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Protein

Olfactory receptor 4D2

Gene

OR4D2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4D2
Alternative name(s):
B-lymphocyte membrane protein BC2009
Olfactory receptor OR17-24
Gene namesi
Name:OR4D2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000255713.1
HGNCiHGNC:8294 OR4D2
neXtProtiNX_P58180

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 49Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini50 – 57CytoplasmicSequence analysis8
Transmembranei58 – 79Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini80 – 100ExtracellularSequence analysisAdd BLAST21
Transmembranei101 – 120Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 158Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini159 – 195ExtracellularSequence analysisAdd BLAST37
Transmembranei196 – 219Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini220 – 235CytoplasmicSequence analysisAdd BLAST16
Transmembranei236 – 258Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini259 – 269ExtracellularSequence analysisAdd BLAST11
Transmembranei270 – 289Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini290 – 307CytoplasmicSequence analysisAdd BLAST18

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000255713
PharmGKBiPA32270

Polymorphism and mutation databases

BioMutaiOR4D2
DMDMi14423786

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505381 – 307Olfactory receptor 4D2Add BLAST307

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP58180
PRIDEiP58180
ProteomicsDBi57053

PTM databases

iPTMnetiP58180
PhosphoSitePlusiP58180

Expressioni

Gene expression databases

CleanExiHS_OR4D2
ExpressionAtlasiP58180 differential
GenevisibleiP58180 HS

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000441354

Structurei

3D structure databases

ProteinModelPortaliP58180
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEFX Eukaryota
ENOG41119VH LUCA
GeneTreeiENSGT00920000148987
HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiP58180
KOiK04257
OMAiGQIFFFH
OrthoDBiEOG091G0AZH
PhylomeDBiP58180
TreeFamiTF338273

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P58180-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METGNLTWVS DFVFLGLSQT RELQRFLFLM FLFVYITTVM GNILIIITVT
60 70 80 90 100
SDSQLHTPMY FLLRNLAVLD LCFSSVTAPK MLVDLLSEKK TISYQGCMGQ
110 120 130 140 150
IFFFHFLGGA MVFFLSVMAF DRLIAISRPL RYVTVMNTQL WVGLVVATWV
160 170 180 190 200
GGFVHSIVQL ALMLPLPFCG PNILDNFYCD VPQVLRLACT DTSLLEFLKI
210 220 230 240 250
SNSGLLDVVW FFLLLMSYLF ILVMLRSHPG EARRKAASTC TTHIIVVSMI
260 270 280 290 300
FVPSIYLYAR PFTPFPMDKL VSIGHTVMTP MLNPMIYTLR NQDMQAAVRR

LGRHRLV
Length:307
Mass (Da):34,958
Last modified:June 20, 2001 - v1
Checksum:i5C8C68269034EBD3
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06203529L → I. Corresponds to variant dbSNP:rs60994383Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF303373 mRNA Translation: AAL26785.1
AB065912 Genomic DNA Translation: BAC06127.1
AC005962 Genomic DNA No translation available.
AF399568 Genomic DNA Translation: AAK95053.1
BK004224 Genomic DNA Translation: DAA04622.1
CCDSiCCDS32688.1
RefSeqiNP_001004707.1, NM_001004707.3
UniGeneiHs.446879

Genome annotation databases

EnsembliENST00000545221; ENSP00000441354; ENSG00000255713
ENST00000641866; ENSP00000493137; ENSG00000255713
GeneIDi124538
KEGGihsa:124538
UCSCiuc010wnp.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOR4D2_HUMAN
AccessioniPrimary (citable) accession number: P58180
Secondary accession number(s): Q6IFN8, Q96R75
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: June 20, 2001
Last modified: June 20, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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