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Protein

Vesicle transport through interaction with t-SNAREs homolog 1B

Gene

Vti1b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers.2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicle transport through interaction with t-SNAREs homolog 1B
Alternative name(s):
Vesicle transport v-SNARE protein Vti1-like 1
Vti1-rp1
Gene namesi
Name:Vti1b
Synonyms:Vti1l1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2323682. Vti1b.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 208CytoplasmicSequence analysisAdd BLAST207
Transmembranei209 – 229Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini230 – 232VesicularSequence analysis3

GO - Cellular componenti

Keywords - Cellular componenti

Endosome, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002182302 – 232Vesicle transport through interaction with t-SNAREs homolog 1BAdd BLAST231

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei103PhosphothreonineBy similarity1
Modified residuei107Omega-N-methylarginineBy similarity1
Modified residuei138PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

PaxDbiP58200.
PRIDEiP58200.

Expressioni

Gene expression databases

BgeeiENSRNOG00000011734.

Interactioni

Subunit structurei

Forms a SNARE complex with STX7, STX8 and VAMP8 which functions in the homotypic fusion of late endosomes. Component of the SNARE complex composed of STX7, STX8, VAMP7 and VIT1B that is required for heterotypic fusion of late endosomes with lysosomes (By similarity). May interact with STX17. Interacts with CLINT1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiP58200. 3 interactors.
STRINGi10116.ENSRNOP00000015814.

Structurei

3D structure databases

ProteinModelPortaliP58200.
SMRiP58200.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 23Interaction with CLINT1By similarityAdd BLAST22
Regioni69 – 73Interaction with CLINT1By similarity5

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili36 – 98Sequence analysisAdd BLAST63
Coiled coili160 – 201Sequence analysisAdd BLAST42

Sequence similaritiesi

Belongs to the VTI1 family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1666. Eukaryota.
ENOG4111J90. LUCA.
HOGENOMiHOG000116573.
HOVERGENiHBG058837.
InParanoidiP58200.
PhylomeDBiP58200.

Family and domain databases

InterProiView protein in InterPro
IPR027027. GOSR2/Membrin/Bos1.
IPR010989. SNARE.
IPR000727. T_SNARE_dom.
IPR007705. Vesicle_trsprt_v-SNARE_N.
PfamiView protein in Pfam
PF05008. V-SNARE. 1 hit.
PIRSFiPIRSF028865. Membrin-2. 1 hit.
SMARTiView protein in SMART
SM00397. t_SNARE. 1 hit.
SUPFAMiSSF47661. SSF47661. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P58200-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATSAASSEH FEKLHEIFRG LLEDLQGVPE RLLGTAGTEE KKKLVRDFDE
60 70 80 90 100
KQQEANETLA EMEEELRYAP LTFRNSMMSK LRNYRKDLAK LHREVRSTPL
110 120 130 140 150
TATPGGRGDL KFGTYTLENE HLNRLQSQRA LLLQGTESLN RATQSIERSH
160 170 180 190 200
RIAAETDQIG SEIIEELGEQ RDQLERTKSR LVNTNENLSK SRKILRSMSR
210 220 230
KVITNKLLLS VIIVLELAIL VGLVYYKFFR HH
Length:232
Mass (Da):26,703
Last modified:October 23, 2007 - v2
Checksum:i017363526CE3B9EA
GO

Sequence cautioni

The sequence AC111403 differs from that shown. Reason: Frameshift at position 78.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti131L → V in BF413866 (Ref. 2) Curated1
Sequence conflicti155E → K in BF413866 (Ref. 2) Curated1
Sequence conflicti162E → K in BF413866 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC111403 mRNA. No translation available.
BF413866 mRNA. No translation available.
UniGeneiRn.48041.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC111403 mRNA. No translation available.
BF413866 mRNA. No translation available.
UniGeneiRn.48041.

3D structure databases

ProteinModelPortaliP58200.
SMRiP58200.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP58200. 3 interactors.
STRINGi10116.ENSRNOP00000015814.

Proteomic databases

PaxDbiP58200.
PRIDEiP58200.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

RGDi2323682. Vti1b.

Phylogenomic databases

eggNOGiKOG1666. Eukaryota.
ENOG4111J90. LUCA.
HOGENOMiHOG000116573.
HOVERGENiHBG058837.
InParanoidiP58200.
PhylomeDBiP58200.

Miscellaneous databases

PROiPR:P58200.

Gene expression databases

BgeeiENSRNOG00000011734.

Family and domain databases

InterProiView protein in InterPro
IPR027027. GOSR2/Membrin/Bos1.
IPR010989. SNARE.
IPR000727. T_SNARE_dom.
IPR007705. Vesicle_trsprt_v-SNARE_N.
PfamiView protein in Pfam
PF05008. V-SNARE. 1 hit.
PIRSFiPIRSF028865. Membrin-2. 1 hit.
SMARTiView protein in SMART
SM00397. t_SNARE. 1 hit.
SUPFAMiSSF47661. SSF47661. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiVTI1B_RAT
AccessioniPrimary (citable) accession number: P58200
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: October 23, 2007
Last modified: June 7, 2017
This is version 100 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.