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P58192

- RPOA2_SULSO

UniProt

P58192 - RPOA2_SULSO

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Protein

DNA-directed RNA polymerase subunit A''

Gene

rpoA2

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. DNA-directed RNA polymerase activity Source: UniProtKB-KW

GO - Biological processi

  1. transcription, DNA-templated Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Transcription

Enzyme and pathway databases

BioCyciSSOL273057:GCH2-212-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase subunit A'' (EC:2.7.7.6)
Gene namesi
Name:rpoA2
Ordered Locus Names:SSO0223
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
ProteomesiUP000001974: Chromosome

Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymerase

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 392392DNA-directed RNA polymerase subunit A''PRO_0000074026Add
BLAST

Interactioni

Subunit structurei

This RNA polymerase is composed of 13 subunits.By similarity

Protein-protein interaction databases

DIPiDIP-60639N.
STRINGi273057.SSO0223.

Structurei

Secondary structure

1
392
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi11 – 177Combined sources
Helixi20 – 234Combined sources
Helixi29 – 346Combined sources
Turni39 – 413Combined sources
Helixi47 – 5610Combined sources
Helixi57 – 593Combined sources
Helixi67 – 748Combined sources
Turni75 – 784Combined sources
Helixi79 – 813Combined sources
Helixi102 – 1098Combined sources
Beta strandi118 – 1225Combined sources
Beta strandi124 – 1263Combined sources
Helixi131 – 1399Combined sources
Helixi146 – 1483Combined sources
Beta strandi151 – 1555Combined sources
Beta strandi157 – 1604Combined sources
Beta strandi162 – 1654Combined sources
Helixi169 – 1735Combined sources
Turni180 – 1823Combined sources
Beta strandi186 – 1883Combined sources
Beta strandi199 – 2035Combined sources
Beta strandi208 – 2114Combined sources
Helixi216 – 2183Combined sources
Helixi221 – 2244Combined sources
Beta strandi228 – 2303Combined sources
Beta strandi238 – 2403Combined sources
Beta strandi243 – 2453Combined sources
Beta strandi247 – 2526Combined sources
Turni256 – 2605Combined sources
Beta strandi261 – 2644Combined sources
Beta strandi265 – 2706Combined sources
Helixi276 – 2816Combined sources
Helixi283 – 29210Combined sources
Turni293 – 2975Combined sources
Helixi298 – 3003Combined sources
Helixi307 – 31711Combined sources
Beta strandi318 – 3225Combined sources
Turni328 – 3314Combined sources
Beta strandi332 – 3365Combined sources
Helixi338 – 3436Combined sources
Helixi350 – 3567Combined sources
Beta strandi365 – 3673Combined sources
Helixi368 – 3725Combined sources
Beta strandi377 – 3793Combined sources
Turni380 – 3823Combined sources
Beta strandi384 – 3863Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2PMZX-ray3.40C/G1-392[»]
3HKZX-ray3.40C/M1-392[»]
ProteinModelPortaliP58192.
SMRiP58192. Positions 8-392.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP58192.

Family & Domainsi

Sequence similaritiesi

Belongs to the RNA polymerase beta' chain family.Curated

Phylogenomic databases

eggNOGiCOG0086.
HOGENOMiHOG000222986.
InParanoidiP58192.
KOiK03042.
OMAiRPIGRHG.

Family and domain databases

HAMAPiMF_00411. RNApol_arch_A.
InterProiIPR007081. RNA_pol_Rpb1_5.
IPR012757. RNAP_A2.
[Graphical view]
PfamiPF04998. RNA_pol_Rpb1_5. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02389. RNA_pol_rpoA2. 1 hit.

Sequencei

Sequence statusi: Complete.

P58192-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIDEKDKPYL EEKVKQASNI LPQKIVDDLK NLILNKEIIV TRDEIDKIFD
60 70 80 90 100
LAIKEYSEGL IAPGEAIGIV AAQSVGEPGT QMTLRTFHFA GIRELNVTLG
110 120 130 140 150
LPRLIEIVDA KKVPSTPMMT IYLTDEYKRD RDKALEVARK LEYTKIENVV
160 170 180 190 200
SSTSIDIASM SIILQLDNEM LKDKGVTVDD VKKAIGRLKL GDFMIEESED
210 220 230 240 250
STLNINFANI DSIAALFKLR DKILNTKIKG IKGIKRAIVQ KKGDEYIILT
260 270 280 290 300
DGSNLSGVLS VKGVDVAKVE TNNIREIEEV FGIEAAREII IREISKVLAE
310 320 330 340 350
QGLDVDIRHI LLIADVMTRT GIVRQIGRHG VTGEKNSVLA RAAFEVTVKH
360 370 380 390
LLDAAARGDV EEFKGVVENI IIGHPIKLGT GMVELTMRPI LR
Length:392
Mass (Da):43,488
Last modified:June 20, 2001 - v1
Checksum:i5B0E871D056CE08B
GO

Sequence cautioni

The sequence AAK40565.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006641 Genomic DNA. Translation: AAK40565.1. Different initiation.
PIRiF90163.
RefSeqiNP_341775.1. NC_002754.1.

Genome annotation databases

EnsemblBacteriaiAAK40565; AAK40565; SSO0223.
GeneIDi1455375.
KEGGisso:SSO0223.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006641 Genomic DNA. Translation: AAK40565.1 . Different initiation.
PIRi F90163.
RefSeqi NP_341775.1. NC_002754.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2PMZ X-ray 3.40 C/G 1-392 [» ]
3HKZ X-ray 3.40 C/M 1-392 [» ]
ProteinModelPortali P58192.
SMRi P58192. Positions 8-392.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-60639N.
STRINGi 273057.SSO0223.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK40565 ; AAK40565 ; SSO0223 .
GeneIDi 1455375.
KEGGi sso:SSO0223.

Phylogenomic databases

eggNOGi COG0086.
HOGENOMi HOG000222986.
InParanoidi P58192.
KOi K03042.
OMAi RPIGRHG.

Enzyme and pathway databases

BioCyci SSOL273057:GCH2-212-MONOMER.

Miscellaneous databases

EvolutionaryTracei P58192.

Family and domain databases

HAMAPi MF_00411. RNApol_arch_A.
InterProi IPR007081. RNA_pol_Rpb1_5.
IPR012757. RNAP_A2.
[Graphical view ]
Pfami PF04998. RNA_pol_Rpb1_5. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02389. RNA_pol_rpoA2. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.
  2. "The X-ray crystal structure of RNA polymerase from Archaea."
    Hirata A., Klein B.J., Murakami K.S.
    Nature 451:851-854(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.4 ANGSTROMS) OF THE RNA POLYMERASE COMPLEX.

Entry informationi

Entry nameiRPOA2_SULSO
AccessioniPrimary (citable) accession number: P58192
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: June 20, 2001
Last modified: October 29, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3