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P58192

- RPOA2_SULSO

UniProt

P58192 - RPOA2_SULSO

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Protein

DNA-directed RNA polymerase subunit A''

Gene
rpoA2, SSO0223
Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.UniRule annotation

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).UniRule annotation

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. DNA-directed RNA polymerase activity Source: UniProtKB-KW

GO - Biological processi

  1. transcription, DNA-templated Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Transcription

Enzyme and pathway databases

BioCyciSSOL273057:GCH2-212-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase subunit A'' (EC:2.7.7.6)
Gene namesi
Name:rpoA2
Ordered Locus Names:SSO0223
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
ProteomesiUP000001974: Chromosome

Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymerase

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 392392DNA-directed RNA polymerase subunit A''UniRule annotationPRO_0000074026Add
BLAST

Interactioni

Subunit structurei

This RNA polymerase is composed of 13 subunits By similarity.

Protein-protein interaction databases

DIPiDIP-60639N.
STRINGi273057.SSO0223.

Structurei

Secondary structure

1
392
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi11 – 177
Helixi20 – 234
Helixi29 – 346
Turni39 – 413
Helixi47 – 5610
Helixi57 – 593
Helixi67 – 748
Turni75 – 784
Helixi79 – 813
Helixi102 – 1098
Beta strandi118 – 1225
Beta strandi124 – 1263
Helixi131 – 1399
Helixi146 – 1483
Beta strandi151 – 1555
Beta strandi157 – 1604
Beta strandi162 – 1654
Helixi169 – 1735
Turni180 – 1823
Beta strandi186 – 1883
Beta strandi199 – 2035
Beta strandi208 – 2114
Helixi216 – 2183
Helixi221 – 2244
Beta strandi228 – 2303
Beta strandi238 – 2403
Beta strandi243 – 2453
Beta strandi247 – 2526
Turni256 – 2605
Beta strandi261 – 2644
Beta strandi265 – 2706
Helixi276 – 2816
Helixi283 – 29210
Turni293 – 2975
Helixi298 – 3003
Helixi307 – 31711
Beta strandi318 – 3225
Turni328 – 3314
Beta strandi332 – 3365
Helixi338 – 3436
Helixi350 – 3567
Beta strandi365 – 3673
Helixi368 – 3725
Beta strandi377 – 3793
Turni380 – 3823
Beta strandi384 – 3863

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2PMZX-ray3.40C/G1-392[»]
3HKZX-ray3.40C/M1-392[»]
ProteinModelPortaliP58192.
SMRiP58192. Positions 8-392.

Miscellaneous databases

EvolutionaryTraceiP58192.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0086.
HOGENOMiHOG000222986.
KOiK03042.
OMAiRPIGRHG.

Family and domain databases

HAMAPiMF_00411. RNApol_arch_A.
InterProiIPR007081. RNA_pol_Rpb1_5.
IPR012757. RNAP_A2.
[Graphical view]
PfamiPF04998. RNA_pol_Rpb1_5. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02389. RNA_pol_rpoA2. 1 hit.

Sequencei

Sequence statusi: Complete.

P58192-1 [UniParc]FASTAAdd to Basket

« Hide

MIDEKDKPYL EEKVKQASNI LPQKIVDDLK NLILNKEIIV TRDEIDKIFD    50
LAIKEYSEGL IAPGEAIGIV AAQSVGEPGT QMTLRTFHFA GIRELNVTLG 100
LPRLIEIVDA KKVPSTPMMT IYLTDEYKRD RDKALEVARK LEYTKIENVV 150
SSTSIDIASM SIILQLDNEM LKDKGVTVDD VKKAIGRLKL GDFMIEESED 200
STLNINFANI DSIAALFKLR DKILNTKIKG IKGIKRAIVQ KKGDEYIILT 250
DGSNLSGVLS VKGVDVAKVE TNNIREIEEV FGIEAAREII IREISKVLAE 300
QGLDVDIRHI LLIADVMTRT GIVRQIGRHG VTGEKNSVLA RAAFEVTVKH 350
LLDAAARGDV EEFKGVVENI IIGHPIKLGT GMVELTMRPI LR 392
Length:392
Mass (Da):43,488
Last modified:June 20, 2001 - v1
Checksum:i5B0E871D056CE08B
GO

Sequence cautioni

The sequence AAK40565.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006641 Genomic DNA. Translation: AAK40565.1. Different initiation.
PIRiF90163.
RefSeqiNP_341775.1. NC_002754.1.

Genome annotation databases

EnsemblBacteriaiAAK40565; AAK40565; SSO0223.
GeneIDi1455375.
KEGGisso:SSO0223.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006641 Genomic DNA. Translation: AAK40565.1 . Different initiation.
PIRi F90163.
RefSeqi NP_341775.1. NC_002754.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2PMZ X-ray 3.40 C/G 1-392 [» ]
3HKZ X-ray 3.40 C/M 1-392 [» ]
ProteinModelPortali P58192.
SMRi P58192. Positions 8-392.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-60639N.
STRINGi 273057.SSO0223.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK40565 ; AAK40565 ; SSO0223 .
GeneIDi 1455375.
KEGGi sso:SSO0223.

Phylogenomic databases

eggNOGi COG0086.
HOGENOMi HOG000222986.
KOi K03042.
OMAi RPIGRHG.

Enzyme and pathway databases

BioCyci SSOL273057:GCH2-212-MONOMER.

Miscellaneous databases

EvolutionaryTracei P58192.

Family and domain databases

HAMAPi MF_00411. RNApol_arch_A.
InterProi IPR007081. RNA_pol_Rpb1_5.
IPR012757. RNAP_A2.
[Graphical view ]
Pfami PF04998. RNA_pol_Rpb1_5. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02389. RNA_pol_rpoA2. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.
  2. "The X-ray crystal structure of RNA polymerase from Archaea."
    Hirata A., Klein B.J., Murakami K.S.
    Nature 451:851-854(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.4 ANGSTROMS) OF THE RNA POLYMERASE COMPLEX.

Entry informationi

Entry nameiRPOA2_SULSO
AccessioniPrimary (citable) accession number: P58192
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: June 20, 2001
Last modified: May 14, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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