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P58181

- O10A3_HUMAN

UniProt

P58181 - O10A3_HUMAN

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Protein
Olfactory receptor 10A3
Gene
OR10A3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Odorant receptor Reviewed prediction.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. detection of chemical stimulus involved in sensory perception of smell Source: GOC
  2. sensory perception of smell Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10A3
Alternative name(s):
HTPCRX12
Olfactory receptor OR11-97
Gene namesi
Name:OR10A3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:8162. OR10A3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525Extracellular Reviewed prediction
Add
BLAST
Transmembranei26 – 4621Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini47 – 548Cytoplasmic Reviewed prediction
Transmembranei55 – 7521Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini76 – 9924Extracellular Reviewed prediction
Add
BLAST
Transmembranei100 – 12021Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini121 – 13919Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei140 – 16021Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini161 – 19737Extracellular Reviewed prediction
Add
BLAST
Transmembranei198 – 21720Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini218 – 23720Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei238 – 25821Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini259 – 27113Extracellular Reviewed prediction
Add
BLAST
Transmembranei272 – 29221Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini293 – 31422Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31951.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Olfactory receptor 10A3
PRO_0000150685Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi97 ↔ 189 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP58181.

Expressioni

Gene expression databases

CleanExiHS_OR10A3.
GenevestigatoriP58181.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000353988.

Structurei

3D structure databases

ProteinModelPortaliP58181.
SMRiP58181. Positions 30-310.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG150795.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiP58181.
KOiK04257.
OMAiMFSWASG.
OrthoDBiEOG7SXW3S.
PhylomeDBiP58181.
TreeFamiTF337350.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P58181-1 [UniParc]FASTAAdd to Basket

« Hide

MKRQNQSCVV EFILLGFSNF PELQVQLFGV FLVIYVVTLM GNAIITVIIS    50
LNQSLHVPMY LFLLNLSVVE VSFSAVITPE MLVVLSTEKT MISFVGCFAQ 100
MYFILLFGGT ECFLLGAMAY DRFAAICHPL NYPVIMNRGV FMKLVIFSWI 150
SGIMVATVQT TWVFSFPFCG PNEINHLFCE TPPVLELVCA DTFLFEIYAF 200
TGTILIVMVP FLLILLSYIR VLFAILKMPS TTGRQKAFST CASHLTSVTL 250
FYGTANMTYL QPKSGYSPET KKLISLAYTL LTPLLNPLIY SLRNSEMKRT 300
LIKLWRRKVI LHTF 314
Length:314
Mass (Da):35,535
Last modified:June 20, 2001 - v1
Checksum:i3355B17F4AFBF647
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti20 – 201F → V.
Corresponds to variant rs16934214 [ dbSNP | Ensembl ].
VAR_053262

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065768 Genomic DNA. Translation: BAC05988.1.
AC044810 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68641.1.
BC137031 mRNA. Translation: AAI37032.1.
BC137032 mRNA. Translation: AAI37033.1.
AF399634 Genomic DNA. Translation: AAK95119.1.
X64986 mRNA. No translation available.
BK004404 Genomic DNA. Translation: DAA04802.1.
CCDSiCCDS31421.1.
RefSeqiNP_001003745.1. NM_001003745.1.
UniGeneiHs.381322.

Genome annotation databases

EnsembliENST00000360759; ENSP00000353988; ENSG00000170683.
GeneIDi26496.
KEGGihsa:26496.
UCSCiuc010rbi.2. human.

Polymorphism databases

DMDMi14423787.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065768 Genomic DNA. Translation: BAC05988.1 .
AC044810 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68641.1 .
BC137031 mRNA. Translation: AAI37032.1 .
BC137032 mRNA. Translation: AAI37033.1 .
AF399634 Genomic DNA. Translation: AAK95119.1 .
X64986 mRNA. No translation available.
BK004404 Genomic DNA. Translation: DAA04802.1 .
CCDSi CCDS31421.1.
RefSeqi NP_001003745.1. NM_001003745.1.
UniGenei Hs.381322.

3D structure databases

ProteinModelPortali P58181.
SMRi P58181. Positions 30-310.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000353988.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 14423787.

Proteomic databases

PRIDEi P58181.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000360759 ; ENSP00000353988 ; ENSG00000170683 .
GeneIDi 26496.
KEGGi hsa:26496.
UCSCi uc010rbi.2. human.

Organism-specific databases

CTDi 26496.
GeneCardsi GC11M007960.
HGNCi HGNC:8162. OR10A3.
neXtProti NX_P58181.
PharmGKBi PA31951.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG150795.
HOGENOMi HOG000041365.
HOVERGENi HBG017625.
InParanoidi P58181.
KOi K04257.
OMAi MFSWASG.
OrthoDBi EOG7SXW3S.
PhylomeDBi P58181.
TreeFami TF337350.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR10A3.
GenomeRNAii 26496.
NextBioi 48758.
PROi P58181.

Gene expression databases

CleanExi HS_OR10A3.
Genevestigatori P58181.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-284.
  6. "Expression of members of the putative olfactory receptor gene family in mammalian germ cells."
    Parmentier M., Libert F., Schurmans S., Schiffmann S., Lefort A., Eggerickx D., Ledent C., Mollereau C., Gerard C., Perret J., Grootegoed A., Vassart G.
    Nature 355:453-455(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 126-239.
    Tissue: Testis.
  7. Cited for: IDENTIFICATION.
  8. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO10A3_HUMAN
AccessioniPrimary (citable) accession number: P58181
Secondary accession number(s): B9EH39, Q6IF58, Q96R11
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: June 20, 2001
Last modified: September 3, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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