P58181 (O10A3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 10A3

Alternative name(s):
HTPCRX12
Olfactory receptor OR11-97

Gene names

Name:

OR10A3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	314 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Non-traceable author statement. Source: UniProtKB plasma membrane Traceable author statement. Source: Reactome
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Non-traceable author statement Ref.6. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 314	314	Olfactory receptor 10A3		PRO_0000150685
Regions
	Topological domain	1 – 25	25	Extracellular Potential
	Transmembrane	26 – 46	21	Helical; Name=1; Potential
	Topological domain	47 – 54	8	Cytoplasmic Potential
	Transmembrane	55 – 75	21	Helical; Name=2; Potential
	Topological domain	76 – 99	24	Extracellular Potential
	Transmembrane	100 – 120	21	Helical; Name=3; Potential
	Topological domain	121 – 139	19	Cytoplasmic Potential
	Transmembrane	140 – 160	21	Helical; Name=4; Potential
	Topological domain	161 – 197	37	Extracellular Potential
	Transmembrane	198 – 217	20	Helical; Name=5; Potential
	Topological domain	218 – 237	20	Cytoplasmic Potential
	Transmembrane	238 – 258	21	Helical; Name=6; Potential
	Topological domain	259 – 271	13	Extracellular Potential
	Transmembrane	272 – 292	21	Helical; Name=7; Potential
	Topological domain	293 – 314	22	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	5	1	N-linked (GlcNAc...) Potential
	Disulfide bond	97 ↔ 189		By similarity
Natural variations
	Natural variant	20	1	F → V. Corresponds to variant rs16934214 [ dbSNP | Ensembl ].		VAR_053262

Sequences

	Sequence		Length	Mass (Da)
	P58181 [UniParc]. Last modified June 20, 2001. Version 1. Checksum: 3355B17F4AFBF647	FASTA	314	35,535
	10 20 30 40 50 60 MKRQNQSCVV EFILLGFSNF PELQVQLFGV FLVIYVVTLM GNAIITVIIS LNQSLHVPMY 70 80 90 100 110 120 LFLLNLSVVE VSFSAVITPE MLVVLSTEKT MISFVGCFAQ MYFILLFGGT ECFLLGAMAY 130 140 150 160 170 180 DRFAAICHPL NYPVIMNRGV FMKLVIFSWI SGIMVATVQT TWVFSFPFCG PNEINHLFCE 190 200 210 220 230 240 TPPVLELVCA DTFLFEIYAF TGTILIVMVP FLLILLSYIR VLFAILKMPS TTGRQKAFST 250 260 270 280 290 300 CASHLTSVTL FYGTANMTYL QPKSGYSPET KKLISLAYTL LTPLLNPLIY SLRNSEMKRT 310 LIKLWRRKVI LHTF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[5]	"DEFOG: a practical scheme for deciphering families of genes." Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R. Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-284.
[6]	"Expression of members of the putative olfactory receptor gene family in mammalian germ cells." Parmentier M., Libert F., Schurmans S., Schiffmann S., Lefort A., Eggerickx D., Ledent C., Mollereau C., Gerard C., Perret J., Grootegoed A., Vassart G. Nature 355:453-455(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 126-239. Tissue: Testis.
[7]	"The human olfactory receptor gene family." Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[8]	Erratum Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB065768 Genomic DNA. Translation: BAC05988.1. AC044810 Genomic DNA. No translation available. CH471064 Genomic DNA. Translation: EAW68641.1. BC137031 mRNA. Translation: AAI37032.1. BC137032 mRNA. Translation: AAI37033.1. AF399634 Genomic DNA. Translation: AAK95119.1. X64986 mRNA. No translation available. BK004404 Genomic DNA. Translation: DAA04802.1.
IPI	IPI00478001.
RefSeq	NP_001003745.1. NM_001003745.1.
UniGene	Hs.381322.
3D structure databases
ProteinModelPortal	P58181.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000353988.
Protein family/group databases
GPCRDB	Search...
Polymorphism databases
DMDM	14423787.
Proteomic databases
PRIDE	P58181.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000360759; ENSP00000353988; ENSG00000170683.
GeneID	26496.
KEGG	hsa:26496.
UCSC	uc010rbi.2. human.
Organism-specific databases
CTD	26496.
GeneCards	GC11M007960.
HGNC	HGNC:8162. OR10A3.
neXtProt	NX_P58181.
PharmGKB	PA31951.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG150795.
HOGENOM	HOG000041365.
HOVERGEN	HBG017625.
InParanoid	P58181.
KO	K04257.
OMA	MFSWASG.
OrthoDB	EOG4VX25P.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
CleanEx	HS_OR10A3.
Genevestigator	P58181.
GermOnline	ENSG00000170683. Homo sapiens.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	26496.
NextBio	48758.

Entry information

Entry name

O10A3_HUMAN

Accession

Primary (citable) accession number: P58181
Secondary accession number(s): B9EH39, Q6IF58, Q96R11

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	June 20, 2001
Last modified:	May 1, 2013
This is version 102 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.