P58166 (INHBE_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Inhibin beta E chain

Alternative name(s):
Activin beta-E chain

Gene names

Name:

INHBE

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	350 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
Subunit structure	Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only By similarity.
Subcellular location	Secreted By similarity.
Sequence similarities	Belongs to the TGF-beta family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Molecular function	Growth factor Hormone
PTM	Cleavage on pair of basic residues Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	growth Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular region Traceable author statement. Source: Reactome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Propeptide	20 – 236	217	Potential		PRO_0000033736
	Chain	237 – 350	114	Inhibin beta E chain		PRO_0000033737
Amino acid modifications
	Glycosylation	198	1	N-linked (GlcNAc...) Ref.4
	Disulfide bond	240 ↔ 248		By similarity
	Disulfide bond	247 ↔ 315		By similarity
	Disulfide bond	276 ↔ 347		By similarity
	Disulfide bond	280 ↔ 349		By similarity
	Disulfide bond	314		Interchain By similarity
Natural variations
	Natural variant	62	1	R → T in a breast cancer sample; somatic mutation. Ref.5		VAR_036198
	Natural variant	215	1	Q → H in a breast cancer sample; somatic mutation. Ref.5		VAR_036199

Sequences

	Sequence		Length	Mass (Da)
	P58166 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: A49C1495677E3E6F	FASTA	350	38,561
	10 20 30 40 50 60 MRLPDVQLWL VLLWALVRAQ GTGSVCPSCG GSKLAPQAER ALVLELAKQQ ILDGLHLTSR 70 80 90 100 110 120 PRITHPPPQA ALTRALRRLQ PGSVAPGNGE EVISFATVTD STSAYSSLLT FHLSTPRSHH 130 140 150 160 170 180 LYHARLWLHV LPTLPGTLCL RIFRWGPRRR RQGSRTLLAE HHITNLGWHT LTLPSSGLRG 190 200 210 220 230 240 EKSGVLKLQL DCRPLEGNST VTGQPRRLLD TAGHQQPFLE LKIRANEPGA GRARRRTPTC 250 260 270 280 290 300 EPATPLCCRR DHYVDFQELG WRDWILQPEG YQLNYCSGQC PPHLAGSPGI AASFHSAVFS 310 320 330 340 350 LLKANNPWPA STSCCVPTAR RPLSLLYLDH NGNVVKTDVP DMVVEACGCS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"cDNA cloning and expression of human activin betaE subunit." Hashimoto O., Tsuchida K., Ushiro Y., Hosoi Y., Hoshi N., Sugino H., Hasegawa Y. Mol. Cell. Endocrinol. 194:117-122(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Muscle.
[4]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-198, MASS SPECTROMETRY. Tissue: Liver.
[5]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] THR-62 AND HIS-215.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF412024 mRNA. Translation: AAN03682.1. AK075285 mRNA. Translation: BAC11521.1. BC005161 mRNA. Translation: AAH05161.1.
IPI	IPI00011036.
RefSeq	NP_113667.1. NM_031479.3.
UniGene	Hs.632713.
3D structure databases
ProteinModelPortal	P58166.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000266646.
Polymorphism databases
DMDM	14285500.
Proteomic databases
PaxDb	P58166.
PeptideAtlas	P58166.
PRIDE	P58166.
Protocols and materials databases
DNASU	83729.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000266646; ENSP00000266646; ENSG00000139269.
GeneID	83729.
KEGG	hsa:83729.
UCSC	uc001snw.3. human.
Organism-specific databases
CTD	83729.
GeneCards	GC12P057849.
HGNC	HGNC:24029. INHBE.
HPA	HPA016843.
MIM	612031. gene.
neXtProt	NX_P58166.
PharmGKB	PA134898991.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG296956.
HOGENOM	HOG000220890.
HOVERGEN	HBG105613.
InParanoid	P58166.
KO	K04667.
OMA	WILQPEG.
OrthoDB	EOG47D9GF.
PhylomeDB	P58166.
Gene expression databases
ArrayExpress	P58166.
Bgee	P58166.
CleanEx	HS_INHBE.
Genevestigator	P58166.
GermOnline	ENSG00000139269. Homo sapiens.
Family and domain databases
InterPro	IPR001318. Inhibin_betaC. IPR001839. TGF-b_C. IPR001111. TGF-b_N. IPR015615. TGF-beta-rel. IPR017948. TGFb_CS. [Graphical view]
PANTHER	PTHR11848. PTHR11848. 1 hit.
Pfam	PF00019. TGF_beta. 1 hit. PF00688. TGFb_propeptide. 1 hit. [Graphical view]
PRINTS	PR00672. INHIBINBC.
SMART	SM00204. TGFB. 1 hit. [Graphical view]
PROSITE	PS00250. TGF_BETA_1. 1 hit. PS51362. TGF_BETA_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	83729.
NextBio	72723.
SOURCE	Search...

Entry information

Entry name

INHBE_HUMAN

Accession

Primary (citable) accession number: P58166

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 2001
Last sequence update:	June 1, 2001
Last modified:	May 1, 2013
This is version 100 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.