Reviewed, UniProtKB/Swiss-Prot P58210 (DAPB1_RHILO)

Names and origin

Protein names

Recommended name:
    Dihydrodipicolinate reductase 1
      Short name=DHPR 1
    EC=1.3.1.26

Gene names

Name:	dapB1
Ordered Locus Names:	mlr4642

Organism

Rhizobium loti (Mesorhizobium loti) [Complete proteome] [HAMAP]

Taxonomic identifier

381 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Phyllobacteriaceae › Mesorhizobium

Protein attributes

Sequence length	273 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2,3,4,5-tetrahydrodipicolinate + NAD(P)+ = 2,3-dihydrodipicolinate + NAD(P)H. HAMAP MF_00102
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4. HAMAP MF_00102
Subcellular location	Cytoplasm By similarity HAMAP MF_00102.
Sequence similarities	Belongs to the dihydrodipicolinate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Diaminopimelate biosynthesis Lysine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	diaminopimelate biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	binding Inferred from electronic annotation. Source: InterPro dihydrodipicolinate reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 273	273	Dihydrodipicolinate reductase 1 HAMAP MF_00102		PRO_0000141474

Sequences

	Sequence		Length	Mass (Da)
	P58210-1 [UniParc]. Last modified June 20, 2001. Version 1. Checksum: D0747FBD044C87D7	FASTA	273	27,893
	10 20 30 40 50 60 MSEAGDMGLV VVGAAGRMGQ TLIRAIHTIP GARVIGAVER ADSPHLGKDA GELAGIGIIN 70 80 90 100 110 120 VPIGDDPLPV FAKADGVLDF TTPASSVEFA GYAAQARIVH VIGTTGCSAD DNARIAAAAR 130 140 150 160 170 180 HATIVKSGNM SLGVNLLAVL VEQAARALDA DDFDIEILEM HHKHKVDAPS GTALLLGEAA 190 200 210 220 230 240 AAGRGIALAG NDVRSRDGHT GVRKTGSIGF ATLRGGSVVG DHSVILAGTG ERITLSHHAE 250 260 270 DRAIFARGAV KAALWARGKK PGLYSMRDVL GLS

References

[1]

"Complete genome structure of the nitrogen-fixing symbiotic bacterium Mesorhizobium loti." Kaneko T., Nakamura Y., Sato S., Asamizu E., Kato T., Sasamoto S., Watanabe A., Idesawa K., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Mochizuki Y., Nakayama S. , Nakazaki N., Shimpo S., Sugimoto M., Takeuchi C., Yamada M., Tabata S. DNA Res. 7:331-338(2000) [PubMed: 11214968] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MAFF303099.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000012 Genomic DNA. Translation: BAB51250.1.
RefSeq	NP_105464.1.
3D structure databases
SMR	P58210. Positions 6-273.
ModBase	Search...
Genome annotation databases
GeneID	1228125.
GenomeReviews	Gene locus mlr4642 in contig BA000012_GR.
KEGG	mlo:mlr4642.
NMPDR	fig|266835.1.peg.3568.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG594002.
OMA	TIGFSTI.
Enzyme and pathway databases
BRENDA	1.3.1.26. 3315.
Family and domain databases
HAMAP	MF_00102. DapB. [Tree]
InterPro	IPR000846. DapB. IPR011770. Dihydrodipicolinate_Rdtase. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR20836. DapB_bac/pln. 1 hit.
Pfam	PF05173. DapB_C. 1 hit. PF01113. DapB_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00036. dapB. 1 hit.
PROSITE	PS01298. DAPB. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DAPB1_RHILO

Accession

Primary (citable) accession number: P58210

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	June 20, 2001
Last modified:	February 9, 2010
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)