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Protein

Leucine--tRNA ligase 1

Gene

leuS1

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei619 – 6191ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSSOL273057:GCH2-482-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase 1UniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetase 1UniRule annotation
Short name:
LeuRS 1UniRule annotation
Gene namesi
Name:leuS1UniRule annotation
Ordered Locus Names:SSO0504
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
ProteomesiUP000001974: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 934934Leucine--tRNA ligase 1PRO_0000152144Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi273057.SSO0504.

Structurei

3D structure databases

ProteinModelPortaliP58176.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi41 – 5111"HIGH" regionAdd
BLAST
Motifi616 – 6205"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000216620.
InParanoidiP58176.
KOiK01869.
OMAiREEYYKG.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_A. Leu_tRNA_synth_A.
InterProiIPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00395. leuS_arch. 1 hit.

Sequencei

Sequence statusi: Complete.

P58176-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYSDFFNSIA FKWQAEWEKS KVFETNMDYS KPKFFITVPF PYTNSPMHVG
60 70 80 90 100
HGRTYITADI YARYLRMKGY NVLFPFAFQF TGTPVLAIAD SIRRGEVDVI
110 120 130 140 150
EFFKNVYEVP QDKIKELEDP YKLAEYFKEE MKNTAKSIGM SIDWRRTFTT
160 170 180 190 200
TDPRFEKFIH WQLGKLKELG YLVTEDDVVG YCPNDGFPVG MHDTRGDIEP
210 220 230 240 250
EITTMNVIMF EGSDSYNFMV ATSRPELIFG VVALMVNHDA NYVVVEYEGK
260 270 280 290 300
NFIISEKAYK KLSFQKNMKL VKTITTSDIV KLYAINPITG RKLEIIKNKY
310 320 330 340 350
VDPSLGTGVV MSYPAHDPFH YLAMTETNKE FEVIPVVETE ELDEIPGESA
360 370 380 390 400
VLQTKNPYAL KDFMESIYKT EYYKGYMKDI ILSLVPDFLK QYVKENIVGK
410 420 430 440 450
QVQEARKNTI ELLKSLNIYD TIYEISNGPI YCRCGSEIVP KRIKDQWFIA
460 470 480 490 500
YDNPKWKASA LKAINNIELI PNPTKTELEK IVFNARKEPI GRSRGIGVKL
510 520 530 540 550
PWDESQIVES LSDSTLYTLL YTVIYKMPIN IEKEIFDFIF LGKGDAKELE
560 570 580 590 600
RKYGTDLIQL REEFLYWYPV DQRHTGRDLI QNHIPFYIYN HLAIFGEKYL
610 620 630 640 650
PKRIVINGFV RVGGRKMSKS LRNIYTLSKA IKEFGVDPVR IALTSTSDLL
660 670 680 690 700
QDLDFNENLV NPIAEQLKKI YDLIDRLLSI NTEIKELRTA DEWISSKVRD
710 720 730 740 750
IIEKVNNNIT SFKYRDAVNL LLYEIYEILR DYFDLVEIPN QEVIRKILSI
760 770 780 790 800
WIRALAPFVP HIAEELWHKI SSTFVSLEKY PEPNELNLYP DAILEISYIN
810 820 830 840 850
KIIENVRELE DIVHKKAEKV IIYINESEKV KELMKNAIKA VNEEIPLREF
860 870 880 890 900
TANTEDKIAE KVYVVVSKLD KAIRDYLLNN EIDEEQIIVK NMNFLLRRLG
910 920 930
VSEIVIYNAE DPTVPDVKGK KSQALPLSPA IVVE
Length:934
Mass (Da):108,527
Last modified:June 20, 2001 - v1
Checksum:i350A9D7C8424DBD0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006641 Genomic DNA. Translation: AAK40823.1.
PIRiH90195.
RefSeqiNP_342033.1. NC_002754.1.

Genome annotation databases

EnsemblBacteriaiAAK40823; AAK40823; SSO0504.
GeneIDi1455633.
KEGGisso:SSO0504.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006641 Genomic DNA. Translation: AAK40823.1.
PIRiH90195.
RefSeqiNP_342033.1. NC_002754.1.

3D structure databases

ProteinModelPortaliP58176.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273057.SSO0504.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK40823; AAK40823; SSO0504.
GeneIDi1455633.
KEGGisso:SSO0504.

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000216620.
InParanoidiP58176.
KOiK01869.
OMAiREEYYKG.

Enzyme and pathway databases

BioCyciSSOL273057:GCH2-482-MONOMER.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_A. Leu_tRNA_synth_A.
InterProiIPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00395. leuS_arch. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.

Entry informationi

Entry nameiSYL1_SULSO
AccessioniPrimary (citable) accession number: P58176
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: June 20, 2001
Last modified: January 7, 2015
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.