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Protein

Olfactory receptor 2B6

Gene

OR2B6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000124657-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2B6
Alternative name(s):
Hs6M1-32
Olfactory receptor 2B1
Olfactory receptor 2B5
Olfactory receptor 5-40
Short name:
OR5-40
Olfactory receptor 6-31
Short name:
OR6-31
Olfactory receptor OR6-4
Gene namesi
Name:OR2B6
Synonyms:OR2B1, OR2B1P, OR2B5, OR2B6P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:8241. OR2B6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 49Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini50 – 57CytoplasmicSequence analysis8
Transmembranei58 – 79Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini80 – 100ExtracellularSequence analysisAdd BLAST21
Transmembranei101 – 120Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 158Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini159 – 195ExtracellularSequence analysisAdd BLAST37
Transmembranei196 – 219Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini220 – 236CytoplasmicSequence analysisAdd BLAST17
Transmembranei237 – 259Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini260 – 272ExtracellularSequence analysisAdd BLAST13
Transmembranei273 – 292Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini293 – 313CytoplasmicSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000124657.
PharmGKBiPA32144.

Polymorphism and mutation databases

BioMutaiOR2B6.
DMDMi14423785.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504621 – 313Olfactory receptor 2B6Add BLAST313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP58173.
PRIDEiP58173.

PTM databases

iPTMnetiP58173.
PhosphoSitePlusiP58173.

Expressioni

Gene expression databases

BgeeiENSG00000124657.
CleanExiHS_OR2B6.
ExpressionAtlasiP58173. baseline and differential.
GenevisibleiP58173. HS.

Organism-specific databases

HPAiCAB009517.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000244623.

Structurei

3D structure databases

ProteinModelPortaliP58173.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JAX5. Eukaryota.
ENOG411179Z. LUCA.
GeneTreeiENSGT00740000115013.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiP58173.
KOiK04257.
OMAiAQLFMFL.
OrthoDBiEOG091G0CU6.
PhylomeDBiP58173.
TreeFamiTF336512.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P58173-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNWVNDSIIQ EFILLGFSDR PWLEFPLLVV FLISYTVTIF GNLTIILVSR
60 70 80 90 100
LDTKLHTPMY FFLTNLSLLD LCYTTCTVPQ MLVNLCSIRK VISYRGCVAQ
110 120 130 140 150
LFIFLALGAT EYLLLAVMSF DRFVAICRPL HYSVIMHQRL CLQLAAASWV
160 170 180 190 200
TGFSNSVWLS TLTLQLPLCD PYVIDHFLCE VPALLKLSCV ETTANEAELF
210 220 230 240 250
LVSELFHLIP LTLILISYAF IVRAVLRIQS AEGRQKAFGT CGSHLIVVSL
260 270 280 290 300
FYSTAVSVYL QPPSPSSKDQ GKMVSLFYGI IAPMLNPLIY TLRNKEVKEG
310
FKRLVARVFL IKK
Length:313
Mass (Da):35,414
Last modified:June 20, 2001 - v1
Checksum:i71D459541ACF5301
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053131117V → I.Corresponds to variant rs7767176dbSNPEnsembl.1
Natural variantiVAR_024090270Q → R.Corresponds to variant rs9380030dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL133267 Genomic DNA. Translation: CAC14158.1.
BC109251 mRNA. Translation: AAI09252.1.
BC110457 mRNA. Translation: AAI10458.1.
U86270 Genomic DNA. Translation: AAC39628.1.
BK004373 Genomic DNA. Translation: DAA04771.1.
CCDSiCCDS4642.1.
RefSeqiNP_036499.1. NM_012367.1.
UniGeneiHs.532145.

Genome annotation databases

EnsembliENST00000244623; ENSP00000244623; ENSG00000124657.
GeneIDi26212.
KEGGihsa:26212.
UCSCiuc011dkx.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL133267 Genomic DNA. Translation: CAC14158.1.
BC109251 mRNA. Translation: AAI09252.1.
BC110457 mRNA. Translation: AAI10458.1.
U86270 Genomic DNA. Translation: AAC39628.1.
BK004373 Genomic DNA. Translation: DAA04771.1.
CCDSiCCDS4642.1.
RefSeqiNP_036499.1. NM_012367.1.
UniGeneiHs.532145.

3D structure databases

ProteinModelPortaliP58173.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000244623.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP58173.
PhosphoSitePlusiP58173.

Polymorphism and mutation databases

BioMutaiOR2B6.
DMDMi14423785.

Proteomic databases

PaxDbiP58173.
PRIDEiP58173.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000244623; ENSP00000244623; ENSG00000124657.
GeneIDi26212.
KEGGihsa:26212.
UCSCiuc011dkx.2. human.

Organism-specific databases

CTDi26212.
GeneCardsiOR2B6.
HGNCiHGNC:8241. OR2B6.
HPAiCAB009517.
neXtProtiNX_P58173.
OpenTargetsiENSG00000124657.
PharmGKBiPA32144.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JAX5. Eukaryota.
ENOG411179Z. LUCA.
GeneTreeiENSGT00740000115013.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiP58173.
KOiK04257.
OMAiAQLFMFL.
OrthoDBiEOG091G0CU6.
PhylomeDBiP58173.
TreeFamiTF336512.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000124657-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR2B6.
GenomeRNAii26212.
PROiP58173.

Gene expression databases

BgeeiENSG00000124657.
CleanExiHS_OR2B6.
ExpressionAtlasiP58173. baseline and differential.
GenevisibleiP58173. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR2B6_HUMAN
AccessioniPrimary (citable) accession number: P58173
Secondary accession number(s): O43883, Q6IF89, Q9H5B0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: June 20, 2001
Last modified: November 30, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.