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Protein

Olfactory receptor 1D5

Gene

OR1D5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  • G-protein coupled receptor activity Source: ProtInc
  • olfactory receptor activity Source: ProtInc

GO - Biological processi

  • detection of chemical stimulus involved in sensory perception of smell Source: GOC
  • G-protein coupled receptor signaling pathway Source: ProtInc
  • sensory perception of smell Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 1D5
Alternative name(s):
Olfactory receptor 17-31
Short name:
OR17-31
Gene namesi
Name:OR1D5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:8186. OR1D5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
BLAST
Transmembranei26 – 4924Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini50 – 578CytoplasmicSequence Analysis
Transmembranei58 – 7922Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini80 – 10021ExtracellularSequence AnalysisAdd
BLAST
Transmembranei101 – 12020Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini121 – 14020CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei141 – 15818Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini159 – 19638ExtracellularSequence AnalysisAdd
BLAST
Transmembranei197 – 22024Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini221 – 23717CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei238 – 26023Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini261 – 27111ExtracellularSequence AnalysisAdd
BLAST
Transmembranei272 – 29120Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini292 – 31221CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32060.

Polymorphism and mutation databases

BioMutaiOR1D5.
DMDMi14423784.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Olfactory receptor 1D5PRO_0000150422Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP58170.

Expressioni

Gene expression databases

CleanExiHS_OR1D5.
GenevestigatoriP58170.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000327564.

Structurei

3D structure databases

ProteinModelPortaliP58170.
SMRiP58170. Positions 32-295.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000119207.
HOVERGENiHBG017625.
InParanoidiP58170.
KOiK04257.
OMAiFMTTSYV.
OrthoDBiEOG7JQBNT.
PhylomeDBiP58170.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P58170-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGDNQSENS QFLLLGISES PEQQRILFWM FLSMYLVTVL GNVLIILAIS
60 70 80 90 100
SDSHLHTPMY FFLANLSFTD LFFVTNTIPK MLVNFQSQNK AISYAGCLTQ
110 120 130 140 150
LYFLVSLVTL DNLILAVMAY DRYVATCCPL HYVTAMSPGL CVLLLSLCWG
160 170 180 190 200
LSVLYGLLLT FLLTRVTFCG PREIHYLFCD MYILLWLACS NTHIIHTALI
210 220 230 240 250
ATGCFIFLTP LGFMTTSYVR IVRTILQMPS ASKKYKTFST CASHLGVVSL
260 270 280 290 300
FYGTLAMVYL QPLHTYSMKD SVATVMYAVL TPMMNPFIYR LRNKDMHGAP
310
GRVLWRPFQR PK
Length:312
Mass (Da):35,424
Last modified:June 20, 2001 - v1
Checksum:i94D238A76AE37829
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087923 Genomic DNA. Translation: AAF37313.1.
U53930 Genomic DNA. Translation: AAD10841.1.
AF399533 Genomic DNA. Translation: AAK95018.1.
CCDSiCCDS58499.1.
RefSeqiNP_055381.1. NM_014566.1.
UniGeneiHs.553508.

Genome annotation databases

EnsembliENST00000575751; ENSP00000459028; ENSG00000262628.
GeneIDi8386.
KEGGihsa:8386.
UCSCiuc021tns.1. human.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087923 Genomic DNA. Translation: AAF37313.1.
U53930 Genomic DNA. Translation: AAD10841.1.
AF399533 Genomic DNA. Translation: AAK95018.1.
CCDSiCCDS58499.1.
RefSeqiNP_055381.1. NM_014566.1.
UniGeneiHs.553508.

3D structure databases

ProteinModelPortaliP58170.
SMRiP58170. Positions 32-295.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000327564.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR1D5.
DMDMi14423784.

Proteomic databases

PRIDEiP58170.

Protocols and materials databases

DNASUi8386.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000575751; ENSP00000459028; ENSG00000262628.
GeneIDi8386.
KEGGihsa:8386.
UCSCiuc021tns.1. human.

Organism-specific databases

CTDi8386.
GeneCardsiGC17M002965.
HGNCiHGNC:8186. OR1D5.
neXtProtiNX_P58170.
PharmGKBiPA32060.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000119207.
HOVERGENiHBG017625.
InParanoidiP58170.
KOiK04257.
OMAiFMTTSYV.
OrthoDBiEOG7JQBNT.
PhylomeDBiP58170.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR1D5.
GenomeRNAii8386.
NextBioi31390.
PROiP58170.

Gene expression databases

CleanExiHS_OR1D5.
GenevestigatoriP58170.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sequence, structure, and evolution of a complete human olfactory receptor gene cluster."
    Glusman G., Sosinsky A., Ben-Asher E., Avidan N., Sonkin D., Bahar A., Rosenthal A., Clifton S., Roe B., Ferraz C., Demaille J.G., Lancet D.
    Genomics 63:227-245(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Ferraz C., Demaille J.G.
    Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-282.

Entry informationi

Entry nameiOR1D5_HUMAN
AccessioniPrimary (citable) accession number: P58170
Secondary accession number(s): Q96RA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: June 20, 2001
Last modified: April 29, 2015
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.