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P58180

- OR4D2_HUMAN

UniProt

P58180 - OR4D2_HUMAN

Protein

Olfactory receptor 4D2

Gene

OR4D2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (20 Jun 2001)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 4D2
    Alternative name(s):
    B-lymphocyte membrane protein BC2009
    Olfactory receptor OR17-24
    Gene namesi
    Name:OR4D2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:8294. OR4D2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32270.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 307307Olfactory receptor 4D2PRO_0000150538Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP58180.
    PRIDEiP58180.

    PTM databases

    PhosphoSiteiP58180.

    Expressioni

    Gene expression databases

    CleanExiHS_OR4D2.
    GenevestigatoriP58180.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000284081.

    Structurei

    3D structure databases

    ProteinModelPortaliP58180.
    SMRiP58180. Positions 25-304.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini50 – 578CytoplasmicSequence Analysis
    Topological domaini80 – 10021ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini159 – 19537ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini220 – 23516CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini259 – 26911ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini290 – 30718CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 4924Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei58 – 7922Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei101 – 12020Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei140 – 15819Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei196 – 21924Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei236 – 25823Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei270 – 28920Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG270173.
    HOGENOMiHOG000041362.
    HOVERGENiHBG017625.
    InParanoidiP58180.
    KOiK04257.
    OMAiTIMNTQH.
    OrthoDBiEOG7KSX95.
    PhylomeDBiP58180.
    TreeFamiTF338273.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P58180-1 [UniParc]FASTAAdd to Basket

    « Hide

    METGNLTWVS DFVFLGLSQT RELQRFLFLM FLFVYITTVM GNILIIITVT    50
    SDSQLHTPMY FLLRNLAVLD LCFSSVTAPK MLVDLLSEKK TISYQGCMGQ 100
    IFFFHFLGGA MVFFLSVMAF DRLIAISRPL RYVTVMNTQL WVGLVVATWV 150
    GGFVHSIVQL ALMLPLPFCG PNILDNFYCD VPQVLRLACT DTSLLEFLKI 200
    SNSGLLDVVW FFLLLMSYLF ILVMLRSHPG EARRKAASTC TTHIIVVSMI 250
    FVPSIYLYAR PFTPFPMDKL VSIGHTVMTP MLNPMIYTLR NQDMQAAVRR 300
    LGRHRLV 307
    Length:307
    Mass (Da):34,958
    Last modified:June 20, 2001 - v1
    Checksum:i5C8C68269034EBD3
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti29 – 291L → I.
    Corresponds to variant rs60994383 [ dbSNP | Ensembl ].
    VAR_062035

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF303373 mRNA. Translation: AAL26785.1.
    AB065912 Genomic DNA. Translation: BAC06127.1.
    AC005962 Genomic DNA. No translation available.
    AF399568 Genomic DNA. Translation: AAK95053.1.
    BK004224 Genomic DNA. Translation: DAA04622.1.
    CCDSiCCDS32688.1.
    RefSeqiNP_001004707.1. NM_001004707.3.
    UniGeneiHs.446879.

    Genome annotation databases

    EnsembliENST00000545221; ENSP00000441354; ENSG00000255713.
    GeneIDi124538.
    KEGGihsa:124538.
    UCSCiuc010wnp.2. human.

    Polymorphism databases

    DMDMi14423786.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF303373 mRNA. Translation: AAL26785.1 .
    AB065912 Genomic DNA. Translation: BAC06127.1 .
    AC005962 Genomic DNA. No translation available.
    AF399568 Genomic DNA. Translation: AAK95053.1 .
    BK004224 Genomic DNA. Translation: DAA04622.1 .
    CCDSi CCDS32688.1.
    RefSeqi NP_001004707.1. NM_001004707.3.
    UniGenei Hs.446879.

    3D structure databases

    ProteinModelPortali P58180.
    SMRi P58180. Positions 25-304.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000284081.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P58180.

    Polymorphism databases

    DMDMi 14423786.

    Proteomic databases

    PaxDbi P58180.
    PRIDEi P58180.

    Protocols and materials databases

    DNASUi 124538.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000545221 ; ENSP00000441354 ; ENSG00000255713 .
    GeneIDi 124538.
    KEGGi hsa:124538.
    UCSCi uc010wnp.2. human.

    Organism-specific databases

    CTDi 124538.
    GeneCardsi GC17P056248.
    HGNCi HGNC:8294. OR4D2.
    neXtProti NX_P58180.
    PharmGKBi PA32270.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG270173.
    HOGENOMi HOG000041362.
    HOVERGENi HBG017625.
    InParanoidi P58180.
    KOi K04257.
    OMAi TIMNTQH.
    OrthoDBi EOG7KSX95.
    PhylomeDBi P58180.
    TreeFami TF338273.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR4D2.
    GenomeRNAii 124538.
    NextBioi 81312.
    PROi P58180.

    Gene expression databases

    CleanExi HS_OR4D2.
    Genevestigatori P58180.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Activated B lymphocyte gene."
      Lu X.-W., Cui L.-X., Li Y.-H.
      Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-280.
    5. Cited for: IDENTIFICATION.
    6. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiOR4D2_HUMAN
    AccessioniPrimary (citable) accession number: P58180
    Secondary accession number(s): Q6IFN8, Q96R75
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: June 20, 2001
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3