P58180 (OR4D2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 4D2

Alternative name(s):
B-lymphocyte membrane protein BC2009
Olfactory receptor OR17-24

Gene names

Name:

OR4D2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	307 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	detection of chemical stimulus involved in sensory perception of smell Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 307	307	Olfactory receptor 4D2		PRO_0000150538
Regions
	Topological domain	1 – 25	25	Extracellular Potential
	Transmembrane	26 – 49	24	Helical; Name=1; Potential
	Topological domain	50 – 57	8	Cytoplasmic Potential
	Transmembrane	58 – 79	22	Helical; Name=2; Potential
	Topological domain	80 – 100	21	Extracellular Potential
	Transmembrane	101 – 120	20	Helical; Name=3; Potential
	Topological domain	121 – 139	19	Cytoplasmic Potential
	Transmembrane	140 – 158	19	Helical; Name=4; Potential
	Topological domain	159 – 195	37	Extracellular Potential
	Transmembrane	196 – 219	24	Helical; Name=5; Potential
	Topological domain	220 – 235	16	Cytoplasmic Potential
	Transmembrane	236 – 258	23	Helical; Name=6; Potential
	Topological domain	259 – 269	11	Extracellular Potential
	Transmembrane	270 – 289	20	Helical; Name=7; Potential
	Topological domain	290 – 307	18	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	5	1	N-linked (GlcNAc...) Potential
	Disulfide bond	97 ↔ 189		By similarity
Natural variations
	Natural variant	29	1	L → I. Corresponds to variant rs60994383 [ dbSNP | Ensembl ].		VAR_062035

Sequences

	Sequence		Length	Mass (Da)
	P58180 [UniParc]. Last modified June 20, 2001. Version 1. Checksum: 5C8C68269034EBD3	FASTA	307	34,958
	10 20 30 40 50 60 METGNLTWVS DFVFLGLSQT RELQRFLFLM FLFVYITTVM GNILIIITVT SDSQLHTPMY 70 80 90 100 110 120 FLLRNLAVLD LCFSSVTAPK MLVDLLSEKK TISYQGCMGQ IFFFHFLGGA MVFFLSVMAF 130 140 150 160 170 180 DRLIAISRPL RYVTVMNTQL WVGLVVATWV GGFVHSIVQL ALMLPLPFCG PNILDNFYCD 190 200 210 220 230 240 VPQVLRLACT DTSLLEFLKI SNSGLLDVVW FFLLLMSYLF ILVMLRSHPG EARRKAASTC 250 260 270 280 290 300 TTHIIVVSMI FVPSIYLYAR PFTPFPMDKL VSIGHTVMTP MLNPMIYTLR NQDMQAAVRR LGRHRLV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Activated B lymphocyte gene." Lu X.-W., Cui L.-X., Li Y.-H. Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"DEFOG: a practical scheme for deciphering families of genes." Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R. Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-280.
[5]	"The human olfactory receptor gene family." Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[6]	Erratum Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF303373 mRNA. Translation: AAL26785.1. AB065912 Genomic DNA. Translation: BAC06127.1. AC005962 Genomic DNA. No translation available. AF399568 Genomic DNA. Translation: AAK95053.1. BK004224 Genomic DNA. Translation: DAA04622.1.
IPI	IPI00011052.
RefSeq	NP_001004707.1. NM_001004707.3.
UniGene	Hs.446879.
3D structure databases
ProteinModelPortal	P58180.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000284081.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P58180.
Polymorphism databases
DMDM	14423786.
Proteomic databases
PaxDb	P58180.
PRIDE	P58180.
Protocols and materials databases
DNASU	124538.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000545221; ENSP00000441354; ENSG00000255713.
GeneID	124538.
KEGG	hsa:124538.
UCSC	uc010wnp.2. human.
Organism-specific databases
CTD	124538.
GeneCards	GC17P056246.
HGNC	HGNC:8294. OR4D2.
neXtProt	NX_P58180.
PharmGKB	PA32270.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG270173.
HOGENOM	HOG000041362.
HOVERGEN	HBG017625.
InParanoid	P58180.
KO	K04257.
OMA	TIMNTQH.
OrthoDB	EOG4TMR2N.
PhylomeDB	P58180.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
CleanEx	HS_OR4D2.
Genevestigator	P58180.
GermOnline	ENSG00000153951. Homo sapiens.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PANTHER	PTHR24236. PTHR24236. 1 hit.
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	124538.
NextBio	81312.

Entry information

Entry name

OR4D2_HUMAN

Accession

Primary (citable) accession number: P58180
Secondary accession number(s): Q6IFN8, Q96R75

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	June 20, 2001
Last modified:	May 1, 2013
This is version 99 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.