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Protein

Phosphoenolpyruvate carboxykinase [GTP]

Gene

pckG

Organism
Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.UniRule annotation

Catalytic activityi

GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 1 Mn2+ ion per subunit.UniRule annotation

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei75SubstrateUniRule annotation1
Metal bindingi216ManganeseUniRule annotation1
Metal bindingi236Manganese; via tele nitrogenUniRule annotation1
Binding sitei258SubstrateUniRule annotation1
Active sitei260UniRule annotation1
Metal bindingi287ManganeseUniRule annotation1
Binding sitei376GTPUniRule annotation1
Binding sitei407GTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi259 – 264GTPUniRule annotation6
Nucleotide bindingi500 – 503GTPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processGluconeogenesis
LigandGTP-binding, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTVOL273116:G1G3C-212-MONOMER
UniPathwayiUPA00138

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxykinase [GTP]UniRule annotation (EC:4.1.1.32UniRule annotation)
Short name:
PEP carboxykinaseUniRule annotation
Short name:
PEPCKUniRule annotation
Gene namesi
Name:pckGUniRule annotation
Ordered Locus Names:TV0200
ORF Names:TVG0204657
OrganismiThermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Taxonomic identifieri273116 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
Proteomesi
  • UP000001017 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001036251 – 589Phosphoenolpyruvate carboxykinase [GTP]Add BLAST589

Proteomic databases

PRIDEiP58306

Interactioni

Protein-protein interaction databases

STRINGi273116.TVN0200

Structurei

3D structure databases

ProteinModelPortaliP58306
SMRiP58306
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni207 – 209Substrate bindingUniRule annotation3
Regioni374 – 376Substrate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG05865 Archaea
COG1274 LUCA
KOiK01596
OMAiCWLALTD
OrthoDBiPOG093Z01SN

Family and domain databases

CDDicd00819 PEPCK_GTP, 1 hit
Gene3Di3.40.449.10, 2 hits
3.90.228.20, 2 hits
HAMAPiMF_00452 PEPCK_GTP, 1 hit
InterProiView protein in InterPro
IPR013035 PEP_carboxykinase_C
IPR008209 PEP_carboxykinase_GTP
IPR035077 PEP_carboxykinase_GTP_C
IPR035078 PEP_carboxykinase_GTP_N
IPR008210 PEP_carboxykinase_N
PANTHERiPTHR11561 PTHR11561, 1 hit
PfamiView protein in Pfam
PF00821 PEPCK_C, 1 hit
PF17297 PEPCK_N, 1 hit
PIRSFiPIRSF001348 PEP_carboxykinase_GTP, 1 hit
SUPFAMiSSF68923 SSF68923, 1 hit

Sequencei

Sequence statusi: Complete.

P58306-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLALDETEIN DGAKRWIVSI AKHLNPSSIY VCDGTKEEFD DLASAMVKDG
60 70 80 90 100
EMIKLNEKNF KNSYLYRSNA TDVARTEERT FISARDKSFV GPLNNFLPLD
110 120 130 140 150
RVKQVWNQFF KGAYTGKTMF VIPYALSSPE SKFADFGIEV TDSKYVVLNL
160 170 180 190 200
HYITRMGKGV IEKIGDRFIK GVHATGNLDP GNKFIIHMPW EKPEGVDADI
210 220 230 240 250
LSVNTNYGGN ALLSKKCHAL RIASVRAREE GWLAEHMLLL EVKDPQGKSH
260 270 280 290 300
FITGAFPSAS GKTNLAMISP PKDYRDAGWS TRLISDDISW IKIVDGKFMA
310 320 330 340 350
TNPENGFFAV VPGTNYNTNK NAMATLSKNT IFTNVGLTMS GDPWWEGLDP
360 370 380 390 400
VYDELYDWKG NKRKIGGEPI AHPNSRYTSP LTNYPYLSDL YEDPEGVPVS
410 420 430 440 450
AILFGGRRAT LIPLVFEAFN WNHGVFLGAT MGVERTAASE GKVGDLRRDP
460 470 480 490 500
MAMRPFCGYN INEYFRHWIE IGERSKNKPK IFYVNWFRRR ADGTFIWPGF
510 520 530 540 550
AENFRVLEWI IYRTSHNDNA VETPIGYIPE SLNLAGLNIS EEDVKELFRI
560 570 580
DKEGWKEEMN EIQKYFSELG NVPEEILKEF ELEKKRLGY
Length:589
Mass (Da):66,908
Last modified:September 26, 2001 - v1
Checksum:iE339F1A18012962B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000011 Genomic DNA Translation: BAB59342.1
RefSeqiWP_010916456.1, NC_002689.2

Genome annotation databases

EnsemblBacteriaiBAB59342; BAB59342; BAB59342
GeneIDi1441686
KEGGitvo:TVG0204657

Similar proteinsi

Entry informationi

Entry nameiPCKG_THEVO
AccessioniPrimary (citable) accession number: P58306
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: September 26, 2001
Last modified: May 23, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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