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P58192

- RPOA2_SULSO

UniProt

P58192 - RPOA2_SULSO

Protein

DNA-directed RNA polymerase subunit A''

Gene

rpoA2

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (20 Jun 2001)
      Previous versions | rss
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    Functioni

    DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

    Catalytic activityi

    Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

    GO - Molecular functioni

    1. DNA binding Source: InterPro
    2. DNA-directed RNA polymerase activity Source: UniProtKB-KW

    GO - Biological processi

    1. transcription, DNA-templated Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    Transcription

    Enzyme and pathway databases

    BioCyciSSOL273057:GCH2-212-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA-directed RNA polymerase subunit A'' (EC:2.7.7.6)
    Gene namesi
    Name:rpoA2
    Ordered Locus Names:SSO0223
    OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
    Taxonomic identifieri273057 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
    ProteomesiUP000001974: Chromosome

    Subcellular locationi

    Keywords - Cellular componenti

    DNA-directed RNA polymerase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 392392DNA-directed RNA polymerase subunit A''PRO_0000074026Add
    BLAST

    Interactioni

    Subunit structurei

    This RNA polymerase is composed of 13 subunits.By similarity

    Protein-protein interaction databases

    DIPiDIP-60639N.
    STRINGi273057.SSO0223.

    Structurei

    Secondary structure

    1
    392
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi11 – 177
    Helixi20 – 234
    Helixi29 – 346
    Turni39 – 413
    Helixi47 – 5610
    Helixi57 – 593
    Helixi67 – 748
    Turni75 – 784
    Helixi79 – 813
    Helixi102 – 1098
    Beta strandi118 – 1225
    Beta strandi124 – 1263
    Helixi131 – 1399
    Helixi146 – 1483
    Beta strandi151 – 1555
    Beta strandi157 – 1604
    Beta strandi162 – 1654
    Helixi169 – 1735
    Turni180 – 1823
    Beta strandi186 – 1883
    Beta strandi199 – 2035
    Beta strandi208 – 2114
    Helixi216 – 2183
    Helixi221 – 2244
    Beta strandi228 – 2303
    Beta strandi238 – 2403
    Beta strandi243 – 2453
    Beta strandi247 – 2526
    Turni256 – 2605
    Beta strandi261 – 2644
    Beta strandi265 – 2706
    Helixi276 – 2816
    Helixi283 – 29210
    Turni293 – 2975
    Helixi298 – 3003
    Helixi307 – 31711
    Beta strandi318 – 3225
    Turni328 – 3314
    Beta strandi332 – 3365
    Helixi338 – 3436
    Helixi350 – 3567
    Beta strandi365 – 3673
    Helixi368 – 3725
    Beta strandi377 – 3793
    Turni380 – 3823
    Beta strandi384 – 3863

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2PMZX-ray3.40C/G1-392[»]
    3HKZX-ray3.40C/M1-392[»]
    ProteinModelPortaliP58192.
    SMRiP58192. Positions 8-392.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP58192.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the RNA polymerase beta' chain family.Curated

    Phylogenomic databases

    eggNOGiCOG0086.
    HOGENOMiHOG000222986.
    KOiK03042.
    OMAiRPIGRHG.

    Family and domain databases

    HAMAPiMF_00411. RNApol_arch_A.
    InterProiIPR007081. RNA_pol_Rpb1_5.
    IPR012757. RNAP_A2.
    [Graphical view]
    PfamiPF04998. RNA_pol_Rpb1_5. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR02389. RNA_pol_rpoA2. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P58192-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIDEKDKPYL EEKVKQASNI LPQKIVDDLK NLILNKEIIV TRDEIDKIFD    50
    LAIKEYSEGL IAPGEAIGIV AAQSVGEPGT QMTLRTFHFA GIRELNVTLG 100
    LPRLIEIVDA KKVPSTPMMT IYLTDEYKRD RDKALEVARK LEYTKIENVV 150
    SSTSIDIASM SIILQLDNEM LKDKGVTVDD VKKAIGRLKL GDFMIEESED 200
    STLNINFANI DSIAALFKLR DKILNTKIKG IKGIKRAIVQ KKGDEYIILT 250
    DGSNLSGVLS VKGVDVAKVE TNNIREIEEV FGIEAAREII IREISKVLAE 300
    QGLDVDIRHI LLIADVMTRT GIVRQIGRHG VTGEKNSVLA RAAFEVTVKH 350
    LLDAAARGDV EEFKGVVENI IIGHPIKLGT GMVELTMRPI LR 392
    Length:392
    Mass (Da):43,488
    Last modified:June 20, 2001 - v1
    Checksum:i5B0E871D056CE08B
    GO

    Sequence cautioni

    The sequence AAK40565.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006641 Genomic DNA. Translation: AAK40565.1. Different initiation.
    PIRiF90163.
    RefSeqiNP_341775.1. NC_002754.1.

    Genome annotation databases

    EnsemblBacteriaiAAK40565; AAK40565; SSO0223.
    GeneIDi1455375.
    KEGGisso:SSO0223.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006641 Genomic DNA. Translation: AAK40565.1 . Different initiation.
    PIRi F90163.
    RefSeqi NP_341775.1. NC_002754.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2PMZ X-ray 3.40 C/G 1-392 [» ]
    3HKZ X-ray 3.40 C/M 1-392 [» ]
    ProteinModelPortali P58192.
    SMRi P58192. Positions 8-392.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-60639N.
    STRINGi 273057.SSO0223.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK40565 ; AAK40565 ; SSO0223 .
    GeneIDi 1455375.
    KEGGi sso:SSO0223.

    Phylogenomic databases

    eggNOGi COG0086.
    HOGENOMi HOG000222986.
    KOi K03042.
    OMAi RPIGRHG.

    Enzyme and pathway databases

    BioCyci SSOL273057:GCH2-212-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei P58192.

    Family and domain databases

    HAMAPi MF_00411. RNApol_arch_A.
    InterProi IPR007081. RNA_pol_Rpb1_5.
    IPR012757. RNAP_A2.
    [Graphical view ]
    Pfami PF04998. RNA_pol_Rpb1_5. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR02389. RNA_pol_rpoA2. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.
    2. "The X-ray crystal structure of RNA polymerase from Archaea."
      Hirata A., Klein B.J., Murakami K.S.
      Nature 451:851-854(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.4 ANGSTROMS) OF THE RNA POLYMERASE COMPLEX.

    Entry informationi

    Entry nameiRPOA2_SULSO
    AccessioniPrimary (citable) accession number: P58192
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: June 20, 2001
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3