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P58215

- LOXL3_HUMAN

UniProt

P58215 - LOXL3_HUMAN

Protein

Lysyl oxidase homolog 3

Gene

LOXL3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 1 (11 Jul 2001)
      Previous versions | rss
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    Functioni

    Both isoforms function as amine oxidases toward elastin and different types of collagens. Isoform 1 shows the highest activity toward collagen type VIII, while Isoform 2 presents the highest activity toward collagen type IV.1 Publication

    Cofactori

    Copper.By similarity
    Contains 1 lysine tyrosylquinone.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi607 – 6071CopperSequence Analysis
    Metal bindingi609 – 6091CopperSequence Analysis
    Metal bindingi611 – 6111CopperSequence Analysis

    GO - Molecular functioni

    1. copper ion binding Source: UniProtKB
    2. protein binding Source: UniProtKB
    3. protein-lysine 6-oxidase activity Source: UniProtKB
    4. scavenger receptor activity Source: InterPro

    GO - Biological processi

    1. epithelial to mesenchymal transition Source: UniProtKB
    2. negative regulation of transcription, DNA-templated Source: UniProtKB

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Copper, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_150206. Crosslinking of collagen fibrils.
    REACT_150366. Elastic fibre formation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysyl oxidase homolog 3 (EC:1.4.3.-)
    Alternative name(s):
    Lysyl oxidase-like protein 3
    Gene namesi
    Name:LOXL3
    Synonyms:LOXL
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:13869. LOXL3.

    Subcellular locationi

    Isoform 2 : Cytoplasm 1 Publication. Secretedextracellular space 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. extracellular region Source: UniProtKB
    3. extracellular space Source: UniProtKB-SubCell
    4. membrane Source: InterPro
    5. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30430.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 753728Lysyl oxidase homolog 3PRO_0000018533Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi70 ↔ 134PROSITE-ProRule annotation
    Disulfide bondi83 ↔ 144PROSITE-ProRule annotation
    Glycosylationi111 – 1111N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi114 ↔ 124PROSITE-ProRule annotation
    Disulfide bondi201 ↔ 271PROSITE-ProRule annotation
    Disulfide bondi214 ↔ 281PROSITE-ProRule annotation
    Disulfide bondi248 ↔ 258PROSITE-ProRule annotation
    Glycosylationi266 – 2661N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi332 ↔ 396PROSITE-ProRule annotation
    Disulfide bondi345 ↔ 406PROSITE-ProRule annotation
    Disulfide bondi376 ↔ 386PROSITE-ProRule annotation
    Glycosylationi390 – 3901N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi446 ↔ 511PROSITE-ProRule annotation
    Disulfide bondi459 ↔ 524PROSITE-ProRule annotation
    Glycosylationi481 – 4811N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi492 ↔ 502PROSITE-ProRule annotation
    Disulfide bondi554 ↔ 560PROSITE-ProRule annotation
    Disulfide bondi606 ↔ 654PROSITE-ProRule annotation
    Glycosylationi625 – 6251N-linked (GlcNAc...)Sequence Analysis
    Cross-linki634 ↔ 670Lysine tyrosylquinone (Lys-Tyr)By similarity
    Disulfide bondi638 ↔ 644PROSITE-ProRule annotation
    Disulfide bondi666 ↔ 676PROSITE-ProRule annotation
    Modified residuei670 – 67012',4',5'-topaquinoneBy similarity
    Disulfide bondi713 ↔ 727PROSITE-ProRule annotation

    Post-translational modificationi

    The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.

    Keywords - PTMi

    Disulfide bond, Glycoprotein, LTQ, TPQ

    Proteomic databases

    PaxDbiP58215.
    PRIDEiP58215.

    PTM databases

    PhosphoSiteiP58215.

    Expressioni

    Tissue specificityi

    Isoform 1 ia predominantly detected in the heart, placenta, lung, and small intestine, while isoform 2 is more highly detected in the kidney, pancreas, spleen, and thymus, and is absent in lung.1 Publication

    Gene expression databases

    ArrayExpressiP58215.
    BgeeiP58215.
    CleanExiHS_LOXL3.
    GenevestigatoriP58215.

    Organism-specific databases

    HPAiHPA035281.

    Interactioni

    Protein-protein interaction databases

    IntActiP58215. 1 interaction.
    MINTiMINT-1427254.
    STRINGi9606.ENSP00000264094.

    Structurei

    3D structure databases

    ProteinModelPortaliP58215.
    SMRiP58215. Positions 56-144, 304-406, 417-529.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini44 – 145102SRCR 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini169 – 282114SRCR 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini307 – 407101SRCR 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini417 – 525109SRCR 4PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni529 – 732204Lysyl-oxidase likeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the lysyl oxidase family.Curated
    Contains 4 SRCR domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG40770.
    HOGENOMiHOG000220841.
    HOVERGENiHBG052336.
    InParanoidiP58215.
    KOiK00280.
    OMAiTWYWDSG.
    PhylomeDBiP58215.
    TreeFamiTF326061.

    Family and domain databases

    Gene3Di3.10.250.10. 4 hits.
    InterProiIPR001695. Lysyl_oxidase.
    IPR019828. Lysyl_oxidase_CS.
    IPR001190. SRCR.
    IPR017448. SRCR-like_dom.
    [Graphical view]
    PfamiPF01186. Lysyl_oxidase. 1 hit.
    PF00530. SRCR. 4 hits.
    [Graphical view]
    PRINTSiPR00074. LYSYLOXIDASE.
    PR00258. SPERACTRCPTR.
    SMARTiSM00202. SR. 4 hits.
    [Graphical view]
    SUPFAMiSSF56487. SSF56487. 4 hits.
    PROSITEiPS00926. LYSYL_OXIDASE. 1 hit.
    PS00420. SRCR_1. 1 hit.
    PS50287. SRCR_2. 4 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P58215-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRPVSVWQWS PWGLLLCLLC SSCLGSPSPS TGPEKKAGSQ GLRFRLAGFP    50
    RKPYEGRVEI QRAGEWGTIC DDDFTLQAAH ILCRELGFTE ATGWTHSAKY 100
    GPGTGRIWLD NLSCSGTEQS VTECASRGWG NSDCTHDEDA GVICKDQRLP 150
    GFSDSNVIEV EHHLQVEEVR IRPAVGWGRR PLPVTEGLVE VRLPDGWSQV 200
    CDKGWSAHNS HVVCGMLGFP SEKRVNAAFY RLLAQRQQHS FGLHGVACVG 250
    TEAHLSLCSL EFYRANDTAR CPGGGPAVVS CVPGPVYAAS SGQKKQQQSK 300
    PQGEARVRLK GGAHPGEGRV EVLKASTWGT VCDRKWDLHA ASVVCRELGF 350
    GSAREALSGA RMGQGMGAIH LSEVRCSGQE LSLWKCPHKN ITAEDCSHSQ 400
    DAGVRCNLPY TGAETRIRLS GGRSQHEGRV EVQIGGPGPL RWGLICGDDW 450
    GTLEAMVACR QLGLGYANHG LQETWYWDSG NITEVVMSGV RCTGTELSLD 500
    QCAHHGTHIT CKRTGTRFTA GVICSETASD LLLHSALVQE TAYIEDRPLH 550
    MLYCAAEENC LASSARSANW PYGHRRLLRF SSQIHNLGRA DFRPKAGRHS 600
    WVWHECHGHY HSMDIFTHYD ILTPNGTKVA EGHKASFCLE DTECQEDVSK 650
    RYECANFGEQ GITVGCWDLY RHDIDCQWID ITDVKPGNYI LQVVINPNFE 700
    VAESDFTNNA MKCNCKYDGH RIWVHNCHIG DAFSEEANRR FERYPGQTSN 750
    QII 753
    Length:753
    Mass (Da):83,166
    Last modified:July 11, 2001 - v1
    Checksum:i582C46DA25E05A69
    GO
    Isoform 2 (identifier: P58215-2) [UniParc]FASTAAdd to Basket

    Also known as: LOXL3-sv1

    The sequence of this isoform differs from the canonical sequence as follows:
         1-361: Missing.

    Note: Misses three SRCR domains.

    Show »
    Length:392
    Mass (Da):44,049
    Checksum:iEF83ED2AB3CE9EC0
    GO
    Isoform 3 (identifier: P58215-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         159-303: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:608
    Mass (Da):67,445
    Checksum:iB33B22A417B184DD
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti159 – 1591E → K in AAK91134. (PubMed:11334717)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti615 – 6151I → F.
    Corresponds to variant rs17010021 [ dbSNP | Ensembl ].
    VAR_050011

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 361361Missing in isoform 2. 1 PublicationVSP_054417Add
    BLAST
    Alternative sequencei159 – 303145Missing in isoform 3. 1 PublicationVSP_054418Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF282619 mRNA. Translation: AAK51671.1.
    AF311313 mRNA. Translation: AAK63205.1.
    AF284815 mRNA. Translation: AAK91134.1.
    DQ378059 mRNA. Translation: ABD23013.1.
    AC005033 Genomic DNA. No translation available.
    AC005041 Genomic DNA. No translation available.
    CH471053 Genomic DNA. Translation: EAW99615.1.
    CH471053 Genomic DNA. Translation: EAW99616.1.
    BC071865 mRNA. Translation: AAH71865.1.
    CCDSiCCDS1953.1. [P58215-1]
    RefSeqiNP_001276093.1. NM_001289164.1. [P58215-3]
    NP_001276094.1. NM_001289165.1. [P58215-2]
    NP_115992.1. NM_032603.3. [P58215-1]
    UniGeneiHs.469045.

    Genome annotation databases

    EnsembliENST00000264094; ENSP00000264094; ENSG00000115318. [P58215-1]
    ENST00000393937; ENSP00000377512; ENSG00000115318. [P58215-3]
    GeneIDi84695.
    KEGGihsa:84695.
    UCSCiuc002smo.1. human. [P58215-1]

    Polymorphism databases

    DMDMi14916616.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF282619 mRNA. Translation: AAK51671.1 .
    AF311313 mRNA. Translation: AAK63205.1 .
    AF284815 mRNA. Translation: AAK91134.1 .
    DQ378059 mRNA. Translation: ABD23013.1 .
    AC005033 Genomic DNA. No translation available.
    AC005041 Genomic DNA. No translation available.
    CH471053 Genomic DNA. Translation: EAW99615.1 .
    CH471053 Genomic DNA. Translation: EAW99616.1 .
    BC071865 mRNA. Translation: AAH71865.1 .
    CCDSi CCDS1953.1. [P58215-1 ]
    RefSeqi NP_001276093.1. NM_001289164.1. [P58215-3 ]
    NP_001276094.1. NM_001289165.1. [P58215-2 ]
    NP_115992.1. NM_032603.3. [P58215-1 ]
    UniGenei Hs.469045.

    3D structure databases

    ProteinModelPortali P58215.
    SMRi P58215. Positions 56-144, 304-406, 417-529.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P58215. 1 interaction.
    MINTi MINT-1427254.
    STRINGi 9606.ENSP00000264094.

    PTM databases

    PhosphoSitei P58215.

    Polymorphism databases

    DMDMi 14916616.

    Proteomic databases

    PaxDbi P58215.
    PRIDEi P58215.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000264094 ; ENSP00000264094 ; ENSG00000115318 . [P58215-1 ]
    ENST00000393937 ; ENSP00000377512 ; ENSG00000115318 . [P58215-3 ]
    GeneIDi 84695.
    KEGGi hsa:84695.
    UCSCi uc002smo.1. human. [P58215-1 ]

    Organism-specific databases

    CTDi 84695.
    GeneCardsi GC02M074760.
    HGNCi HGNC:13869. LOXL3.
    HPAi HPA035281.
    MIMi 607163. gene.
    neXtProti NX_P58215.
    PharmGKBi PA30430.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG40770.
    HOGENOMi HOG000220841.
    HOVERGENi HBG052336.
    InParanoidi P58215.
    KOi K00280.
    OMAi TWYWDSG.
    PhylomeDBi P58215.
    TreeFami TF326061.

    Enzyme and pathway databases

    Reactomei REACT_150206. Crosslinking of collagen fibrils.
    REACT_150366. Elastic fibre formation.

    Miscellaneous databases

    ChiTaRSi LOXL3. human.
    GeneWikii LOXL3.
    GenomeRNAii 84695.
    NextBioi 74768.
    PROi P58215.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P58215.
    Bgeei P58215.
    CleanExi HS_LOXL3.
    Genevestigatori P58215.

    Family and domain databases

    Gene3Di 3.10.250.10. 4 hits.
    InterProi IPR001695. Lysyl_oxidase.
    IPR019828. Lysyl_oxidase_CS.
    IPR001190. SRCR.
    IPR017448. SRCR-like_dom.
    [Graphical view ]
    Pfami PF01186. Lysyl_oxidase. 1 hit.
    PF00530. SRCR. 4 hits.
    [Graphical view ]
    PRINTSi PR00074. LYSYLOXIDASE.
    PR00258. SPERACTRCPTR.
    SMARTi SM00202. SR. 4 hits.
    [Graphical view ]
    SUPFAMi SSF56487. SSF56487. 4 hits.
    PROSITEi PS00926. LYSYL_OXIDASE. 1 hit.
    PS00420. SRCR_1. 1 hit.
    PS50287. SRCR_2. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of a fourth human lysyl oxidase isoenzyme."
      Maki J.M., Kivirikko K.I.
      Biochem. J. 355:381-387(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Central nervous system, uterus, heart, and leukocyte expression of the LOXL3 gene, encoding a novel lysyl oxidase-like protein."
      Jourdan-Le Saux C., Tomshe A., Ujfalusi A., Jia L., Csiszar K.
      Genomics 74:211-218(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Cloning and characterization of a human lysyl oxidase-like 3 gene (hLOXL3)."
      Huang Y., Dai J., Tang R., Zhao W., Zhou Z., Wang W., Ying K., Xie Y., Mao Y.
      Matrix Biol. 20:153-157(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    4. "A tissue-specific variant of the human lysyl oxidase-like protein 3 (LOXL3) functions as an amine oxidase with substrate specificity."
      Lee J.-E., Kim Y.
      J. Biol. Chem. 281:37282-37290(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, SUBCELLULAR LOCATION (ISOFORM 2), TISSUE SPECIFICITY.
    5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Ovary.

    Entry informationi

    Entry nameiLOXL3_HUMAN
    AccessioniPrimary (citable) accession number: P58215
    Secondary accession number(s): D6W5J1
    , Q2EHP2, Q6IPL7, Q96RS1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2001
    Last sequence update: July 11, 2001
    Last modified: October 1, 2014
    This is version 121 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3