P58170 (OR1D5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 1D5

Alternative name(s):
Olfactory receptor 17-31
Short name=OR17-31

Gene names

Name:

OR1D5

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	312 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	G-protein coupled receptor activity Traceable author statement PubMed 1315913. Source: ProtInc olfactory receptor activity Traceable author statement PubMed 1315913. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 312	312	Olfactory receptor 1D5		PRO_0000150422
Regions
	Topological domain	1 – 25	25	Extracellular Potential
	Transmembrane	26 – 49	24	Helical; Name=1; Potential
	Topological domain	50 – 57	8	Cytoplasmic Potential
	Transmembrane	58 – 79	22	Helical; Name=2; Potential
	Topological domain	80 – 100	21	Extracellular Potential
	Transmembrane	101 – 120	20	Helical; Name=3; Potential
	Topological domain	121 – 140	20	Cytoplasmic Potential
	Transmembrane	141 – 158	18	Helical; Name=4; Potential
	Topological domain	159 – 196	38	Extracellular Potential
	Transmembrane	197 – 220	24	Helical; Name=5; Potential
	Topological domain	221 – 237	17	Cytoplasmic Potential
	Transmembrane	238 – 260	23	Helical; Name=6; Potential
	Topological domain	261 – 271	11	Extracellular Potential
	Transmembrane	272 – 291	20	Helical; Name=7; Potential
	Topological domain	292 – 312	21	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	5	1	N-linked (GlcNAc...) Potential
	Disulfide bond	97 ↔ 189		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P58170 [UniParc]. Last modified June 20, 2001. Version 1. Checksum: 94D238A76AE37829	FASTA	312	35,424
	10 20 30 40 50 60 MDGDNQSENS QFLLLGISES PEQQRILFWM FLSMYLVTVL GNVLIILAIS SDSHLHTPMY 70 80 90 100 110 120 FFLANLSFTD LFFVTNTIPK MLVNFQSQNK AISYAGCLTQ LYFLVSLVTL DNLILAVMAY 130 140 150 160 170 180 DRYVATCCPL HYVTAMSPGL CVLLLSLCWG LSVLYGLLLT FLLTRVTFCG PREIHYLFCD 190 200 210 220 230 240 MYILLWLACS NTHIIHTALI ATGCFIFLTP LGFMTTSYVR IVRTILQMPS ASKKYKTFST 250 260 270 280 290 300 CASHLGVVSL FYGTLAMVYL QPLHTYSMKD SVATVMYAVL TPMMNPFIYR LRNKDMHGAP 310 GRVLWRPFQR PK

References

[1]	"Sequence, structure, and evolution of a complete human olfactory receptor gene cluster." Glusman G., Sosinsky A., Ben-Asher E., Avidan N., Sonkin D., Bahar A., Rosenthal A., Clifton S., Roe B., Ferraz C., Demaille J.G., Lancet D. Genomics 63:227-245(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	Ferraz C., Demaille J.G. Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"DEFOG: a practical scheme for deciphering families of genes." Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R. Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-282.

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF087923 Genomic DNA. Translation: AAF37313.1. U53930 Genomic DNA. Translation: AAD10841.1. AF399533 Genomic DNA. Translation: AAK95018.1.
IPI	IPI00419401.
RefSeq	NP_055381.1. NM_014566.1.
UniGene	Hs.553508.
3D structure databases
ProteinModelPortal	P58170.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000327564.
Protein family/group databases
GPCRDB	Search...
Polymorphism databases
DMDM	14423784.
Proteomic databases
PRIDE	P58170.
Protocols and materials databases
DNASU	8386.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000575751; ENSP00000459028; ENSG00000262628.
GeneID	8386.
KEGG	hsa:8386.
UCSC	uc021tns.1. human.
Organism-specific databases
CTD	8386.
GeneCards	GC17M002965. GC17M002966.
HGNC	HGNC:8186. OR1D5.
neXtProt	NX_P58170.
PharmGKB	PA32060.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG017625.
InParanoid	P58170.
KO	K04257.
PhylomeDB	P58170.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	P58170.
CleanEx	HS_OR1D5.
Genevestigator	P58170.
GermOnline	ENSG00000182880. Homo sapiens.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PANTHER	PTHR24236. PTHR24236. 1 hit.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	8386.
NextBio	31390.

Entry information

Entry name

OR1D5_HUMAN

Accession

Primary (citable) accession number: P58170
Secondary accession number(s): Q96RA6

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	June 20, 2001
Last modified:	May 1, 2013
This is version 97 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.