SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P58182

- O12D2_HUMAN

UniProt

P58182 - O12D2_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Olfactory receptor 12D2

Gene
OR12D2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Odorant receptor Reviewed prediction.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 12D2
Alternative name(s):
Hs6M1-20
Olfactory receptor OR6-28
Gene namesi
Name:OR12D2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:8178. OR12D2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323Extracellular Reviewed predictionAdd
BLAST
Transmembranei24 – 4421Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini45 – 528Cytoplasmic Reviewed prediction
Transmembranei53 – 7321Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini74 – 9724Extracellular Reviewed predictionAdd
BLAST
Transmembranei98 – 11821Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini119 – 13719Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei138 – 15821Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini159 – 19537Extracellular Reviewed predictionAdd
BLAST
Transmembranei196 – 21520Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini216 – 23621Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei237 – 25721Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini258 – 27013Extracellular Reviewed predictionAdd
BLAST
Transmembranei271 – 29121Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini292 – 30716Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32028.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 307307Olfactory receptor 12D2PRO_0000150728Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi95 ↔ 187 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP58182.
PRIDEiP58182.

PTM databases

PhosphoSiteiP58182.

Expressioni

Gene expression databases

BgeeiP58182.
CleanExiHS_OR12D2.
GenevestigatoriP58182.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000415065.

Structurei

3D structure databases

ProteinModelPortaliP58182.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG78202.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiP58182.
KOiK04257.
OMAiFAMENET.
OrthoDBiEOG7V766W.
PhylomeDBiP58182.
TreeFamiTF338273.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P58182-1 [UniParc]FASTAAdd to Basket

« Hide

MLNTTSVTEF LLLGVTDIQE LQPFLFVVFL TIYFISVTGN GAVLMIVISD    50
PRLHSLMYFF LGNLSYLDIC YSTVTLPKML QNFLSTHKAI SFLGCISQLH 100
FFHSLGSTES MLFAVMAFDL SVAICKPLRY TVIMNPQLCT QMAITIWVIG 150
FFHALLHSVM TSRLNFCGSN RIHHFLCDIK PLLKLACGNT ELNQWLLSTV 200
TGTIAMGPFF LTLLSYFYII TYLFFKTRSC SMLCKALSTC ASHFMVVILF 250
YAPVLFTYIH PALESFMDQD RIVAIMYTVV TPVLNPLIYT LRNKEVKGAL 300
GRVIRRL 307
Length:307
Mass (Da):34,813
Last modified:February 9, 2010 - v2
Checksum:i982907668FCFDE8A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti47 – 471V → F.
Corresponds to variant rs9257834 [ dbSNP | Ensembl ].
VAR_057569
Natural varianti56 – 561L → P.
Corresponds to variant rs4987411 [ dbSNP | Ensembl ].
VAR_057570
Natural varianti104 – 1041S → F.4 Publications
Corresponds to variant rs3128853 [ dbSNP | Ensembl ].
VAR_058967
Natural varianti113 – 1131F → L.
Corresponds to variant rs2073154 [ dbSNP | Ensembl ].
VAR_057571
Natural varianti120 – 1201L → R.
Corresponds to variant rs2073153 [ dbSNP | Ensembl ].
VAR_057572
Natural varianti121 – 1211S → C.
Corresponds to variant rs2073152 [ dbSNP | Ensembl ].
VAR_057573
Natural varianti132 – 1321V → G.
Corresponds to variant rs11752608 [ dbSNP | Ensembl ].
VAR_057574
Natural varianti159 – 1591V → I.
Corresponds to variant rs2073151 [ dbSNP | Ensembl ].
VAR_057575

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC004171 Genomic DNA. No translation available.
AL035542 Genomic DNA. Translation: CAB44510.1.
AL645927 Genomic DNA. Translation: CAI18051.1.
AL662869 Genomic DNA. Translation: CAI17482.1.
CR759808 Genomic DNA. Translation: CAQ07998.1.
BX927232 Genomic DNA. Translation: CAQ08991.1.
CH471081 Genomic DNA. Translation: EAX03191.1.
BC069123 mRNA. Translation: AAH69123.1.
BC101742 mRNA. Translation: AAI01743.1.
BC101746 mRNA. Translation: AAI01747.1.
BK004523 Genomic DNA. Translation: DAA04921.1.
CCDSiCCDS4659.1.
RefSeqiNP_039224.2. NM_013936.3.
UniGeneiHs.247862.

