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P58170 (OR1D5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 1D5
Alternative name(s):
Olfactory receptor 17-31
Short name=OR17-31
Gene names
Name:OR1D5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length312 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 312312Olfactory receptor 1D5
PRO_0000150422

Regions

Topological domain1 – 2525Extracellular Potential
Transmembrane26 – 4924Helical; Name=1; Potential
Topological domain50 – 578Cytoplasmic Potential
Transmembrane58 – 7922Helical; Name=2; Potential
Topological domain80 – 10021Extracellular Potential
Transmembrane101 – 12020Helical; Name=3; Potential
Topological domain121 – 14020Cytoplasmic Potential
Transmembrane141 – 15818Helical; Name=4; Potential
Topological domain159 – 19638Extracellular Potential
Transmembrane197 – 22024Helical; Name=5; Potential
Topological domain221 – 23717Cytoplasmic Potential
Transmembrane238 – 26023Helical; Name=6; Potential
Topological domain261 – 27111Extracellular Potential
Transmembrane272 – 29120Helical; Name=7; Potential
Topological domain292 – 31221Cytoplasmic Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Disulfide bond97 ↔ 189 By similarity

Sequences

Sequence LengthMass (Da)Tools
P58170 [UniParc].

Last modified June 20, 2001. Version 1.
Checksum: 94D238A76AE37829

FASTA31235,424
        10         20         30         40         50         60 
MDGDNQSENS QFLLLGISES PEQQRILFWM FLSMYLVTVL GNVLIILAIS SDSHLHTPMY 

        70         80         90        100        110        120 
FFLANLSFTD LFFVTNTIPK MLVNFQSQNK AISYAGCLTQ LYFLVSLVTL DNLILAVMAY 

       130        140        150        160        170        180 
DRYVATCCPL HYVTAMSPGL CVLLLSLCWG LSVLYGLLLT FLLTRVTFCG PREIHYLFCD 

       190        200        210        220        230        240 
MYILLWLACS NTHIIHTALI ATGCFIFLTP LGFMTTSYVR IVRTILQMPS ASKKYKTFST 

       250        260        270        280        290        300 
CASHLGVVSL FYGTLAMVYL QPLHTYSMKD SVATVMYAVL TPMMNPFIYR LRNKDMHGAP 

       310 
GRVLWRPFQR PK 

« Hide

References

[1]"Sequence, structure, and evolution of a complete human olfactory receptor gene cluster."
Glusman G., Sosinsky A., Ben-Asher E., Avidan N., Sonkin D., Bahar A., Rosenthal A., Clifton S., Roe B., Ferraz C., Demaille J.G., Lancet D.
Genomics 63:227-245(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]Ferraz C., Demaille J.G.
Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"DEFOG: a practical scheme for deciphering families of genes."
Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R.
Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-282.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF087923 Genomic DNA. Translation: AAF37313.1.
U53930 Genomic DNA. Translation: AAD10841.1.
AF399533 Genomic DNA. Translation: AAK95018.1.
RefSeqNP_055381.1. NM_014566.1.
UniGeneHs.553508.

3D structure databases

ProteinModelPortalP58170.
SMRP58170. Positions 32-307.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000327564.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM14423784.

Proteomic databases

PRIDEP58170.

Protocols and materials databases

DNASU8386.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000575751; ENSP00000459028; ENSG00000262628.
GeneID8386.
KEGGhsa:8386.
UCSCuc021tns.1. human.

Organism-specific databases

CTD8386.
GeneCardsGC17M002965.
HGNCHGNC:8186. OR1D5.
neXtProtNX_P58170.
PharmGKBPA32060.
GenAtlasSearch...

Phylogenomic databases

HOVERGENHBG017625.
InParanoidP58170.
KOK04257.
OMAVTFCGPR.
OrthoDBEOG7JQBNT.
PhylomeDBP58170.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR1D5.
GenevestigatorP58170.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR1D5.
GenomeRNAi8386.
NextBio31390.
PROP58170.

Entry information

Entry nameOR1D5_HUMAN
AccessionPrimary (citable) accession number: P58170
Secondary accession number(s): Q96RA6
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: June 20, 2001
Last modified: April 16, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries