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Protein

Olfactory receptor 10A3

Gene

OR10A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  • G-protein coupled receptor activity Source: UniProtKB-KW
  • olfactory receptor activity Source: UniProtKB

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: GO_Central
  • sensory perception of smell Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000170683-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10A3
Alternative name(s):
HTPCRX12
Olfactory receptor OR11-97
Gene namesi
Name:OR10A3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:8162. OR10A3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 99ExtracellularSequence analysisAdd BLAST24
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 197ExtracellularSequence analysisAdd BLAST37
Transmembranei198 – 217Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini218 – 237CytoplasmicSequence analysisAdd BLAST20
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini259 – 271ExtracellularSequence analysisAdd BLAST13
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 314CytoplasmicSequence analysisAdd BLAST22

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000170683.
ENSG00000273953.
ENSG00000281680.
PharmGKBiPA31951.

Polymorphism and mutation databases

BioMutaiOR10A3.
DMDMi14423787.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506851 – 314Olfactory receptor 10A3Add BLAST314

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP58181.
PRIDEiP58181.

PTM databases

iPTMnetiP58181.
PhosphoSitePlusiP58181.

Expressioni

Gene expression databases

CleanExiHS_OR10A3.
ExpressionAtlasiP58181. baseline and differential.
GenevisibleiP58181. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000353988.

Structurei

3D structure databases

ProteinModelPortaliP58181.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKK8. Eukaryota.
ENOG410YDA3. LUCA.
GeneTreeiENSGT00760000119002.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiP58181.
KOiK04257.
OMAiMFSWASG.
OrthoDBiEOG091G0FFM.
PhylomeDBiP58181.
TreeFamiTF337350.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P58181-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRQNQSCVV EFILLGFSNF PELQVQLFGV FLVIYVVTLM GNAIITVIIS
60 70 80 90 100
LNQSLHVPMY LFLLNLSVVE VSFSAVITPE MLVVLSTEKT MISFVGCFAQ
110 120 130 140 150
MYFILLFGGT ECFLLGAMAY DRFAAICHPL NYPVIMNRGV FMKLVIFSWI
160 170 180 190 200
SGIMVATVQT TWVFSFPFCG PNEINHLFCE TPPVLELVCA DTFLFEIYAF
210 220 230 240 250
TGTILIVMVP FLLILLSYIR VLFAILKMPS TTGRQKAFST CASHLTSVTL
260 270 280 290 300
FYGTANMTYL QPKSGYSPET KKLISLAYTL LTPLLNPLIY SLRNSEMKRT
310
LIKLWRRKVI LHTF
Length:314
Mass (Da):35,535
Last modified:June 20, 2001 - v1
Checksum:i3355B17F4AFBF647
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05326220F → V.Corresponds to variant rs16934214dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065768 Genomic DNA. Translation: BAC05988.1.
AC044810 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68641.1.
BC137031 mRNA. Translation: AAI37032.1.
BC137032 mRNA. Translation: AAI37033.1.
AF399634 Genomic DNA. Translation: AAK95119.1.
X64986 mRNA. No translation available.
BK004404 Genomic DNA. Translation: DAA04802.1.
CCDSiCCDS31421.1.
RefSeqiNP_001003745.1. NM_001003745.1.
UniGeneiHs.381322.

Genome annotation databases

EnsembliENST00000360759; ENSP00000353988; ENSG00000170683.
ENST00000612788; ENSP00000484096; ENSG00000273953.
ENST00000626843; ENSP00000487530; ENSG00000281680.
GeneIDi26496.
KEGGihsa:26496.
UCSCiuc010rbi.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065768 Genomic DNA. Translation: BAC05988.1.
AC044810 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68641.1.
BC137031 mRNA. Translation: AAI37032.1.
BC137032 mRNA. Translation: AAI37033.1.
AF399634 Genomic DNA. Translation: AAK95119.1.
X64986 mRNA. No translation available.
BK004404 Genomic DNA. Translation: DAA04802.1.
CCDSiCCDS31421.1.
RefSeqiNP_001003745.1. NM_001003745.1.
UniGeneiHs.381322.

3D structure databases

ProteinModelPortaliP58181.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000353988.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP58181.
PhosphoSitePlusiP58181.

Polymorphism and mutation databases

BioMutaiOR10A3.
DMDMi14423787.

Proteomic databases

PaxDbiP58181.
PRIDEiP58181.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360759; ENSP00000353988; ENSG00000170683.
ENST00000612788; ENSP00000484096; ENSG00000273953.
ENST00000626843; ENSP00000487530; ENSG00000281680.
GeneIDi26496.
KEGGihsa:26496.
UCSCiuc010rbi.3. human.

Organism-specific databases

CTDi26496.
GeneCardsiOR10A3.
HGNCiHGNC:8162. OR10A3.
neXtProtiNX_P58181.
OpenTargetsiENSG00000170683.
ENSG00000273953.
ENSG00000281680.
PharmGKBiPA31951.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKK8. Eukaryota.
ENOG410YDA3. LUCA.
GeneTreeiENSGT00760000119002.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiP58181.
KOiK04257.
OMAiMFSWASG.
OrthoDBiEOG091G0FFM.
PhylomeDBiP58181.
TreeFamiTF337350.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000170683-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR10A3.
GenomeRNAii26496.
PROiP58181.

Gene expression databases

CleanExiHS_OR10A3.
ExpressionAtlasiP58181. baseline and differential.
GenevisibleiP58181. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO10A3_HUMAN
AccessioniPrimary (citable) accession number: P58181
Secondary accession number(s): B9EH39, Q6IF58, Q96R11
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: June 20, 2001
Last modified: November 30, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.