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Protein

Inhibin beta E chain

Gene

INHBE

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

GO - Molecular functioni

  1. cytokine activity Source: GO_Central
  2. transforming growth factor beta receptor binding Source: GO_Central

GO - Biological processi

  1. cell development Source: GO_Central
  2. growth Source: InterPro
  3. positive regulation of pathway-restricted SMAD protein phosphorylation Source: GO_Central
  4. regulation of apoptotic process Source: GO_Central
  5. regulation of MAPK cascade Source: GO_Central
  6. SMAD protein signal transduction Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Growth factor, Hormone

Enzyme and pathway databases

ReactomeiREACT_15398. Glycoprotein hormones.
SignaLinkiP58166.

Names & Taxonomyi

Protein namesi
Recommended name:
Inhibin beta E chain
Alternative name(s):
Activin beta-E chain
Gene namesi
Name:INHBE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:24029. INHBE.

Subcellular locationi

  1. Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134898991.

Polymorphism and mutation databases

BioMutaiINHBE.
DMDMi14285500.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Propeptidei20 – 236217Sequence AnalysisPRO_0000033736Add
BLAST
Chaini237 – 350114Inhibin beta E chainPRO_0000033737Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi198 – 1981N-linked (GlcNAc...)1 Publication
Disulfide bondi240 ↔ 248By similarity
Disulfide bondi247 ↔ 315By similarity
Disulfide bondi276 ↔ 347By similarity
Disulfide bondi280 ↔ 349By similarity
Disulfide bondi314 – 314InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP58166.
PaxDbiP58166.
PeptideAtlasiP58166.
PRIDEiP58166.

Expressioni

Gene expression databases

BgeeiP58166.
CleanExiHS_INHBE.
ExpressionAtlasiP58166. baseline and differential.
GenevestigatoriP58166.

Organism-specific databases

HPAiCAB034017.
HPA016843.

Interactioni

Subunit structurei

Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only (By similarity).By similarity

Protein-protein interaction databases

BioGridi123742. 6 interactions.
STRINGi9606.ENSP00000266646.

Structurei

3D structure databases

SMRiP58166. Positions 246-350.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG296956.
GeneTreeiENSGT00760000119112.
HOGENOMiHOG000220890.
HOVERGENiHBG105613.
InParanoidiP58166.
KOiK04667.
OMAiGYQLNYC.
PhylomeDBiP58166.
TreeFamiTF318514.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001318. Inhibin_betaC.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PRINTSiPR00672. INHIBINBC.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P58166-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLPDVQLWL VLLWALVRAQ GTGSVCPSCG GSKLAPQAER ALVLELAKQQ
60 70 80 90 100
ILDGLHLTSR PRITHPPPQA ALTRALRRLQ PGSVAPGNGE EVISFATVTD
110 120 130 140 150
STSAYSSLLT FHLSTPRSHH LYHARLWLHV LPTLPGTLCL RIFRWGPRRR
160 170 180 190 200
RQGSRTLLAE HHITNLGWHT LTLPSSGLRG EKSGVLKLQL DCRPLEGNST
210 220 230 240 250
VTGQPRRLLD TAGHQQPFLE LKIRANEPGA GRARRRTPTC EPATPLCCRR
260 270 280 290 300
DHYVDFQELG WRDWILQPEG YQLNYCSGQC PPHLAGSPGI AASFHSAVFS
310 320 330 340 350
LLKANNPWPA STSCCVPTAR RPLSLLYLDH NGNVVKTDVP DMVVEACGCS
Length:350
Mass (Da):38,561
Last modified:June 1, 2001 - v1
Checksum:iA49C1495677E3E6F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti62 – 621R → T in a breast cancer sample; somatic mutation. 1 Publication
VAR_036198
Natural varianti215 – 2151Q → H in a breast cancer sample; somatic mutation. 1 Publication
VAR_036199

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF412024 mRNA. Translation: AAN03682.1.
AK075285 mRNA. Translation: BAC11521.1.
BC005161 mRNA. Translation: AAH05161.1.
CCDSiCCDS8939.1.
RefSeqiNP_113667.1. NM_031479.3.
UniGeneiHs.632713.

Genome annotation databases

EnsembliENST00000266646; ENSP00000266646; ENSG00000139269.
GeneIDi83729.
KEGGihsa:83729.
UCSCiuc001snw.3. human.

Polymorphism and mutation databases

BioMutaiINHBE.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF412024 mRNA. Translation: AAN03682.1.
AK075285 mRNA. Translation: BAC11521.1.
BC005161 mRNA. Translation: AAH05161.1.
CCDSiCCDS8939.1.
RefSeqiNP_113667.1. NM_031479.3.
UniGeneiHs.632713.

3D structure databases

SMRiP58166. Positions 246-350.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123742. 6 interactions.
STRINGi9606.ENSP00000266646.

Polymorphism and mutation databases

BioMutaiINHBE.
DMDMi14285500.

Proteomic databases

MaxQBiP58166.
PaxDbiP58166.
PeptideAtlasiP58166.
PRIDEiP58166.

Protocols and materials databases

DNASUi83729.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000266646; ENSP00000266646; ENSG00000139269.
GeneIDi83729.
KEGGihsa:83729.
UCSCiuc001snw.3. human.

Organism-specific databases

CTDi83729.
GeneCardsiGC12P057849.
HGNCiHGNC:24029. INHBE.
HPAiCAB034017.
HPA016843.
MIMi612031. gene.
neXtProtiNX_P58166.
PharmGKBiPA134898991.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG296956.
GeneTreeiENSGT00760000119112.
HOGENOMiHOG000220890.
HOVERGENiHBG105613.
InParanoidiP58166.
KOiK04667.
OMAiGYQLNYC.
PhylomeDBiP58166.
TreeFamiTF318514.

Enzyme and pathway databases

ReactomeiREACT_15398. Glycoprotein hormones.
SignaLinkiP58166.

Miscellaneous databases

GenomeRNAii83729.
NextBioi72723.
PROiP58166.
SOURCEiSearch...

Gene expression databases

BgeeiP58166.
CleanExiHS_INHBE.
ExpressionAtlasiP58166. baseline and differential.
GenevestigatoriP58166.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001318. Inhibin_betaC.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PRINTSiPR00672. INHIBINBC.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Muscle.
  4. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-198.
    Tissue: Liver.
  5. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  6. Cited for: VARIANTS [LARGE SCALE ANALYSIS] THR-62 AND HIS-215.

Entry informationi

Entry nameiINHBE_HUMAN
AccessioniPrimary (citable) accession number: P58166
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: June 1, 2001
Last modified: April 29, 2015
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.