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P58170

- OR1D5_HUMAN

UniProt

P58170 - OR1D5_HUMAN

Protein

Olfactory receptor 1D5

Gene

OR1D5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (20 Jun 2001)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: ProtInc
    2. olfactory receptor activity Source: ProtInc

    GO - Biological processi

    1. detection of chemical stimulus involved in sensory perception of smell Source: GOC
    2. G-protein coupled receptor signaling pathway Source: ProtInc
    3. sensory perception of smell Source: ProtInc

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 1D5
    Alternative name(s):
    Olfactory receptor 17-31
    Short name:
    OR17-31
    Gene namesi
    Name:OR1D5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:8186. OR1D5.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32060.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 312312Olfactory receptor 1D5PRO_0000150422Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP58170.

    Expressioni

    Gene expression databases

    CleanExiHS_OR1D5.
    GenevestigatoriP58170.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000327564.

    Structurei

    3D structure databases

    ProteinModelPortaliP58170.
    SMRiP58170. Positions 32-295.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini50 – 578CytoplasmicSequence Analysis
    Topological domaini80 – 10021ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini121 – 14020CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini159 – 19638ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini221 – 23717CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini261 – 27111ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini292 – 31221CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 4924Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei58 – 7922Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei101 – 12020Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei141 – 15818Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei197 – 22024Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei238 – 26023Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei272 – 29120Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG017625.
    InParanoidiP58170.
    KOiK04257.
    OMAiVTFCGPR.
    OrthoDBiEOG7JQBNT.
    PhylomeDBiP58170.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P58170-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDGDNQSENS QFLLLGISES PEQQRILFWM FLSMYLVTVL GNVLIILAIS    50
    SDSHLHTPMY FFLANLSFTD LFFVTNTIPK MLVNFQSQNK AISYAGCLTQ 100
    LYFLVSLVTL DNLILAVMAY DRYVATCCPL HYVTAMSPGL CVLLLSLCWG 150
    LSVLYGLLLT FLLTRVTFCG PREIHYLFCD MYILLWLACS NTHIIHTALI 200
    ATGCFIFLTP LGFMTTSYVR IVRTILQMPS ASKKYKTFST CASHLGVVSL 250
    FYGTLAMVYL QPLHTYSMKD SVATVMYAVL TPMMNPFIYR LRNKDMHGAP 300
    GRVLWRPFQR PK 312
    Length:312
    Mass (Da):35,424
    Last modified:June 20, 2001 - v1
    Checksum:i94D238A76AE37829
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF087923 Genomic DNA. Translation: AAF37313.1.
    U53930 Genomic DNA. Translation: AAD10841.1.
    AF399533 Genomic DNA. Translation: AAK95018.1.
    CCDSiCCDS58499.1.
    RefSeqiNP_055381.1. NM_014566.1.
    UniGeneiHs.553508.

    Genome annotation databases

    EnsembliENST00000575751; ENSP00000459028; ENSG00000262628.
    GeneIDi8386.
    KEGGihsa:8386.
    UCSCiuc021tns.1. human.

    Polymorphism databases

    DMDMi14423784.

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF087923 Genomic DNA. Translation: AAF37313.1 .
    U53930 Genomic DNA. Translation: AAD10841.1 .
    AF399533 Genomic DNA. Translation: AAK95018.1 .
    CCDSi CCDS58499.1.
    RefSeqi NP_055381.1. NM_014566.1.
    UniGenei Hs.553508.

    3D structure databases

    ProteinModelPortali P58170.
    SMRi P58170. Positions 32-295.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000327564.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 14423784.

    Proteomic databases

    PRIDEi P58170.

    Protocols and materials databases

    DNASUi 8386.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000575751 ; ENSP00000459028 ; ENSG00000262628 .
    GeneIDi 8386.
    KEGGi hsa:8386.
    UCSCi uc021tns.1. human.

    Organism-specific databases

    CTDi 8386.
    GeneCardsi GC17M002965.
    HGNCi HGNC:8186. OR1D5.
    neXtProti NX_P58170.
    PharmGKBi PA32060.
    GenAtlasi Search...

    Phylogenomic databases

    HOVERGENi HBG017625.
    InParanoidi P58170.
    KOi K04257.
    OMAi VTFCGPR.
    OrthoDBi EOG7JQBNT.
    PhylomeDBi P58170.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR1D5.
    GenomeRNAii 8386.
    NextBioi 31390.
    PROi P58170.

    Gene expression databases

    CleanExi HS_OR1D5.
    Genevestigatori P58170.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence, structure, and evolution of a complete human olfactory receptor gene cluster."
      Glusman G., Sosinsky A., Ben-Asher E., Avidan N., Sonkin D., Bahar A., Rosenthal A., Clifton S., Roe B., Ferraz C., Demaille J.G., Lancet D.
      Genomics 63:227-245(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Ferraz C., Demaille J.G.
      Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-282.

    Entry informationi

    Entry nameiOR1D5_HUMAN
    AccessioniPrimary (citable) accession number: P58170
    Secondary accession number(s): Q96RA6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: June 20, 2001
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3