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Protein

DNA-directed RNA polymerase subunit A''

Gene

rpoA2

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Transcription

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase subunit A'' (EC:2.7.7.6)
Gene namesi
Name:rpoA2
Ordered Locus Names:SSO0223
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001974 Componenti: Chromosome

Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymerase

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000740261 – 392DNA-directed RNA polymerase subunit A''Add BLAST392

Interactioni

Subunit structurei

This RNA polymerase is composed of 13 subunits.By similarity

Protein-protein interaction databases

DIPiDIP-60639N.
STRINGi273057.SSO0223.

Structurei

Secondary structure

1392
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi11 – 17Combined sources7
Helixi20 – 23Combined sources4
Helixi29 – 34Combined sources6
Turni39 – 41Combined sources3
Helixi47 – 56Combined sources10
Helixi57 – 59Combined sources3
Helixi67 – 74Combined sources8
Turni75 – 78Combined sources4
Helixi79 – 81Combined sources3
Helixi102 – 109Combined sources8
Beta strandi118 – 122Combined sources5
Beta strandi124 – 126Combined sources3
Helixi131 – 139Combined sources9
Helixi146 – 148Combined sources3
Beta strandi151 – 155Combined sources5
Beta strandi157 – 160Combined sources4
Beta strandi162 – 165Combined sources4
Helixi169 – 173Combined sources5
Turni180 – 182Combined sources3
Beta strandi186 – 188Combined sources3
Beta strandi199 – 203Combined sources5
Beta strandi208 – 211Combined sources4
Helixi216 – 218Combined sources3
Helixi221 – 224Combined sources4
Beta strandi228 – 230Combined sources3
Beta strandi238 – 240Combined sources3
Beta strandi243 – 245Combined sources3
Beta strandi247 – 252Combined sources6
Turni256 – 260Combined sources5
Beta strandi261 – 264Combined sources4
Beta strandi265 – 270Combined sources6
Helixi276 – 281Combined sources6
Helixi283 – 292Combined sources10
Turni293 – 297Combined sources5
Helixi298 – 300Combined sources3
Helixi307 – 317Combined sources11
Beta strandi318 – 322Combined sources5
Turni328 – 331Combined sources4
Beta strandi332 – 336Combined sources5
Helixi338 – 343Combined sources6
Helixi350 – 356Combined sources7
Beta strandi365 – 367Combined sources3
Helixi368 – 372Combined sources5
Beta strandi377 – 379Combined sources3
Turni380 – 382Combined sources3
Beta strandi384 – 386Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PMZX-ray3.40C/G1-392[»]
3HKZX-ray3.40C/M1-392[»]
ProteinModelPortaliP58192.
SMRiP58192.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP58192.

Family & Domainsi

Sequence similaritiesi

Belongs to the RNA polymerase beta' chain family.Curated

Phylogenomic databases

eggNOGiarCOG04256. Archaea.
COG0086. LUCA.
HOGENOMiHOG000222986.
InParanoidiP58192.
KOiK03042.
OMAiRPIGRHG.

Family and domain databases

CDDicd06528. RNAP_A''. 1 hit.
HAMAPiMF_00411. RNApol_arch_A. 1 hit.
InterProiIPR007081. RNA_pol_Rpb1_5.
IPR012757. RNAP_A2.
[Graphical view]
PfamiPF04998. RNA_pol_Rpb1_5. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02389. RNA_pol_rpoA2. 1 hit.

Sequencei

Sequence statusi: Complete.

P58192-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIDEKDKPYL EEKVKQASNI LPQKIVDDLK NLILNKEIIV TRDEIDKIFD
60 70 80 90 100
LAIKEYSEGL IAPGEAIGIV AAQSVGEPGT QMTLRTFHFA GIRELNVTLG
110 120 130 140 150
LPRLIEIVDA KKVPSTPMMT IYLTDEYKRD RDKALEVARK LEYTKIENVV
160 170 180 190 200
SSTSIDIASM SIILQLDNEM LKDKGVTVDD VKKAIGRLKL GDFMIEESED
210 220 230 240 250
STLNINFANI DSIAALFKLR DKILNTKIKG IKGIKRAIVQ KKGDEYIILT
260 270 280 290 300
DGSNLSGVLS VKGVDVAKVE TNNIREIEEV FGIEAAREII IREISKVLAE
310 320 330 340 350
QGLDVDIRHI LLIADVMTRT GIVRQIGRHG VTGEKNSVLA RAAFEVTVKH
360 370 380 390
LLDAAARGDV EEFKGVVENI IIGHPIKLGT GMVELTMRPI LR
Length:392
Mass (Da):43,488
Last modified:June 20, 2001 - v1
Checksum:i5B0E871D056CE08B
GO

Sequence cautioni

The sequence AAK40565 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006641 Genomic DNA. Translation: AAK40565.1. Different initiation.
PIRiF90163.
RefSeqiWP_009990475.1. NC_002754.1.

Genome annotation databases

EnsemblBacteriaiAAK40565; AAK40565; SSO0223.
GeneIDi27426519.
KEGGisso:SSO0223.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006641 Genomic DNA. Translation: AAK40565.1. Different initiation.
PIRiF90163.
RefSeqiWP_009990475.1. NC_002754.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PMZX-ray3.40C/G1-392[»]
3HKZX-ray3.40C/M1-392[»]
ProteinModelPortaliP58192.
SMRiP58192.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60639N.
STRINGi273057.SSO0223.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK40565; AAK40565; SSO0223.
GeneIDi27426519.
KEGGisso:SSO0223.

Phylogenomic databases

eggNOGiarCOG04256. Archaea.
COG0086. LUCA.
HOGENOMiHOG000222986.
InParanoidiP58192.
KOiK03042.
OMAiRPIGRHG.

Miscellaneous databases

EvolutionaryTraceiP58192.

Family and domain databases

CDDicd06528. RNAP_A''. 1 hit.
HAMAPiMF_00411. RNApol_arch_A. 1 hit.
InterProiIPR007081. RNA_pol_Rpb1_5.
IPR012757. RNAP_A2.
[Graphical view]
PfamiPF04998. RNA_pol_Rpb1_5. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02389. RNA_pol_rpoA2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRPOA2_SULSO
AccessioniPrimary (citable) accession number: P58192
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: June 20, 2001
Last modified: November 2, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.