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P58176

- SYL1_SULSO

UniProt

P58176 - SYL1_SULSO

Protein

Leucine--tRNA ligase 1

Gene

leuS1

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (20 Jun 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei619 – 6191ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSSOL273057:GCH2-482-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligase 1UniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetase 1UniRule annotation
    Short name:
    LeuRS 1UniRule annotation
    Gene namesi
    Name:leuS1UniRule annotation
    Ordered Locus Names:SSO0504
    OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
    Taxonomic identifieri273057 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
    ProteomesiUP000001974: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 934934Leucine--tRNA ligase 1PRO_0000152144Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi273057.SSO0504.

    Structurei

    3D structure databases

    ProteinModelPortaliP58176.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi41 – 5111"HIGH" regionAdd
    BLAST
    Motifi616 – 6205"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000216620.
    KOiK01869.
    OMAiQFTGTPI.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_A. Leu_tRNA_synth_A.
    InterProiIPR002300. aa-tRNA-synth_Ia.
    IPR020791. Leu-tRNA-lgase_arc.
    IPR004493. Leu-tRNA-synth_Ia_arc/euk.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00395. leuS_arch. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P58176-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYSDFFNSIA FKWQAEWEKS KVFETNMDYS KPKFFITVPF PYTNSPMHVG    50
    HGRTYITADI YARYLRMKGY NVLFPFAFQF TGTPVLAIAD SIRRGEVDVI 100
    EFFKNVYEVP QDKIKELEDP YKLAEYFKEE MKNTAKSIGM SIDWRRTFTT 150
    TDPRFEKFIH WQLGKLKELG YLVTEDDVVG YCPNDGFPVG MHDTRGDIEP 200
    EITTMNVIMF EGSDSYNFMV ATSRPELIFG VVALMVNHDA NYVVVEYEGK 250
    NFIISEKAYK KLSFQKNMKL VKTITTSDIV KLYAINPITG RKLEIIKNKY 300
    VDPSLGTGVV MSYPAHDPFH YLAMTETNKE FEVIPVVETE ELDEIPGESA 350
    VLQTKNPYAL KDFMESIYKT EYYKGYMKDI ILSLVPDFLK QYVKENIVGK 400
    QVQEARKNTI ELLKSLNIYD TIYEISNGPI YCRCGSEIVP KRIKDQWFIA 450
    YDNPKWKASA LKAINNIELI PNPTKTELEK IVFNARKEPI GRSRGIGVKL 500
    PWDESQIVES LSDSTLYTLL YTVIYKMPIN IEKEIFDFIF LGKGDAKELE 550
    RKYGTDLIQL REEFLYWYPV DQRHTGRDLI QNHIPFYIYN HLAIFGEKYL 600
    PKRIVINGFV RVGGRKMSKS LRNIYTLSKA IKEFGVDPVR IALTSTSDLL 650
    QDLDFNENLV NPIAEQLKKI YDLIDRLLSI NTEIKELRTA DEWISSKVRD 700
    IIEKVNNNIT SFKYRDAVNL LLYEIYEILR DYFDLVEIPN QEVIRKILSI 750
    WIRALAPFVP HIAEELWHKI SSTFVSLEKY PEPNELNLYP DAILEISYIN 800
    KIIENVRELE DIVHKKAEKV IIYINESEKV KELMKNAIKA VNEEIPLREF 850
    TANTEDKIAE KVYVVVSKLD KAIRDYLLNN EIDEEQIIVK NMNFLLRRLG 900
    VSEIVIYNAE DPTVPDVKGK KSQALPLSPA IVVE 934
    Length:934
    Mass (Da):108,527
    Last modified:June 20, 2001 - v1
    Checksum:i350A9D7C8424DBD0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006641 Genomic DNA. Translation: AAK40823.1.
    PIRiH90195.
    RefSeqiNP_342033.1. NC_002754.1.

    Genome annotation databases

    EnsemblBacteriaiAAK40823; AAK40823; SSO0504.
    GeneIDi1455633.
    KEGGisso:SSO0504.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006641 Genomic DNA. Translation: AAK40823.1 .
    PIRi H90195.
    RefSeqi NP_342033.1. NC_002754.1.

    3D structure databases

    ProteinModelPortali P58176.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 273057.SSO0504.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK40823 ; AAK40823 ; SSO0504 .
    GeneIDi 1455633.
    KEGGi sso:SSO0504.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000216620.
    KOi K01869.
    OMAi QFTGTPI.

    Enzyme and pathway databases

    BioCyci SSOL273057:GCH2-482-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_A. Leu_tRNA_synth_A.
    InterProi IPR002300. aa-tRNA-synth_Ia.
    IPR020791. Leu-tRNA-lgase_arc.
    IPR004493. Leu-tRNA-synth_Ia_arc/euk.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00395. leuS_arch. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.

    Entry informationi

    Entry nameiSYL1_SULSO
    AccessioniPrimary (citable) accession number: P58176
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: June 20, 2001
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3