Genome annotation databases

EnsembliENST00000377140; ENSP00000366345; ENSG00000204690.
ENST00000383555; ENSP00000373047; ENSG00000168787.
ENST00000414415; ENSP00000414137; ENSG00000233481.
ENST00000438569; ENSP00000415065; ENSG00000235966.
GeneIDi26529.
KEGGihsa:26529.
UCSCiuc003nmf.4. human.

Polymorphism databases

DMDMi288558820.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC004171 Genomic DNA. No translation available.
AL035542 Genomic DNA. Translation: CAB44510.1 .
AL645927 Genomic DNA. Translation: CAI18051.1 .
AL662869 Genomic DNA. Translation: CAI17482.1 .
CR759808 Genomic DNA. Translation: CAQ07998.1 .
BX927232 Genomic DNA. Translation: CAQ08991.1 .
CH471081 Genomic DNA. Translation: EAX03191.1 .
BC069123 mRNA. Translation: AAH69123.1 .
BC101742 mRNA. Translation: AAI01743.1 .
BC101746 mRNA. Translation: AAI01747.1 .
BK004523 Genomic DNA. Translation: DAA04921.1 .
CCDSi CCDS4659.1.
RefSeqi NP_039224.2. NM_013936.3.
UniGenei Hs.247862.

3D structure databases

ProteinModelPortali P58182.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000415065.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P58182.

Polymorphism databases

DMDMi 288558820.

Proteomic databases

PaxDbi P58182.
PRIDEi P58182.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000377140 ; ENSP00000366345 ; ENSG00000204690 .
ENST00000383555 ; ENSP00000373047 ; ENSG00000168787 .
ENST00000414415 ; ENSP00000414137 ; ENSG00000233481 .
ENST00000438569 ; ENSP00000415065 ; ENSG00000235966 .
GeneIDi 26529.
KEGGi hsa:26529.
UCSCi uc003nmf.4. human.

Organism-specific databases

CTDi 26529.
GeneCardsi GC06P029364.
GC06Pj29361.
GC06Pl29364.
GC06Pm29364.
H-InvDB HIX0166173.
HIX0166712.
HIX0166973.
HIX0167454.
HIX0207641.
HIX0207710.
HIX0207764.
HGNCi HGNC:8178. OR12D2.
neXtProti NX_P58182.
PharmGKBi PA32028.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG78202.
HOGENOMi HOG000041362.
HOVERGENi HBG017625.
InParanoidi P58182.
KOi K04257.
OMAi FAMENET.
OrthoDBi EOG7V766W.
PhylomeDBi P58182.
TreeFami TF338273.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR12D2.
GenomeRNAii 26529.
NextBioi 48870.
PROi P58182.

Gene expression databases

Bgeei P58182.
CleanExi HS_OR12D2.
Genevestigatori P58182.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Large scale sequence analysis of the human MHC class I region."
    Janer M.M., Guillaudeux T., Vu Q., Kutyavin T., Harter H., Geraghty D.E.
    Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT PHE-104.
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT PHE-104.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT PHE-104.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PHE-104.
    Tissue: Cerebellum.
  5. Cited for: IDENTIFICATION.
  6. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO12D2_HUMAN
AccessioniPrimary (citable) accession number: P58182
Secondary accession number(s): B0S862, Q5SUN9, Q6IET9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: February 9, 2010
Last modified: September 3, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi