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Protein

Olfactory receptor 12D2

Gene

OR12D2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
  3. transmembrane signaling receptor activity Source: GO_Central

GO - Biological processi

  1. detection of chemical stimulus involved in sensory perception Source: GO_Central
  2. G-protein coupled receptor signaling pathway Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 12D2
Alternative name(s):
Hs6M1-20
Olfactory receptor OR6-28
Gene namesi
Name:OR12D2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6, UP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:8178. OR12D2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323ExtracellularSequence AnalysisAdd
BLAST
Transmembranei24 – 4421Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini45 – 528CytoplasmicSequence Analysis
Transmembranei53 – 7321Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini74 – 9724ExtracellularSequence AnalysisAdd
BLAST
Transmembranei98 – 11821Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini119 – 13719CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei138 – 15821Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini159 – 19537ExtracellularSequence AnalysisAdd
BLAST
Transmembranei196 – 21520Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini216 – 23621CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei237 – 25721Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini258 – 27013ExtracellularSequence AnalysisAdd
BLAST
Transmembranei271 – 29121Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini292 – 30716CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: GO_Central
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32028.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 307307Olfactory receptor 12D2PRO_0000150728Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi95 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP58182.
PRIDEiP58182.

PTM databases

PhosphoSiteiP58182.

Expressioni

Gene expression databases

BgeeiP58182.
CleanExiHS_OR12D2.
GenevestigatoriP58182.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000415065.

Structurei

3D structure databases

ProteinModelPortaliP58182.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG78202.
GeneTreeiENSGT00390000018942.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiP58182.
KOiK04257.
OMAiELACENT.
OrthoDBiEOG7V766W.
PhylomeDBiP58182.
TreeFamiTF338273.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P58182-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLNTTSVTEF LLLGVTDIQE LQPFLFVVFL TIYFISVTGN GAVLMIVISD
60 70 80 90 100
PRLHSLMYFF LGNLSYLDIC YSTVTLPKML QNFLSTHKAI SFLGCISQLH
110 120 130 140 150
FFHSLGSTES MLFAVMAFDL SVAICKPLRY TVIMNPQLCT QMAITIWVIG
160 170 180 190 200
FFHALLHSVM TSRLNFCGSN RIHHFLCDIK PLLKLACGNT ELNQWLLSTV
210 220 230 240 250
TGTIAMGPFF LTLLSYFYII TYLFFKTRSC SMLCKALSTC ASHFMVVILF
260 270 280 290 300
YAPVLFTYIH PALESFMDQD RIVAIMYTVV TPVLNPLIYT LRNKEVKGAL

GRVIRRL
Length:307
Mass (Da):34,813
Last modified:February 9, 2010 - v2
Checksum:i982907668FCFDE8A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti47 – 471V → F.
Corresponds to variant rs9257834 [ dbSNP | Ensembl ].
VAR_057569
Natural varianti56 – 561L → P.
Corresponds to variant rs4987411 [ dbSNP | Ensembl ].
VAR_057570
Natural varianti104 – 1041S → F.4 Publications
Corresponds to variant rs3128853 [ dbSNP | Ensembl ].
VAR_058967
Natural varianti113 – 1131F → L.
Corresponds to variant rs2073154 [ dbSNP | Ensembl ].
VAR_057571
Natural varianti120 – 1201L → R.
Corresponds to variant rs2073153 [ dbSNP | Ensembl ].
VAR_057572
Natural varianti121 – 1211S → C.
Corresponds to variant rs2073152 [ dbSNP | Ensembl ].
VAR_057573
Natural varianti132 – 1321V → G.
Corresponds to variant rs11752608 [ dbSNP | Ensembl ].
VAR_057574
Natural varianti159 – 1591V → I.
Corresponds to variant rs2073151 [ dbSNP | Ensembl ].
VAR_057575

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004171 Genomic DNA. No translation available.
AL035542 Genomic DNA. Translation: CAB44510.1.
AL645927 Genomic DNA. Translation: CAI18051.1.
AL662869 Genomic DNA. Translation: CAI17482.1.
CR759808 Genomic DNA. Translation: CAQ07998.1.
BX927232 Genomic DNA. Translation: CAQ08991.1.
CH471081 Genomic DNA. Translation: EAX03191.1.
BC069123 mRNA. Translation: AAH69123.1.
BC101742 mRNA. Translation: AAI01743.1.
BC101746 mRNA. Translation: AAI01747.1.
BK004523 Genomic DNA. Translation: DAA04921.1.
CCDSiCCDS4659.1.
RefSeqiNP_039224.2. NM_013936.3.
UniGeneiHs.247862.

