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P58306

- PCKG_THEVO

UniProt

P58306 - PCKG_THEVO

Protein

Phosphoenolpyruvate carboxykinase [GTP]

Gene

pckG

Organism
Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (26 Sep 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.UniRule annotation

    Catalytic activityi

    GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.UniRule annotation

    Cofactori

    Binds 1 manganese ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei75 – 751SubstrateUniRule annotation
    Binding sitei209 – 2091Substrate; via amide nitrogenUniRule annotation
    Metal bindingi216 – 2161ManganeseUniRule annotation
    Binding sitei216 – 2161SubstrateUniRule annotation
    Metal bindingi236 – 2361Manganese; via tele nitrogenUniRule annotation
    Binding sitei258 – 2581SubstrateUniRule annotation
    Active sitei260 – 2601UniRule annotation
    Metal bindingi287 – 2871ManganeseUniRule annotation
    Binding sitei376 – 3761GTPUniRule annotation
    Binding sitei407 – 4071GTPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi259 – 2646GTPUniRule annotation
    Nucleotide bindingi500 – 5034GTPUniRule annotation

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-HAMAP
    2. manganese ion binding Source: UniProtKB-HAMAP
    3. phosphoenolpyruvate carboxykinase (GTP) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Gluconeogenesis

    Keywords - Ligandi

    GTP-binding, Manganese, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTVOL273116:GC31-205-MONOMER.
    UniPathwayiUPA00138.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoenolpyruvate carboxykinase [GTP]UniRule annotation (EC:4.1.1.32UniRule annotation)
    Short name:
    PEP carboxykinaseUniRule annotation
    Short name:
    PEPCKUniRule annotation
    Gene namesi
    Name:pckGUniRule annotation
    Ordered Locus Names:TV0200
    ORF Names:TVG0204657
    OrganismiThermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
    Taxonomic identifieri273116 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 589589Phosphoenolpyruvate carboxykinase [GTP]PRO_0000103625Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi273116.TVN0200.

    Structurei

    3D structure databases

    ProteinModelPortaliP58306.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni374 – 3763Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1274.
    KOiK01596.
    OMAiWDNPAGV.

    Family and domain databases

    Gene3Di3.40.449.10. 1 hit.
    3.90.228.20. 2 hits.
    HAMAPiMF_00452. PEPCK_GTP.
    InterProiIPR013035. PEP_carboxykinase_C.
    IPR008209. PEP_carboxykinase_GTP.
    IPR008210. PEP_carboxykinase_N.
    [Graphical view]
    PANTHERiPTHR11561. PTHR11561. 1 hit.
    PfamiPF00821. PEPCK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001348. PEP_carboxykinase_GTP. 1 hit.
    SUPFAMiSSF68923. SSF68923. 1 hit.
    ProtoNetiSearch...

    Sequencei

    Sequence statusi: Complete.

    P58306-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLALDETEIN DGAKRWIVSI AKHLNPSSIY VCDGTKEEFD DLASAMVKDG    50
    EMIKLNEKNF KNSYLYRSNA TDVARTEERT FISARDKSFV GPLNNFLPLD 100
    RVKQVWNQFF KGAYTGKTMF VIPYALSSPE SKFADFGIEV TDSKYVVLNL 150
    HYITRMGKGV IEKIGDRFIK GVHATGNLDP GNKFIIHMPW EKPEGVDADI 200
    LSVNTNYGGN ALLSKKCHAL RIASVRAREE GWLAEHMLLL EVKDPQGKSH 250
    FITGAFPSAS GKTNLAMISP PKDYRDAGWS TRLISDDISW IKIVDGKFMA 300
    TNPENGFFAV VPGTNYNTNK NAMATLSKNT IFTNVGLTMS GDPWWEGLDP 350
    VYDELYDWKG NKRKIGGEPI AHPNSRYTSP LTNYPYLSDL YEDPEGVPVS 400
    AILFGGRRAT LIPLVFEAFN WNHGVFLGAT MGVERTAASE GKVGDLRRDP 450
    MAMRPFCGYN INEYFRHWIE IGERSKNKPK IFYVNWFRRR ADGTFIWPGF 500
    AENFRVLEWI IYRTSHNDNA VETPIGYIPE SLNLAGLNIS EEDVKELFRI 550
    DKEGWKEEMN EIQKYFSELG NVPEEILKEF ELEKKRLGY 589
    Length:589
    Mass (Da):66,908
    Last modified:September 26, 2001 - v1
    Checksum:iE339F1A18012962B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000011 Genomic DNA. Translation: BAB59342.1.
    RefSeqiNP_110719.1. NC_002689.2.

    Genome annotation databases

    EnsemblBacteriaiBAB59342; BAB59342; BAB59342.
    GeneIDi1441686.
    KEGGitvo:TVN0200.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000011 Genomic DNA. Translation: BAB59342.1 .
    RefSeqi NP_110719.1. NC_002689.2.

    3D structure databases

    ProteinModelPortali P58306.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 273116.TVN0200.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB59342 ; BAB59342 ; BAB59342 .
    GeneIDi 1441686.
    KEGGi tvo:TVN0200.

    Phylogenomic databases

    eggNOGi COG1274.
    KOi K01596.
    OMAi WDNPAGV.

    Enzyme and pathway databases

    UniPathwayi UPA00138 .
    BioCyci TVOL273116:GC31-205-MONOMER.

    Family and domain databases

    Gene3Di 3.40.449.10. 1 hit.
    3.90.228.20. 2 hits.
    HAMAPi MF_00452. PEPCK_GTP.
    InterProi IPR013035. PEP_carboxykinase_C.
    IPR008209. PEP_carboxykinase_GTP.
    IPR008210. PEP_carboxykinase_N.
    [Graphical view ]
    PANTHERi PTHR11561. PTHR11561. 1 hit.
    Pfami PF00821. PEPCK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001348. PEP_carboxykinase_GTP. 1 hit.
    SUPFAMi SSF68923. SSF68923. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1.

    Entry informationi

    Entry nameiPCKG_THEVO
    AccessioniPrimary (citable) accession number: P58306
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2001
    Last sequence update: September 26, 2001
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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