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P58180 (OR4D2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 4D2
Alternative name(s):
B-lymphocyte membrane protein BC2009
Olfactory receptor OR17-24
Gene names
Name:OR4D2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length307 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 307307Olfactory receptor 4D2
PRO_0000150538

Regions

Topological domain1 – 2525Extracellular Potential
Transmembrane26 – 4924Helical; Name=1; Potential
Topological domain50 – 578Cytoplasmic Potential
Transmembrane58 – 7922Helical; Name=2; Potential
Topological domain80 – 10021Extracellular Potential
Transmembrane101 – 12020Helical; Name=3; Potential
Topological domain121 – 13919Cytoplasmic Potential
Transmembrane140 – 15819Helical; Name=4; Potential
Topological domain159 – 19537Extracellular Potential
Transmembrane196 – 21924Helical; Name=5; Potential
Topological domain220 – 23516Cytoplasmic Potential
Transmembrane236 – 25823Helical; Name=6; Potential
Topological domain259 – 26911Extracellular Potential
Transmembrane270 – 28920Helical; Name=7; Potential
Topological domain290 – 30718Cytoplasmic Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Disulfide bond97 ↔ 189 By similarity

Natural variations

Natural variant291L → I.
Corresponds to variant rs60994383 [ dbSNP | Ensembl ].
VAR_062035

Sequences

Sequence LengthMass (Da)Tools
P58180 [UniParc].

Last modified June 20, 2001. Version 1.
Checksum: 5C8C68269034EBD3

FASTA30734,958
        10         20         30         40         50         60 
METGNLTWVS DFVFLGLSQT RELQRFLFLM FLFVYITTVM GNILIIITVT SDSQLHTPMY 

        70         80         90        100        110        120 
FLLRNLAVLD LCFSSVTAPK MLVDLLSEKK TISYQGCMGQ IFFFHFLGGA MVFFLSVMAF 

       130        140        150        160        170        180 
DRLIAISRPL RYVTVMNTQL WVGLVVATWV GGFVHSIVQL ALMLPLPFCG PNILDNFYCD 

       190        200        210        220        230        240 
VPQVLRLACT DTSLLEFLKI SNSGLLDVVW FFLLLMSYLF ILVMLRSHPG EARRKAASTC 

       250        260        270        280        290        300 
TTHIIVVSMI FVPSIYLYAR PFTPFPMDKL VSIGHTVMTP MLNPMIYTLR NQDMQAAVRR 


LGRHRLV 

« Hide

References

« Hide 'large scale' references
[1]"Activated B lymphocyte gene."
Lu X.-W., Cui L.-X., Li Y.-H.
Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. expand/collapse author list , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"DEFOG: a practical scheme for deciphering families of genes."
Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R.
Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-280.
[5]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[6]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF303373 mRNA. Translation: AAL26785.1.
AB065912 Genomic DNA. Translation: BAC06127.1.
AC005962 Genomic DNA. No translation available.
AF399568 Genomic DNA. Translation: AAK95053.1.
BK004224 Genomic DNA. Translation: DAA04622.1.
CCDSCCDS32688.1.
RefSeqNP_001004707.1. NM_001004707.3.
UniGeneHs.446879.

3D structure databases

ProteinModelPortalP58180.
SMRP58180. Positions 25-304.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000284081.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP58180.

Polymorphism databases

DMDM14423786.

Proteomic databases

PaxDbP58180.
PRIDEP58180.

Protocols and materials databases

DNASU124538.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000545221; ENSP00000441354; ENSG00000255713.
GeneID124538.
KEGGhsa:124538.
UCSCuc010wnp.2. human.

Organism-specific databases

CTD124538.
GeneCardsGC17P056248.
HGNCHGNC:8294. OR4D2.
neXtProtNX_P58180.
PharmGKBPA32270.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG270173.
HOGENOMHOG000041362.
HOVERGENHBG017625.
InParanoidP58180.
KOK04257.
OMATIMNTQH.
OrthoDBEOG7KSX95.
PhylomeDBP58180.
TreeFamTF338273.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR4D2.
GenevestigatorP58180.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR4D2.
GenomeRNAi124538.
NextBio81312.
PROP58180.

Entry information

Entry nameOR4D2_HUMAN
AccessionPrimary (citable) accession number: P58180
Secondary accession number(s): Q6IFN8, Q96R75
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: June 20, 2001
Last modified: July 9, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries