ID OR1D5_HUMAN Reviewed; 312 AA. AC P58170; A0AUK4; Q96RA6; DT 20-JUN-2001, integrated into UniProtKB/Swiss-Prot. DT 20-JUN-2001, sequence version 1. DT 24-JAN-2024, entry version 164. DE RecName: Full=Olfactory receptor 1D5; DE AltName: Full=Olfactory receptor 17-31; DE Short=OR17-31; GN Name=OR1D5; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=10673334; DOI=10.1006/geno.1999.6030; RA Glusman G., Sosinsky A., Ben-Asher E., Avidan N., Sonkin D., Bahar A., RA Rosenthal A., Clifton S., Roe B., Ferraz C., Demaille J.G., Lancet D.; RT "Sequence, structure, and evolution of a complete human olfactory receptor RT gene cluster."; RL Genomics 63:227-245(2000). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RA Ferraz C., Demaille J.G.; RL Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-282. RX PubMed=12213199; DOI=10.1006/geno.2002.6830; RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., RA Lehrach H., Lancet D., Shamir R.; RT "DEFOG: a practical scheme for deciphering families of genes."; RL Genomics 80:295-302(2002). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6-197. RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: Odorant receptor. {ECO:0000305}. CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC {ECO:0000255|PROSITE-ProRule:PRU00521}. CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE); CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR1D5"; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF087923; AAF37313.1; -; Genomic_DNA. DR EMBL; U53930; AAD10841.1; -; Genomic_DNA. DR EMBL; AF399533; AAK95018.1; -; Genomic_DNA. DR EMBL; BC106876; AAI06877.1; -; mRNA. DR CCDS; CCDS58499.1; -. DR RefSeq; NP_055381.1; NM_014566.1. DR AlphaFoldDB; P58170; -. DR SMR; P58170; -. DR BioGRID; 113976; 19. DR IntAct; P58170; 1. DR STRING; 9606.ENSP00000459028; -. DR GlyCosmos; P58170; 1 site, No reported glycans. DR GlyGen; P58170; 1 site. DR BioMuta; OR1D5; -. DR DMDM; 14423784; -. DR PaxDb; 9606-ENSP00000459028; -. DR Antibodypedia; 62120; 88 antibodies from 20 providers. DR DNASU; 8386; -. DR Ensembl; ENST00000575751.1; ENSP00000459028.1; ENSG00000262628.1. DR GeneID; 8386; -. DR KEGG; hsa:8386; -. DR MANE-Select; ENST00000575751.1; ENSP00000459028.1; NM_014566.1; NP_055381.1. DR UCSC; uc021tns.1; human. DR AGR; HGNC:8186; -. DR CTD; 8386; -. DR GeneCards; OR1D5; -. DR HGNC; HGNC:8186; OR1D5. DR HPA; ENSG00000262628; Not detected. DR neXtProt; NX_P58170; -. DR PharmGKB; PA32060; -. DR VEuPathDB; HostDB:ENSG00000262628; -. DR eggNOG; ENOG502T9JB; Eukaryota. DR GeneTree; ENSGT00940000164752; -. DR HOGENOM; CLU_012526_5_5_1; -. DR InParanoid; P58170; -. DR OMA; EIHYLFC; -. DR OrthoDB; 5401587at2759; -. DR PhylomeDB; P58170; -. DR PathwayCommons; P58170; -. DR Reactome; R-HSA-381753; Olfactory Signaling Pathway. DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors. DR BioGRID-ORCS; 8386; 12 hits in 692 CRISPR screens. DR GeneWiki; OR1D5; -. DR GenomeRNAi; 8386; -. DR Pharos; P58170; Tdark. DR PRO; PR:P58170; -. DR Proteomes; UP000005640; Chromosome 17. DR RNAct; P58170; Protein. DR Bgee; ENSG00000262628; Expressed in male germ line stem cell (sensu Vertebrata) in testis. DR ExpressionAtlas; P58170; baseline and differential. DR Genevisible; P58170; HS. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0004930; F:G protein-coupled receptor activity; TAS:ProtInc. DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central. DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; TAS:ProtInc. DR GO; GO:0007608; P:sensory perception of smell; TAS:ProtInc. DR GO; GO:0007165; P:signal transduction; IBA:GO_Central. DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR InterPro; IPR000725; Olfact_rcpt. DR PANTHER; PTHR48001; OLFACTORY RECEPTOR; 1. DR PANTHER; PTHR48001:SF70; OLFACTORY RECEPTOR 1D4-RELATED; 1. DR Pfam; PF13853; 7tm_4; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 2: Evidence at transcript level; KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein; KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction; KW Transducer; Transmembrane; Transmembrane helix. FT CHAIN 1..312 FT /note="Olfactory receptor 1D5" FT /id="PRO_0000150422" FT TOPO_DOM 1..25 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 26..49 FT /note="Helical; Name=1" FT /evidence="ECO:0000255" FT TOPO_DOM 50..57 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 58..79 FT /note="Helical; Name=2" FT /evidence="ECO:0000255" FT TOPO_DOM 80..100 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 101..120 FT /note="Helical; Name=3" FT /evidence="ECO:0000255" FT TOPO_DOM 121..140 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 141..158 FT /note="Helical; Name=4" FT /evidence="ECO:0000255" FT TOPO_DOM 159..196 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 197..220 FT /note="Helical; Name=5" FT /evidence="ECO:0000255" FT TOPO_DOM 221..237 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 238..260 FT /note="Helical; Name=6" FT /evidence="ECO:0000255" FT TOPO_DOM 261..271 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 272..291 FT /note="Helical; Name=7" FT /evidence="ECO:0000255" FT TOPO_DOM 292..312 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT CARBOHYD 5 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT DISULFID 97..189 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521" SQ SEQUENCE 312 AA; 35424 MW; 94D238A76AE37829 CRC64; MDGDNQSENS QFLLLGISES PEQQRILFWM FLSMYLVTVL GNVLIILAIS SDSHLHTPMY FFLANLSFTD LFFVTNTIPK MLVNFQSQNK AISYAGCLTQ LYFLVSLVTL DNLILAVMAY DRYVATCCPL HYVTAMSPGL CVLLLSLCWG LSVLYGLLLT FLLTRVTFCG PREIHYLFCD MYILLWLACS NTHIIHTALI ATGCFIFLTP LGFMTTSYVR IVRTILQMPS ASKKYKTFST CASHLGVVSL FYGTLAMVYL QPLHTYSMKD SVATVMYAVL TPMMNPFIYR LRNKDMHGAP GRVLWRPFQR PK //