ID   OR4D2_HUMAN             Reviewed;         307 AA.
AC   P58180; Q6IFN8; Q96R75;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   20-JUN-2001, sequence version 1.
DT   24-JAN-2024, entry version 166.
DE   RecName: Full=Olfactory receptor 4D2;
DE   AltName: Full=B-lymphocyte membrane protein BC2009;
DE   AltName: Full=Olfactory receptor OR17-24;
GN   Name=OR4D2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Lu X.-W., Cui L.-X., Li Y.-H.;
RT   "Activated B lymphocyte gene.";
RL   Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA   Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA   Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA   LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA   Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA   Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA   Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT   human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-280.
RX   PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA   Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA   Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA   Lehrach H., Lancet D., Shamir R.;
RT   "DEFOG: a practical scheme for deciphering families of genes.";
RL   Genomics 80:295-302(2002).
RN   [5]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [6]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR4D2";
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF303373; AAL26785.1; -; mRNA.
DR   EMBL; AB065912; BAC06127.1; -; Genomic_DNA.
DR   EMBL; AC005962; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AF399568; AAK95053.1; -; Genomic_DNA.
DR   EMBL; BK004224; DAA04622.1; -; Genomic_DNA.
DR   CCDS; CCDS32688.1; -.
DR   RefSeq; NP_001004707.1; NM_001004707.3.
DR   AlphaFoldDB; P58180; -.
DR   SMR; P58180; -.
DR   BioGRID; 125872; 23.
DR   STRING; 9606.ENSP00000493137; -.
DR   GlyCosmos; P58180; 1 site, No reported glycans.
DR   GlyGen; P58180; 1 site.
DR   iPTMnet; P58180; -.
DR   PhosphoSitePlus; P58180; -.
DR   BioMuta; OR4D2; -.
DR   DMDM; 14423786; -.
DR   jPOST; P58180; -.
DR   PaxDb; 9606-ENSP00000441354; -.
DR   Antibodypedia; 65981; 74 antibodies from 19 providers.
DR   DNASU; 124538; -.
DR   Ensembl; ENST00000545221.2; ENSP00000441354.1; ENSG00000255713.2.
DR   Ensembl; ENST00000641866.1; ENSP00000493137.1; ENSG00000255713.2.
DR   GeneID; 124538; -.
DR   KEGG; hsa:124538; -.
DR   MANE-Select; ENST00000545221.2; ENSP00000441354.1; NM_001004707.4; NP_001004707.1.
DR   UCSC; uc010wnp.2; human.
DR   AGR; HGNC:8294; -.
DR   CTD; 124538; -.
DR   GeneCards; OR4D2; -.
DR   HGNC; HGNC:8294; OR4D2.
DR   HPA; ENSG00000255713; Not detected.
DR   neXtProt; NX_P58180; -.
DR   OpenTargets; ENSG00000255713; -.
DR   PharmGKB; PA32270; -.
DR   VEuPathDB; HostDB:ENSG00000255713; -.
DR   eggNOG; ENOG502SIBY; Eukaryota.
DR   GeneTree; ENSGT00940000154503; -.
DR   HOGENOM; CLU_012526_8_1_1; -.
DR   InParanoid; P58180; -.
DR   OMA; IYQLALM; -.
DR   OrthoDB; 4634745at2759; -.
DR   PhylomeDB; P58180; -.
DR   TreeFam; TF338273; -.
DR   PathwayCommons; P58180; -.
DR   Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 124538; 7 hits in 739 CRISPR screens.
DR   GeneWiki; OR4D2; -.
DR   GenomeRNAi; 124538; -.
DR   Pharos; P58180; Tdark.
DR   PRO; PR:P58180; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   RNAct; P58180; Protein.
DR   ExpressionAtlas; P58180; baseline and differential.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   CDD; cd15936; 7tmA_OR4D-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR48002; OLFACTORY RECEPTOR; 1.
DR   PANTHER; PTHR48002:SF132; OLFACTORY RECEPTOR 4D2; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   Genevisible; P58180; HS.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..307
FT                   /note="Olfactory receptor 4D2"
FT                   /id="PRO_0000150538"
FT   TOPO_DOM        1..25
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        26..49
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        50..57
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        58..79
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        80..100
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..120
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        121..139
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..158
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        159..195
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        196..219
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        220..235
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        236..258
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        259..269
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        270..289
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        290..307
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        5
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        97..189
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         29
FT                   /note="L -> I (in dbSNP:rs60994383)"
FT                   /id="VAR_062035"
SQ   SEQUENCE   307 AA;  34958 MW;  5C8C68269034EBD3 CRC64;
     METGNLTWVS DFVFLGLSQT RELQRFLFLM FLFVYITTVM GNILIIITVT SDSQLHTPMY
     FLLRNLAVLD LCFSSVTAPK MLVDLLSEKK TISYQGCMGQ IFFFHFLGGA MVFFLSVMAF
     DRLIAISRPL RYVTVMNTQL WVGLVVATWV GGFVHSIVQL ALMLPLPFCG PNILDNFYCD
     VPQVLRLACT DTSLLEFLKI SNSGLLDVVW FFLLLMSYLF ILVMLRSHPG EARRKAASTC
     TTHIIVVSMI FVPSIYLYAR PFTPFPMDKL VSIGHTVMTP MLNPMIYTLR NQDMQAAVRR
     LGRHRLV
//