL2434819.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP58307.
PhosphoSiteiP58307.

Proteomic databases

PaxDbiP58307.
PRIDEiP58307.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030562; ENSMUSP00000030562; ENSMUSG00000028778.
ENSMUST00000119423; ENSMUSP00000112630; ENSMUSG00000028778.
ENSMUST00000120154; ENSMUSP00000113198; ENSMUSG00000028778.
ENSMUST00000164887; ENSMUSP00000127290; ENSMUSG00000028778.
GeneIDi230777.
KEGGimmu:230777.
UCSCiuc008uyx.1. mouse.

Organism-specific databases

CTDi3061.
MGIiMGI:2385650. Hcrtr1.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118781.
HOGENOMiHOG000230498.
HOVERGENiHBG101173.
InParanoidiP58307.
KOiK04238.
OMAiLMEPSAT.
OrthoDBiEOG7CG72H.
TreeFamiTF315303.

Enzyme and pathway databases

ReactomeiR-MMU-389397. Orexin and neuropeptides FF and QRFP bind to their respective receptors.
R-MMU-416476. G alpha (q) signalling events.

Miscellaneous databases

PROiP58307.
SOURCEiSearch...

Gene expression databases

BgeeiP58307.
CleanExiMM_HCRTR1.
GenevisibleiP58307. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000204. Orexin_rcpt.
IPR004059. Orexin_rcpt_1.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01521. OREXIN1R.
PR01064. OREXINR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic organization of mouse orexin receptors: characterization of two novel tissue-specific splice variants."
    Chen J., Randeva H.S.
    Mol. Endocrinol. 18:2790-2804(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: BALB/cJ.
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Corpora quadrigemina.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Cloning of mouse orexin receptors."
    Szendro P.I., Maevers K., Eichele G.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 134-393.
    Strain: C57BL/6J.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 141-339.
  7. "Hypocretin/orexin, sleep and narcolepsy."
    Hungs M., Mignot E.
    Bioessays 23:397-408(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  8. "To eat or to sleep? Orexin in the regulation of feeding and wakefulness."
    Willie J.T., Chemelli R.M., Sinton C.M., Yanagisawa M.
    Annu. Rev. Neurosci. 24:429-458(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiOX1R_MOUSE
AccessioniPrimary (citable) accession number: P58307
Secondary accession number(s): Q0VDP5
, Q3USS9, Q6VNS3, Q80T45
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: July 27, 2011
Last modified: June 8, 2016
This is version 120 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.