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Protein

Orexin receptor type 1

Gene

Hcrtr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Triggers an increase in cytoplasmic Ca2+ levels in response to orexin-A binding.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei36Important for responses to orexinBy similarity1
Binding sitei318AgonistBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-389397. Orexin and neuropeptides FF and QRFP bind to their respective receptors.
R-MMU-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Orexin receptor type 1
Short name:
Ox-1-R
Short name:
Ox1-R
Short name:
Ox1R
Alternative name(s):
Hypocretin receptor type 1
Gene namesi
Name:Hcrtr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2385650. Hcrtr1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 46ExtracellularBy similarityAdd BLAST46
Transmembranei47 – 67Helical; Name=1By similarityAdd BLAST21
Topological domaini68 – 82CytoplasmicBy similarityAdd BLAST15
Transmembranei83 – 105Helical; Name=2By similarityAdd BLAST23
Topological domaini106 – 119ExtracellularBy similarityAdd BLAST14
Transmembranei120 – 140Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini141 – 160CytoplasmicBy similarityAdd BLAST20
Transmembranei161 – 182Helical; Name=4By similarityAdd BLAST22
Topological domaini183 – 213ExtracellularBy similarityAdd BLAST31
Transmembranei214 – 235Helical; Name=5By similarityAdd BLAST22
Topological domaini236 – 298CytoplasmicBy similarityAdd BLAST63
Transmembranei299 – 321Helical; Name=6By similarityAdd BLAST23
Topological domaini322 – 336ExtracellularBy similarityAdd BLAST15
Transmembranei337 – 360Helical; Name=7By similarityAdd BLAST24
Topological domaini361 – 416CytoplasmicBy similarityAdd BLAST56

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2434819.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000699851 – 416Orexin receptor type 1Add BLAST416

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi119 ↔ 202By similarity
Glycosylationi194N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP58307.
PRIDEiP58307.

PTM databases

iPTMnetiP58307.
PhosphoSitePlusiP58307.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSMUSG00000028778.
CleanExiMM_HCRTR1.
GenevisibleiP58307. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030562.

Chemistry databases

BindingDBiP58307.

Structurei

3D structure databases

ProteinModelPortaliP58307.
SMRiP58307.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni26 – 41Required for response to orexin-ABy similarityAdd BLAST16

Domaini

The N-terminal region is required for orexin signaling.By similarity

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118781.
HOGENOMiHOG000230498.
HOVERGENiHBG101173.
InParanoidiP58307.
KOiK04238.
OMAiCCLPGLG.
OrthoDBiEOG091G0ZDG.
TreeFamiTF315303.

Family and domain databases

CDDicd15208. 7tmA_OXR. 1 hit.
InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000204. Orexin_rcpt.
IPR004059. Orexin_rcpt_1.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR01521. OREXIN1R.
PR01064. OREXINR.
SMARTiView protein in SMART
SM01381. 7TM_GPCR_Srsx. 1 hit.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P58307-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPSATPGAQ PGVPTSSGEP FHLPPDYEDE FLRYLWRDYL YPKQYEWVLI
60 70 80 90 100
AAYVAVFLIA LVGNTLVCLA VWRNHHMRTV TNYFIVNLSL ADVLVTAICL
110 120 130 140 150
PASLLVDITE SWLFGQALCK VIPYLQAVSV SVAVLTLSFI ALDRWYAICH
160 170 180 190 200
PLLFKSTARR ARGSILGIWA VSLAVMVPQA AVMECSSVLP ELANRTRLFS
210 220 230 240 250
VCDEHWADEL YPKIYHSCFF IVTYLAPLGL MAMAYFQIFR KLWGRQIPGT
260 270 280 290 300
TSALVRNWKR PSEQLEAQHQ GLCTEPQPRA RAFLAEVKQM RARRKTAKML
310 320 330 340 350
MVVLLVFALC YLPISVLNVL KRVFGMFRQA SDREAVYACF TFSHWLVYAN
360 370 380 390 400
SAANPIIYNF LSGKFREQFK AAFSCCLPGL GPGSSARHKS LSLQSRCSVS
410
KVSEHVVLTT VTTVLS
Length:416
Mass (Da):46,781
Last modified:July 27, 2011 - v3
Checksum:iAB338FFCEF905E06
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti139F → V in AAK71326 (Ref. 5) Curated1
Sequence conflicti232A → G in AAR01326 (PubMed:15256537).Curated1
Sequence conflicti232A → G in AAK71326 (Ref. 5) Curated1
Sequence conflicti232A → G in AAO85111 (PubMed:12679517).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY336083 mRNA. Translation: AAR01326.1.
AK140137 mRNA. Translation: BAE24252.1.
AL606925 Genomic DNA. Translation: CAM45913.1.
CU207372, CU210846 Genomic DNA. Translation: CAQ51584.1.
CU210846, CU207372 Genomic DNA. Translation: CAQ51833.1.
BC119583 mRNA. Translation: AAI19584.1.
AF394596 mRNA. Translation: AAK71326.1.
AY255599 mRNA. Translation: AAO85111.1.
CCDSiCCDS18707.1.
RefSeqiNP_001156499.1. NM_001163027.1.
NP_945197.2. NM_198959.2.
XP_017175645.1. XM_017320156.1.
XP_017175646.1. XM_017320157.1.
UniGeneiMm.246595.

Genome annotation databases

EnsembliENSMUST00000030562; ENSMUSP00000030562; ENSMUSG00000028778.
ENSMUST00000119423; ENSMUSP00000112630; ENSMUSG00000028778.
ENSMUST00000120154; ENSMUSP00000113198; ENSMUSG00000028778.
ENSMUST00000164887; ENSMUSP00000127290; ENSMUSG00000028778.
GeneIDi230777.
KEGGimmu:230777.
UCSCiuc008uyx.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiOX1R_MOUSE
AccessioniPrimary (citable) accession number: P58307
Secondary accession number(s): Q0VDP5
, Q3USS9, Q6VNS3, Q80T45
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: July 27, 2011
Last modified: August 30, 2017
This is version 129 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families