ID   O10A3_HUMAN             Reviewed;         314 AA.
AC   P58181; B9EH39; Q6IF58; Q96R11;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   20-JUN-2001, sequence version 1.
DT   24-JAN-2024, entry version 167.
DE   RecName: Full=Olfactory receptor 10A3;
DE   AltName: Full=HTPCRX12;
DE   AltName: Full=Olfactory receptor OR11-97;
GN   Name=OR10A3;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-284.
RX   PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA   Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA   Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA   Lehrach H., Lancet D., Shamir R.;
RT   "DEFOG: a practical scheme for deciphering families of genes.";
RL   Genomics 80:295-302(2002).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 126-239.
RC   TISSUE=Testis;
RX   PubMed=1370859; DOI=10.1038/355453a0;
RA   Parmentier M., Libert F., Schurmans S., Schiffmann S., Lefort A.,
RA   Eggerickx D., Ledent C., Mollereau C., Gerard C., Perret J., Grootegoed A.,
RA   Vassart G.;
RT   "Expression of members of the putative olfactory receptor gene family in
RT   mammalian germ cells.";
RL   Nature 355:453-455(1992).
RN   [7]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [8]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR10A3";
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DR   EMBL; AB065768; BAC05988.1; -; Genomic_DNA.
DR   EMBL; AC044810; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471064; EAW68641.1; -; Genomic_DNA.
DR   EMBL; BC137031; AAI37032.1; -; mRNA.
DR   EMBL; BC137032; AAI37033.1; -; mRNA.
DR   EMBL; AF399634; AAK95119.1; -; Genomic_DNA.
DR   EMBL; X64986; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; BK004404; DAA04802.1; -; Genomic_DNA.
DR   CCDS; CCDS31421.1; -.
DR   RefSeq; NP_001003745.1; NM_001003745.1.
DR   AlphaFoldDB; P58181; -.
DR   SMR; P58181; -.
DR   STRING; 9606.ENSP00000493303; -.
DR   GlyCosmos; P58181; 1 site, No reported glycans.
DR   GlyGen; P58181; 1 site.
DR   iPTMnet; P58181; -.
DR   PhosphoSitePlus; P58181; -.
DR   BioMuta; OR10A3; -.
DR   DMDM; 14423787; -.
DR   MassIVE; P58181; -.
DR   PaxDb; 9606-ENSP00000353988; -.
DR   PeptideAtlas; P58181; -.
DR   Antibodypedia; 55077; 18 antibodies from 12 providers.
DR   DNASU; 26496; -.
DR   Ensembl; ENST00000612788.1; ENSP00000484096.1; ENSG00000273953.1.
DR   Ensembl; ENST00000626843.1; ENSP00000487530.1; ENSG00000281680.2.
DR   Ensembl; ENST00000641438.1; ENSP00000493029.1; ENSG00000281680.2.
DR   Ensembl; ENST00000642047.1; ENSP00000493303.1; ENSG00000170683.7.
DR   GeneID; 26496; -.
DR   KEGG; hsa:26496; -.
DR   MANE-Select; ENST00000642047.1; ENSP00000493303.1; NM_001003745.2; NP_001003745.1.
DR   UCSC; uc010rbi.3; human.
DR   AGR; HGNC:8162; -.
DR   CTD; 26496; -.
DR   GeneCards; OR10A3; -.
DR   HGNC; HGNC:8162; OR10A3.
DR   HPA; ENSG00000170683; Not detected.
DR   neXtProt; NX_P58181; -.
DR   OpenTargets; ENSG00000170683; -.
DR   PharmGKB; PA31951; -.
DR   VEuPathDB; HostDB:ENSG00000170683; -.
DR   eggNOG; ENOG502QVH7; Eukaryota.
DR   GeneTree; ENSGT01040000240406; -.
DR   HOGENOM; CLU_012526_1_2_1; -.
DR   InParanoid; P58181; -.
DR   OMA; FLKLVMF; -.
DR   OrthoDB; 4811967at2759; -.
DR   PhylomeDB; P58181; -.
DR   TreeFam; TF337350; -.
DR   PathwayCommons; P58181; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 26496; 5 hits in 740 CRISPR screens.
DR   GeneWiki; OR10A3; -.
DR   GenomeRNAi; 26496; -.
DR   Pharos; P58181; Tdark.
DR   PRO; PR:P58181; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; P58181; Protein.
DR   Bgee; ENSG00000170683; Expressed in skin of leg and 2 other cell types or tissues.
DR   ExpressionAtlas; P58181; baseline and differential.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IBA:GO_Central.
DR   GO; GO:0007608; P:sensory perception of smell; NAS:UniProtKB.
DR   CDD; cd15225; 7tmA_OR10A-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR26453; OLFACTORY RECEPTOR; 1.
DR   PANTHER; PTHR26453:SF30; OLFACTORY RECEPTOR 10A3; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   Genevisible; P58181; HS.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..314
FT                   /note="Olfactory receptor 10A3"
FT                   /id="PRO_0000150685"
FT   TOPO_DOM        1..25
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        26..46
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        47..54
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..75
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        76..99
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        121..139
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..160
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        161..197
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        198..217
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        218..237
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        238..258
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        259..271
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        272..292
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        293..314
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        5
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        97..189
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         20
FT                   /note="F -> V (in dbSNP:rs16934214)"
FT                   /id="VAR_053262"
SQ   SEQUENCE   314 AA;  35535 MW;  3355B17F4AFBF647 CRC64;
     MKRQNQSCVV EFILLGFSNF PELQVQLFGV FLVIYVVTLM GNAIITVIIS LNQSLHVPMY
     LFLLNLSVVE VSFSAVITPE MLVVLSTEKT MISFVGCFAQ MYFILLFGGT ECFLLGAMAY
     DRFAAICHPL NYPVIMNRGV FMKLVIFSWI SGIMVATVQT TWVFSFPFCG PNEINHLFCE
     TPPVLELVCA DTFLFEIYAF TGTILIVMVP FLLILLSYIR VLFAILKMPS TTGRQKAFST
     CASHLTSVTL FYGTANMTYL QPKSGYSPET KKLISLAYTL LTPLLNPLIY SLRNSEMKRT
     LIKLWRRKVI LHTF
//