Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P58306

- PCKG_THEVO

UniProt

P58306 - PCKG_THEVO

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Phosphoenolpyruvate carboxykinase [GTP]

Gene

pckG

Organism
Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.UniRule annotation

Catalytic activityi

GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.UniRule annotation

Cofactori

Binds 1 manganese ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei75 – 751SubstrateUniRule annotation
Binding sitei209 – 2091Substrate; via amide nitrogenUniRule annotation
Metal bindingi216 – 2161ManganeseUniRule annotation
Binding sitei216 – 2161SubstrateUniRule annotation
Metal bindingi236 – 2361Manganese; via tele nitrogenUniRule annotation
Binding sitei258 – 2581SubstrateUniRule annotation
Active sitei260 – 2601UniRule annotation
Metal bindingi287 – 2871ManganeseUniRule annotation
Binding sitei376 – 3761GTPUniRule annotation
Binding sitei407 – 4071GTPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi259 – 2646GTPUniRule annotation
Nucleotide bindingi500 – 5034GTPUniRule annotation

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-HAMAP
  2. manganese ion binding Source: UniProtKB-HAMAP
  3. phosphoenolpyruvate carboxykinase (GTP) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Gluconeogenesis

Keywords - Ligandi

GTP-binding, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTVOL273116:GC31-205-MONOMER.
UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxykinase [GTP]UniRule annotation (EC:4.1.1.32UniRule annotation)
Short name:
PEP carboxykinaseUniRule annotation
Short name:
PEPCKUniRule annotation
Gene namesi
Name:pckGUniRule annotation
Ordered Locus Names:TV0200
ORF Names:TVG0204657
OrganismiThermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Taxonomic identifieri273116 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
ProteomesiUP000001017: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 589589Phosphoenolpyruvate carboxykinase [GTP]PRO_0000103625Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi273116.TVN0200.

Structurei

3D structure databases

ProteinModelPortaliP58306.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni374 – 3763Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1274.
KOiK01596.
OMAiWDNPAGV.

Family and domain databases

Gene3Di3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPiMF_00452. PEPCK_GTP.
InterProiIPR013035. PEP_carboxykinase_C.
IPR008209. PEP_carboxykinase_GTP.
IPR008210. PEP_carboxykinase_N.
[Graphical view]
PANTHERiPTHR11561. PTHR11561. 1 hit.
PfamiPF00821. PEPCK. 1 hit.
[Graphical view]
PIRSFiPIRSF001348. PEP_carboxykinase_GTP. 1 hit.
SUPFAMiSSF68923. SSF68923. 1 hit.

Sequencei

Sequence statusi: Complete.

P58306-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLALDETEIN DGAKRWIVSI AKHLNPSSIY VCDGTKEEFD DLASAMVKDG
60 70 80 90 100
EMIKLNEKNF KNSYLYRSNA TDVARTEERT FISARDKSFV GPLNNFLPLD
110 120 130 140 150
RVKQVWNQFF KGAYTGKTMF VIPYALSSPE SKFADFGIEV TDSKYVVLNL
160 170 180 190 200
HYITRMGKGV IEKIGDRFIK GVHATGNLDP GNKFIIHMPW EKPEGVDADI
210 220 230 240 250
LSVNTNYGGN ALLSKKCHAL RIASVRAREE GWLAEHMLLL EVKDPQGKSH
260 270 280 290 300
FITGAFPSAS GKTNLAMISP PKDYRDAGWS TRLISDDISW IKIVDGKFMA
310 320 330 340 350
TNPENGFFAV VPGTNYNTNK NAMATLSKNT IFTNVGLTMS GDPWWEGLDP
360 370 380 390 400
VYDELYDWKG NKRKIGGEPI AHPNSRYTSP LTNYPYLSDL YEDPEGVPVS
410 420 430 440 450
AILFGGRRAT LIPLVFEAFN WNHGVFLGAT MGVERTAASE GKVGDLRRDP
460 470 480 490 500
MAMRPFCGYN INEYFRHWIE IGERSKNKPK IFYVNWFRRR ADGTFIWPGF
510 520 530 540 550
AENFRVLEWI IYRTSHNDNA VETPIGYIPE SLNLAGLNIS EEDVKELFRI
560 570 580
DKEGWKEEMN EIQKYFSELG NVPEEILKEF ELEKKRLGY
Length:589
Mass (Da):66,908
Last modified:September 26, 2001 - v1
Checksum:iE339F1A18012962B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000011 Genomic DNA. Translation: BAB59342.1.
RefSeqiNP_110719.1. NC_002689.2.
WP_010916456.1. NC_002689.2.

Genome annotation databases

EnsemblBacteriaiBAB59342; BAB59342; BAB59342.
GeneIDi1441686.
KEGGitvo:TVN0200.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000011 Genomic DNA. Translation: BAB59342.1 .
RefSeqi NP_110719.1. NC_002689.2.
WP_010916456.1. NC_002689.2.

3D structure databases

ProteinModelPortali P58306.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273116.TVN0200.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB59342 ; BAB59342 ; BAB59342 .
GeneIDi 1441686.
KEGGi tvo:TVN0200.

Phylogenomic databases

eggNOGi COG1274.
KOi K01596.
OMAi WDNPAGV.

Enzyme and pathway databases

UniPathwayi UPA00138 .
BioCyci TVOL273116:GC31-205-MONOMER.

Family and domain databases

Gene3Di 3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPi MF_00452. PEPCK_GTP.
InterProi IPR013035. PEP_carboxykinase_C.
IPR008209. PEP_carboxykinase_GTP.
IPR008210. PEP_carboxykinase_N.
[Graphical view ]
PANTHERi PTHR11561. PTHR11561. 1 hit.
Pfami PF00821. PEPCK. 1 hit.
[Graphical view ]
PIRSFi PIRSF001348. PEP_carboxykinase_GTP. 1 hit.
SUPFAMi SSF68923. SSF68923. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1.

Entry informationi

Entry nameiPCKG_THEVO
AccessioniPrimary (citable) accession number: P58306
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: September 26, 2001
Last modified: October 29, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3