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P58166

- INHBE_HUMAN

UniProt

P58166 - INHBE_HUMAN

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Protein
Inhibin beta E chain
Gene
INHBE
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

GO - Biological processi

  1. growth Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Growth factor, Hormone

Enzyme and pathway databases

ReactomeiREACT_15398. Glycoprotein hormones.
SignaLinkiP58166.

Names & Taxonomyi

Protein namesi
Recommended name:
Inhibin beta E chain
Alternative name(s):
Activin beta-E chain
Gene namesi
Name:INHBE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:24029. INHBE.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134898991.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed prediction
Add
BLAST
Propeptidei20 – 236217 Reviewed prediction
PRO_0000033736Add
BLAST
Chaini237 – 350114Inhibin beta E chain
PRO_0000033737Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi198 – 1981N-linked (GlcNAc...)1 Publication
Disulfide bondi240 ↔ 248 By similarity
Disulfide bondi247 ↔ 315 By similarity
Disulfide bondi276 ↔ 347 By similarity
Disulfide bondi280 ↔ 349 By similarity
Disulfide bondi314 – 314Interchain By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP58166.
PaxDbiP58166.
PeptideAtlasiP58166.
PRIDEiP58166.

Expressioni

Gene expression databases

ArrayExpressiP58166.
BgeeiP58166.
CleanExiHS_INHBE.
GenevestigatoriP58166.

Organism-specific databases

HPAiHPA016843.

Interactioni

Subunit structurei

Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only By similarity.

Protein-protein interaction databases

BioGridi123742. 3 interactions.
STRINGi9606.ENSP00000266646.

Structurei

3D structure databases

ProteinModelPortaliP58166.
SMRiP58166. Positions 246-350.

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG296956.
HOGENOMiHOG000220890.
HOVERGENiHBG105613.
InParanoidiP58166.
KOiK04667.
OMAiWILQPEG.
PhylomeDBiP58166.
TreeFamiTF318514.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001318. Inhibin_betaC.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PRINTSiPR00672. INHIBINBC.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P58166-1 [UniParc]FASTAAdd to Basket

« Hide

MRLPDVQLWL VLLWALVRAQ GTGSVCPSCG GSKLAPQAER ALVLELAKQQ    50
ILDGLHLTSR PRITHPPPQA ALTRALRRLQ PGSVAPGNGE EVISFATVTD 100
STSAYSSLLT FHLSTPRSHH LYHARLWLHV LPTLPGTLCL RIFRWGPRRR 150
RQGSRTLLAE HHITNLGWHT LTLPSSGLRG EKSGVLKLQL DCRPLEGNST 200
VTGQPRRLLD TAGHQQPFLE LKIRANEPGA GRARRRTPTC EPATPLCCRR 250
DHYVDFQELG WRDWILQPEG YQLNYCSGQC PPHLAGSPGI AASFHSAVFS 300
LLKANNPWPA STSCCVPTAR RPLSLLYLDH NGNVVKTDVP DMVVEACGCS 350
Length:350
Mass (Da):38,561
Last modified:June 1, 2001 - v1
Checksum:iA49C1495677E3E6F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti62 – 621R → T in a breast cancer sample; somatic mutation. 1 Publication
VAR_036198
Natural varianti215 – 2151Q → H in a breast cancer sample; somatic mutation. 1 Publication
VAR_036199

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF412024 mRNA. Translation: AAN03682.1.
AK075285 mRNA. Translation: BAC11521.1.
BC005161 mRNA. Translation: AAH05161.1.
CCDSiCCDS8939.1.
RefSeqiNP_113667.1. NM_031479.3.
UniGeneiHs.632713.

Genome annotation databases

EnsembliENST00000266646; ENSP00000266646; ENSG00000139269.
GeneIDi83729.
KEGGihsa:83729.
UCSCiuc001snw.3. human.

Polymorphism databases

DMDMi14285500.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF412024 mRNA. Translation: AAN03682.1 .
AK075285 mRNA. Translation: BAC11521.1 .
BC005161 mRNA. Translation: AAH05161.1 .
CCDSi CCDS8939.1.
RefSeqi NP_113667.1. NM_031479.3.
UniGenei Hs.632713.

3D structure databases

ProteinModelPortali P58166.
SMRi P58166. Positions 246-350.
ModBasei Search...

Protein-protein interaction databases

BioGridi 123742. 3 interactions.
STRINGi 9606.ENSP00000266646.

Polymorphism databases

DMDMi 14285500.

Proteomic databases

MaxQBi P58166.
PaxDbi P58166.
PeptideAtlasi P58166.
PRIDEi P58166.

Protocols and materials databases

DNASUi 83729.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000266646 ; ENSP00000266646 ; ENSG00000139269 .
GeneIDi 83729.
KEGGi hsa:83729.
UCSCi uc001snw.3. human.

Organism-specific databases

CTDi 83729.
GeneCardsi GC12P057849.
HGNCi HGNC:24029. INHBE.
HPAi HPA016843.
MIMi 612031. gene.
neXtProti NX_P58166.
PharmGKBi PA134898991.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG296956.
HOGENOMi HOG000220890.
HOVERGENi HBG105613.
InParanoidi P58166.
KOi K04667.
OMAi WILQPEG.
PhylomeDBi P58166.
TreeFami TF318514.

Enzyme and pathway databases

Reactomei REACT_15398. Glycoprotein hormones.
SignaLinki P58166.

Miscellaneous databases

GenomeRNAii 83729.
NextBioi 72723.
PROi P58166.
SOURCEi Search...

Gene expression databases

ArrayExpressi P58166.
Bgeei P58166.
CleanExi HS_INHBE.
Genevestigatori P58166.

Family and domain databases

Gene3Di 2.10.90.10. 1 hit.
InterProi IPR029034. Cystine-knot_cytokine.
IPR001318. Inhibin_betaC.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view ]
PANTHERi PTHR11848. PTHR11848. 1 hit.
Pfami PF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view ]
PRINTSi PR00672. INHIBINBC.
SMARTi SM00204. TGFB. 1 hit.
[Graphical view ]
SUPFAMi SSF57501. SSF57501. 1 hit.
PROSITEi PS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Muscle.
  4. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-198.
    Tissue: Liver.
  5. Cited for: VARIANTS [LARGE SCALE ANALYSIS] THR-62 AND HIS-215.

Entry informationi

Entry nameiINHBE_HUMAN
AccessioniPrimary (citable) accession number: P58166
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: June 1, 2001
Last modified: September 3, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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