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P58202

- PCP2_SULSO

UniProt

P58202 - PCP2_SULSO

Protein

Pyrrolidone-carboxylate peptidase 2

Gene

pcp2

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (20 Jun 2001)
      Previous versions | rss
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    • Comment

    Functioni

    Removes 5-oxoproline from various penultimate amino acid residues except L-proline.By similarity

    Catalytic activityi

    Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei79 – 791By similarity
    Active sitei142 – 1421By similarity
    Active sitei164 – 1641By similarity

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Enzyme and pathway databases

    BioCyciSSOL273057:GCH2-1503-MONOMER.

    Protein family/group databases

    MEROPSiC15.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyrrolidone-carboxylate peptidase 2 (EC:3.4.19.3)
    Alternative name(s):
    5-oxoprolyl-peptidase 2
    Pyroglutamyl-peptidase I 2
    Short name:
    PGP-I 2
    Short name:
    Pyrase 2
    Gene namesi
    Name:pcp2
    Ordered Locus Names:SSO1607
    OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
    Taxonomic identifieri273057 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
    ProteomesiUP000001974: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 209209Pyrrolidone-carboxylate peptidase 2PRO_0000184759Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP58202.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase C15 family.Curated

    Phylogenomic databases

    eggNOGiCOG2039.
    HOGENOMiHOG000242641.
    KOiK01304.
    OMAiCYEMELE.

    Family and domain databases

    Gene3Di3.40.630.20. 1 hit.
    HAMAPiMF_00417. Pyrrolid_peptidase.
    InterProiIPR000816. Peptidase_C15.
    IPR016125. Peptidase_C15-like.
    [Graphical view]
    PANTHERiPTHR23402. PTHR23402. 1 hit.
    PfamiPF01470. Peptidase_C15. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015592. Prld-crbxl_pptds. 1 hit.
    PRINTSiPR00706. PYROGLUPTASE.
    PROSITEiPS01334. PYRASE_CYS. 1 hit.
    PS01333. PYRASE_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P58202-1 [UniParc]FASTAAdd to Basket

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    MTVLLFGFEP FLEYKENPSQ LIVEALNGST ILKEEVKGVI LPVEYEKIED    50
    LIVTKIREMK PILTLGIGVA PGRAKITPEK IAINYKYSRE GDNAGKKYKG 100
    EKIDPLGQDG IFTNIPVEDL VDLLNENGIP AELSLSAGSY LCNNAMYIII 150
    REARKYNSLG GFIHVPLHES YAARIQRPIP SMSLDTMIRG IRLSMEFILT 200
    NKKENLTFS 209
    Length:209
    Mass (Da):23,404
    Last modified:June 20, 2001 - v1
    Checksum:iAAE205344FD024B7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006641 Genomic DNA. Translation: AAK41818.1.
    PIRiC90320.
    RefSeqiNP_343028.1. NC_002754.1.

    Genome annotation databases

    EnsemblBacteriaiAAK41818; AAK41818; SSO1607.
    GeneIDi1454597.
    KEGGisso:SSO1607.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006641 Genomic DNA. Translation: AAK41818.1 .
    PIRi C90320.
    RefSeqi NP_343028.1. NC_002754.1.

    3D structure databases

    ProteinModelPortali P58202.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi C15.001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK41818 ; AAK41818 ; SSO1607 .
    GeneIDi 1454597.
    KEGGi sso:SSO1607.

    Phylogenomic databases

    eggNOGi COG2039.
    HOGENOMi HOG000242641.
    KOi K01304.
    OMAi CYEMELE.

    Enzyme and pathway databases

    BioCyci SSOL273057:GCH2-1503-MONOMER.

    Family and domain databases

    Gene3Di 3.40.630.20. 1 hit.
    HAMAPi MF_00417. Pyrrolid_peptidase.
    InterProi IPR000816. Peptidase_C15.
    IPR016125. Peptidase_C15-like.
    [Graphical view ]
    PANTHERi PTHR23402. PTHR23402. 1 hit.
    Pfami PF01470. Peptidase_C15. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015592. Prld-crbxl_pptds. 1 hit.
    PRINTSi PR00706. PYROGLUPTASE.
    PROSITEi PS01334. PYRASE_CYS. 1 hit.
    PS01333. PYRASE_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.

    Entry informationi

    Entry nameiPCP2_SULSO
    AccessioniPrimary (citable) accession number: P58202
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: June 20, 2001
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3