Genome annotation databases

EnsembliENST00000377140; ENSP00000366345; ENSG00000204690.
ENST00000383555; ENSP00000373047; ENSG00000168787.
ENST00000414415; ENSP00000414137; ENSG00000233481.
ENST00000438569; ENSP00000415065; ENSG00000235966.
ENST00000623183; ENSP00000485112; ENSG00000280236.
ENST00000623508; ENSP00000485068; ENSG00000280236.
GeneIDi26529.
KEGGihsa:26529.
UCSCiuc003nmf.4. human.

Polymorphism databases

DMDMi288558820.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004171 Genomic DNA. No translation available.
AL035542 Genomic DNA. Translation: CAB44510.1.
AL645927 Genomic DNA. Translation: CAI18051.1.
AL662869 Genomic DNA. Translation: CAI17482.1.
CR759808 Genomic DNA. Translation: CAQ07998.1.
BX927232 Genomic DNA. Translation: CAQ08991.1.
CH471081 Genomic DNA. Translation: EAX03191.1.
BC069123 mRNA. Translation: AAH69123.1.
BC101742 mRNA. Translation: AAI01743.1.
BC101746 mRNA. Translation: AAI01747.1.
BK004523 Genomic DNA. Translation: DAA04921.1.
CCDSiCCDS4659.1.
RefSeqiNP_039224.2. NM_013936.3.
UniGeneiHs.247862.

3D structure databases

ProteinModelPortaliP58182.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000415065.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP58182.

Polymorphism databases

DMDMi288558820.

Proteomic databases

PaxDbiP58182.
PRIDEiP58182.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377140; ENSP00000366345; ENSG00000204690.
ENST00000383555; ENSP00000373047; ENSG00000168787.
ENST00000414415; ENSP00000414137; ENSG00000233481.
ENST00000438569; ENSP00000415065; ENSG00000235966.
ENST00000623183; ENSP00000485112; ENSG00000280236.
ENST00000623508; ENSP00000485068; ENSG00000280236.
GeneIDi26529.
KEGGihsa:26529.
UCSCiuc003nmf.4. human.

Organism-specific databases

CTDi26529.
GeneCardsiGC06P029364.
GC06Pj29361.
GC06Pl29364.
GC06Pm29364.
H-InvDBHIX0166173.
HIX0166712.
HIX0166973.
HIX0167454.
HIX0207641.
HIX0207710.
HIX0207764.
HGNCiHGNC:8178. OR12D2.
neXtProtiNX_P58182.
PharmGKBiPA32028.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG78202.
GeneTreeiENSGT00390000018942.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiP58182.
KOiK04257.
OMAiELACENT.
OrthoDBiEOG7V766W.
PhylomeDBiP58182.
TreeFamiTF338273.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR12D2.
GenomeRNAii26529.
NextBioi48870.
PROiP58182.

Gene expression databases

BgeeiP58182.
CleanExiHS_OR12D2.
GenevestigatoriP58182.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Large scale sequence analysis of the human MHC class I region."
    Janer M.M., Guillaudeux T., Vu Q., Kutyavin T., Harter H., Geraghty D.E.
    Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT PHE-104.
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT PHE-104.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT PHE-104.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PHE-104.
    Tissue: Cerebellum.
  5. Cited for: IDENTIFICATION.
  6. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO12D2_HUMAN
AccessioniPrimary (citable) accession number: P58182
Secondary accession number(s): B0S862, Q5SUN9, Q6IET9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: February 9, 2010
Last modified: February 4, 2015
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.