P58211 (DAPB2_RHILO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dihydrodipicolinate reductase 2
Short name=DHPR 2
EC=1.3.1.26

Gene names

Name:	dapB2
Ordered Locus Names:	mlr7948

Organism

Rhizobium loti (strain MAFF303099) (Mesorhizobium loti) [Complete proteome] [HAMAP]

Taxonomic identifier

266835 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Phyllobacteriaceae › Mesorhizobium

Protein attributes

Sequence length	258 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-2,3,4,5-tetrahydrodipicolinate + NAD(P)+ = (S)-2,3-dihydrodipicolinate + NAD(P)H. HAMAP MF_00102
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4. HAMAP MF_00102
Subcellular location	Cytoplasm By similarity HAMAP MF_00102.
Sequence similarities	Belongs to the dihydrodipicolinate reductase family.
Sequence caution	The sequence BAB53612.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Diaminopimelate biosynthesis Lysine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	diaminopimelate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NADPH binding Inferred from electronic annotation. Source: InterPro dihydrodipicolinate reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 258	258	Dihydrodipicolinate reductase 2 HAMAP MF_00102		PRO_0000141475

Sequences

	Sequence		Length	Mass (Da)
	P58211 [UniParc]. Last modified June 20, 2001. Version 1. Checksum: 7D0F44E40067A7F0	FASTA	258	26,726
	10 20 30 40 50 60 MAQPPIRIAI AGALGRMGRQ MVEAVQADPR LALAARFHRP DSVGDGLVSR DEALAMADVV 70 80 90 100 110 120 IDFTTPAASA DLARVSANRG GPALVIGSTG FDAAELADIA DAAKTVPIVR SGSFSLGLNM 130 140 150 160 170 180 LVGLVEQAAR AFAPEDWDAE IFEAHHRHKI DAPSGTALML GQAVAGGRGA ELDAVARRVR 190 200 210 220 230 240 DGVTGARPPG EIGFAVVRGG SIVGEHSVSF CAEGELVTLS HAAGDRIMFA RGAIAAALWV 250 SGRPPGEYDM RDVLGFDR

References

[1]

"Complete genome structure of the nitrogen-fixing symbiotic bacterium Mesorhizobium loti." Kaneko T., Nakamura Y., Sato S., Asamizu E., Kato T., Sasamoto S., Watanabe A., Idesawa K., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Mochizuki Y., Nakayama S. , Nakazaki N., Shimpo S., Sugimoto M., Takeuchi C., Yamada M., Tabata S. DNA Res. 7:331-338(2000) [PubMed: 11214968] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MAFF303099.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000012 Genomic DNA. Translation: BAB53612.1. Different initiation.
RefSeq	NP_108151.1. NC_002678.2.
3D structure databases
ProteinModelPortal	P58211.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1230803.
GenomeReviews	Gene locus mlr7948 in contig BA000012_GR.
KEGG	mlo:mlr7948.
NMPDR	fig|266835.1.peg.6250.
PATRIC	22486961. VBIMesLot2464_6357.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG594002.
ProtClustDB	PRK00048.
Family and domain databases
HAMAP	MF_00102. DapB. [Tree]
InterPro	IPR022663. DapB_C. IPR000846. DapB_N. IPR022664. DapB_N_CS. IPR011770. Dihydrodipicolinate_Rdtase. IPR023940. Dihydrodipicolinate_Rdtase_bac. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00215.
PANTHER	PTHR20836. DapB_bac/pln. 1 hit.
Pfam	PF05173. DapB_C. 1 hit. PF01113. DapB_N. 1 hit. [Graphical view]
PIRSF	PIRSF000161. DHPR. 1 hit.
TIGRFAMs	TIGR00036. DapB. 1 hit.
PROSITE	PS01298. DAPB. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DAPB2_RHILO

Accession

Primary (citable) accession number: P58211

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	June 20, 2001
Last modified:	January 25, 2012
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program