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Protein

Olfactory receptor 12D2

Gene

OR12D2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 12D2
Alternative name(s):
Hs6M1-20
Olfactory receptor OR6-28
Gene namesi
Name:OR12D2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:8178. OR12D2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 44Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini45 – 52CytoplasmicSequence analysis8
Transmembranei53 – 73Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini74 – 97ExtracellularSequence analysisAdd BLAST24
Transmembranei98 – 118Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini119 – 137CytoplasmicSequence analysisAdd BLAST19
Transmembranei138 – 158Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini159 – 195ExtracellularSequence analysisAdd BLAST37
Transmembranei196 – 215Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini216 – 236CytoplasmicSequence analysisAdd BLAST21
Transmembranei237 – 257Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini258 – 270ExtracellularSequence analysisAdd BLAST13
Transmembranei271 – 291Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini292 – 307CytoplasmicSequence analysisAdd BLAST16

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi26529.
OpenTargetsiENSG00000280236.
PharmGKBiPA32028.

Polymorphism and mutation databases

BioMutaiOR12D2.
DMDMi288558820.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507281 – 307Olfactory receptor 12D2Add BLAST307

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi95 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP58182.
PeptideAtlasiP58182.
PRIDEiP58182.

PTM databases

iPTMnetiP58182.
PhosphoSitePlusiP58182.

Expressioni

Gene expression databases

BgeeiENSG00000168787.
CleanExiHS_OR12D2.
ExpressionAtlasiP58182. baseline and differential.
GenevisibleiP58182. HS.

Structurei

3D structure databases

ProteinModelPortaliP58182.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IH3D. Eukaryota.
ENOG410YBP5. LUCA.
GeneTreeiENSGT00390000018942.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiP58182.
KOiK04257.
OMAiLACENTE.
OrthoDBiEOG09370DTX.
PhylomeDBiP58182.
TreeFamiTF338273.

Family and domain databases

InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiView protein in PROSITE
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P58182-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNTTSVTEF LLLGVTDIQE LQPFLFVVFL TIYFISVTGN GAVLMIVISD
60 70 80 90 100
PRLHSLMYFF LGNLSYLDIC YSTVTLPKML QNFLSTHKAI SFLGCISQLH
110 120 130 140 150
FFHSLGSTES MLFAVMAFDL SVAICKPLRY TVIMNPQLCT QMAITIWVIG
160 170 180 190 200
FFHALLHSVM TSRLNFCGSN RIHHFLCDIK PLLKLACGNT ELNQWLLSTV
210 220 230 240 250
TGTIAMGPFF LTLLSYFYII TYLFFKTRSC SMLCKALSTC ASHFMVVILF
260 270 280 290 300
YAPVLFTYIH PALESFMDQD RIVAIMYTVV TPVLNPLIYT LRNKEVKGAL

GRVIRRL
Length:307
Mass (Da):34,813
Last modified:February 9, 2010 - v2
Checksum:i982907668FCFDE8A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05756947V → F. Corresponds to variant dbSNP:rs9257834Ensembl.1
Natural variantiVAR_05757056L → P. Corresponds to variant dbSNP:rs4987411Ensembl.1
Natural variantiVAR_058967104S → F4 PublicationsCorresponds to variant dbSNP:rs3128853Ensembl.1
Natural variantiVAR_057571113F → L. Corresponds to variant dbSNP:rs2073154Ensembl.1
Natural variantiVAR_057572120L → R. Corresponds to variant dbSNP:rs2073153Ensembl.1
Natural variantiVAR_057573121S → C. Corresponds to variant dbSNP:rs2073152Ensembl.1
Natural variantiVAR_057574132V → G. Corresponds to variant dbSNP:rs11752608Ensembl.1
Natural variantiVAR_057575159V → I. Corresponds to variant dbSNP:rs2073151Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004171 Genomic DNA. No translation available.
AL035542 Genomic DNA. Translation: CAB44510.1.
AL645927 Genomic DNA. Translation: CAI18051.1.
AL662869 Genomic DNA. Translation: CAI17482.1.
CR759808 Genomic DNA. Translation: CAQ07998.1.
BX927232 Genomic DNA. Translation: CAQ08991.1.
CH471081 Genomic DNA. Translation: EAX03191.1.
BC069123 mRNA. Translation: AAH69123.1.
BC101742 mRNA. Translation: AAI01743.1.
BC101746 mRNA. Translation: AAI01747.1.
BK004523 Genomic DNA. Translation: DAA04921.1.
RefSeqiNP_039224.2. NM_013936.3.
UniGeneiHs.247862.

Genome annotation databases

EnsembliENST00000377140; ENSP00000366345; ENSG00000204690.
ENST00000414415; ENSP00000414137; ENSG00000233481.
ENST00000438569; ENSP00000415065; ENSG00000235966.
ENST00000623183; ENSP00000485112; ENSG00000280236.
GeneIDi26529.
KEGGihsa:26529.
UCSCiuc003nmf.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004171 Genomic DNA. No translation available.
AL035542 Genomic DNA. Translation: CAB44510.1.
AL645927 Genomic DNA. Translation: CAI18051.1.
AL662869 Genomic DNA. Translation: CAI17482.1.
CR759808 Genomic DNA. Translation: CAQ07998.1.
BX927232 Genomic DNA. Translation: CAQ08991.1.
CH471081 Genomic DNA. Translation: EAX03191.1.
BC069123 mRNA. Translation: AAH69123.1.
BC101742 mRNA. Translation: AAI01743.1.
BC101746 mRNA. Translation: AAI01747.1.
BK004523 Genomic DNA. Translation: DAA04921.1.
RefSeqiNP_039224.2. NM_013936.3.
UniGeneiHs.247862.

3D structure databases

ProteinModelPortaliP58182.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP58182.
PhosphoSitePlusiP58182.

Polymorphism and mutation databases

BioMutaiOR12D2.
DMDMi288558820.

Proteomic databases

PaxDbiP58182.
PeptideAtlasiP58182.
PRIDEiP58182.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377140; ENSP00000366345; ENSG00000204690.
ENST00000414415; ENSP00000414137; ENSG00000233481.
ENST00000438569; ENSP00000415065; ENSG00000235966.
ENST00000623183; ENSP00000485112; ENSG00000280236.
GeneIDi26529.
KEGGihsa:26529.
UCSCiuc003nmf.4. human.

Organism-specific databases

CTDi26529.
DisGeNETi26529.
GeneCardsiOR12D2.
H-InvDBHIX0166173.
HIX0166712.
HIX0166973.
HIX0167454.
HIX0207641.
HIX0207710.
HIX0207764.
HGNCiHGNC:8178. OR12D2.
neXtProtiNX_P58182.
OpenTargetsiENSG00000280236.
PharmGKBiPA32028.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH3D. Eukaryota.
ENOG410YBP5. LUCA.
GeneTreeiENSGT00390000018942.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiP58182.
KOiK04257.
OMAiLACENTE.
OrthoDBiEOG09370DTX.
PhylomeDBiP58182.
TreeFamiTF338273.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR12D2.
GenomeRNAii26529.
PROiP58182.

Gene expression databases

BgeeiENSG00000168787.
CleanExiHS_OR12D2.
ExpressionAtlasiP58182. baseline and differential.
GenevisibleiP58182. HS.

Family and domain databases

InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiView protein in PROSITE
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiO12D2_HUMAN
AccessioniPrimary (citable) accession number: P58182
Secondary accession number(s): B0S862, Q5SUN9, Q6IET9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: February 9, 2010
Last modified: March 15, 2017
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.