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P58166

- INHBE_HUMAN

UniProt

P58166 - INHBE_HUMAN

Protein

Inhibin beta E chain

Gene

INHBE

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

    GO - Biological processi

    1. growth Source: InterPro

    Keywords - Molecular functioni

    Growth factor, Hormone

    Enzyme and pathway databases

    ReactomeiREACT_15398. Glycoprotein hormones.
    SignaLinkiP58166.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inhibin beta E chain
    Alternative name(s):
    Activin beta-E chain
    Gene namesi
    Name:INHBE
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:24029. INHBE.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134898991.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Propeptidei20 – 236217Sequence AnalysisPRO_0000033736Add
    BLAST
    Chaini237 – 350114Inhibin beta E chainPRO_0000033737Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi198 – 1981N-linked (GlcNAc...)1 Publication
    Disulfide bondi240 ↔ 248By similarity
    Disulfide bondi247 ↔ 315By similarity
    Disulfide bondi276 ↔ 347By similarity
    Disulfide bondi280 ↔ 349By similarity
    Disulfide bondi314 – 314InterchainBy similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiP58166.
    PaxDbiP58166.
    PeptideAtlasiP58166.
    PRIDEiP58166.

    Expressioni

    Gene expression databases

    ArrayExpressiP58166.
    BgeeiP58166.
    CleanExiHS_INHBE.
    GenevestigatoriP58166.

    Organism-specific databases

    HPAiHPA016843.

    Interactioni

    Subunit structurei

    Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only By similarity.By similarity

    Protein-protein interaction databases

    BioGridi123742. 3 interactions.
    STRINGi9606.ENSP00000266646.

    Structurei

    3D structure databases

    ProteinModelPortaliP58166.
    SMRiP58166. Positions 246-350.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TGF-beta family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG296956.
    HOGENOMiHOG000220890.
    HOVERGENiHBG105613.
    InParanoidiP58166.
    KOiK04667.
    OMAiWILQPEG.
    PhylomeDBiP58166.
    TreeFamiTF318514.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR001318. Inhibin_betaC.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    [Graphical view]
    PANTHERiPTHR11848. PTHR11848. 1 hit.
    PfamiPF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view]
    PRINTSiPR00672. INHIBINBC.
    SMARTiSM00204. TGFB. 1 hit.
    [Graphical view]
    SUPFAMiSSF57501. SSF57501. 1 hit.
    PROSITEiPS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P58166-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRLPDVQLWL VLLWALVRAQ GTGSVCPSCG GSKLAPQAER ALVLELAKQQ    50
    ILDGLHLTSR PRITHPPPQA ALTRALRRLQ PGSVAPGNGE EVISFATVTD 100
    STSAYSSLLT FHLSTPRSHH LYHARLWLHV LPTLPGTLCL RIFRWGPRRR 150
    RQGSRTLLAE HHITNLGWHT LTLPSSGLRG EKSGVLKLQL DCRPLEGNST 200
    VTGQPRRLLD TAGHQQPFLE LKIRANEPGA GRARRRTPTC EPATPLCCRR 250
    DHYVDFQELG WRDWILQPEG YQLNYCSGQC PPHLAGSPGI AASFHSAVFS 300
    LLKANNPWPA STSCCVPTAR RPLSLLYLDH NGNVVKTDVP DMVVEACGCS 350
    Length:350
    Mass (Da):38,561
    Last modified:June 1, 2001 - v1
    Checksum:iA49C1495677E3E6F
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti62 – 621R → T in a breast cancer sample; somatic mutation. 1 Publication
    VAR_036198
    Natural varianti215 – 2151Q → H in a breast cancer sample; somatic mutation. 1 Publication
    VAR_036199

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF412024 mRNA. Translation: AAN03682.1.
    AK075285 mRNA. Translation: BAC11521.1.
    BC005161 mRNA. Translation: AAH05161.1.
    CCDSiCCDS8939.1.
    RefSeqiNP_113667.1. NM_031479.3.
    UniGeneiHs.632713.

    Genome annotation databases

    EnsembliENST00000266646; ENSP00000266646; ENSG00000139269.
    GeneIDi83729.
    KEGGihsa:83729.
    UCSCiuc001snw.3. human.

    Polymorphism databases

    DMDMi14285500.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF412024 mRNA. Translation: AAN03682.1 .
    AK075285 mRNA. Translation: BAC11521.1 .
    BC005161 mRNA. Translation: AAH05161.1 .
    CCDSi CCDS8939.1.
    RefSeqi NP_113667.1. NM_031479.3.
    UniGenei Hs.632713.

    3D structure databases

    ProteinModelPortali P58166.
    SMRi P58166. Positions 246-350.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123742. 3 interactions.
    STRINGi 9606.ENSP00000266646.

    Polymorphism databases

    DMDMi 14285500.

    Proteomic databases

    MaxQBi P58166.
    PaxDbi P58166.
    PeptideAtlasi P58166.
    PRIDEi P58166.

    Protocols and materials databases

    DNASUi 83729.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000266646 ; ENSP00000266646 ; ENSG00000139269 .
    GeneIDi 83729.
    KEGGi hsa:83729.
    UCSCi uc001snw.3. human.

    Organism-specific databases

    CTDi 83729.
    GeneCardsi GC12P057849.
    HGNCi HGNC:24029. INHBE.
    HPAi HPA016843.
    MIMi 612031. gene.
    neXtProti NX_P58166.
    PharmGKBi PA134898991.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG296956.
    HOGENOMi HOG000220890.
    HOVERGENi HBG105613.
    InParanoidi P58166.
    KOi K04667.
    OMAi WILQPEG.
    PhylomeDBi P58166.
    TreeFami TF318514.

    Enzyme and pathway databases

    Reactomei REACT_15398. Glycoprotein hormones.
    SignaLinki P58166.

    Miscellaneous databases

    GenomeRNAii 83729.
    NextBioi 72723.
    PROi P58166.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P58166.
    Bgeei P58166.
    CleanExi HS_INHBE.
    Genevestigatori P58166.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR001318. Inhibin_betaC.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    [Graphical view ]
    PANTHERi PTHR11848. PTHR11848. 1 hit.
    Pfami PF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view ]
    PRINTSi PR00672. INHIBINBC.
    SMARTi SM00204. TGFB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57501. SSF57501. 1 hit.
    PROSITEi PS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Muscle.
    4. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-198.
      Tissue: Liver.
    5. Cited for: VARIANTS [LARGE SCALE ANALYSIS] THR-62 AND HIS-215.

    Entry informationi

    Entry nameiINHBE_HUMAN
    AccessioniPrimary (citable) accession number: P58166
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 2001
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3