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P58166 (INHBE_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Inhibin beta E chain
Alternative name(s):
Activin beta-E chain
Gene names
Name:INHBE
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length350 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

Subunit structure

Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only By similarity.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the TGF-beta family.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainSignal
   Molecular functionGrowth factor
Hormone
   PTMCleavage on pair of basic residues
Disulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processgrowth

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Propeptide20 – 236217 Potential
PRO_0000033736
Chain237 – 350114Inhibin beta E chain
PRO_0000033737

Amino acid modifications

Glycosylation1981N-linked (GlcNAc...) Ref.4
Disulfide bond240 ↔ 248 By similarity
Disulfide bond247 ↔ 315 By similarity
Disulfide bond276 ↔ 347 By similarity
Disulfide bond280 ↔ 349 By similarity
Disulfide bond314Interchain By similarity

Natural variations

Natural variant621R → T in a breast cancer sample; somatic mutation. Ref.5
VAR_036198
Natural variant2151Q → H in a breast cancer sample; somatic mutation. Ref.5
VAR_036199

Sequences

Sequence LengthMass (Da)Tools
P58166 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: A49C1495677E3E6F

FASTA35038,561
        10         20         30         40         50         60 
MRLPDVQLWL VLLWALVRAQ GTGSVCPSCG GSKLAPQAER ALVLELAKQQ ILDGLHLTSR 

        70         80         90        100        110        120 
PRITHPPPQA ALTRALRRLQ PGSVAPGNGE EVISFATVTD STSAYSSLLT FHLSTPRSHH 

       130        140        150        160        170        180 
LYHARLWLHV LPTLPGTLCL RIFRWGPRRR RQGSRTLLAE HHITNLGWHT LTLPSSGLRG 

       190        200        210        220        230        240 
EKSGVLKLQL DCRPLEGNST VTGQPRRLLD TAGHQQPFLE LKIRANEPGA GRARRRTPTC 

       250        260        270        280        290        300 
EPATPLCCRR DHYVDFQELG WRDWILQPEG YQLNYCSGQC PPHLAGSPGI AASFHSAVFS 

       310        320        330        340        350 
LLKANNPWPA STSCCVPTAR RPLSLLYLDH NGNVVKTDVP DMVVEACGCS 

« Hide

References

« Hide 'large scale' references
[1]"cDNA cloning and expression of human activin betaE subunit."
Hashimoto O., Tsuchida K., Ushiro Y., Hosoi Y., Hoshi N., Sugino H., Hasegawa Y.
Mol. Cell. Endocrinol. 194:117-122(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Muscle.
[4]"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-198.
Tissue: Liver.
[5]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS [LARGE SCALE ANALYSIS] THR-62 AND HIS-215.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF412024 mRNA. Translation: AAN03682.1.
AK075285 mRNA. Translation: BAC11521.1.
BC005161 mRNA. Translation: AAH05161.1.
CCDSCCDS8939.1.
RefSeqNP_113667.1. NM_031479.3.
UniGeneHs.632713.

3D structure databases

ProteinModelPortalP58166.
SMRP58166. Positions 246-350.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid123742. 3 interactions.
STRING9606.ENSP00000266646.

Polymorphism databases

DMDM14285500.

Proteomic databases

MaxQBP58166.
PaxDbP58166.
PeptideAtlasP58166.
PRIDEP58166.

Protocols and materials databases

DNASU83729.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000266646; ENSP00000266646; ENSG00000139269.
GeneID83729.
KEGGhsa:83729.
UCSCuc001snw.3. human.

Organism-specific databases

CTD83729.
GeneCardsGC12P057849.
HGNCHGNC:24029. INHBE.
HPAHPA016843.
MIM612031. gene.
neXtProtNX_P58166.
PharmGKBPA134898991.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG296956.
HOGENOMHOG000220890.
HOVERGENHBG105613.
InParanoidP58166.
KOK04667.
OMAWILQPEG.
PhylomeDBP58166.
TreeFamTF318514.

Enzyme and pathway databases

SignaLinkP58166.

Gene expression databases

ArrayExpressP58166.
BgeeP58166.
CleanExHS_INHBE.
GenevestigatorP58166.

Family and domain databases

Gene3D2.10.90.10. 1 hit.
InterProIPR029034. Cystine-knot_cytokine.
IPR001318. Inhibin_betaC.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERPTHR11848. PTHR11848. 1 hit.
PfamPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PRINTSPR00672. INHIBINBC.
SMARTSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMSSF57501. SSF57501. 1 hit.
PROSITEPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi83729.
NextBio72723.
PROP58166.
SOURCESearch...

Entry information

Entry nameINHBE_HUMAN
AccessionPrimary (citable) accession number: P58166
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM