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Protein

Olfactory receptor 4D2

Gene

OR4D2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: GO_Central

GO - Biological processi

  1. detection of chemical stimulus involved in sensory perception of smell Source: GO_Central
  2. G-protein coupled receptor signaling pathway Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4D2
Alternative name(s):
B-lymphocyte membrane protein BC2009
Olfactory receptor OR17-24
Gene namesi
Name:OR4D2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:8294. OR4D2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
BLAST
Transmembranei26 – 4924Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini50 – 578CytoplasmicSequence Analysis
Transmembranei58 – 7922Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini80 – 10021ExtracellularSequence AnalysisAdd
BLAST
Transmembranei101 – 12020Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei140 – 15819Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini159 – 19537ExtracellularSequence AnalysisAdd
BLAST
Transmembranei196 – 21924Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini220 – 23516CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei236 – 25823Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini259 – 26911ExtracellularSequence AnalysisAdd
BLAST
Transmembranei270 – 28920Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini290 – 30718CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: GO_Central
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32270.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 307307Olfactory receptor 4D2PRO_0000150538Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP58180.
PRIDEiP58180.

PTM databases

PhosphoSiteiP58180.

Expressioni

Gene expression databases

CleanExiHS_OR4D2.
GenevestigatoriP58180.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000284081.

Structurei

3D structure databases

ProteinModelPortaliP58180.
SMRiP58180. Positions 25-304.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG270173.
GeneTreeiENSGT00760000119104.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiP58180.
KOiK04257.
OMAiGQIFFFH.
OrthoDBiEOG7KSX95.
PhylomeDBiP58180.
TreeFamiTF338273.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P58180-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
METGNLTWVS DFVFLGLSQT RELQRFLFLM FLFVYITTVM GNILIIITVT
60 70 80 90 100
SDSQLHTPMY FLLRNLAVLD LCFSSVTAPK MLVDLLSEKK TISYQGCMGQ
110 120 130 140 150
IFFFHFLGGA MVFFLSVMAF DRLIAISRPL RYVTVMNTQL WVGLVVATWV
160 170 180 190 200
GGFVHSIVQL ALMLPLPFCG PNILDNFYCD VPQVLRLACT DTSLLEFLKI
210 220 230 240 250
SNSGLLDVVW FFLLLMSYLF ILVMLRSHPG EARRKAASTC TTHIIVVSMI
260 270 280 290 300
FVPSIYLYAR PFTPFPMDKL VSIGHTVMTP MLNPMIYTLR NQDMQAAVRR

LGRHRLV
Length:307
Mass (Da):34,958
Last modified:June 20, 2001 - v1
Checksum:i5C8C68269034EBD3
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti29 – 291L → I.
Corresponds to variant rs60994383 [ dbSNP | Ensembl ].
VAR_062035

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF303373 mRNA. Translation: AAL26785.1.
AB065912 Genomic DNA. Translation: BAC06127.1.
AC005962 Genomic DNA. No translation available.
AF399568 Genomic DNA. Translation: AAK95053.1.
BK004224 Genomic DNA. Translation: DAA04622.1.
CCDSiCCDS32688.1.
RefSeqiNP_001004707.1. NM_001004707.3.
UniGeneiHs.446879.

Genome annotation databases

EnsembliENST00000545221; ENSP00000441354; ENSG00000255713.
GeneIDi124538.
KEGGihsa:124538.
UCSCiuc010wnp.2. human.

Polymorphism databases

DMDMi14423786.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF303373 mRNA. Translation: AAL26785.1.
AB065912 Genomic DNA. Translation: BAC06127.1.
AC005962 Genomic DNA. No translation available.
AF399568 Genomic DNA. Translation: AAK95053.1.
BK004224 Genomic DNA. Translation: DAA04622.1.
CCDSiCCDS32688.1.
RefSeqiNP_001004707.1. NM_001004707.3.
UniGeneiHs.446879.

3D structure databases

ProteinModelPortaliP58180.
SMRiP58180. Positions 25-304.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000284081.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP58180.

Polymorphism databases

DMDMi14423786.

Proteomic databases

PaxDbiP58180.
PRIDEiP58180.

Protocols and materials databases

DNASUi124538.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000545221; ENSP00000441354; ENSG00000255713.
GeneIDi124538.
KEGGihsa:124538.
UCSCiuc010wnp.2. human.

Organism-specific databases

CTDi124538.
GeneCardsiGC17P056253.
HGNCiHGNC:8294. OR4D2.
neXtProtiNX_P58180.
PharmGKBiPA32270.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG270173.
GeneTreeiENSGT00760000119104.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiP58180.
KOiK04257.
OMAiGQIFFFH.
OrthoDBiEOG7KSX95.
PhylomeDBiP58180.
TreeFamiTF338273.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR4D2.
GenomeRNAii124538.
NextBioi81312.
PROiP58180.

Gene expression databases

CleanExiHS_OR4D2.
GenevestigatoriP58180.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Activated B lymphocyte gene."
    Lu X.-W., Cui L.-X., Li Y.-H.
    Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-280.
  5. Cited for: IDENTIFICATION.
  6. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR4D2_HUMAN
AccessioniPrimary (citable) accession number: P58180
Secondary accession number(s): Q6IFN8, Q96R75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: June 20, 2001
Last modified: February 4, 2015
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.