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P58280

- MT1_BOVIN

UniProt

P58280 - MT1_BOVIN

Protein

Metallothionein-1

Gene

MT1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi5 – 51Divalent metal cation; cluster B
    Metal bindingi7 – 71Divalent metal cation; cluster B
    Metal bindingi13 – 131Divalent metal cation; cluster B
    Metal bindingi15 – 151Divalent metal cation; cluster B
    Metal bindingi19 – 191Divalent metal cation; cluster B
    Metal bindingi21 – 211Divalent metal cation; cluster B
    Metal bindingi24 – 241Divalent metal cation; cluster B
    Metal bindingi26 – 261Divalent metal cation; cluster B
    Metal bindingi29 – 291Divalent metal cation; cluster B
    Metal bindingi33 – 331Divalent metal cation; cluster A
    Metal bindingi34 – 341Divalent metal cation; cluster A
    Metal bindingi36 – 361Divalent metal cation; cluster A
    Metal bindingi37 – 371Divalent metal cation; cluster A
    Metal bindingi41 – 411Divalent metal cation; cluster A
    Metal bindingi44 – 441Divalent metal cation; cluster A
    Metal bindingi48 – 481Divalent metal cation; cluster A
    Metal bindingi50 – 501Divalent metal cation; cluster A
    Metal bindingi57 – 571Divalent metal cation; cluster A
    Metal bindingi59 – 591Divalent metal cation; cluster A
    Metal bindingi60 – 601Divalent metal cation; cluster A

    GO - Molecular functioni

    1. zinc ion binding Source: UniProtKB

    GO - Biological processi

    1. cellular response to zinc ion Source: UniProtKB
    2. negative regulation of growth Source: UniProtKB

    Keywords - Ligandi

    Cadmium, Copper, Metal-binding, Metal-thiolate cluster, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Metallothionein-1
    Short name:
    MT-1
    Alternative name(s):
    Metallothionein-I
    Short name:
    MT-I
    Gene namesi
    Name:MT1
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. nucleus Source: UniProtKB
    3. perinuclear region of cytoplasm Source: UniProtKB

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 6161Metallothionein-1PRO_0000197197Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiP58280.
    PRIDEiP58280.

    Interactioni

    Subunit structurei

    Monomer.

    Structurei

    3D structure databases

    ProteinModelPortaliP58280.
    SMRiP58280. Positions 1-61.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 2929BetaAdd
    BLAST
    Regioni30 – 6132AlphaAdd
    BLAST

    Domaini

    Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG138665.
    HOVERGENiHBG009063.
    InParanoidiP58280.

    Family and domain databases

    Gene3Di4.10.10.10. 1 hit.
    InterProiIPR017854. Metalthion_dom.
    IPR023587. Metalthion_dom_vert.
    IPR003019. Metalthion_sfam_euk.
    IPR000006. Metalthion_vert.
    IPR018064. Metalthion_vert_metal_BS.
    [Graphical view]
    PANTHERiPTHR23299. PTHR23299. 1 hit.
    PfamiPF00131. Metallothio. 1 hit.
    [Graphical view]
    PRINTSiPR00860. MTVERTEBRATE.
    SUPFAMiSSF57868. SSF57868. 1 hit.
    PROSITEiPS00203. METALLOTHIONEIN_VRT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P58280-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDPNCSCPTG GSCTCAGSCK CKACRCPSCK KSCCSCCPVG CAKCAQGCVC   50
    KGASDKCSCC A 61
    Length:61
    Mass (Da):5,992
    Last modified:September 26, 2001 - v1
    Checksum:i3B4F7AF88ABC6993
    GO

    Sequence databases

    PIRiA23889.

    Cross-referencesi

    Sequence databases

    PIRi A23889.

    3D structure databases

    ProteinModelPortali P58280.
    SMRi P58280. Positions 1-61.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi P58280.
    PRIDEi P58280.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi NOG138665.
    HOVERGENi HBG009063.
    InParanoidi P58280.

    Family and domain databases

    Gene3Di 4.10.10.10. 1 hit.
    InterProi IPR017854. Metalthion_dom.
    IPR023587. Metalthion_dom_vert.
    IPR003019. Metalthion_sfam_euk.
    IPR000006. Metalthion_vert.
    IPR018064. Metalthion_vert_metal_BS.
    [Graphical view ]
    PANTHERi PTHR23299. PTHR23299. 1 hit.
    Pfami PF00131. Metallothio. 1 hit.
    [Graphical view ]
    PRINTSi PR00860. MTVERTEBRATE.
    SUPFAMi SSF57868. SSF57868. 1 hit.
    PROSITEi PS00203. METALLOTHIONEIN_VRT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "(Cu,Zn)-metallothioneins from fetal bovine liver. Chemical and spectroscopic properties."
      Muenger K., Germann U.A., Beltramini M., Niedermann D., Baitella-Eberle G., Kaegi J.H.R., Lerch K.
      J. Biol. Chem. 260:10032-10038(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE.
      Tissue: Liver.

    Entry informationi

    Entry nameiMT1_BOVIN
    AccessioniPrimary (citable) accession number: P58280
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2001
    Last sequence update: September 26, 2001
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Metallothioneins
      Classification of metallothioneins and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3