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P58181

- O10A3_HUMAN

UniProt

P58181 - O10A3_HUMAN

Protein

Olfactory receptor 10A3

Gene

OR10A3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (20 Jun 2001)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: UniProtKB

    GO - Biological processi

    1. detection of chemical stimulus involved in sensory perception of smell Source: GOC
    2. sensory perception of smell Source: UniProtKB

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 10A3
    Alternative name(s):
    HTPCRX12
    Olfactory receptor OR11-97
    Gene namesi
    Name:OR10A3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:8162. OR10A3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31951.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 314314Olfactory receptor 10A3PRO_0000150685Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP58181.

    Expressioni

    Gene expression databases

    CleanExiHS_OR10A3.
    GenevestigatoriP58181.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000353988.

    Structurei

    3D structure databases

    ProteinModelPortaliP58181.
    SMRiP58181. Positions 30-310.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini47 – 548CytoplasmicSequence Analysis
    Topological domaini76 – 9924ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini161 – 19737ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini218 – 23720CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini259 – 27113ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini293 – 31422CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 4621Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei55 – 7521Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei100 – 12021Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei140 – 16021Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei198 – 21720Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei238 – 25821Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei272 – 29221Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG150795.
    HOGENOMiHOG000041365.
    HOVERGENiHBG017625.
    InParanoidiP58181.
    KOiK04257.
    OMAiMFSWASG.
    OrthoDBiEOG7SXW3S.
    PhylomeDBiP58181.
    TreeFamiTF337350.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P58181-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKRQNQSCVV EFILLGFSNF PELQVQLFGV FLVIYVVTLM GNAIITVIIS    50
    LNQSLHVPMY LFLLNLSVVE VSFSAVITPE MLVVLSTEKT MISFVGCFAQ 100
    MYFILLFGGT ECFLLGAMAY DRFAAICHPL NYPVIMNRGV FMKLVIFSWI 150
    SGIMVATVQT TWVFSFPFCG PNEINHLFCE TPPVLELVCA DTFLFEIYAF 200
    TGTILIVMVP FLLILLSYIR VLFAILKMPS TTGRQKAFST CASHLTSVTL 250
    FYGTANMTYL QPKSGYSPET KKLISLAYTL LTPLLNPLIY SLRNSEMKRT 300
    LIKLWRRKVI LHTF 314
    Length:314
    Mass (Da):35,535
    Last modified:June 20, 2001 - v1
    Checksum:i3355B17F4AFBF647
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti20 – 201F → V.
    Corresponds to variant rs16934214 [ dbSNP | Ensembl ].
    VAR_053262

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065768 Genomic DNA. Translation: BAC05988.1.
    AC044810 Genomic DNA. No translation available.
    CH471064 Genomic DNA. Translation: EAW68641.1.
    BC137031 mRNA. Translation: AAI37032.1.
    BC137032 mRNA. Translation: AAI37033.1.
    AF399634 Genomic DNA. Translation: AAK95119.1.
    X64986 mRNA. No translation available.
    BK004404 Genomic DNA. Translation: DAA04802.1.
    CCDSiCCDS31421.1.
    RefSeqiNP_001003745.1. NM_001003745.1.
    UniGeneiHs.381322.

    Genome annotation databases

    EnsembliENST00000360759; ENSP00000353988; ENSG00000170683.
    GeneIDi26496.
    KEGGihsa:26496.
    UCSCiuc010rbi.2. human.

    Polymorphism databases

    DMDMi14423787.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065768 Genomic DNA. Translation: BAC05988.1 .
    AC044810 Genomic DNA. No translation available.
    CH471064 Genomic DNA. Translation: EAW68641.1 .
    BC137031 mRNA. Translation: AAI37032.1 .
    BC137032 mRNA. Translation: AAI37033.1 .
    AF399634 Genomic DNA. Translation: AAK95119.1 .
    X64986 mRNA. No translation available.
    BK004404 Genomic DNA. Translation: DAA04802.1 .
    CCDSi CCDS31421.1.
    RefSeqi NP_001003745.1. NM_001003745.1.
    UniGenei Hs.381322.

    3D structure databases

    ProteinModelPortali P58181.
    SMRi P58181. Positions 30-310.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000353988.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 14423787.

    Proteomic databases

    PRIDEi P58181.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000360759 ; ENSP00000353988 ; ENSG00000170683 .
    GeneIDi 26496.
    KEGGi hsa:26496.
    UCSCi uc010rbi.2. human.

    Organism-specific databases

    CTDi 26496.
    GeneCardsi GC11M007960.
    HGNCi HGNC:8162. OR10A3.
    neXtProti NX_P58181.
    PharmGKBi PA31951.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG150795.
    HOGENOMi HOG000041365.
    HOVERGENi HBG017625.
    InParanoidi P58181.
    KOi K04257.
    OMAi MFSWASG.
    OrthoDBi EOG7SXW3S.
    PhylomeDBi P58181.
    TreeFami TF337350.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR10A3.
    GenomeRNAii 26496.
    NextBioi 48758.
    PROi P58181.

    Gene expression databases

    CleanExi HS_OR10A3.
    Genevestigatori P58181.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-284.
    6. "Expression of members of the putative olfactory receptor gene family in mammalian germ cells."
      Parmentier M., Libert F., Schurmans S., Schiffmann S., Lefort A., Eggerickx D., Ledent C., Mollereau C., Gerard C., Perret J., Grootegoed A., Vassart G.
      Nature 355:453-455(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 126-239.
      Tissue: Testis.
    7. Cited for: IDENTIFICATION.
    8. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiO10A3_HUMAN
    AccessioniPrimary (citable) accession number: P58181
    Secondary accession number(s): B9EH39, Q6IF58, Q96R11
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: June 20, 2001
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3