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Protein

Leucine--tRNA ligase 1

Gene

leuS1

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei619ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase 1UniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetase 1UniRule annotation
Short name:
LeuRS 1UniRule annotation
Gene namesi
Name:leuS1UniRule annotation
Ordered Locus Names:SSO0504
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001974 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001521441 – 934Leucine--tRNA ligase 1Add BLAST934

Proteomic databases

PRIDEiP58176

Interactioni

Protein-protein interaction databases

STRINGi273057.SSO0504

Structurei

3D structure databases

ProteinModelPortaliP58176
SMRiP58176
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi41 – 51"HIGH" regionAdd BLAST11
Motifi616 – 620"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00809 Archaea
COG0495 LUCA
HOGENOMiHOG000216620
InParanoidiP58176
KOiK01869
OMAiIVKDRRY
OrthoDBiPOG093Z006D

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_A Leu_tRNA_synth_A, 1 hit
InterProiView protein in InterPro
IPR002300 aa-tRNA-synth_Ia
IPR020791 Leu-tRNA-lgase_arc
IPR004493 Leu-tRNA-synth_Ia_arc/euk
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR11946:SF51 PTHR11946:SF51, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00395 leuS_arch, 1 hit

Sequencei

Sequence statusi: Complete.

P58176-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYSDFFNSIA FKWQAEWEKS KVFETNMDYS KPKFFITVPF PYTNSPMHVG
60 70 80 90 100
HGRTYITADI YARYLRMKGY NVLFPFAFQF TGTPVLAIAD SIRRGEVDVI
110 120 130 140 150
EFFKNVYEVP QDKIKELEDP YKLAEYFKEE MKNTAKSIGM SIDWRRTFTT
160 170 180 190 200
TDPRFEKFIH WQLGKLKELG YLVTEDDVVG YCPNDGFPVG MHDTRGDIEP
210 220 230 240 250
EITTMNVIMF EGSDSYNFMV ATSRPELIFG VVALMVNHDA NYVVVEYEGK
260 270 280 290 300
NFIISEKAYK KLSFQKNMKL VKTITTSDIV KLYAINPITG RKLEIIKNKY
310 320 330 340 350
VDPSLGTGVV MSYPAHDPFH YLAMTETNKE FEVIPVVETE ELDEIPGESA
360 370 380 390 400
VLQTKNPYAL KDFMESIYKT EYYKGYMKDI ILSLVPDFLK QYVKENIVGK
410 420 430 440 450
QVQEARKNTI ELLKSLNIYD TIYEISNGPI YCRCGSEIVP KRIKDQWFIA
460 470 480 490 500
YDNPKWKASA LKAINNIELI PNPTKTELEK IVFNARKEPI GRSRGIGVKL
510 520 530 540 550
PWDESQIVES LSDSTLYTLL YTVIYKMPIN IEKEIFDFIF LGKGDAKELE
560 570 580 590 600
RKYGTDLIQL REEFLYWYPV DQRHTGRDLI QNHIPFYIYN HLAIFGEKYL
610 620 630 640 650
PKRIVINGFV RVGGRKMSKS LRNIYTLSKA IKEFGVDPVR IALTSTSDLL
660 670 680 690 700
QDLDFNENLV NPIAEQLKKI YDLIDRLLSI NTEIKELRTA DEWISSKVRD
710 720 730 740 750
IIEKVNNNIT SFKYRDAVNL LLYEIYEILR DYFDLVEIPN QEVIRKILSI
760 770 780 790 800
WIRALAPFVP HIAEELWHKI SSTFVSLEKY PEPNELNLYP DAILEISYIN
810 820 830 840 850
KIIENVRELE DIVHKKAEKV IIYINESEKV KELMKNAIKA VNEEIPLREF
860 870 880 890 900
TANTEDKIAE KVYVVVSKLD KAIRDYLLNN EIDEEQIIVK NMNFLLRRLG
910 920 930
VSEIVIYNAE DPTVPDVKGK KSQALPLSPA IVVE
Length:934
Mass (Da):108,527
Last modified:June 20, 2001 - v1
Checksum:i350A9D7C8424DBD0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006641 Genomic DNA Translation: AAK40823.1
PIRiH90195
RefSeqiWP_009991397.1, NC_002754.1

Genome annotation databases

EnsemblBacteriaiAAK40823; AAK40823; SSO0504
GeneIDi27426801
KEGGisso:SSO0504
PATRICifig|273057.12.peg.498

Similar proteinsi

Entry informationi

Entry nameiSYL1_SULSO
AccessioniPrimary (citable) accession number: P58176
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: June 20, 2001
Last modified: May 23, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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