P58182 (O12D2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 12D2

Alternative name(s):
Hs6M1-20
Olfactory receptor OR6-28

Gene names

Name:

OR12D2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	307 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	detection of chemical stimulus involved in sensory perception of smell Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 307	307	Olfactory receptor 12D2		PRO_0000150728
Regions
	Topological domain	1 – 23	23	Extracellular Potential
	Transmembrane	24 – 44	21	Helical; Name=1; Potential
	Topological domain	45 – 52	8	Cytoplasmic Potential
	Transmembrane	53 – 73	21	Helical; Name=2; Potential
	Topological domain	74 – 97	24	Extracellular Potential
	Transmembrane	98 – 118	21	Helical; Name=3; Potential
	Topological domain	119 – 137	19	Cytoplasmic Potential
	Transmembrane	138 – 158	21	Helical; Name=4; Potential
	Topological domain	159 – 195	37	Extracellular Potential
	Transmembrane	196 – 215	20	Helical; Name=5; Potential
	Topological domain	216 – 236	21	Cytoplasmic Potential
	Transmembrane	237 – 257	21	Helical; Name=6; Potential
	Topological domain	258 – 270	13	Extracellular Potential
	Transmembrane	271 – 291	21	Helical; Name=7; Potential
	Topological domain	292 – 307	16	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	3	1	N-linked (GlcNAc...) Potential
	Disulfide bond	95 ↔ 187		By similarity
Natural variations
	Natural variant	47	1	V → F. Corresponds to variant rs9257834 [ dbSNP | Ensembl ].		VAR_057569
	Natural variant	56	1	L → P. Corresponds to variant rs4987411 [ dbSNP | Ensembl ].		VAR_057570
	Natural variant	104	1	S → F. Ref.1 Ref.2 Ref.3 Ref.4 Corresponds to variant rs3128853 [ dbSNP | Ensembl ].		VAR_058967
	Natural variant	113	1	F → L. Corresponds to variant rs2073154 [ dbSNP | Ensembl ].		VAR_057571
	Natural variant	120	1	L → R. Corresponds to variant rs2073153 [ dbSNP | Ensembl ].		VAR_057572
	Natural variant	121	1	S → C. Corresponds to variant rs2073152 [ dbSNP | Ensembl ].		VAR_057573
	Natural variant	132	1	V → G. Corresponds to variant rs11752608 [ dbSNP | Ensembl ].		VAR_057574
	Natural variant	159	1	V → I. Corresponds to variant rs2073151 [ dbSNP | Ensembl ].		VAR_057575

Sequences

	Sequence		Length	Mass (Da)
	P58182 [UniParc]. Last modified February 9, 2010. Version 2. Checksum: 982907668FCFDE8A	FASTA	307	34,813
	10 20 30 40 50 60 MLNTTSVTEF LLLGVTDIQE LQPFLFVVFL TIYFISVTGN GAVLMIVISD PRLHSLMYFF 70 80 90 100 110 120 LGNLSYLDIC YSTVTLPKML QNFLSTHKAI SFLGCISQLH FFHSLGSTES MLFAVMAFDL 130 140 150 160 170 180 SVAICKPLRY TVIMNPQLCT QMAITIWVIG FFHALLHSVM TSRLNFCGSN RIHHFLCDIK 190 200 210 220 230 240 PLLKLACGNT ELNQWLLSTV TGTIAMGPFF LTLLSYFYII TYLFFKTRSC SMLCKALSTC 250 260 270 280 290 300 ASHFMVVILF YAPVLFTYIH PALESFMDQD RIVAIMYTVV TPVLNPLIYT LRNKEVKGAL GRVIRRL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Large scale sequence analysis of the human MHC class I region." Janer M.M., Guillaudeux T., Vu Q., Kutyavin T., Harter H., Geraghty D.E. Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT PHE-104.
[2]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT PHE-104.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT PHE-104.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PHE-104. Tissue: Cerebellum.
[5]	"The human olfactory receptor gene family." Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[6]	Erratum Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)
+	Additional computationally mapped references.

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC004171 Genomic DNA. No translation available. AL035542 Genomic DNA. Translation: CAB44510.1. AL645927 Genomic DNA. Translation: CAI18051.1. AL662869 Genomic DNA. Translation: CAI17482.1. CR759808 Genomic DNA. Translation: CAQ07998.1. BX927232 Genomic DNA. Translation: CAQ08991.1. CH471081 Genomic DNA. Translation: EAX03191.1. BC069123 mRNA. Translation: AAH69123.1. BC101742 mRNA. Translation: AAI01743.1. BC101746 mRNA. Translation: AAI01747.1. BK004523 Genomic DNA. Translation: DAA04921.1.
IPI	IPI00011054.
RefSeq	NP_039224.2. NM_013936.3.
UniGene	Hs.247862.
3D structure databases
ProteinModelPortal	P58182.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000415065.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P58182.
Polymorphism databases
DMDM	288558820.
Proteomic databases
PaxDb	P58182.
PRIDE	P58182.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000377140; ENSP00000366345; ENSG00000204690. ENST00000383555; ENSP00000373047; ENSG00000168787. ENST00000414415; ENSP00000414137; ENSG00000233481. ENST00000438569; ENSP00000415065; ENSG00000235966.
GeneID	26529.
KEGG	hsa:26529.
UCSC	uc003nmf.4. human.
Organism-specific databases
CTD	26529.
GeneCards	GC06P029364.
H-InvDB	HIX0166173. HIX0166712. HIX0166973. HIX0167454. HIX0207641. HIX0207710. HIX0207764.
HGNC	HGNC:8178. OR12D2.
neXtProt	NX_P58182.
PharmGKB	PA32028.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG78202.
HOGENOM	HOG000041362.
HOVERGEN	HBG017625.
InParanoid	P58182.
KO	K04257.
OMA	TIYFINI.
OrthoDB	EOG4X3H1X.
PhylomeDB	P58182.
Gene expression databases
Bgee	P58182.
CleanEx	HS_OR12D2.
Genevestigator	P58182.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	26529.
NextBio	48870.

Entry information

Entry name

O12D2_HUMAN

Accession

Primary (citable) accession number: P58182
Secondary accession number(s): B0S862, Q5SUN9, Q6IET9

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	February 9, 2010
Last modified:	May 1, 2013
This is version 99 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.