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P58182

- O12D2_HUMAN

UniProt

P58182 - O12D2_HUMAN

Protein

Olfactory receptor 12D2

Gene

OR12D2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 2 (09 Feb 2010)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 12D2
    Alternative name(s):
    Hs6M1-20
    Olfactory receptor OR6-28
    Gene namesi
    Name:OR12D2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:8178. OR12D2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32028.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 307307Olfactory receptor 12D2PRO_0000150728Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi95 ↔ 187PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP58182.
    PRIDEiP58182.

    PTM databases

    PhosphoSiteiP58182.

    Expressioni

    Gene expression databases

    BgeeiP58182.
    CleanExiHS_OR12D2.
    GenevestigatoriP58182.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000415065.

    Structurei

    3D structure databases

    ProteinModelPortaliP58182.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2323ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini45 – 528CytoplasmicSequence Analysis
    Topological domaini74 – 9724ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini119 – 13719CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini159 – 19537ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini216 – 23621CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini258 – 27013ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini292 – 30716CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei24 – 4421Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei53 – 7321Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei98 – 11821Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei138 – 15821Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei196 – 21520Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei237 – 25721Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei271 – 29121Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG78202.
    HOGENOMiHOG000041362.
    HOVERGENiHBG017625.
    InParanoidiP58182.
    KOiK04257.
    OMAiFAMENET.
    OrthoDBiEOG7V766W.
    PhylomeDBiP58182.
    TreeFamiTF338273.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P58182-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLNTTSVTEF LLLGVTDIQE LQPFLFVVFL TIYFISVTGN GAVLMIVISD    50
    PRLHSLMYFF LGNLSYLDIC YSTVTLPKML QNFLSTHKAI SFLGCISQLH 100
    FFHSLGSTES MLFAVMAFDL SVAICKPLRY TVIMNPQLCT QMAITIWVIG 150
    FFHALLHSVM TSRLNFCGSN RIHHFLCDIK PLLKLACGNT ELNQWLLSTV 200
    TGTIAMGPFF LTLLSYFYII TYLFFKTRSC SMLCKALSTC ASHFMVVILF 250
    YAPVLFTYIH PALESFMDQD RIVAIMYTVV TPVLNPLIYT LRNKEVKGAL 300
    GRVIRRL 307
    Length:307
    Mass (Da):34,813
    Last modified:February 9, 2010 - v2
    Checksum:i982907668FCFDE8A
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti47 – 471V → F.
    Corresponds to variant rs9257834 [ dbSNP | Ensembl ].
    VAR_057569
    Natural varianti56 – 561L → P.
    Corresponds to variant rs4987411 [ dbSNP | Ensembl ].
    VAR_057570
    Natural varianti104 – 1041S → F.4 Publications
    Corresponds to variant rs3128853 [ dbSNP | Ensembl ].
    VAR_058967
    Natural varianti113 – 1131F → L.
    Corresponds to variant rs2073154 [ dbSNP | Ensembl ].
    VAR_057571
    Natural varianti120 – 1201L → R.
    Corresponds to variant rs2073153 [ dbSNP | Ensembl ].
    VAR_057572
    Natural varianti121 – 1211S → C.
    Corresponds to variant rs2073152 [ dbSNP | Ensembl ].
    VAR_057573
    Natural varianti132 – 1321V → G.
    Corresponds to variant rs11752608 [ dbSNP | Ensembl ].
    VAR_057574
    Natural varianti159 – 1591V → I.
    Corresponds to variant rs2073151 [ dbSNP | Ensembl ].
    VAR_057575

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC004171 Genomic DNA. No translation available.
    AL035542 Genomic DNA. Translation: CAB44510.1.
    AL645927 Genomic DNA. Translation: CAI18051.1.
    AL662869 Genomic DNA. Translation: CAI17482.1.
    CR759808 Genomic DNA. Translation: CAQ07998.1.
    BX927232 Genomic DNA. Translation: CAQ08991.1.
    CH471081 Genomic DNA. Translation: EAX03191.1.
    BC069123 mRNA. Translation: AAH69123.1.
    BC101742 mRNA. Translation: AAI01743.1.
    BC101746 mRNA. Translation: AAI01747.1.
    BK004523 Genomic DNA. Translation: DAA04921.1.
    CCDSiCCDS4659.1.
    RefSeqiNP_039224.2. NM_013936.3.
    UniGeneiHs.247862.

    Genome annotation databases

    EnsembliENST00000377140; ENSP00000366345; ENSG00000204690.
    ENST00000383555; ENSP00000373047; ENSG00000168787.
    ENST00000414415; ENSP00000414137; ENSG00000233481.
    ENST00000438569; ENSP00000415065; ENSG00000235966.
    GeneIDi26529.
    KEGGihsa:26529.
    UCSCiuc003nmf.4. human.

    Polymorphism databases

    DMDMi288558820.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC004171 Genomic DNA. No translation available.
    AL035542 Genomic DNA. Translation: CAB44510.1 .
    AL645927 Genomic DNA. Translation: CAI18051.1 .
    AL662869 Genomic DNA. Translation: CAI17482.1 .
    CR759808 Genomic DNA. Translation: CAQ07998.1 .
    BX927232 Genomic DNA. Translation: CAQ08991.1 .
    CH471081 Genomic DNA. Translation: EAX03191.1 .
    BC069123 mRNA. Translation: AAH69123.1 .
    BC101742 mRNA. Translation: AAI01743.1 .
    BC101746 mRNA. Translation: AAI01747.1 .
    BK004523 Genomic DNA. Translation: DAA04921.1 .
    CCDSi CCDS4659.1.
    RefSeqi NP_039224.2. NM_013936.3.
    UniGenei Hs.247862.

    3D structure databases

    ProteinModelPortali P58182.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000415065.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P58182.

    Polymorphism databases

    DMDMi 288558820.

    Proteomic databases

    PaxDbi P58182.
    PRIDEi P58182.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000377140 ; ENSP00000366345 ; ENSG00000204690 .
    ENST00000383555 ; ENSP00000373047 ; ENSG00000168787 .
    ENST00000414415 ; ENSP00000414137 ; ENSG00000233481 .
    ENST00000438569 ; ENSP00000415065 ; ENSG00000235966 .
    GeneIDi 26529.
    KEGGi hsa:26529.
    UCSCi uc003nmf.4. human.

    Organism-specific databases

    CTDi 26529.
    GeneCardsi GC06P029364.
    GC06Pj29361.
    GC06Pl29364.
    GC06Pm29364.
    H-InvDB HIX0166173.
    HIX0166712.
    HIX0166973.
    HIX0167454.
    HIX0207641.
    HIX0207710.
    HIX0207764.
    HGNCi HGNC:8178. OR12D2.
    neXtProti NX_P58182.
    PharmGKBi PA32028.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG78202.
    HOGENOMi HOG000041362.
    HOVERGENi HBG017625.
    InParanoidi P58182.
    KOi K04257.
    OMAi FAMENET.
    OrthoDBi EOG7V766W.
    PhylomeDBi P58182.
    TreeFami TF338273.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR12D2.
    GenomeRNAii 26529.
    NextBioi 48870.
    PROi P58182.

    Gene expression databases

    Bgeei P58182.
    CleanExi HS_OR12D2.
    Genevestigatori P58182.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Large scale sequence analysis of the human MHC class I region."
      Janer M.M., Guillaudeux T., Vu Q., Kutyavin T., Harter H., Geraghty D.E.
      Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT PHE-104.
    2. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT PHE-104.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT PHE-104.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PHE-104.
      Tissue: Cerebellum.
    5. Cited for: IDENTIFICATION.
    6. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiO12D2_HUMAN
    AccessioniPrimary (citable) accession number: P58182
    Secondary accession number(s): B0S862, Q5SUN9, Q6IET9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: February 9, 2010
    Last modified: October 1, 2014
    This is version 112 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3