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P58182 (O12D2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 12D2
Alternative name(s):
Hs6M1-20
Olfactory receptor OR6-28
Gene names
Name:OR12D2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length307 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 307307Olfactory receptor 12D2
PRO_0000150728

Regions

Topological domain1 – 2323Extracellular Potential
Transmembrane24 – 4421Helical; Name=1; Potential
Topological domain45 – 528Cytoplasmic Potential
Transmembrane53 – 7321Helical; Name=2; Potential
Topological domain74 – 9724Extracellular Potential
Transmembrane98 – 11821Helical; Name=3; Potential
Topological domain119 – 13719Cytoplasmic Potential
Transmembrane138 – 15821Helical; Name=4; Potential
Topological domain159 – 19537Extracellular Potential
Transmembrane196 – 21520Helical; Name=5; Potential
Topological domain216 – 23621Cytoplasmic Potential
Transmembrane237 – 25721Helical; Name=6; Potential
Topological domain258 – 27013Extracellular Potential
Transmembrane271 – 29121Helical; Name=7; Potential
Topological domain292 – 30716Cytoplasmic Potential

Amino acid modifications

Glycosylation31N-linked (GlcNAc...) Potential
Disulfide bond95 ↔ 187 By similarity

Natural variations

Natural variant471V → F.
Corresponds to variant rs9257834 [ dbSNP | Ensembl ].
VAR_057569
Natural variant561L → P.
Corresponds to variant rs4987411 [ dbSNP | Ensembl ].
VAR_057570
Natural variant1041S → F. Ref.1 Ref.2 Ref.3 Ref.4
Corresponds to variant rs3128853 [ dbSNP | Ensembl ].
VAR_058967
Natural variant1131F → L.
Corresponds to variant rs2073154 [ dbSNP | Ensembl ].
VAR_057571
Natural variant1201L → R.
Corresponds to variant rs2073153 [ dbSNP | Ensembl ].
VAR_057572
Natural variant1211S → C.
Corresponds to variant rs2073152 [ dbSNP | Ensembl ].
VAR_057573
Natural variant1321V → G.
Corresponds to variant rs11752608 [ dbSNP | Ensembl ].
VAR_057574
Natural variant1591V → I.
Corresponds to variant rs2073151 [ dbSNP | Ensembl ].
VAR_057575

Sequences

Sequence LengthMass (Da)Tools
P58182 [UniParc].

Last modified February 9, 2010. Version 2.
Checksum: 982907668FCFDE8A

FASTA30734,813
        10         20         30         40         50         60 
MLNTTSVTEF LLLGVTDIQE LQPFLFVVFL TIYFISVTGN GAVLMIVISD PRLHSLMYFF 

        70         80         90        100        110        120 
LGNLSYLDIC YSTVTLPKML QNFLSTHKAI SFLGCISQLH FFHSLGSTES MLFAVMAFDL 

       130        140        150        160        170        180 
SVAICKPLRY TVIMNPQLCT QMAITIWVIG FFHALLHSVM TSRLNFCGSN RIHHFLCDIK 

       190        200        210        220        230        240 
PLLKLACGNT ELNQWLLSTV TGTIAMGPFF LTLLSYFYII TYLFFKTRSC SMLCKALSTC 

       250        260        270        280        290        300 
ASHFMVVILF YAPVLFTYIH PALESFMDQD RIVAIMYTVV TPVLNPLIYT LRNKEVKGAL 


GRVIRRL 

« Hide

References

« Hide 'large scale' references
[1]"Large scale sequence analysis of the human MHC class I region."
Janer M.M., Guillaudeux T., Vu Q., Kutyavin T., Harter H., Geraghty D.E.
Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT PHE-104.
[2]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT PHE-104.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT PHE-104.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PHE-104.
Tissue: Cerebellum.
[5]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[6]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC004171 Genomic DNA. No translation available.
AL035542 Genomic DNA. Translation: CAB44510.1.
AL645927 Genomic DNA. Translation: CAI18051.1.
AL662869 Genomic DNA. Translation: CAI17482.1.
CR759808 Genomic DNA. Translation: CAQ07998.1.
BX927232 Genomic DNA. Translation: CAQ08991.1.
CH471081 Genomic DNA. Translation: EAX03191.1.
BC069123 mRNA. Translation: AAH69123.1.
BC101742 mRNA. Translation: AAI01743.1.
BC101746 mRNA. Translation: AAI01747.1.
BK004523 Genomic DNA. Translation: DAA04921.1.
CCDSCCDS4659.1.
RefSeqNP_039224.2. NM_013936.3.
UniGeneHs.247862.

3D structure databases

ProteinModelPortalP58182.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000415065.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP58182.

Polymorphism databases

DMDM288558820.

Proteomic databases

PaxDbP58182.
PRIDEP58182.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000377140; ENSP00000366345; ENSG00000204690.
ENST00000383555; ENSP00000373047; ENSG00000168787.
ENST00000414415; ENSP00000414137; ENSG00000233481.
ENST00000438569; ENSP00000415065; ENSG00000235966.
GeneID26529.
KEGGhsa:26529.
UCSCuc003nmf.4. human.

Organism-specific databases

CTD26529.
GeneCardsGC06P029364.
GC06Pj29361.
GC06Pl29364.
GC06Pm29364.
H-InvDBHIX0166173.
HIX0166712.
HIX0166973.
HIX0167454.
HIX0207641.
HIX0207710.
HIX0207764.
HGNCHGNC:8178. OR12D2.
neXtProtNX_P58182.
PharmGKBPA32028.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG78202.
HOGENOMHOG000041362.
HOVERGENHBG017625.
InParanoidP58182.
KOK04257.
OMAFAMENET.
OrthoDBEOG7V766W.
PhylomeDBP58182.
TreeFamTF338273.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeP58182.
CleanExHS_OR12D2.
GenevestigatorP58182.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR12D2.
GenomeRNAi26529.
NextBio48870.
PROP58182.

Entry information

Entry nameO12D2_HUMAN
AccessionPrimary (citable) accession number: P58182
Secondary accession number(s): B0S862, Q5SUN9, Q6IET9
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: February 9, 2010
Last modified: July 9, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries