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P58176 (SYL1_SULSO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase 1

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase 1
Short name=LeuRS 1
Gene names
Name:leuS1
Ordered Locus Names:SSO0504
OrganismSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) [Reference proteome] [HAMAP]
Taxonomic identifier273057 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus

Protein attributes

Sequence length934 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 934934Leucine--tRNA ligase 1 HAMAP-Rule MF_00049
PRO_0000152144

Regions

Motif41 – 5111"HIGH" region HAMAP-Rule MF_00049
Motif616 – 6205"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site6191ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
P58176 [UniParc].

Last modified June 20, 2001. Version 1.
Checksum: 350A9D7C8424DBD0

FASTA934108,527
        10         20         30         40         50         60 
MYSDFFNSIA FKWQAEWEKS KVFETNMDYS KPKFFITVPF PYTNSPMHVG HGRTYITADI 

        70         80         90        100        110        120 
YARYLRMKGY NVLFPFAFQF TGTPVLAIAD SIRRGEVDVI EFFKNVYEVP QDKIKELEDP 

       130        140        150        160        170        180 
YKLAEYFKEE MKNTAKSIGM SIDWRRTFTT TDPRFEKFIH WQLGKLKELG YLVTEDDVVG 

       190        200        210        220        230        240 
YCPNDGFPVG MHDTRGDIEP EITTMNVIMF EGSDSYNFMV ATSRPELIFG VVALMVNHDA 

       250        260        270        280        290        300 
NYVVVEYEGK NFIISEKAYK KLSFQKNMKL VKTITTSDIV KLYAINPITG RKLEIIKNKY 

       310        320        330        340        350        360 
VDPSLGTGVV MSYPAHDPFH YLAMTETNKE FEVIPVVETE ELDEIPGESA VLQTKNPYAL 

       370        380        390        400        410        420 
KDFMESIYKT EYYKGYMKDI ILSLVPDFLK QYVKENIVGK QVQEARKNTI ELLKSLNIYD 

       430        440        450        460        470        480 
TIYEISNGPI YCRCGSEIVP KRIKDQWFIA YDNPKWKASA LKAINNIELI PNPTKTELEK 

       490        500        510        520        530        540 
IVFNARKEPI GRSRGIGVKL PWDESQIVES LSDSTLYTLL YTVIYKMPIN IEKEIFDFIF 

       550        560        570        580        590        600 
LGKGDAKELE RKYGTDLIQL REEFLYWYPV DQRHTGRDLI QNHIPFYIYN HLAIFGEKYL 

       610        620        630        640        650        660 
PKRIVINGFV RVGGRKMSKS LRNIYTLSKA IKEFGVDPVR IALTSTSDLL QDLDFNENLV 

       670        680        690        700        710        720 
NPIAEQLKKI YDLIDRLLSI NTEIKELRTA DEWISSKVRD IIEKVNNNIT SFKYRDAVNL 

       730        740        750        760        770        780 
LLYEIYEILR DYFDLVEIPN QEVIRKILSI WIRALAPFVP HIAEELWHKI SSTFVSLEKY 

       790        800        810        820        830        840 
PEPNELNLYP DAILEISYIN KIIENVRELE DIVHKKAEKV IIYINESEKV KELMKNAIKA 

       850        860        870        880        890        900 
VNEEIPLREF TANTEDKIAE KVYVVVSKLD KAIRDYLLNN EIDEEQIIVK NMNFLLRRLG 

       910        920        930 
VSEIVIYNAE DPTVPDVKGK KSQALPLSPA IVVE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE006641 Genomic DNA. Translation: AAK40823.1.
PIRH90195.
RefSeqNP_342033.1. NC_002754.1.

3D structure databases

ProteinModelPortalP58176.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING273057.SSO0504.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK40823; AAK40823; SSO0504.
GeneID1455633.
KEGGsso:SSO0504.

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000216620.
KOK01869.
OMAQFTGTPI.
ProtClustDBPRK12300.

Enzyme and pathway databases

BioCycSSOL273057:GCH2-482-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_A. Leu_tRNA_synth_A.
InterProIPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00395. leuS_arch. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSYL1_SULSO
AccessionPrimary (citable) accession number: P58176
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: June 20, 2001
Last modified: April 16, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries