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P58306

- PCKG_THEVO

UniProt

P58306 - PCKG_THEVO

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Protein
Phosphoenolpyruvate carboxykinase [GTP]
Gene
pckG, TV0200, TVG0204657
Organism
Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle By similarity.UniRule annotation

Catalytic activityi

GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.UniRule annotation

Cofactori

Binds 1 manganese ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei75 – 751Substrate By similarity
Binding sitei209 – 2091Substrate; via amide nitrogen By similarity
Metal bindingi216 – 2161Manganese By similarity
Binding sitei216 – 2161Substrate By similarity
Metal bindingi236 – 2361Manganese; via tele nitrogen By similarity
Binding sitei258 – 2581Substrate By similarity
Active sitei260 – 2601 By similarity
Metal bindingi287 – 2871Manganese By similarity
Binding sitei376 – 3761GTP By similarity
Binding sitei407 – 4071GTP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi259 – 2646GTP By similarity
Nucleotide bindingi500 – 5034GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-HAMAP
  2. manganese ion binding Source: UniProtKB-HAMAP
  3. phosphoenolpyruvate carboxykinase (GTP) activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Gluconeogenesis

Keywords - Ligandi

GTP-binding, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTVOL273116:GC31-205-MONOMER.
UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxykinase [GTP] (EC:4.1.1.32)
Short name:
PEP carboxykinase
Short name:
PEPCK
Gene namesi
Name:pckG
Ordered Locus Names:TV0200
ORF Names:TVG0204657
OrganismiThermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Taxonomic identifieri273116 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
ProteomesiUP000001017: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 589589Phosphoenolpyruvate carboxykinase [GTP]UniRule annotation
PRO_0000103625Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi273116.TVN0200.

Structurei

3D structure databases

ProteinModelPortaliP58306.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni374 – 3763Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1274.
KOiK01596.
OMAiWDNPAGV.

Family and domain databases

Gene3Di3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPiMF_00452. PEPCK_GTP.
InterProiIPR013035. PEP_carboxykinase_C.
IPR008209. PEP_carboxykinase_GTP.
IPR008210. PEP_carboxykinase_N.
[Graphical view]
PANTHERiPTHR11561. PTHR11561. 1 hit.
PfamiPF00821. PEPCK. 1 hit.
[Graphical view]
PIRSFiPIRSF001348. PEP_carboxykinase_GTP. 1 hit.
SUPFAMiSSF68923. SSF68923. 1 hit.

Sequencei

Sequence statusi: Complete.

P58306-1 [UniParc]FASTAAdd to Basket

« Hide

MLALDETEIN DGAKRWIVSI AKHLNPSSIY VCDGTKEEFD DLASAMVKDG    50
EMIKLNEKNF KNSYLYRSNA TDVARTEERT FISARDKSFV GPLNNFLPLD 100
RVKQVWNQFF KGAYTGKTMF VIPYALSSPE SKFADFGIEV TDSKYVVLNL 150
HYITRMGKGV IEKIGDRFIK GVHATGNLDP GNKFIIHMPW EKPEGVDADI 200
LSVNTNYGGN ALLSKKCHAL RIASVRAREE GWLAEHMLLL EVKDPQGKSH 250
FITGAFPSAS GKTNLAMISP PKDYRDAGWS TRLISDDISW IKIVDGKFMA 300
TNPENGFFAV VPGTNYNTNK NAMATLSKNT IFTNVGLTMS GDPWWEGLDP 350
VYDELYDWKG NKRKIGGEPI AHPNSRYTSP LTNYPYLSDL YEDPEGVPVS 400
AILFGGRRAT LIPLVFEAFN WNHGVFLGAT MGVERTAASE GKVGDLRRDP 450
MAMRPFCGYN INEYFRHWIE IGERSKNKPK IFYVNWFRRR ADGTFIWPGF 500
AENFRVLEWI IYRTSHNDNA VETPIGYIPE SLNLAGLNIS EEDVKELFRI 550
DKEGWKEEMN EIQKYFSELG NVPEEILKEF ELEKKRLGY 589
Length:589
Mass (Da):66,908
Last modified:September 26, 2001 - v1
Checksum:iE339F1A18012962B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000011 Genomic DNA. Translation: BAB59342.1.
RefSeqiNP_110719.1. NC_002689.2.

Genome annotation databases

EnsemblBacteriaiBAB59342; BAB59342; BAB59342.
GeneIDi1441686.
KEGGitvo:TVN0200.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000011 Genomic DNA. Translation: BAB59342.1 .
RefSeqi NP_110719.1. NC_002689.2.

3D structure databases

ProteinModelPortali P58306.
ModBasei Search...

Protein-protein interaction databases

STRINGi 273116.TVN0200.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB59342 ; BAB59342 ; BAB59342 .
GeneIDi 1441686.
KEGGi tvo:TVN0200.

Phylogenomic databases

eggNOGi COG1274.
KOi K01596.
OMAi WDNPAGV.

Enzyme and pathway databases

UniPathwayi UPA00138 .
BioCyci TVOL273116:GC31-205-MONOMER.

Family and domain databases

Gene3Di 3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPi MF_00452. PEPCK_GTP.
InterProi IPR013035. PEP_carboxykinase_C.
IPR008209. PEP_carboxykinase_GTP.
IPR008210. PEP_carboxykinase_N.
[Graphical view ]
PANTHERi PTHR11561. PTHR11561. 1 hit.
Pfami PF00821. PEPCK. 1 hit.
[Graphical view ]
PIRSFi PIRSF001348. PEP_carboxykinase_GTP. 1 hit.
SUPFAMi SSF68923. SSF68923. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1.

Entry informationi

Entry nameiPCKG_THEVO
AccessioniPrimary (citable) accession number: P58306
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: September 26, 2001
Last modified: May 14, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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